Anand T N Kumar

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Fluorescence lifetime detection in turbid media using spatial frequency domain filtering of time domain measurements
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 38:1440-2. 2013
  2. pmc Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 37:4783-5. 2012
  3. ncbi request reprint Fluorescence-lifetime-based tomography for turbid media
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 30:3347-9. 2005
  4. pmc Comparison of frequency-domain and time-domain fluorescence lifetime tomography
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Opt Lett 33:470-2. 2008
  5. pmc A time domain fluorescence tomography system for small animal imaging
    Anand T N Kumar
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 27:1152-63. 2008
  6. pmc Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Opt Lett 34:2066-8. 2009
  7. doi request reprint Fluorescence lifetime-based optical molecular imaging
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Methods Mol Biol 680:165-80. 2011
  8. doi request reprint Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy
    Phillip B Jones
    Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disorders, 114 16th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:014008. 2008
  9. pmc Lifetime-based tomographic multiplexing
    Scott B Raymond
    The Harvard MIT Division of Health Sciences and Technology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:046011. 2010
  10. ncbi request reprint Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays
    Phill B Jones
    Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054024. 2006

Collaborators

Detail Information

Publications13

  1. pmc Fluorescence lifetime detection in turbid media using spatial frequency domain filtering of time domain measurements
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 38:1440-2. 2013
    ..The basis of this approach is the separation of diffuse fluorescence signals into diffuse and fluorescent components with distinct spatiotemporal behavior...
  2. pmc Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 37:4783-5. 2012
    ..We validate this method using simulations with both a slab and a heterogeneous model of the mouse head...
  3. ncbi request reprint Fluorescence-lifetime-based tomography for turbid media
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 30:3347-9. 2005
    ....
  4. pmc Comparison of frequency-domain and time-domain fluorescence lifetime tomography
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Opt Lett 33:470-2. 2008
    ..We also demonstrate experimentally, using complex-shaped phantoms, the advantages of the asymptotic time-domain approach over a Fourier-based approach for analyzing time-domain fluorescence data...
  5. pmc A time domain fluorescence tomography system for small animal imaging
    Anand T N Kumar
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 27:1152-63. 2008
    ..These results suggest the practical feasibility and advantages of a time domain approach for whole body small animal fluorescence molecular imaging, particularly with the use of lifetime as a contrast mechanism...
  6. pmc Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Opt Lett 34:2066-8. 2009
    ..These results suggest the potential for exploiting fluorescence lifetime for imaging FPs for a variety of whole-body small-animal imaging applications...
  7. doi request reprint Fluorescence lifetime-based optical molecular imaging
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Methods Mol Biol 680:165-80. 2011
    ..This feature has potential applications for longitudinal pre-clinical evaluation of drug treatment response as well as to address fundamental questions related to tumor physiology and metastasis...
  8. doi request reprint Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy
    Phillip B Jones
    Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disorders, 114 16th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:014008. 2008
    ....
  9. pmc Lifetime-based tomographic multiplexing
    Scott B Raymond
    The Harvard MIT Division of Health Sciences and Technology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:046011. 2010
    ..Finally, we demonstrate tomographic imaging of two and three fluorophores in nude mice with fluorophores that localize to distinct organ systems. This technique should be widely applicable to imaging multiple NIR fluorophores in 3-D...
  10. ncbi request reprint Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays
    Phill B Jones
    Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054024. 2006
    ..Presenilin 1 (PS1) is known to be important in Amyloid Precursor Protein (APP) processing in Alzheimer's disease. Using transfected cells, we demonstrate APP-PS1 interactions by FRET in a cell-based, 96-well plate format...
  11. pmc Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes
    Alexei A Bogdanov
    The Laboratory of Molecular Imaging Probes S6 434, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Mol Biosyst 8:2166-73. 2012
    ..We anticipate that the observed effects will be instrumental for developing sensors enabling non-invasive imaging in cells that undergo activation of NF-κB...
  12. doi request reprint The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores
    Valeri Metelev
    The Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Biosyst 9:2447-53. 2013
    ....
  13. pmc The PEG-fluorochrome shielding approach for targeted probe design
    Yanyan Guo
    Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    J Am Chem Soc 134:19338-41. 2012
    ..Using PEG to block fluorochrome-mediated interactions, rather than synthesizing de novo fluorochromes, can yield new approaches for the design of actively or passively targeted near-infrared fluorescent probes...