Research Topics
| Gina KuperbergSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Neural mechanisms of language comprehension: challenges to syntaxGina R Kuperberg
Department of Psychology, Tufts University, Medford, MA 02155, USA
Brain Res 1146:23-49. 2007..Finally, I suggest that that these two processing streams may generalize beyond the language system to real-world visual event comprehension...
An investigation of concurrent ERP and self-paced reading methodologiesTali Ditman
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychophysiology 44:927-35. 2007....- Neuroanatomical distinctions within the semantic system during sentence comprehension: evidence from functional magnetic resonance imagingGina R Kuperberg
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
Neuroimage 40:367-88. 2008.... - Task and semantic relationship influence both the polarity and localization of hemodynamic modulation during lexico-semantic processingGina R Kuperberg
Department of Psychology, Tufts University, Medford, MA 02155, USA
Hum Brain Mapp 29:544-61. 2008..These findings are discussed in relation to the specific neurocognitive processes thought to underlie implicit and explicit semantic processes. Hum Brain Mapp, 2008. (c) 2007 Wiley-Liss, Inc... - Increased temporal and prefrontal activity in response to semantic associations in schizophreniaGina R Kuperberg
Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Arch Gen Psychiatry 64:138-51. 2007..Loosening of associations has long been considered a core feature of schizophrenia, but its neural correlate remains poorly understood... - Building meaning in schizophreniaGina R Kuperberg
Department of Psychology, Tufts University, Medford, Massachusetts, USA
Clin EEG Neurosci 39:99-102. 2008.... - Making sense of discourse: an fMRI study of causal inferencing across sentencesGina R Kuperberg
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
Neuroimage 33:343-61. 2006..We suggest that this network reflects the activation, retrieval and integration of information from long-term semantic memory into incoming discourse structure during causal inferencing... - Building up linguistic context in schizophrenia: evidence from self-paced readingGina R Kuperberg
Department of Psychology, Tufts University, and Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
Neuropsychology 20:442-52. 2006..The relative insensitivity to these violations in patients with schizophrenia may arise from impairments in combining semantic and syntactic information to build up sentence context... - Making sense of sentences in schizophrenia: electrophysiological evidence for abnormal interactions between semantic and syntactic processingGina R Kuperberg
Department of Psychology, Tufts University, Medford, MA, USA
J Abnorm Psychol 115:251-65. 2006.... - The role of animacy and thematic relationships in processing active English sentences: evidence from event-related potentialsGina R Kuperberg
Department of Psychology, Tufts University, Medford, MA 02155, and Department of Psychiatry, Massachusetts General Hospital, Bldg 149, 13th Street, Charlestown, MA 02129, USA
Brain Lang 100:223-37. 2007..These findings suggest that semantic-thematic relations, related to animacy constraints on verbs' arguments, are computed online and can immediately impact verb processing within active, English sentences... - Functional magnetic resonance imaging reveals neuroanatomical dissociations during semantic integration in schizophreniaGina R Kuperberg
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 64:407-18. 2008..Integration demands were manipulated by varying the nature (concrete vs. abstract) and the congruity (incongruous vs. congruous) of words within sentences... - Selective emotional processing deficits to social vignettes in schizophrenia: an ERP studyGina R Kuperberg
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
Schizophr Bull 37:148-63. 2011..These findings suggest that schizophrenia is associated with a specific neural deficit during the online evaluation of emotionally valent, socially relevant information... - Regionally localized thinning of the cerebral cortex in schizophreniaGina R Kuperberg
Department of Psychiatry, Massachusetts General Hospital and Athinoula A Martinos Center for Biomedical Imaging, Charlestown, 02129, USA
Arch Gen Psychiatry 60:878-88. 2003.... - Electrophysiological distinctions in processing conceptual relationships within simple sentencesGina R Kuperberg
Department of Psychiatry, Massachusetts General Hospital, Bldg 149, 13th Street, Charlestown, MA 02129, USA
Brain Res Cogn Brain Res 17:117-29. 2003..Our findings suggest a qualitative neural distinction in processing these two types of conceptual anomalies within simple, unambiguous sentences... - Electrophysiological correlates of complement coercionGina R Kuperberg
Departmentof Psychology, Tufts University, 490 Boston Ave, Medford, MA 02155, USA
J Cogn Neurosci 22:2685-701. 2010..We suggest that this effect reflected delayed attempts to retrieve the specific event(s) implied by coerced complement nouns... - What can Event-related Potentials tell us about language, and perhaps even thought, in schizophrenia?Gina R Kuperberg
Department of Psychology, Tufts University, Medford, MA 02155, USA
Int J Psychophysiol 75:66-76. 2010..Further investigation of language dysfunction may also provide insights into other aspects of psychotic thought... - Establishing causal coherence across sentences: an ERP studyGina R Kuperberg
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
J Cogn Neurosci 23:1230-46. 2011..Further, they suggest that causal coherence, at the situation level, can influence incremental word-by-word discourse comprehension, even when semantic relationships between individual words are matched... - Electrophysiological insights into language processing in schizophreniaTatiana Sitnikova
Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
Psychophysiology 39:851-60. 2002..This showed that language abnormalities in schizophrenia may be related to deficient processing of context-irrelevant semantic representations of words from the discourse... - Why all the confusion? Experimental task explains discrepant semantic priming effects in schizophrenia under "automatic" conditions: evidence from Event-Related PotentialsDonna A Kreher
Department of Psychology, Tufts University, 490 Boston Ave, Medford, MA 02155, USA
Schizophr Res 111:174-81. 2009.... - Vascular responses to syntactic processing: event-related fMRI study of relative clausesDavid Caplan
Neuropsychology Laboratory, Department of Neurology, Vincent Burnham 827, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
Hum Brain Mapp 15:26-38. 2002..This study shows that a hemodynamic response associated with processing the syntactically complex portions of a sentence can be localized to one part of the dominant perisylvian association cortex... - Neural evidence for faster and further automatic spreading activation in schizophrenic thought disorderDonna A Kreher
Department of Psychology, University of Massachusetts, Amherst, MA 01003, USA
Schizophr Bull 34:473-82. 2008.... - Time travel through language: temporal shifts rapidly decrease information accessibility during readingTali Ditman
Tufts University, Medford, Massachusetts 02155, USA
Psychon Bull Rev 15:750-6. 2008..For the anaphor, the N400 was modulated in the opposite direction. Thus, the introduction of a temporal discontinuity leads to immediate neural integration costs, as well as to decreased accessibility of earlier information... - Semantic integration in videos of real-world events: an electrophysiological investigationTatiana Sitnikova
Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
Psychophysiology 40:160-4. 2003.... - The misattribution of salience in delusional patients with schizophreniaDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, United States
Schizophr Res 83:247-56. 2006..In this study, we tested the hypothesis that delusional schizophrenia patients are more likely than non-delusional schizophrenia patients and healthy participants to assign affective meanings to neutral stimuli... - The time course of building discourse coherence in schizophrenia: an ERP investigationTali Ditman
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychophysiology 44:991-1001. 2007..Results suggest that schizophrenia patients, particularly those with positive thought disorder, fail to make immediate use of discourse context to build up semantic coherence in the brain... - Electrophysiological insights into the processing of nominal metaphorsSophie De Grauwe
Department of Psychology, Tufts University, USA
Neuropsychologia 48:1965-84. 2010.... - Neurophysiological correlates of comprehending emotional meaning in contextDaphne J Holt
Massachusetts General Hospital, Boston, MA, USA
J Cogn Neurosci 21:2245-62. 2009..negative) of words. Thus, emotional processing networks within the brain appear to exert a continuous influence, evident at several stages, on the construction of the emotional meaning of language... - Developments in the pharmacological treatment of schizophreniaGina Kuperberg
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Expert Opin Investig Drugs 11:1335-41. 2002..Finally, the implications of the introduction of these new drugs for the management of schizophrenia, are discussed... - Distinct patterns of neural modulation during the processing of conceptual and syntactic anomaliesGina R Kuperberg
Massachusetts General Hospital, Charlestown, MA 02129, USA
J Cogn Neurosci 15:272-93. 2003..This suggests that morphosyntactic and pragmatic information can be processed in different ways but by the same neural systems... - Neurocognitive mechanisms of conceptual processing in healthy adults and patients with schizophreniaTatiana Sitnikova
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Int J Psychophysiol 75:86-99. 2010.... - The neural organization of semantic memory: Electrophysiological activity suggests feature-based segregationTatiana Sitnikova
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Biol Psychol 71:326-40. 2006..The high temporal resolution of ERPs allowed us to demonstrate that differences in processing animals and tools occurred specifically within the time-window encompassing semantic analysis... - Neurocognitive abnormalities during comprehension of real-world goal-directed behaviors in schizophreniaTatiana Sitnikova
Athinoula A Martinos Center for Biomedical Imaging, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Abnorm Psychol 118:256-77. 2009..Thus, distinct neurocognitive abnormalities may underlie disorganization and goal-directed behavior deficits in schizophrenia... - When the truth is not too hard to handle: an event-related potential study on the pragmatics of negationMante S Nieuwland
Department of Psychology, Tufts University, 490 Boston Ave, Medford, MA 02155, USA
Psychol Sci 19:1213-8. 2008..g., "A baby bunny's fur isn't very hard/soft..."). These results suggest that negation poses no principled obstacle for readers to immediately relate incoming words to what they hold to be true... - An electrophysiological investigation of indirect semantic primingDonna A Kreher
Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychophysiology 43:550-63. 2006..These findings are discussed in the context of current theoretical models of semantic memory and semantic priming... - Two neurocognitive mechanisms of semantic integration during the comprehension of visual real-world eventsTatiana Sitnikova
Harvard Medical School, Cambridge, MA, USA
J Cogn Neurosci 20:2037-57. 2008.... - Slow and steady: sustained effects of lexico-semantic associations can mediate referential impairments in schizophreniaTali Ditman
Department of Psychology, Tufts University, Medford, MA, USA
Cogn Affect Behav Neurosci 11:245-58. 2011..These results suggest that at least some types of referential impairments may be driven by sustained activation of contextually inappropriate lexico-semantic associations... - Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRIJonathan J Wisco
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
Schizophr Res 94:317-27. 2007..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia... - A source-monitoring account of auditory verbal hallucinations in patients with schizophreniaTali Ditman
Department of Psychology, Tufts University, Medford, MA 02155, USA
Harv Rev Psychiatry 13:280-99. 2005..To draw firmer conclusions, however, it is imperative that future studies select patient populations precisely, match control groups, and use consistent criteria for defining hallucinators...
Research Grants
- LANGUAGE PROCESSING IN SCHIZOPHRENIAGina Kuperberg; Fiscal Year: 2005..This training and research program will advance the candidate to the stage when she can establish herself as an independent investigator of the cognitive neuroscience of schizophrenia. ..
- Spatiotemporal imaging of language in schizophreniaGina Kuperberg; Fiscal Year: 2009....
- Spatiotemporal imaging of language in schizophreniaGina R Kuperberg; Fiscal Year: 2010..This is essential for targeting key neurocognitive systems for the development of new pharmacological and cognitive approaches for remediation. ..