M Kubicki

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Decreased axial diffusivity within language connections: a possible biomarker of schizophrenia risk
    M Kubicki
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 148:67-73. 2013
  2. pmc DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Neuroimage 26:1109-18. 2005
  3. pmc Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia
    Marek Kubicki
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 55:1657-64. 2011
  4. pmc Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum
    M Kubicki
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, United States
    Schizophr Res 106:125-31. 2008
  5. pmc The application of DTI to investigate white matter abnormalities in schizophrenia
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry 116A, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Ann N Y Acad Sci 1064:134-48. 2005
  6. pmc An fMRI study of semantic processing in men with schizophrenia
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Neuroimage 20:1923-33. 2003
  7. pmc A functional magnetic resonance imaging study of auditory mismatch in schizophrenia
    C G Wible
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 158:938-43. 2001
  8. pmc Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study
    Z Kikinis
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 141:35-9. 2012
  9. pmc Diffusion tractography of the fornix in schizophrenia
    J Fitzsimmons
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 107:39-46. 2009
  10. pmc Voxel-based morphometric analysis of gray matter in first episode schizophrenia
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Massachusetts, USA
    Neuroimage 17:1711-9. 2002

Research Grants

Collaborators

Detail Information

Publications48

  1. pmc Decreased axial diffusivity within language connections: a possible biomarker of schizophrenia risk
    M Kubicki
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 148:67-73. 2013
    ..AX should be considered a possible biomarker of risk for developing schizophrenia. ..
  2. pmc DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Neuroimage 26:1109-18. 2005
    ....
  3. pmc Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia
    Marek Kubicki
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 55:1657-64. 2011
    ..However, due to technical challenges, anatomical connectivity abnormalities within this network and their involvement in clinical and cognitive deficits have not been studied...
  4. pmc Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum
    M Kubicki
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, United States
    Schizophr Res 106:125-31. 2008
    ..Moreover, none of these studies has investigated corpus callosum systematically, using anatomical subdivisions...
  5. pmc The application of DTI to investigate white matter abnormalities in schizophrenia
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry 116A, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Ann N Y Acad Sci 1064:134-48. 2005
    ..With the development of DTI, we are now able to investigate white matter abnormalities in schizophrenia...
  6. pmc An fMRI study of semantic processing in men with schizophrenia
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Neuroimage 20:1923-33. 2003
    ....
  7. pmc A functional magnetic resonance imaging study of auditory mismatch in schizophrenia
    C G Wible
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 158:938-43. 2001
    ..CONCLUSIONS: This result is consistent with those of mismatch negativity event-related potential studies and suggests that early auditory processing is abnormal in chronic schizophrenia...
  8. pmc Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study
    Z Kikinis
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 141:35-9. 2012
    ..Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructural pathology in 22q11.2DS than in patients with schizophrenia...
  9. pmc Diffusion tractography of the fornix in schizophrenia
    J Fitzsimmons
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 107:39-46. 2009
    ..We applied these techniques to quantify fornix diffusion anisotropy in schizophrenia...
  10. pmc Voxel-based morphometric analysis of gray matter in first episode schizophrenia
    M Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Massachusetts, USA
    Neuroimage 17:1711-9. 2002
    ..They further suggest the importance of comparing VBM findings with more traditional ROI analyses until the reasons for the differences between methods are determined...
  11. pmc Human middle longitudinal fascicle: variations in patterns of anatomical connections
    N Makris
    Department of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Brain Struct Funct 218:951-68. 2013
    ....
  12. pmc Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia
    Z Kikinis
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 123:153-9. 2010
    ..This method of parcellation offers a more precise way of measuring MR-MFG that will likely be important in further documentation of DLPFC anomalies in schizophrenia...
  13. pmc Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography
    N Makris
    Departments of Psychiatry and Neurology Services, Center for Neural Systems Investigations, Center for Morphometric Analysis, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA, 02129, USA
    Brain Imaging Behav 7:335-52. 2013
    ....
  14. pmc Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia
    T J Whitford
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
    Psychol Med 41:959-69. 2011
    ..The nature of these abnormalities is unknown. This study investigated whether SZ patients experience CDs that are abnormally delayed in their arrival at the sensory cortex...
  15. pmc Thalamo-frontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography study
    Jungsu S Oh
    Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 30:3812-25. 2009
    ..These findings suggest that our method can enhance the regional and functional specificity of DTI group studies, thus improving our understanding of brain function...
  16. pmc Restoration of DWI data using a Rician LMMSE estimator
    Santiago Aja-Fernandez
    Laboratory for Mathematics in Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Med Imaging 27:1389-403. 2008
    ..Filtering diffusion weighted magnetic resonance imaging (DW-MRI) with the proposed methodology leads to more accurate tensor estimations. Real and synthetic datasets are analyzed...
  17. pmc Age-related deficits in fronto-temporal connections in schizophrenia: a diffusion tensor imaging study
    Gudrun Rosenberger
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, United States
    Schizophr Res 102:181-8. 2008
    ..Using diffusion tensor imaging tractography, we investigated the relationship between age and fiber integrity in patients with schizophrenia vs. healthy adults...
  18. pmc White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study
    Hae Jeong Park
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
    Neuroimage 23:213-23. 2004
    ..These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neurodevelopmental abnormalities in schizophrenia...
  19. pmc A kernel-based approach for user-guided fiber bundling using diffusion tensor data
    Raul San Jose Estepar
    Lab of Math in Imaging, Brigham and Women s Hosp, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2626-9. 2006
    ..The method analyzes the responses obtained from the convolution with a kernel function along the fiber with the ROI data. Results in real data shows the feasibility of the approach to fiber bundling...
  20. pmc Structural neuroimaging in schizophrenia: from methods to insights to treatments
    Martha E Shenton
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, 1249 Boylston Street Boston, MA 02215, USA
    Dialogues Clin Neurosci 12:317-32. 2010
    ..We then review future prospects that need to be explored and pursued in order to translate our current knowledge into an understanding of the neurobiology of schizophrenia, which can then be translated into novel treatments...
  21. pmc A review of diffusion tensor imaging studies in schizophrenia
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, 940 Belmont Street, Brockton, Boston, MA 02301, United States
    J Psychiatr Res 41:15-30. 2007
    ..Finally, we review MR-DTI findings in schizophrenia...
  22. pmc Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophrenia
    Bumseok Jeong
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System, Boston, Massachusetts, USA
    Hum Brain Mapp 30:4138-51. 2009
    ....
  23. pmc Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging study
    KangUk Lee
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
    Schizophr Res 108:33-40. 2009
    ..The goal of this study was to conduct the first Diffusion Tensor Imaging (DTI) study to investigate altered structural integrity in STG gray and white matter in patients with chronic schizophrenia compared with healthy controls...
  24. ncbi request reprint Connectivity among semantic associates: an fMRI study of semantic priming
    Cynthia G Wible
    Clinical Neuroscience Division, Laboratory of Neuroscience, Harvard Medical School, Boston, MA, USA
    Brain Lang 97:294-305. 2006
    ..fMRI activity located primarily in bilateral posterior superior and middle temporal regions showed modulation by connectivity and relatedness. The results suggest that these regions are involved in semantic processing...
  25. pmc Corpus callosum abnormalities and their association with psychotic symptoms in patients with schizophrenia
    Thomas J Whitford
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Biol Psychiatry 68:70-7. 2010
    ....
  26. doi request reprint A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia
    James J Levitt
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Brockton, MA 02301 and Harvard Medical School, Boston, MA 02115, United States
    Psychiatry Res 184:143-50. 2010
    ..Despite not demonstrating a group difference in FA, we found that AL-IC FA was a good predictor of spatial and verbal declarative/episodic memory performance in schizophrenia...
  27. pmc Attentional networks and cingulum bundle in chronic schizophrenia
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
    Schizophr Res 90:308-15. 2007
    ..In addition, left CB fractional anisotropy correlated significantly with orienting of attention. Smaller right CB volume also correlated with reduced alertness, but not when covarying for medication and illness duration...
  28. doi request reprint Altered language network activity in young people at familial high-risk for schizophrenia
    H W Thermenos
    Harvard Medical School, Boston, MA, USA Massachusetts Mental Health Center Division of Public Psychiatry, Boston, MA, USA Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Electronic address
    Schizophr Res 151:229-37. 2013
    ..The neural underpinnings of these deficits in people with FHR are unclear...
  29. pmc Comparing prefrontal gray and white matter contributions to intelligence and decision making in schizophrenia and healthy controls
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston and Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Brockton, Massachusetts 02125 3393, USA
    Neuropsychology 24:121-9. 2010
    ..These results point to the potentially important role of CB white matter in the neuropsychological disturbance in schizophrenia...
  30. pmc Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System Brockton Division, MA 02301, USA
    Am J Psychiatry 159:813-20. 2002
    ..Here the authors focus on fiber tracts forming temporal-frontal connections...
  31. pmc Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 54:1171-80. 2003
    ..These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities...
  32. pmc Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: a diffusion tensor imaging study
    Toshiro Kawashima
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 110:119-26. 2009
    ..The CB abnormalities reported in chronic schizophrenia may develop during the later course of the disease...
  33. pmc Fornix integrity and hippocampal volume in male schizophrenic patients
    Noriomi Kuroki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, Brockton, Massachusetts, USA
    Biol Psychiatry 60:22-31. 2006
    ..Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia...
  34. pmc Neuropsychological disturbance in schizophrenia: a diffusion tensor imaging study
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
    Neuropsychology 22:246-54. 2008
    ..Reduced white matter of the CB and the UF may each make distinct contributions to neuropsychological disturbance in schizophrenia...
  35. pmc Spatial normalization of diffusion tensor MRI using multiple channels
    Hae Jeong Park
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 20:1995-2009. 2003
    ....
  36. pmc Comparison of single-shot echo-planar and line scan protocols for diffusion tensor imaging
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, Department of Psychiatry, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Acad Radiol 11:224-32. 2004
    ..To date, there has been no comparison of EPI and LSDI. Because EPI is the most commonly used technique for acquiring diffusion tensor data, it is important to understand the limitations and advantages of LSDI relative to EPI...
  37. pmc Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging study
    Motoaki Nakamura
    Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
    Biol Psychiatry 58:468-78. 2005
    ..Here, we investigate these two bundles in unmedicated subjects with schizotypal personality disorder (SPD)...
  38. pmc Neuropsychological correlates of diffusion tensor imaging in schizophrenia
    Paul G Nestor
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston Veterans Affairs Health Care System Brockton Division, Brockton, MA 02301, USA
    Neuropsychology 18:629-37. 2004
    ..The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia...
  39. pmc Method for combining information from white matter fiber tracking and gray matter parcellation
    Hae Jeong Park
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
    AJNR Am J Neuroradiol 25:1318-24. 2004
    ..We conclude that this new method for combining structural and DT imaging data is useful for understanding cortical connectivity and the localization of fiber tracts and their relationship with cortical anatomy and brain abnormalities...
  40. pmc A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury
    M E Shenton
    Clinical Neuroscience Laboratory, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA, USA
    Brain Imaging Behav 6:137-92. 2012
    ..Finally, we end with a discussion of future directions in research that will lead to the improved care of patients diagnosed with mTBI...
  41. ncbi request reprint Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 63:1090-100. 2006
    ..Structural brain abnormalities, including larger cerebrospinal fluid (CSF) volumes, have been observed in men diagnosed as having schizotypal personality disorder (SPD)...
  42. pmc An MRI study of spatial probability brain map differences between first-episode schizophrenia and normal controls
    Hae Jeong Park
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 22:1231-46. 2004
    ..Apparent group differences in activation may simply reflect a greater heterogeneity of spatial distribution in schizophrenia...
  43. pmc Color Stroop and negative priming in schizophrenia: an fMRI study
    Lida Ungar
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street 3rd Floor, Boston, MA 02215, USA
    Psychiatry Res 181:24-9. 2010
    ..These different patterns of fMRI activation may reflect faulty interaction in schizophrenia within networks of brain regions that are vital to selective attention...
  44. ncbi request reprint Episodic memory and neuroimaging of hippocampus and fornix in chronic schizophrenia
    Paul G Nestor
    Department of Psychology, University of Massachusetts, Boston, MA 02125 3393, USA
    Psychiatry Res 155:21-8. 2007
    ..However, increased hippocampal volume correlated, in the negative direction, with lower scores for executive functioning and IQ in the control subset. Implications of these results are discussed...
  45. pmc Occipital lobe gray matter volume in male patients with chronic schizophrenia: A quantitative MRI study
    Toshiaki Onitsuka
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA, USA
    Schizophr Res 92:197-206. 2007
    ..These results suggest that reduced bilateral VAA may be a neurobiological substrate of some of the deficits observed in early visual processing in schizophrenia...
  46. pmc Diffusion tensor imaging and its application to neuropsychiatric disorders
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Mass 02301, USA
    Harv Rev Psychiatry 10:324-36. 2002
    ..quot; Finally, we consider potential future uses of DTI, including fiber tracking and surgical planning and follow-up...
  47. pmc The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging study
    Ronald J Gurrera
    Schizophr Res 90:360-2. 2007
  48. pmc Finsler tractography for white matter connectivity analysis of the cingulum bundle
    John Melonakos
    Department of Electrical and Computer Engineering, Georgia Institute of Technology, USA
    Med Image Comput Comput Assist Interv 10:36-43. 2007
    ..We demonstrate the effectiveness of the algorithm for segmenting the cingulum bundle...

Research Grants1

  1. White matter myelin abnormalities in schizophrenia
    Marek Kubicki; Fiscal Year: 2004
    ..Results from this study will allow us to understand better white matter alterations in schizophrenia, and add to what we know about connectivity abnormalities in schizophrenia. ..