Rohit N Kulkarni

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 114:828-36. 2004
  2. ncbi request reprint Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1
    H Joseph Goren
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 145:3307-23. 2004
  3. pmc Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
    Terumasa Okada
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:8977-82. 2007
  4. ncbi request reprint Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells
    Anita M Hennige
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 289:E337-46. 2005
  5. pmc Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:3463-74. 2007
  6. pmc Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2
    Anke Assmann
    Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:3219-28. 2009
  7. ncbi request reprint Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:1528-34. 2003
  8. ncbi request reprint Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
    Jenny E Gunton
    Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Cell 122:337-49. 2005
  9. ncbi request reprint Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance
    Katrine Almind
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:1535-43. 2003
  10. pmc Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes
    Anita M Hennige
    Howard Hughes Medical Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1521-32. 2003

Detail Information

Publications70

  1. pmc PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 114:828-36. 2004
    ..This study shows that, in postdevelopmental states of beta cell growth, PDX-1 is a critical regulator of beta cell replication and is required for the compensatory response to insulin resistance...
  2. ncbi request reprint Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1
    H Joseph Goren
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 145:3307-23. 2004
    ....
  3. pmc Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
    Terumasa Okada
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:8977-82. 2007
    ..Together these data provide direct genetic evidence that insulin/FoxO1/Pdx-1 signaling is one pathway that is crucial for islet compensatory growth response to insulin resistance...
  4. ncbi request reprint Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells
    Anita M Hennige
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 289:E337-46. 2005
    ....
  5. pmc Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:3463-74. 2007
    ..These data clearly illustrate a causal role for muscle PGC-1alpha in maintenance of glucose homeostasis and highlight an unexpected cytokine-mediated crosstalk between skeletal muscle and pancreatic islets...
  6. pmc Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2
    Anke Assmann
    Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:3219-28. 2009
    ..Together, these studies provide compelling evidence that the growth and survival effects of glucose on beta-cells require activation of proteins in the insulin signaling pathway...
  7. ncbi request reprint Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:1528-34. 2003
    ....
  8. ncbi request reprint Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
    Jenny E Gunton
    Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Cell 122:337-49. 2005
    ..Together, these data suggest an important role for decreased ARNT and altered gene expression in the impaired islet function of human type 2 diabetes...
  9. ncbi request reprint Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance
    Katrine Almind
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:1535-43. 2003
    ....
  10. pmc Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes
    Anita M Hennige
    Howard Hughes Medical Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1521-32. 2003
    ..Thus, pharmacological approaches that promote Irs2 expression in beta cells, especially specific cAMP agonists, could be rational treatments for beta cell failure and diabetes...
  11. pmc Insulin signaling in alpha cells modulates glucagon secretion in vivo
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 9:350-61. 2009
    ..Together, these data indicate a significant role for intraislet insulin signaling in the regulation of alpha cell function in both normo- and hypoglycemic conditions...
  12. pmc Insulin signaling regulates mitochondrial function in pancreatic beta-cells
    Siming Liu
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7983. 2009
    ..These data indicate that insulin signaling regulates mitochondrial function and have implications for beta-cell dysfunction in type 2 diabetes...
  13. pmc Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle
    Ho Jin Koh
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Nat Commun 4:1871. 2013
    ..These data demonstrate that tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle...
  14. pmc Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states
    Abdelfattah El Ouaamari
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 3:401-10. 2013
    ..These data implicate the liver as a critical source of β cell growth factor(s) in insulin-resistant states...
  15. pmc The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells
    Chong Wee Liew
    Section of Islet Cell and Regenerative Medicine, Department of Medicine, Harvard Medical School, Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Clin Invest 120:2876-88. 2010
    ..These data link a missense polymorphism in human TRB3 to impaired insulin exocytosis and thus increased risk for T2DM...
  16. pmc Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:7222-9. 2003
    ....
  17. pmc Enhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling
    Tomoaki Morioka
    Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Endocrinol 26:967-76. 2012
    ..These data support enhanced insulinotropic effects of glucose, GLP-1, and sulfonylureas in the islets lacking leptin signaling with potential therapeutic implications...
  18. ncbi request reprint Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes
    Rohit N Kulkarni
    Department of Cell and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Science 303:1311-2. 2004
  19. pmc Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog
    Thomas Reiner
    Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 108:12815-20. 2011
    ..This near-infrared imaging probe, as well as future radioisotope-labeled versions of it, should prove to be important tools for monitoring diabetes, progression, and treatment in both experimental and clinical contexts...
  20. pmc Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice
    Tomoaki Morioka
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    J Clin Invest 117:2860-8. 2007
    ....
  21. pmc Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young)
    Helge Ræder
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60229. 2013
    ..We therefore aimed to create and phenotype a mouse model specifically over-expressing mutated CEL in the pancreas...
  22. pmc X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function
    Masaru Akiyama
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 62:2439-49. 2013
    ..Together, these data indicate that XBP1 deficiency in pancreatic α-cells induces altered insulin signaling and dysfunctional glucagon secretion. ..
  23. pmc Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
    Chong Wee Liew
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:217-26. 2013
    ....
  24. pmc Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans
    Florencia Halperin
    1Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 61:301-9. 2012
    ..This is consistent with an effect of insulin to regulate β-cell function in humans in vivo with therapeutic implications...
  25. ncbi request reprint Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
    Kohjiro Ueki
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Genet 38:583-8. 2006
    ..We propose that therapeutic improvement of insulin and IGF-I signaling in beta cells might protect against type 2 diabetes...
  26. pmc Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3
    Ho Jin Koh
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 26:8217-27. 2006
    ..LKB1-mediated TRB3 expression provides a novel link between LKB1 and Akt, critical kinases involved in both tumor genesis and cell metabolism...
  27. doi request reprint Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Adv Exp Med Biol 654:421-45. 2010
    ..Therefore, understanding the molecular mechanism of how glucagon secretion is regulated is critical for treating the alpha-cell dysfunction observed in diabetes...
  28. ncbi request reprint Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia
    Zhiheng He
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 26:787-93. 2006
    ..This study characterized the role of insulin receptors and resistance on vascular endothelial growth factor (VEGF) expression and myocardial vascularization in physiological conditions and after ischemia...
  29. pmc Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice
    Charlotte Hinault
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 60:1210-22. 2011
    ....
  30. pmc Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid
    Helge Ræder
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, MA
    Diabetes 63:259-69. 2014
    ....
  31. pmc Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice
    Palle G Laustsen
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genes Dev 16:3213-22. 2002
    ..The results indicate that IRS-1 and IRS-3 play important complementary roles in adipogenesis and establish the Irs1(-/-)/Irs3(-/-) double knockout mouse as a novel model of lipoatrophic diabetes...
  32. ncbi request reprint The islet beta-cell
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Int J Biochem Cell Biol 36:365-71. 2004
    ....
  33. pmc High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis
    Zhaoyun Zhang
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 24:1497-505. 2010
    ..G6PD plays an important role in beta-cell function and survival. High-glucose-mediated decrease in G6PD activity may provide a mechanistic explanation for the gradual loss of beta cells in patients with diabetes...
  34. ncbi request reprint Molecular approaches to study control of glucose homeostasis
    Nicole Neubauer
    Department of Cellular and Molecular Physiology, the Joslin Diabetes Center, Boston, MA, USA
    ILAR J 47:199-211. 2006
    ....
  35. ncbi request reprint Melanin concentrating hormone is a novel regulator of islet function and growth
    Pavlos Pissios
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 56:311-9. 2007
    ..Together, these data provide novel evidence for an autocrine role for MCH in the regulation of beta-cell mass dynamics and in islet secretory function and suggest that MCH is part of a hypothalamic-islet (pancreatic) axis...
  36. pmc New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    Yu Hua Tseng
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 454:1000-4. 2008
    ..These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity...
  37. pmc Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young
    Adrian K K Teo
    Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 288:5353-6. 2013
    ..This knowledge will aid future attempts aimed at deriving functional mature beta cells from hPSCs...
  38. pmc Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids
    Ximena Lopez
    Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 96:3811-21. 2011
    ..Islet β-cells express both insulin receptors and insulin signaling proteins. Recent studies suggest insulin signaling is physiologically important for glucose sensing...
  39. pmc Insulin enhances glucose-stimulated insulin secretion in healthy humans
    Clara Bouche
    Cellular and Molecular Physiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:4770-5. 2010
    ..In addition, hyperinsulinemia increases C-peptide clearance, which may lead to modest underestimation of beta-cell secretory response when using these methods during prolonged dynamic testing...
  40. ncbi request reprint New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass
    Rohit N Kulkarni
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Rev Endocr Metab Disord 6:199-210. 2005
  41. ncbi request reprint Tissue-specific targeting of the insulin receptor gene
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Endocrine 19:257-66. 2002
    ....
  42. doi request reprint Insulin modulation of glucagon secretion: the role of insulin and other factors in the regulation of glucagon secretion
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA USA
    Islets 1:276-9. 2009
    ....
  43. ncbi request reprint Lessons for human diabetes from experimental mouse models
    Rohit N Kulkarni
    Joslin Diabetes Center, One Joslin Place, Room 602, Boston, MA 02215, USA
    Curr Diab Rep 3:168-75. 2003
    ..We review some of the models created recently and discuss their impact on human diabetes...
  44. pmc Insulin resistance alters islet morphology in nondiabetic humans
    Teresa Mezza
    Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Diabetes 63:994-1007. 2014
    ..Our data in this series of studies suggest that neogenesis from duct cells and transdifferentiation of α-cells are potential contributors to the β-cell compensatory response to insulin resistance in the absence of overt diabetes. ..
  45. pmc Human β-cell proliferation and intracellular signaling: driving in the dark without a road map
    Rohit N Kulkarni
    Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:2205-13. 2012
    ....
  46. ncbi request reprint Ephs and ephrins keep pancreatic Beta cells connected
    Rohit N Kulkarni
    Division of Cell and Molecular Physiology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston MA 02215, USA
    Cell 129:241-3. 2007
    ..2007) show that the signaling proteins EphA and ephrin-A modulate insulin secretion, providing fresh insights into the functional significance of the clustering of beta cells, which occurs in islets...
  47. doi request reprint Wnt signaling: relevance to beta-cell biology and diabetes
    Hannah J Welters
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Trends Endocrinol Metab 19:349-55. 2008
    ..Together, these studies point towards a role for Wnt signaling in the pathogenesis of type 2 diabetes, highlighting the importance of further investigation of this pathway to develop new therapies for this disease...
  48. ncbi request reprint Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis
    Zhen Y Jiang
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:31964-71. 2003
    ..The in vivo results provide direct evidence that insulin can modulate hypoxia-induced angiogenesis via reduction in VEGF expression in vivo...
  49. ncbi request reprint Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3
    Rohit N Kulkarni
    Rm 602, Joslin Diabetes Center, One Joslin Pl, Boston MA 02215, USA
    Diabetes 53:1517-25. 2004
    ....
  50. pmc Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells
    Chong Wee Liew
    Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612
    Proc Natl Acad Sci U S A 111:E2319-28. 2014
    ....
  51. pmc Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor
    Adrian Kee Keong Teo
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    EMBO J 31:3956-7. 2012
    ..Hinke et al (2012) illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2B to mediate nutrient-stimulated insulin secretion and thus modulate glucose homeostasis...
  52. pmc Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction
    Maciej Borowiec
    Research Division, Department of Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 106:14460-5. 2009
    ..1. These actions are greatly attenuated by the Ala71Thr mutation. These findings point to BLK as a previously unrecognized modulator of beta-cell function, the deficit of which may lead to the development of diabetes...
  53. pmc New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism
    Adrian Kee Keong Teo
    Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 18:775-91. 2013
    ....
  54. doi request reprint GIP: no longer the neglected incretin twin?
    Rohit N Kulkarni
    Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Sci Transl Med 2:49ps47. 2010
    ..These findings warrant further studies to unravel the mechanism of action of GIP in β-cells of the endocrine pancreas and to evaluate the possibility of designing novel therapeutics that target both incretin hormones...
  55. pmc Near-infrared fluorescent probe for imaging of pancreatic beta cells
    Thomas Reiner
    Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Bioconjug Chem 21:1362-8. 2010
    ..Serial imaging revealed rapid accumulation kinetics (with initial signal within the islets detectable within 3 min and peak fluorescence within 20 min of injection), making this an ideal agent for in vivo imaging...
  56. ncbi request reprint Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, U S A
    Biochem Soc Trans 30:317-22. 2002
    ....
  57. ncbi request reprint The regulation of pre- and post-maturational plasticity of mammalian islet cell mass
    Teresa Mezza
    Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, 1 Joslin Place, Boston, MA, 02215, USA
    Diabetologia 57:1291-303. 2014
    ....
  58. pmc Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1
    Wenchu Lin
    Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:13379-86. 2011
    ..These studies link RBP2 histone demethylase activity to tumorigenesis and nominate RBP2 as a potential target for cancer therapy...
  59. pmc cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2
    Ulupi S Jhala
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 17:1575-80. 2003
    ..As induction of IRS2by cAMP enhanced activation of the survival kinase Akt in response to insulin and IGF-1, our results demonstrate a novel mechanism by which opposing pathways cooperate in promoting cell survival...
  60. ncbi request reprint TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
    Keyong Du
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 1002, USA
    Science 300:1574-7. 2003
    ..Our results suggest that, by interfering with Akt activation, TRB3 contributes to insulin resistance in individuals with susceptibility to type II diabetes...
  61. ncbi request reprint Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice
    Kenichi Otani
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8066, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 286:E41-9. 2004
    ..In addition, altered glucose sensing may also contribute to defective insulin secretion in mutant animals that develop diabetes...
  62. ncbi request reprint Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
    Franck Mauvais-Jarvis
    Department of Endocrinology and Diabetes, Saint Louis Hospital and University of Paris VII Medical School, France
    Clin Endocrinol (Oxf) 57:1-9. 2002
    ..The development of type 2 diabetes is linked to insulin resistance coupled with a failure of pancreatic beta-cells to compensate by adequate insulin secretion...
  63. ncbi request reprint Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells
    Michael G Roper
    Department of Chemistry, University of Florida, Gainesville, FL, USA
    Diabetes 51:S43-9. 2002
    ..It is concluded that L-783,281 evokes [Ca(2+)](i) increases and exocytosis in beta-cells via an IRS-1/PI3-K-dependent pathway and that the [Ca(2+)](i) increase involves release of Ca(2+) from intracellular stores...
  64. ncbi request reprint Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
    Sarah H Bates
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell Metab 1:169-78. 2005
    ..Thus, in addition to LRb/STAT3-mediated adiposity signals, non-LRb/STAT3 leptin signals mediate an important adiposity-independent role in promoting glycemic control...
  65. ncbi request reprint TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism
    Ling Qi
    Peptide Biology Laboratories and Gene Expression Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 312:1763-6. 2006
    ....
  66. ncbi request reprint Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis
    Li Wang
    Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Endocrinol 20:2671-81. 2006
    ....
  67. pmc Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion
    Kazuhiro Matsumura
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:6026-37. 2007
    ..In conclusion, we found that pancreatic beta cells express AQP7, which appears to be a key regulator of intraislet glycerol content as well as insulin production and secretion...
  68. pmc Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism
    Anthony M Deangelis
    Center for Diabetes and Endocrine Research and the Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio, USA
    Diabetes 57:2296-303. 2008
    ..To discern whether this phenotype reflects a physiological function of CEACAM1 rather than the effect of the dominant-negative transgene, we characterized the metabolic phenotype of mice with null mutation of the Ceacam1 gene (Cc1(-/-))...
  69. ncbi request reprint A patient with type B insulin resistance syndrome, responsive to immune therapy
    Kathleen A Page
    Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520 8020, USA
    Nat Clin Pract Endocrinol Metab 3:835-40. 2007
    ..She remained hyperglycemic (blood glucose levels 16.7-27.8 mmol/l), despite intravenous insulin at doses as high as 30,000 U/day...
  70. pmc Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues
    Vladislav A Petyuk
    Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Proteome Res 7:3114-26. 2008
    ..The mouse islet protein and peptide database accessible at (http://ncrr.pnl.gov), provides an important reference resource for the research community to facilitate research in the diabetes and metabolism fields...