Rob J Kulathinal

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Compensated deleterious mutations in insect genomes
    Rob J Kulathinal
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Science 306:1553-4. 2004
  2. ncbi request reprint Male sex drive and the masculinization of the genome
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Bioessays 27:518-25. 2005
  3. ncbi request reprint Rapid evolution of the sex-determining gene, transformer: structural diversity and rate heterogeneity among sibling species of Drosophila
    Rob J Kulathinal
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 20:441-52. 2003
  4. ncbi request reprint The nature of genetic variation in sex and reproduction-related genes among sibling species of the Drosophila melanogaster complex
    Rob J Kulathinal
    Department of Biology, McMaster University, Hamilton, Ont, Canada L8S 4K1
    Genetica 120:245-52. 2004
  5. pmc Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
  6. ncbi request reprint Mammalian sperm proteins are rapidly evolving: evidence of positive selection in functionally diverse genes
    Dara G Torgerson
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 19:1973-80. 2002
  7. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
  8. pmc Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes
    Michael F Lin
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Genome Res 17:1823-36. 2007
  9. pmc The latest buzz in comparative genomics
    Rob J Kulathinal
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Genome Biol 6:201. 2005
  10. ncbi request reprint Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection
    Stanley A Sawyer
    Department of Mathematics, Washington University, St Louis, MO 63130, USA
    J Mol Evol 57:S154-64. 2003

Detail Information

Publications12

  1. ncbi request reprint Compensated deleterious mutations in insect genomes
    Rob J Kulathinal
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Science 306:1553-4. 2004
    ..Surprisingly, the fraction 10% is not affected by phylogenetic distance. These results support a selection-driven process that allows compensated amino acid substitutions to become rapidly fixed in taxa with large populations...
  2. ncbi request reprint Male sex drive and the masculinization of the genome
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Bioessays 27:518-25. 2005
    ..Male sex-drive theory complements the female-choice theory of sexual selection and allows for the genetic variation of costly sexual traits to be continuously replenished...
  3. ncbi request reprint Rapid evolution of the sex-determining gene, transformer: structural diversity and rate heterogeneity among sibling species of Drosophila
    Rob J Kulathinal
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 20:441-52. 2003
    ..A comparison of tra orthologs across the genus Drosophila suggest that TRA maintains an assortment of RS domains for proper sex determining function while much of the protein evolves relatively unconstrained...
  4. ncbi request reprint The nature of genetic variation in sex and reproduction-related genes among sibling species of the Drosophila melanogaster complex
    Rob J Kulathinal
    Department of Biology, McMaster University, Hamilton, Ont, Canada L8S 4K1
    Genetica 120:245-52. 2004
    ..These results follow a general trend observed in other taxa and demonstrate the preferential involvement of SRR genes in reproductive isolation and species formation...
  5. pmc Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
    ..SFP genes also show evidence of lineage-specific gene loss and/or gain. These results bring us closer to understanding the details of the evolutionary dynamics of SRR genes with respect to species divergence...
  6. ncbi request reprint Mammalian sperm proteins are rapidly evolving: evidence of positive selection in functionally diverse genes
    Dara G Torgerson
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 19:1973-80. 2002
    ..These results demonstrate the rapid evolution of sperm-specific genes and highlight the molecular action of sexual selection on a variety of characters involved in mammalian sperm function...
  7. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  8. pmc Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes
    Michael F Lin
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Genome Res 17:1823-36. 2007
    ..These results affect >10% of annotated fly genes and demonstrate the power of comparative genomics to enhance our understanding of genome organization, even in a model organism as intensively studied as Drosophila melanogaster...
  9. pmc The latest buzz in comparative genomics
    Rob J Kulathinal
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Genome Biol 6:201. 2005
    ..The publication of the Drosophila pseudoobscura sequence provides a snapshot of how genomes have changed over tens of millions of years and sets the stage for the analysis of more fly genomes...
  10. ncbi request reprint Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection
    Stanley A Sawyer
    Department of Mathematics, Washington University, St Louis, MO 63130, USA
    J Mol Evol 57:S154-64. 2003
    ..These results are model dependent and we discuss possible modifications of the model that might allow more neutral and nearly neutral amino acid replacements to be fixed...
  11. pmc Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence
    Rob J Kulathinal
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:10051-6. 2008
    ..We propose that it is not cross-overs per se that are mutagenic, but rather repair of DNA double-strand break precursors via crossing over and gene conversion...
  12. pmc The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint
    Cristian I Castillo-Davis
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genome Res 14:802-11. 2004
    ..Thus, strong purifying selection appears to act on the same core cellular processes in both mammalian and nematode lineages, whereas positive and/or relaxed selection acts on different biological processes in each lineage...