Gina Kuperberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Neural mechanisms of language comprehension: challenges to syntax
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Brain Res 1146:23-49. 2007
  2. pmc Neuroanatomical distinctions within the semantic system during sentence comprehension: evidence from functional magnetic resonance imaging
    Gina R Kuperberg
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Neuroimage 40:367-88. 2008
  3. pmc An investigation of concurrent ERP and self-paced reading methodologies
    Tali Ditman
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychophysiology 44:927-35. 2007
  4. pmc Task and semantic relationship influence both the polarity and localization of hemodynamic modulation during lexico-semantic processing
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Hum Brain Mapp 29:544-61. 2008
  5. ncbi request reprint Increased temporal and prefrontal activity in response to semantic associations in schizophrenia
    Gina R Kuperberg
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Arch Gen Psychiatry 64:138-51. 2007
  6. pmc Building meaning in schizophrenia
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, Massachusetts, USA
    Clin EEG Neurosci 39:99-102. 2008
  7. ncbi request reprint Making sense of discourse: an fMRI study of causal inferencing across sentences
    Gina R Kuperberg
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Neuroimage 33:343-61. 2006
  8. ncbi request reprint Building up linguistic context in schizophrenia: evidence from self-paced reading
    Gina R Kuperberg
    Department of Psychology, Tufts University, and Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Neuropsychology 20:442-52. 2006
  9. ncbi request reprint Making sense of sentences in schizophrenia: electrophysiological evidence for abnormal interactions between semantic and syntactic processing
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA, USA
    J Abnorm Psychol 115:251-65. 2006
  10. ncbi request reprint The role of animacy and thematic relationships in processing active English sentences: evidence from event-related potentials
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA 02155, and Department of Psychiatry, Massachusetts General Hospital, Bldg 149, 13th Street, Charlestown, MA 02129, USA
    Brain Lang 100:223-37. 2007

Research Grants

  1. LANGUAGE PROCESSING IN SCHIZOPHRENIA
    Gina Kuperberg; Fiscal Year: 2005
  2. Spatiotemporal imaging of language in schizophrenia
    Gina Kuperberg; Fiscal Year: 2009
  3. Spatiotemporal imaging of language in schizophrenia
    Gina R Kuperberg; Fiscal Year: 2010

Detail Information

Publications38

  1. ncbi request reprint Neural mechanisms of language comprehension: challenges to syntax
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Brain Res 1146:23-49. 2007
    ..Finally, I suggest that that these two processing streams may generalize beyond the language system to real-world visual event comprehension...
  2. pmc Neuroanatomical distinctions within the semantic system during sentence comprehension: evidence from functional magnetic resonance imaging
    Gina R Kuperberg
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Neuroimage 40:367-88. 2008
    ....
  3. pmc An investigation of concurrent ERP and self-paced reading methodologies
    Tali Ditman
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychophysiology 44:927-35. 2007
    ....
  4. pmc Task and semantic relationship influence both the polarity and localization of hemodynamic modulation during lexico-semantic processing
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Hum Brain Mapp 29:544-61. 2008
    ..These findings are discussed in relation to the specific neurocognitive processes thought to underlie implicit and explicit semantic processes. Hum Brain Mapp, 2008. (c) 2007 Wiley-Liss, Inc...
  5. ncbi request reprint Increased temporal and prefrontal activity in response to semantic associations in schizophrenia
    Gina R Kuperberg
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Arch Gen Psychiatry 64:138-51. 2007
    ..Loosening of associations has long been considered a core feature of schizophrenia, but its neural correlate remains poorly understood...
  6. pmc Building meaning in schizophrenia
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, Massachusetts, USA
    Clin EEG Neurosci 39:99-102. 2008
    ....
  7. ncbi request reprint Making sense of discourse: an fMRI study of causal inferencing across sentences
    Gina R Kuperberg
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Neuroimage 33:343-61. 2006
    ..We suggest that this network reflects the activation, retrieval and integration of information from long-term semantic memory into incoming discourse structure during causal inferencing...
  8. ncbi request reprint Building up linguistic context in schizophrenia: evidence from self-paced reading
    Gina R Kuperberg
    Department of Psychology, Tufts University, and Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Neuropsychology 20:442-52. 2006
    ..The relative insensitivity to these violations in patients with schizophrenia may arise from impairments in combining semantic and syntactic information to build up sentence context...
  9. ncbi request reprint Making sense of sentences in schizophrenia: electrophysiological evidence for abnormal interactions between semantic and syntactic processing
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA, USA
    J Abnorm Psychol 115:251-65. 2006
    ....
  10. ncbi request reprint The role of animacy and thematic relationships in processing active English sentences: evidence from event-related potentials
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA 02155, and Department of Psychiatry, Massachusetts General Hospital, Bldg 149, 13th Street, Charlestown, MA 02129, USA
    Brain Lang 100:223-37. 2007
    ..These findings suggest that semantic-thematic relations, related to animacy constraints on verbs' arguments, are computed online and can immediately impact verb processing within active, English sentences...
  11. pmc Functional magnetic resonance imaging reveals neuroanatomical dissociations during semantic integration in schizophrenia
    Gina R Kuperberg
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 64:407-18. 2008
    ..Integration demands were manipulated by varying the nature (concrete vs. abstract) and the congruity (incongruous vs. congruous) of words within sentences...
  12. pmc Selective emotional processing deficits to social vignettes in schizophrenia: an ERP study
    Gina R Kuperberg
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Schizophr Bull 37:148-63. 2011
    ..These findings suggest that schizophrenia is associated with a specific neural deficit during the online evaluation of emotionally valent, socially relevant information...
  13. ncbi request reprint Regionally localized thinning of the cerebral cortex in schizophrenia
    Gina R Kuperberg
    Department of Psychiatry, Massachusetts General Hospital and Athinoula A Martinos Center for Biomedical Imaging, Charlestown, 02129, USA
    Arch Gen Psychiatry 60:878-88. 2003
    ....
  14. ncbi request reprint Electrophysiological distinctions in processing conceptual relationships within simple sentences
    Gina R Kuperberg
    Department of Psychiatry, Massachusetts General Hospital, Bldg 149, 13th Street, Charlestown, MA 02129, USA
    Brain Res Cogn Brain Res 17:117-29. 2003
    ..Our findings suggest a qualitative neural distinction in processing these two types of conceptual anomalies within simple, unambiguous sentences...
  15. pmc Electrophysiological correlates of complement coercion
    Gina R Kuperberg
    Departmentof Psychology, Tufts University, 490 Boston Ave, Medford, MA 02155, USA
    J Cogn Neurosci 22:2685-701. 2010
    ..We suggest that this effect reflected delayed attempts to retrieve the specific event(s) implied by coerced complement nouns...
  16. pmc What can Event-related Potentials tell us about language, and perhaps even thought, in schizophrenia?
    Gina R Kuperberg
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Int J Psychophysiol 75:66-76. 2010
    ..Further investigation of language dysfunction may also provide insights into other aspects of psychotic thought...
  17. pmc Establishing causal coherence across sentences: an ERP study
    Gina R Kuperberg
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    J Cogn Neurosci 23:1230-46. 2011
    ..Further, they suggest that causal coherence, at the situation level, can influence incremental word-by-word discourse comprehension, even when semantic relationships between individual words are matched...
  18. ncbi request reprint Electrophysiological insights into language processing in schizophrenia
    Tatiana Sitnikova
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    Psychophysiology 39:851-60. 2002
    ..This showed that language abnormalities in schizophrenia may be related to deficient processing of context-irrelevant semantic representations of words from the discourse...
  19. pmc Why all the confusion? Experimental task explains discrepant semantic priming effects in schizophrenia under "automatic" conditions: evidence from Event-Related Potentials
    Donna A Kreher
    Department of Psychology, Tufts University, 490 Boston Ave, Medford, MA 02155, USA
    Schizophr Res 111:174-81. 2009
    ....
  20. ncbi request reprint Vascular responses to syntactic processing: event-related fMRI study of relative clauses
    David Caplan
    Neuropsychology Laboratory, Department of Neurology, Vincent Burnham 827, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Hum Brain Mapp 15:26-38. 2002
    ..This study shows that a hemodynamic response associated with processing the syntactically complex portions of a sentence can be localized to one part of the dominant perisylvian association cortex...
  21. pmc Neural evidence for faster and further automatic spreading activation in schizophrenic thought disorder
    Donna A Kreher
    Department of Psychology, University of Massachusetts, Amherst, MA 01003, USA
    Schizophr Bull 34:473-82. 2008
    ....
  22. pmc Time travel through language: temporal shifts rapidly decrease information accessibility during reading
    Tali Ditman
    Tufts University, Medford, Massachusetts 02155, USA
    Psychon Bull Rev 15:750-6. 2008
    ..For the anaphor, the N400 was modulated in the opposite direction. Thus, the introduction of a temporal discontinuity leads to immediate neural integration costs, as well as to decreased accessibility of earlier information...
  23. ncbi request reprint Semantic integration in videos of real-world events: an electrophysiological investigation
    Tatiana Sitnikova
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    Psychophysiology 40:160-4. 2003
    ....
  24. ncbi request reprint The misattribution of salience in delusional patients with schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:247-56. 2006
    ..In this study, we tested the hypothesis that delusional schizophrenia patients are more likely than non-delusional schizophrenia patients and healthy participants to assign affective meanings to neutral stimuli...
  25. ncbi request reprint The time course of building discourse coherence in schizophrenia: an ERP investigation
    Tali Ditman
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychophysiology 44:991-1001. 2007
    ..Results suggest that schizophrenia patients, particularly those with positive thought disorder, fail to make immediate use of discourse context to build up semantic coherence in the brain...
  26. pmc Electrophysiological insights into the processing of nominal metaphors
    Sophie De Grauwe
    Department of Psychology, Tufts University, USA
    Neuropsychologia 48:1965-84. 2010
    ....
  27. pmc Neurophysiological correlates of comprehending emotional meaning in context
    Daphne J Holt
    Massachusetts General Hospital, Boston, MA, USA
    J Cogn Neurosci 21:2245-62. 2009
    ..negative) of words. Thus, emotional processing networks within the brain appear to exert a continuous influence, evident at several stages, on the construction of the emotional meaning of language...
  28. ncbi request reprint Developments in the pharmacological treatment of schizophrenia
    Gina Kuperberg
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Expert Opin Investig Drugs 11:1335-41. 2002
    ..Finally, the implications of the introduction of these new drugs for the management of schizophrenia, are discussed...
  29. ncbi request reprint Distinct patterns of neural modulation during the processing of conceptual and syntactic anomalies
    Gina R Kuperberg
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Cogn Neurosci 15:272-93. 2003
    ..This suggests that morphosyntactic and pragmatic information can be processed in different ways but by the same neural systems...
  30. pmc Neurocognitive mechanisms of conceptual processing in healthy adults and patients with schizophrenia
    Tatiana Sitnikova
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Int J Psychophysiol 75:86-99. 2010
    ....
  31. pmc The neural organization of semantic memory: Electrophysiological activity suggests feature-based segregation
    Tatiana Sitnikova
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Biol Psychol 71:326-40. 2006
    ..The high temporal resolution of ERPs allowed us to demonstrate that differences in processing animals and tools occurred specifically within the time-window encompassing semantic analysis...
  32. pmc Neurocognitive abnormalities during comprehension of real-world goal-directed behaviors in schizophrenia
    Tatiana Sitnikova
    Athinoula A Martinos Center for Biomedical Imaging, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Abnorm Psychol 118:256-77. 2009
    ..Thus, distinct neurocognitive abnormalities may underlie disorganization and goal-directed behavior deficits in schizophrenia...
  33. pmc When the truth is not too hard to handle: an event-related potential study on the pragmatics of negation
    Mante S Nieuwland
    Department of Psychology, Tufts University, 490 Boston Ave, Medford, MA 02155, USA
    Psychol Sci 19:1213-8. 2008
    ..g., "A baby bunny's fur isn't very hard/soft..."). These results suggest that negation poses no principled obstacle for readers to immediately relate incoming words to what they hold to be true...
  34. pmc An electrophysiological investigation of indirect semantic priming
    Donna A Kreher
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Psychophysiology 43:550-63. 2006
    ..These findings are discussed in the context of current theoretical models of semantic memory and semantic priming...
  35. pmc Two neurocognitive mechanisms of semantic integration during the comprehension of visual real-world events
    Tatiana Sitnikova
    Harvard Medical School, Cambridge, MA, USA
    J Cogn Neurosci 20:2037-57. 2008
    ....
  36. pmc Slow and steady: sustained effects of lexico-semantic associations can mediate referential impairments in schizophrenia
    Tali Ditman
    Department of Psychology, Tufts University, Medford, MA, USA
    Cogn Affect Behav Neurosci 11:245-58. 2011
    ..These results suggest that at least some types of referential impairments may be driven by sustained activation of contextually inappropriate lexico-semantic associations...
  37. pmc Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI
    Jonathan J Wisco
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
    Schizophr Res 94:317-27. 2007
    ..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia...
  38. ncbi request reprint A source-monitoring account of auditory verbal hallucinations in patients with schizophrenia
    Tali Ditman
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Harv Rev Psychiatry 13:280-99. 2005
    ..To draw firmer conclusions, however, it is imperative that future studies select patient populations precisely, match control groups, and use consistent criteria for defining hallucinators...

Research Grants8

  1. LANGUAGE PROCESSING IN SCHIZOPHRENIA
    Gina Kuperberg; Fiscal Year: 2005
    ..This training and research program will advance the candidate to the stage when she can establish herself as an independent investigator of the cognitive neuroscience of schizophrenia. ..
  2. Spatiotemporal imaging of language in schizophrenia
    Gina Kuperberg; Fiscal Year: 2009
    ....
  3. Spatiotemporal imaging of language in schizophrenia
    Gina R Kuperberg; Fiscal Year: 2010
    ..This is essential for targeting key neurocognitive systems for the development of new pharmacological and cognitive approaches for remediation. ..