Research Topics
| Karen M KuntzSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
Cost-effectiveness of diagnostic strategies for patients with chest painK M Kuntz
Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Ann Intern Med 130:709-18. 1999..Many noninvasive tests exist to determine whether patients should undergo coronary angiography. The routine use of coronary angiography without previous noninvasive testing is typically not advocated...- Expert panel vs decision-analysis recommendations for postdischarge coronary angiography after myocardial infarctionK M Kuntz
Program on the Economic Evaluation of Medical Technology, Department of Health Policy and Management, Harvard School of Public Health, Boston, Mass 02115 5924, USA
JAMA 282:2246-51. 1999..Expert panels and decision-analytic techniques are increasingly used to determine the appropriateness of medical interventions, but these 2 approaches use different methods to process evidence... - Cost-effectiveness of fusion with and without instrumentation for patients with degenerative spondylolisthesis and spinal stenosisK M Kuntz
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115 5924, USA
Spine (Phila Pa 1976) 25:1132-9. 2000..A cost-effectiveness study was performed from the societal perspective... - A novel approach to defining the relationship between lung function and symptom status in asthmaKaren M Kuntz
Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Ave, Boston, MA, USA
J Clin Epidemiol 55:11-8. 2002..Functional relationships between FEV(1) percent predicted and asthma-related symptoms can be useful for inferring the effect on the symptoms of a population associated with overall improvements in lung function... - Assessing the sensitivity of decision-analytic results to unobserved markers of risk: defining the effects of heterogeneity biasKaren M Kuntz
Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115, USA
Med Decis Making 22:218-27. 2002..This analysis provides a general framework to determine when issues of heterogeneity may be important... - The impact of tumor progesterone receptor status on optimal adjuvant endocrine therapy for postmenopausal patients with early-stage breast cancer: a decision analysisRinaa S Punglia
Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Cancer 106:2576-82. 2006..Patients with ER+/PR+ tumors achieved optimal 10-year DFS estimates with tamoxifen followed by a crossover to AI therapy, whereas patients with ER+/PR- tumors fared best when they initiated treatment with AI... 
Exploring the cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer in China in anticipation of clinical trial resultsJennifer M Yeh
Department of Health Policy and Management, Program in Health Decision Science, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 124:157-66. 2009..These results illustrate the potential promise of a gastric cancer screening program and provide rationale for urgent clinical studies to move the prevention agenda forward...- Effects of Helicobacter pylori infection and smoking on gastric cancer incidence in China: a population-level analysis of trends and projectionsJennifer M Yeh
Center for Health Decision Science, Harvard School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115, USA
Cancer Causes Control 20:2021-9. 2009..Our aim was to (1) retrospectively estimate the effects of Helicobacter pylori (H. pylori) and smoking on past gastric cancer incidence and (2) project how interventions on these two risk factors can reduce future incidence... - Forced expiratory volume in 1 second percentage improves the classification of severity among children with asthmaAnne L Fuhlbrigge
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatrics 118:e347-55. 2006..The objective of this analysis was to examine the association between FEV1% and future risk of exacerbations among a well-characterized population of children with asthma... - Cost-effectiveness analysis of computerized tomography in the routine follow-up of patients after primary treatment for Hodgkin's diseaseBeverly A Guadagnolo
Joint Center for Radiation Therapy Harvard Radiation Oncology Program, Harvard School of Public Health, Harvard University, Boston, MA 02215, USA
J Clin Oncol 24:4116-22. 2006..To estimate the clinical benefits and cost effectiveness of computed tomography (CT) in the follow-up of patients with complete response (CR) after treatment for Hodgkin's disease (HD)... - Cost-effectiveness of interferon beta-1a, interferon beta-1b, and glatiramer acetate in newly diagnosed non-primary progressive multiple sclerosisLisa A Prosser
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Value Health 7:554-68. 2004..To perform a cost-effectiveness analysis of three immunomodulatory treatments for newly diagnosed nonprimary progressive MS: interferon beta-1a, interferon beta-1b, and glatiramer acetate... - Modeling the potential impact of a prescription drug copayment increase on the adult asthmatic medicaid populationSeung Jin Bae
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, USA
Value Health 11:110-8. 2008..We sought to determine the likely health outcomes and cost shifts attributable to this copayment increase using the example of inhaled corticosteroids (ICS) use among adult asthmatic Medicaid beneficiaries... - Cost effectiveness and screening interval of lipid screening in Hodgkin's lymphoma survivorsAileen B Chen
Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
J Clin Oncol 27:5383-9. 2009..We evaluated the cost effectiveness of lipid screening in survivors of HL and compared different screening intervals... - Cost-effectiveness of cervical cancer screening with human papillomavirus DNA testing and HPV-16,18 vaccinationJeremy D Goldhaber-Fiebert
Doctoral Program in Health Policy, Decision Science Concentration, Harvard University, Cambridge, MA, USA
J Natl Cancer Inst 100:308-20. 2008.... - Optimizing adjuvant endocrine therapy in postmenopausal women with early-stage breast cancer: a decision analysisRinaa S Punglia
Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 23:5178-87. 2005..5 years yields improved outcomes compared with either drug alone or cross-over treatment after 5 years of tamoxifen... 
Estimating long-term effectiveness of lung cancer screening in the Mayo CT screening studyPamela M McMahon
Institute for Technology Assessment, Massachusetts General Hospital, 101 Merrimac St, 10th Floor, Boston, MA 02114, USA
Radiology 248:278-87. 2008....- Impact of preoperative staging and chemoradiation versus postoperative chemoradiation on outcome in patients with rectal cancer: a decision analysisJennifer J Telford
Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA
J Natl Cancer Inst 96:191-201. 2004.... - Cost-effectiveness of inhaled steroids in asthma: impact of effect on bone mineral densityAnne L Fuhlbrigge
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 117:359-66. 2006..The effects of inhaled corticosteroid (ICS) preparations on bone health have been debated. Multiple analyses have been published examining the question, with mixed results... - Association between preference-based health-related quality of life and asthma severityMarilyn L Moy
Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Allergy Asthma Immunol 92:329-34. 2004..International guidelines have been developed to guide medical management according to asthma severity defined by lung function and symptom frequency... - Potential cost-effectiveness of C-reactive protein screening followed by targeted statin therapy for the primary prevention of cardiovascular disease among patients without overt hyperlipidemiaGavin J Blake
Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Med 114:485-94. 2003.... - Using economic analysis to evaluate the potential of multimodality therapy for elderly patients with locally advanced pancreatic cancerMonika K Krzyzanowska
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA, USA
Int J Radiat Oncol Biol Phys 67:211-8. 2007..Economic modeling can be used to explore the potential of such novel therapies and to inform clinical trial design... - A single measure of FEV1 is associated with risk of asthma attacks in long-term follow-upBarrett T Kitch
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Chest 126:1875-82. 2004..Clinical practice guidelines for asthma care emphasize the use of objective measures of asthma severity, and yet little data exist on the relationship between FEV(1) and asthma outcomes over long-term follow-up... - Cost-effectiveness of omalizumab in adults with severe asthma: results from the Asthma Policy ModelAnn C Wu
Department of Ambulatory Care and Prevention, Harvard Medical School and Children s Hospital, Boston, MA 02215 5301, USA
J Allergy Clin Immunol 120:1146-52. 2007..Given the high acquisition cost of omalizumab, its role and cost-effectiveness in disease management require definition... - Rescreening of persons with a negative colonoscopy result: results from a microsimulation modelAmy B Knudsen
Institute for Technology Assessment, Massachusetts General Hospital, 101 Merrimac Street, 10th Floor, Boston, MA 02114, USA
Ann Intern Med 157:611-20. 2012..Persons with a negative result on screening colonoscopy are recommended to repeat the procedure in 10 years... - Estimation of mortality rates for disease simulation models using Bayesian evidence synthesisPamela M McMahon
Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA 02114, USA
Med Decis Making 26:497-511. 2006..This approach is suggested when modeling a disease that causes a large proportion of all-cause mortality, particularly when mortality from the disease of interest and other-cause mortality are both affected by the same risk factor... - Cost-effectiveness of treatment and endoscopic surveillance of precancerous lesions to prevent gastric cancerJennifer M Yeh
Center for Health Decision Science, Harvard School of Public Health, Boston, MA 02115, USA
Cancer 116:2941-53. 2010..The objective of this study was to estimate the clinical benefits and cost-effectiveness of treatment and endoscopic surveillance to prevent gastric cancer... - A potential error in evaluating cancer screening: a comparison of 2 approaches for modeling underlying disease progressionSue J Goldie
Harvard Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115 5924, USA
Med Decis Making 23:232-41. 2003..Evaluating cancer screening often requires modeling the underlying disease process and not observed disease, particularly in the absence of direct evidence linking screening to a survival benefit... - Limitations of acceptability curves for presenting uncertainty in cost-effectiveness analysisBas Groot Koerkamp
Harvard Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, USA
Med Decis Making 27:101-11. 2007..Presenting the value of information in addition to these intervals allows policy makers to evaluate the need for more empirical research... - Multiparameter calibration of a natural history model of cervical cancerJane J Kim
Program in Health Decision Science, Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 166:137-50. 2007..The authors found that leveraging primary data from longitudinal studies provides unique opportunities for model parameterization of the unobservable nature of HPV infection and its role in the development of cervical cancer... - Impact of age, benign prostatic hyperplasia, and cancer on prostate-specific antigen levelRinaa S Punglia
Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA 02115, USA
Cancer 106:1507-13. 2006..Therefore, the current threshold of 4.0 ng/mL should not be applied indiscriminately... - Development of an empirically calibrated model of gastric cancer in two high-risk countriesJennifer M Yeh
Program in Health Decision Science, Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Avenue, 2nd Floor, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 17:1179-87. 2008..As better data become available, the model can be refined and recalibrated, and, as such, be used as an iterative tool to assess the likely health and economic outcomes associated with gastric cancer prevention strategies... - Effects of categorizing continuous variables in decision-analytic modelsTanya G K Bentley
Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA
Med Decis Making 29:549-56. 2009..This analysis assessed the tradeoffs between model bias and complexity and/or data limitations when categorizing continuous risk factors in Markov models... - A cost-effectiveness analysis of folic acid fortification policy in the United StatesTanya Gk Bentley
The Faculty of Arts and Sciences, Harvard University PhD Program in Health Policy, Cambridge, MA, USA
Public Health Nutr 12:455-67. 2009..To quantify the health and economic outcomes associated with changes in folic acid consumption following the fortification of enriched grain products in the USA... - Modeling human papillomavirus and cervical cancer in the United States for analyses of screening and vaccinationJeremy D Goldhaber-Fiebert
Department of Health Policy and Management, Harvard School of Public Health, Boston, USA
Popul Health Metr 5:11. 2007..S. policy choices for cervical cancer prevention, we developed a model of human papillomavirus (HPV) and cervical cancer, explicitly incorporating uncertainty about the natural history of disease... - Effects of rofecoxib and naproxen on life expectancy among patients with rheumatoid arthritis: a decision analysisHyon K Choi
Department of Health Policy and Management, Boston, Massachusetts, USA
Am J Med 116:621-9. 2004..We examined the effects of these competing adverse events on life expectancy in patients with rheumatoid arthritis... - Estimating the energy gap among US children: a counterfactual approachY Claire Wang
Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Ave, 2nd Floor, Boston, MA 02115, USA
Pediatrics 118:e1721-33. 2006..Our goal was to quantify the magnitude of energy imbalance responsible for the increase in body weight among US children during the periods 1988-1994 and 1999-2002... - Patient and community preferences for treatments and health states in multiple sclerosisLisa A Prosser
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Mult Scler 9:311-9. 2003..To examine preferences for treatments and health states for patients with relapsing-remitting MS and members of the community... - Cost-effectiveness of hepatic metastasectomy in patients with metastatic colorectal carcinoma: a state-transition Monte Carlo decision analysisG Scott Gazelle
Institute for Technology Assessment, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Zero Emerson Place, Suite 2H, Boston, MA 02114, USA
Ann Surg 237:544-55. 2003.... - Radiation therapy plus tamoxifen versus tamoxifen alone after breast-conserving surgery in postmenopausal women with stage I breast cancer: a decision analysisRinaa S Punglia
Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA, USA
J Clin Oncol 21:2260-7. 2003.... - Outcomes and cost-effectiveness of alternative staging strategies for non-small-cell lung cancerNestor F Esnaola
Department of Surgery, Brigham and Women s Hospital, Harvard School of Public Health, Boston, MA, USA
J Clin Oncol 20:263-73. 2002..To identify the optimal strategy for staging the mediastinum of patients with known non-small-cell lung cancer (NSCLC), stratified by tumor (T) classification... - Projected life-expectancy gains with statin therapy for individuals with elevated C-reactive protein levelsGavin J Blake
Center for Cardiovascular Disease Prevention, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 40:49-55. 2002..This analysis supports a crucial need for direct intervention trials aimed at subjects with elevated CRP levels... - Effect of verification bias on screening for prostate cancer by measurement of prostate-specific antigenRinaa S Punglia
Joint Center for Radiation Therapy, Harvard Medical School, Boston, USA
N Engl J Med 349:335-42. 2003..CONCLUSIONS: A lower threshold level of PSA for recommending prostate biopsy, particularly in younger men, may improve the clinical value of the PSA test... - Forecasting the obesity epidemic in the aging U.S. populationY Claire Wang
Department of Health Policy and Management, Columbia Mailman School of Public Health, 600 W 168th Street, 6th Floor, New York, NY 10032, USA
Obesity (Silver Spring) 15:2855-65. 2007..The objective was to forecast BMI distribution in the U.S. population along with demographic changes based on past race-, sex-, and birth cohort-specific secular trends... - Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritisKunihiro Nishimura
Department of Health Policy Management, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Ann Intern Med 146:797-808. 2007..Rheumatoid factor (RF) and autoantibodies against cyclic citrullinated peptide (CCP) are markers that might help physicians diagnose rheumatoid arthritis... - The relationship between risk attitude and treatment choice in patients with relapsing-remitting multiple sclerosisLisa A Prosser
Department of Ambulatory Care and Prevention, Harvard Medical School, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
Med Decis Making 22:506-13. 2002.... - The impact of a partially effective HIV vaccine on a population of intravenous drug users in Bangkok, Thailand: a dynamic modelElizabeth Bogard
Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Acquir Immune Defic Syndr 29:132-41. 2002..These results agree with analyses of the epidemic among gay men. If injection drug behavior is indeed modifiable, our findings have significant policy and planning implications... - Pretreatment imaging workup for patients with intermittent claudication: a cost-effectiveness analysisKaren Visser
Program for the Assessment of Radiological Technology Program, Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center Rotterdam, The Netherlands
J Vasc Interv Radiol 14:53-62. 2003..To determine the optimal imaging strategy in pretreatment workup of patients with intermittent claudication with use of noninvasive imaging modalities and intraarterial digital subtraction angiography (DSA)... - Cost effectiveness of mammography screening for Chinese womenIrene O L Wong
Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
Cancer 110:885-95. 2007..The authors estimated the cost effectiveness of biennial mammography in Hong Kong Chinese women to inform evidence-based screening policies... - A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritisHyon K Choi
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Rheumatol 29:1156-65. 2002..Given wide variability in efficacy and cost among different treatment options, we sought to determine their relative cost effectiveness to help guide policy in different cost constrained settings... - Adjuvant ovarian suppression versus chemotherapy for premenopausal, hormone-responsive breast cancer: quality of life and efficacy tradeoffsElena B Elkin
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 44, New York, NY 10021, USA
Breast Cancer Res Treat 93:25-34. 2005..We used a decision-analytic framework to evaluate tradeoffs between efficacy and quality of life in the choice between these treatments... - HER-2 testing and trastuzumab therapy for metastatic breast cancer: a cost-effectiveness analysisElena B Elkin
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 44, New York, NY 10021, USA
J Clin Oncol 22:854-63. 2004..Several tests of varying accuracy and cost are available to identify candidates for trastuzumab. We estimated the cost-effectiveness of alternative HER-2 testing and trastuzumab treatment strategies... - Cost-effectiveness targets for multi-detector row CT angiography in the work-up of patients with intermittent claudicationKaren Visser
Program for the Assessment of Radiological Technology, Department of Epidemiology and Biostatistics, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, Rm Ee21 40B, 3015GE Rotterdam, The Netherlands
Radiology 227:647-56. 2003.... - Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart diseaseJean Michel Gaspoz
Clinique de Médecine II and the Division of Cardiology, Hopitaux Universitaires, Geneva, Switzerland
N Engl J Med 346:1800-6. 2002..We estimated the cost effectiveness of the increased use of aspirin, clopidogrel, or both for secondary prevention in patients with coronary heart disease... - Economic evaluation of weight loss interventions in overweight and obese womenLarissa Roux
Department of Community Health Sciences, University of Calgary, Canada
Obesity (Silver Spring) 14:1093-106. 2006..To conduct a clinical and economic evaluation of outpatient weight loss strategies in overweight and obese adult U.S. women... - Evaluating test strategies for colorectal cancer screening: a decision analysis for the U.S. Preventive Services Task ForceAnn G Zauber
Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Ann Intern Med 149:659-69. 2008..The U.S. Preventive Services Task Force requested a decision analysis to inform their update of recommendations for colorectal cancer screening... - Correction: cost-effectiveness of statins in older patients with myocardial infarctionDavid A Ganz
Ann Intern Med 136:635. 2002 - Population-level changes in folate intake by age, gender, and race/ethnicity after folic acid fortificationTanya G K Bentley
Faculty of Arts and Sciences, Harvard University, Cambridge, Mass, USA
Am J Public Health 96:2040-7. 2006..CONCLUSIONS: Since fortification, folic acid intake among the US population has increased, and there are substantial variations by age, gender, and race/ethnicity...