Research Topics
| M KubickiSummaryAffiliation: Harvard University Country: USA Publications
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Publications
An fMRI study of semantic processing in men with schizophreniaM Kubicki
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
Neuroimage 20:1923-33. 2003....- The application of DTI to investigate white matter abnormalities in schizophreniaMarek Kubicki
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry 116A, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
Ann N Y Acad Sci 1064:134-48. 2005..With the development of DTI, we are now able to investigate white matter abnormalities in schizophrenia... - Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosumM Kubicki
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, United States
Schizophr Res 106:125-31. 2008..Moreover, none of these studies has investigated corpus callosum systematically, using anatomical subdivisions... - DTI and MTR abnormalities in schizophrenia: analysis of white matter integrityM Kubicki
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
Neuroimage 26:1109-18. 2005.... - Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophreniaMarek Kubicki
Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Neuroimage 55:1657-64. 2011..However, due to technical challenges, anatomical connectivity abnormalities within this network and their involvement in clinical and cognitive deficits have not been studied... - A functional magnetic resonance imaging study of auditory mismatch in schizophreniaC G Wible
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Am J Psychiatry 158:938-43. 2001..CONCLUSIONS: This result is consistent with those of mismatch negativity event-related potential studies and suggests that early auditory processing is abnormal in chronic schizophrenia... - Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot studyZ Kikinis
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Schizophr Res 141:35-9. 2012..Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructural pathology in 22q11.2DS than in patients with schizophrenia... - Diffusion tractography of the fornix in schizophreniaJ Fitzsimmons
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Schizophr Res 107:39-46. 2009..We applied these techniques to quantify fornix diffusion anisotropy in schizophrenia... 
Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophreniaT J Whitford
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
Psychol Med 41:959-69. 2011..The nature of these abnormalities is unknown. This study investigated whether SZ patients experience CDs that are abnormally delayed in their arrival at the sensory cortex...- Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophreniaZ Kikinis
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Schizophr Res 123:153-9. 2010..This method of parcellation offers a more precise way of measuring MR-MFG that will likely be important in further documentation of DLPFC anomalies in schizophrenia... - Voxel-based morphometric analysis of gray matter in first episode schizophreniaM Kubicki
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Massachusetts, USA
Neuroimage 17:1711-9. 2002..They further suggest the importance of comparing VBM findings with more traditional ROI analyses until the reasons for the differences between methods are determined... - Thalamo-frontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography studyJungsu S Oh
Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Hum Brain Mapp 30:3812-25. 2009..These findings suggest that our method can enhance the regional and functional specificity of DTI group studies, thus improving our understanding of brain function... - Restoration of DWI data using a Rician LMMSE estimatorSantiago Aja-Fernandez
Laboratory for Mathematics in Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
IEEE Trans Med Imaging 27:1389-403. 2008..Filtering diffusion weighted magnetic resonance imaging (DW-MRI) with the proposed methodology leads to more accurate tensor estimations. Real and synthetic datasets are analyzed... - Age-related deficits in fronto-temporal connections in schizophrenia: a diffusion tensor imaging studyGudrun Rosenberger
Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, United States
Schizophr Res 102:181-8. 2008..Using diffusion tensor imaging tractography, we investigated the relationship between age and fiber integrity in patients with schizophrenia vs. healthy adults... - White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI studyHae-Jeong Park
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
Neuroimage 23:213-23. 2004..These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neurodevelopmental abnormalities in schizophrenia... - A review of diffusion tensor imaging studies in schizophreniaMarek Kubicki
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, 940 Belmont Street, Brockton, Boston, MA 02301, United States
J Psychiatr Res 41:15-30. 2007..Finally, we review MR-DTI findings in schizophrenia... - Structural neuroimaging in schizophrenia: from methods to insights to treatmentsMartha E Shenton
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, 1249 Boylston Street Boston, MA 02215, USA
Dialogues Clin Neurosci 12:317-32. 2010..We then review future prospects that need to be explored and pursued in order to translate our current knowledge into an understanding of the neurobiology of schizophrenia, which can then be translated into novel treatments... 
Connectivity among semantic associates: an fMRI study of semantic primingCynthia G Wible
Clinical Neuroscience Division, Laboratory of Neuroscience, Harvard Medical School, Boston, MA, USA
Brain Lang 97:294-305. 2006..fMRI activity located primarily in bilateral posterior superior and middle temporal regions showed modulation by connectivity and relatedness. The results suggest that these regions are involved in semantic processing...- Corpus callosum abnormalities and their association with psychotic symptoms in patients with schizophreniaThomas J Whitford
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Biol Psychiatry 68:70-7. 2010.... - Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging studyKangUk Lee
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
Schizophr Res 108:33-40. 2009..The goal of this study was to conduct the first Diffusion Tensor Imaging (DTI) study to investigate altered structural integrity in STG gray and white matter in patients with chronic schizophrenia compared with healthy controls... - A kernel-based approach for user-guided fiber bundling using diffusion tensor dataRaul San Jose Estepar
Lab of Math in Imaging, Brigham and Women s Hosp, Boston, MA, USA
Conf Proc IEEE Eng Med Biol Soc 1:2626-9. 2006..The method analyzes the responses obtained from the convolution with a kernel function along the fiber with the ROI data. Results in real data shows the feasibility of the approach to fiber bundling... - Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophreniaBumseok Jeong
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System, Boston, Massachusetts, USA
Hum Brain Mapp 30:4138-51. 2009.... - A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophreniaJames J Levitt
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Brockton, MA 02301 and Harvard Medical School, Boston, MA 02115, United States
Psychiatry Res 184:143-50. 2010..Despite not demonstrating a group difference in FA, we found that AL-IC FA was a good predictor of spatial and verbal declarative/episodic memory performance in schizophrenia... - Attentional networks and cingulum bundle in chronic schizophreniaPaul G Nestor
Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
Schizophr Res 90:308-15. 2007..In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration... - Comparing prefrontal gray and white matter contributions to intelligence and decision making in schizophrenia and healthy controlsPaul G Nestor
Department of Psychology, University of Massachusetts, Boston and Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Brockton, Massachusetts 02125 3393, USA
Neuropsychology 24:121-9. 2010..These results point to the potentially important role of CB white matter in the neuropsychological disturbance in schizophrenia... - Fornix integrity and hippocampal volume in male schizophrenic patientsNoriomi Kuroki
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, Brockton, Massachusetts, USA
Biol Psychiatry 60:22-31. 2006..CONCLUSIONS: These findings demonstrate a disruption in fornix integrity in patients with schizophrenia... - Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: a diffusion tensor imaging studyToshiro Kawashima
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
Schizophr Res 110:119-26. 2009..The CB abnormalities reported in chronic schizophrenia may develop during the later course of the disease... - Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging studyMarek Kubicki
Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System-Brockton Division, MA 02301, USA
Am J Psychiatry 159:813-20. 2002.... - Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging studyMarek Kubicki
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
Biol Psychiatry 54:1171-80. 2003..These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities... - Neuropsychological disturbance in schizophrenia: a diffusion tensor imaging studyPaul G Nestor
Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
Neuropsychology 22:246-54. 2008..Reduced white matter of the CB and the UF may each make distinct contributions to neuropsychological disturbance in schizophrenia... - Spatial normalization of diffusion tensor MRI using multiple channelsHae-Jeong Park
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Neuroimage 20:1995-2009. 2003.... - Method for combining information from white matter fiber tracking and gray matter parcellationHae-Jeong Park
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
AJNR Am J Neuroradiol 25:1318-24. 2004..We conclude that this new method for combining structural and DT imaging data is useful for understanding cortical connectivity and the localization of fiber tracts and their relationship with cortical anatomy and brain abnormalities... - Comparison of single-shot echo-planar and line scan protocols for diffusion tensor imagingMarek Kubicki
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
Acad Radiol 11:224-32. 2004..CONCLUSION: Results indicate that both EPI- and LSDI-derived FA measures are sufficiently robust. However, when higher accuracy is needed, LSDI provides smaller error and smaller inter-subject and inter-session variability than EPI... - Neuropsychological correlates of diffusion tensor imaging in schizophreniaPaul G Nestor
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston Veterans Affairs Health Care System Brockton Division, Brockton, MA 02301, USA
Neuropsychology 18:629-37. 2004..The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia... - Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging studyMotoaki Nakamura
Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
Biol Psychiatry 58:468-78. 2005.... - A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injuryM E Shenton
Clinical Neuroscience Laboratory, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA, USA
Brain Imaging Behav 6:137-92. 2012..Finally, we end with a discussion of future directions in research that will lead to the improved care of patients diagnosed with mTBI... - Color Stroop and negative priming in schizophrenia: an fMRI studyLida Ungar
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street 3rd Floor, Boston, MA 02215, USA
Psychiatry Res 181:24-9. 2010..These different patterns of fMRI activation may reflect faulty interaction in schizophrenia within networks of brain regions that are vital to selective attention... - An MRI study of spatial probability brain map differences between first-episode schizophrenia and normal controlsHae-Jeong Park
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Neuroimage 22:1231-46. 2004..Apparent group differences in activation may simply reflect a greater heterogeneity of spatial distribution in schizophrenia... - Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorderMin-Seong Koo
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
Arch Gen Psychiatry 63:1090-100. 2006..CONCLUSIONS: The smaller neocortical gray matter volume and larger sulcal CSF volume provide evidence of the brain basis of this personality disorder and emphasize the communality of brain abnormalities in the schizophrenia spectrum... - Episodic memory and neuroimaging of hippocampus and fornix in chronic schizophreniaPaul G Nestor
Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
Psychiatry Res 155:21-8. 2007..However, increased hippocampal volume correlated, in the negative direction, with lower scores for executive functioning and IQ in the control subset. Implications of these results are discussed... - Occipital lobe gray matter volume in male patients with chronic schizophrenia: A quantitative MRI studyToshiaki Onitsuka
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA, USA
Schizophr Res 92:197-206. 2007..These results suggest that reduced bilateral VAA may be a neurobiological substrate of some of the deficits observed in early visual processing in schizophrenia... - Diffusion tensor imaging and its application to neuropsychiatric disordersMarek Kubicki
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Mass 02301, USA
Harv Rev Psychiatry 10:324-36. 2002..quot; Finally, we consider potential future uses of DTI, including fiber tracking and surgical planning and follow-up... - The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging studyRonald J Gurrera
Schizophr Res 90:360-2. 2007 - Finsler tractography for white matter connectivity analysis of the cingulum bundleJohn Melonakos
Department of Electrical and Computer Engineering, Georgia Institute of Technology, USA
Med Image Comput Comput Assist Interv 10:36-43. 2007..We demonstrate the effectiveness of the algorithm for segmenting the cingulum bundle...
Research Grants
- White matter myelin abnormalities in schizophreniaMarek Kubicki; Fiscal Year: 2004..Results from this study will allow us to understand better white matter alterations in schizophrenia, and add to what we know about connectivity abnormalities in schizophrenia. ..