ANDRZEJ KROLEWSKI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Serum concentration of cystatin C and risk of end-stage renal disease in diabetes
    Andrzej S Krolewski
    Research and Clinic Divisions, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Diabetes Care 35:2311-6. 2012
  2. pmc High risk of ESRD in type 1 diabetes: new strategies are needed to retard progressive renal function decline
    Andrzej S Krolewski
    Research Division of the Joslin Diabetes Center, Harvard Medicial School, Boston, MA, USA
    Semin Nephrol 32:407-14. 2012
  3. pmc Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes
    Tomohito Gohda
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    J Am Soc Nephrol 23:516-24. 2012
  4. pmc Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes
    Monika A Niewczas
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 23:507-15. 2012
  5. ncbi request reprint A genome-wide linkage scan for genes controlling variation in urinary albumin excretion in type II diabetes
    A S Krolewski
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 69:129-36. 2006
  6. pmc High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up
    Linda H Ficociello
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 33:1337-43. 2010
  7. ncbi request reprint TGF-beta 1 as a genetic susceptibility locus for advanced diabetic nephropathy in type 1 diabetes mellitus: an investigation of multiple known DNA sequence variants
    Daniel P K Ng
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Am J Kidney Dis 41:22-8. 2003
  8. pmc A novel framework for sib pair linkage analysis
    G David Poznik
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Am J Hum Genet 78:222-30. 2006
  9. pmc High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes
    Elizabeth T Rosolowsky
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 3:706-13. 2008
  10. ncbi request reprint Genetic studies of late diabetic complications: the overlooked importance of diabetes duration before complication onset
    John J Rogus
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215 5397, USA
    Diabetes 51:1655-62. 2002

Research Grants

  1. Mapping genes for proteinuria in type II diabetes
    Andrzej S Krolewski; Fiscal Year: 2010
  2. Mapping Genes for Nephropathy in Type 2 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2005
  3. IDENTIFICATION OF SUSCEPTIBILITY GENES FOR NIDDM
    ANDRZEJ KROLEWSKI; Fiscal Year: 2004
  4. Natural History of Microalbuminuria in Type 1 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2007
  5. Natural History of Microalbuminuria in Type 1 Diabetes
    Andrzej S Krolewski; Fiscal Year: 2010
  6. Natural History of Microalbuminuria in Type 1 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2009
  7. Mapping Genes for End-Stage Renal Disease in Type 1 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2007
  8. Mapping genes for proteinuria in type II diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2007
  9. The Urinary Proteome and Renal Function Loss in Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2007
  10. NATURAL HISTORY OF MICROALBUMINURIA IN TYPE I DIABETICS
    ANDRZEJ KROLEWSKI; Fiscal Year: 2002

Collaborators

Detail Information

Publications48

  1. pmc Serum concentration of cystatin C and risk of end-stage renal disease in diabetes
    Andrzej S Krolewski
    Research and Clinic Divisions, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Diabetes Care 35:2311-6. 2012
    ....
  2. pmc High risk of ESRD in type 1 diabetes: new strategies are needed to retard progressive renal function decline
    Andrzej S Krolewski
    Research Division of the Joslin Diabetes Center, Harvard Medicial School, Boston, MA, USA
    Semin Nephrol 32:407-14. 2012
    ..Consistent with concepts of personalized medicine, the new interventions should be tailored to and evaluated in patients predicted to have rapid, moderate, or even slow progression to ESRD...
  3. pmc Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes
    Tomohito Gohda
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    J Am Soc Nephrol 23:516-24. 2012
    ..In conclusion, early GFR loss in patients with type 1 diabetes without proteinuria is strongly associated with circulating TNF receptor levels but not TNF╬▒ levels (free or total)...
  4. pmc Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes
    Monika A Niewczas
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 23:507-15. 2012
    ..In conclusion, elevated concentrations of circulating TNFRs in patients with type 2 diabetes at baseline are very strong predictors of the subsequent progression to ESRD in subjects with and without proteinuria...
  5. ncbi request reprint A genome-wide linkage scan for genes controlling variation in urinary albumin excretion in type II diabetes
    A S Krolewski
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 69:129-36. 2006
    ..4). In conclusion, genes on chromosomes 22q, 5q and 7q may contribute to variation in urinary albumin excretion in diabetic and nondiabetic individuals...
  6. pmc High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up
    Linda H Ficociello
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 33:1337-43. 2010
    ..Here, we prospectively investigated whether baseline uric acid impacts the risk of early progressive renal function loss (early GFR loss) in these patients...
  7. ncbi request reprint TGF-beta 1 as a genetic susceptibility locus for advanced diabetic nephropathy in type 1 diabetes mellitus: an investigation of multiple known DNA sequence variants
    Daniel P K Ng
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Am J Kidney Dis 41:22-8. 2003
    ..However, its potential role as a susceptibility gene for the development of this microvascular complication is unresolved...
  8. pmc A novel framework for sib pair linkage analysis
    G David Poznik
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Am J Hum Genet 78:222-30. 2006
    ..The application of Splat will be illustrated with data from studies on the genetics of diabetic nephropathy...
  9. pmc High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes
    Elizabeth T Rosolowsky
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 3:706-13. 2008
    ..The association of elevated serum uric acid with advanced impaired renal function prompts an examination of its role in early renal function decline in patients before proteinuria develops...
  10. ncbi request reprint Genetic studies of late diabetic complications: the overlooked importance of diabetes duration before complication onset
    John J Rogus
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215 5397, USA
    Diabetes 51:1655-62. 2002
    ..Our results indicate that problems can be minimized by selecting case subjects with short diabetes duration and, to a lesser extent, control subjects with long duration or, perhaps, by adjusting for duration during analysis...
  11. ncbi request reprint Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-beta1 (PRKCB1) gene locus
    Shin Ichi Araki
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 14:2015-24. 2003
    ..It is concluded that DNA sequence differences in the promoter of PRKCB1 contribute to diabetic nephropathy susceptibility in type I diabetes mellitus...
  12. ncbi request reprint Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes
    Bruce A Perkins
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Am Soc Nephrol 18:1353-61. 2007
    ..Together with testing for microalbuminuria, clinical protocols using cystatin C to diagnose early renal function decline and track response to therapeutic interventions should be developed...
  13. doi request reprint Between hyperfiltration and impairment: demystifying early renal functional changes in diabetic nephropathy
    Elizabeth T Rosolowsky
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetes Res Clin Pract 82:S46-53. 2008
    ..To date, serum uric acid and components of the TNFalpha pathway appear to be involved...
  14. pmc Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes
    Monika A Niewczas
    Research Division of Joslin Diabetes Center, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 4:62-70. 2009
    ..The aim of our study was to examine serum markers of the TNF and Fas pathways for association with cystatin-C based estimated glomerular filtration rate (cC-GFR) in subjects with type 1 diabetes (T1DM) and no proteinuria...
  15. ncbi request reprint Early nephropathy in type 1 diabetes: a new perspective on who will and who will not progress
    Bruce A Perkins
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Curr Diab Rep 5:455-63. 2005
    ..Therefore, early renal function decline, rather than microalbuminuria, may be considered as the early marker of the committed process underlying progressive diabetic nephropathy...
  16. pmc Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:1403-10. 2009
    ..To search for genes that contribute to diabetic nephropathy, a genome-wide association scan was implemented on the Genetics of Kidneys in Diabetes collection...
  17. ncbi request reprint Methylenetetrahydrofolate reductase gene polymorphism and susceptibility to diabetic nephropathy in type 1 diabetes
    Yuichiro Makita
    Research Division, Joslin Diabetes Center, Boston, MA 02215 5397, USA
    Am J Kidney Dis 41:1189-94. 2003
    ..We examined this hypothesis in both a case-control and a follow-up study in individuals with type 1 diabetes...
  18. ncbi request reprint Genetic modifiers of the age at diagnosis of diabetes (MODY3) in carriers of hepatocyte nuclear factor-1alpha mutations map to chromosomes 5p15, 9q22, and 14q24
    Sung Hoon Kim
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 52:2182-6. 2003
    ..Identification of these genes will offer new insights into the pathophysiology of MODY that may, in turn, increase our understanding of the cellular events underlying more common forms of diabetes...
  19. pmc Renal hyperfiltration and the development of microalbuminuria in type 1 diabetes
    Linda H Ficociello
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 32:889-93. 2009
    ..The purpose of this study was to examine prospectively whether renal hyperfiltration is associated with the development of microalbuminuria in patients with type 1 diabetes, after taking into account known risk factors...
  20. ncbi request reprint Minor effect of GLUT1 polymorphisms on susceptibility to diabetic nephropathy in type 1 diabetes
    Daniel P K Ng
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 51:2264-9. 2002
    ..Although these SNPs confer a considerable personal risk for diabetic nephropathy, they account for a limited proportion of cases among type 1 diabetic patients...
  21. ncbi request reprint Determinants of progression from microalbuminuria to proteinuria in patients who have type 1 diabetes and are treated with angiotensin-converting enzyme inhibitors
    Linda H Ficociello
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Clin J Am Soc Nephrol 2:461-9. 2007
    ..The mechanisms that are responsible for the frequent failure of ACE-I to prevent progression of microalbuminuria to proteinuria in a clinical setting are not clear...
  22. pmc High-density single nucleotide polymorphism genome-wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: discordant sibpair approach
    John J Rogus
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 57:2519-26. 2008
    ..Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes...
  23. pmc Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics
    Pawel P Wolkow
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Am Soc Nephrol 19:789-97. 2008
    ..These results support the hypothesis that inflammatory processes in the kidney contribute to the progression of nephropathy in patients with type 1 diabetes...
  24. ncbi request reprint Regression of microalbuminuria in type 1 diabetes
    Bruce A Perkins
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 348:2285-93. 2003
    ..In the present study, we aimed to determine the frequency of a significant reduction in urinary albumin excretion and factors affecting such reduction in patients with type 1 diabetes and microalbuminuria...
  25. ncbi request reprint A genome-wide linkage scan for genes controlling variation in renal function estimated by serum cystatin C levels in extended families with type 2 diabetes
    Grzegorz Placha
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:3358-65. 2006
    ..None of these genes overlaps with genes controlling variation in urinary albumin excretion...
  26. ncbi request reprint Polymorphism in ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene (ENPP1/PC-1) and early development of advanced diabetic nephropathy in type 1 diabetes
    Luis H Canani
    Research Division, Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts
    Diabetes 51:1188-93. 2002
    ..Similar findings were obtained in a family-based study. We conclude that carriers of the Q variant of ENPP1 are at increased risk for developing ESRD early in the course of type 1 diabetes...
  27. ncbi request reprint Examination of candidate chromosomal regions for type 2 diabetes reveals a susceptibility locus on human chromosome 8p23.1
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 53:486-91. 2004
    ..Although we were able to replicate linkage in our pedigrees on chromosome 2p, we did not find evidence of linkage for regions on 1q, 2q, 3q, 5q, 9q, or 10q...
  28. pmc Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:2698-702. 2009
    ....
  29. ncbi request reprint Identification of a locus for maturity-onset diabetes of the young on chromosome 8p23
    Sung Hoon Kim
    Research Division, Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 53:1375-84. 2004
    ..Another novel MODY locus may be present on 2q37. Cloning these new MODY genes may offer insights to disease pathways that are relevant to the cause of common type 2 diabetes...
  30. pmc Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study
    Bruce A Perkins
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 16:1404-12. 2005
    ..35). Serial measures of serum cystatin C accurately detect trends in renal function in patients with normal or elevated GFR and provide means for studying early renal function decline in diabetes...
  31. ncbi request reprint Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sex-specific effect
    Wojciech M Mlynarski
    Section on GeneticsEpidemiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetes 54:3331-5. 2005
    ..In conclusion, two functional polymorphisms in CCR5 that decrease expression of the RANTES receptor on immunocompetent cells are associated with increased risk of diabetic nephropathy in type 1 diabetes, but only in men...
  32. pmc Risk for ESRD in type 1 diabetes remains high despite renoprotection
    Elizabeth T Rosolowsky
    Section on Genetics and Epidemiology, Research and Clinic Divisions, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Am Soc Nephrol 22:545-53. 2011
    ..In conclusion, despite the widespread adoption of renoprotective treatment, patients with type 1 diabetes and macroalbuminuria remain at high risk for ESRD, suggesting that more effective therapies are desperately needed...
  33. ncbi request reprint A method for developing high-density SNP maps and its application at the type 1 angiotensin II receptor (AGTR1) locus
    Anthony Antonellis
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts, 02215, USA
    Genomics 79:326-32. 2002
    ..Using this technique, we efficiently validated and genotyped 18 polymorphisms spanning the 60.5-kb AGTR1 locus. Our panel of polymorphisms has an average spacing of 3.2 kb and an average minor allele frequency of 24%...
  34. ncbi request reprint Evidence for different susceptibility genes for proteinuria and ESRD in type 2 diabetes
    Grzegorz Placha
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Adv Chronic Kidney Dis 12:155-69. 2005
    ..Meanwhile, significant efforts that make use of the candidate-gene approach have been directed to the search for susceptibility genes for diabetic nephropathy. Unfortunately, positive findings have not been consistent...
  35. pmc Identification of a locus modulating serum C-reactive protein levels on chromosome 5p15
    Hillary A Keenan
    Research Division, Joslin Diabetes Center, Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Atherosclerosis 196:863-70. 2008
    ..To identify genes involved in this modulation, we performed a 10cM genome screen for linkage with plasma C-reactive protein in 38 extended families including 317 non-diabetic and 177 type 2 diabetic family members (2547 relative pairs)...
  36. pmc Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction
    Maciej Borowiec
    Research Division, Department of Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 106:14460-5. 2009
    ..1. These actions are greatly attenuated by the Ala71Thr mutation. These findings point to BLK as a previously unrecognized modulator of beta-cell function, the deficit of which may lead to the development of diabetes...
  37. doi request reprint Genetic variation at the SLC12A3 locus is unlikely to explain risk for advanced diabetic nephropathy in Caucasians with type 2 diabetes
    Daniel P K Ng
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
    Nephrol Dial Transplant 23:2260-4. 2008
    ..However, it is not known whether these polymorphisms confer a risk for this complication in type 2 diabetic Caucasians...
  38. ncbi request reprint The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes
    Luis H Canani
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes 54:3326-30. 2005
    ..7 [1.0-7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients...
  39. pmc Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies
    Krzysztof Wanic
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
    Diabetes 57:2547-51. 2008
    ....
  40. pmc Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes
    Patricia W Mueller
    Centers for Disease Control and Prevention, Diabetes and Molecular Risk Assessment Laboratory, Atlanta, Georgia, USA
    J Am Soc Nephrol 17:1782-90. 2006
    ..This overview of the GoKinD study examines in detail the power of each study component and discusses analytic challenges that investigators will face in using this resource...
  41. ncbi request reprint A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus
    Daniel P K Ng
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
    Diabetes 55:2660-3. 2006
    ..T.D risk haplotype in case subjects (0.136) compared with control subjects (0.075) (P = 0.009), thus providing first evidence for a disease haplotype for advanced diabetic nephropathy at the ACE locus...
  42. ncbi request reprint Cystatin C and the risk of death
    Bruce A Perkins
    N Engl J Med 353:842-4; author reply 842-4. 2005
  43. ncbi request reprint New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals
    Jacek Bochenski
    Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetes 55:2626-30. 2006
    ..In conclusion, we found a new SNP, rs997509, in intron 1 that is strongly associated with risk of type 2 diabetes in obese individuals. The molecular mechanisms underlying this association are unknown...
  44. ncbi request reprint Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy
    Daniel P K Ng
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 53:865-9. 2004
    ..Similar results were obtained among type 2 diabetic subjects (202 case and 114 control subjects). Genetic variation in GFPT1 is thus unlikely to have a major impact on susceptibility to diabetic nephropathy...
  45. pmc An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients
    Daniel P K Ng
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Kidney Int 74:521-7. 2008
    ..Our study has found a specific IL-6 haplotype conferring risk for impaired renal function in patients with type 2 diabetes...
  46. ncbi request reprint Determinants of the development of diabetes (maturity-onset diabetes of the young-3) in carriers of HNF-1alpha mutations: evidence for parent-of-origin effect
    Tomasz Klupa
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 25:2292-301. 2002
    ..To determine the distribution of the age at onset of diabetes (maturity-onset diabetes of the young-3 [MODY3]) and to identify determinants of the onset of diabetes in carriers of HNF-1alpha mutations...
  47. ncbi request reprint Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity
    Csaba Szabo
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Circulation 106:2680-6. 2002
    ....
  48. ncbi request reprint Epidemic of end-stage renal disease in people with diabetes in the United States population: do we know the cause?
    Camille A Jones
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 67:1684-91. 2005
    ..In this report we examined factors that may account for the increase to determine whether it truly represents an epidemic of ESRD due to diabetes...

Research Grants50

  1. Mapping genes for proteinuria in type II diabetes
    Andrzej S Krolewski; Fiscal Year: 2010
    ..Furthermore while the proposed study aims to limit genetic and phenotypic heterogeneity to increase effectiveness, the generalizability of the findings will be verified by examining multi-center collections such as GoKinD and FIND. ..
  2. Mapping Genes for Nephropathy in Type 2 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2005
    ..This study design seems to be more efficient in detecting linkage for nephropathy than the traditional ASP (affected sib-pair) design. ..
  3. IDENTIFICATION OF SUSCEPTIBILITY GENES FOR NIDDM
    ANDRZEJ KROLEWSKI; Fiscal Year: 2004
    ..abstract_text> ..
  4. Natural History of Microalbuminuria in Type 1 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2007
    ..If our research is successful, individuals at high risk of renal function loss can be identified and targeted for intervention 5-10 years earlier than currently achievable, possibly with protocols aimed at new therapeutic targets. ..
  5. Natural History of Microalbuminuria in Type 1 Diabetes
    Andrzej S Krolewski; Fiscal Year: 2010
    ..The second is to develop diagnostic tools to identify those patients at risk of ESRD 5-10 year earlier than current methods. ..
  6. Natural History of Microalbuminuria in Type 1 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2009
    ..The second is to develop diagnostic tools to identify those patients at risk of ESRD 5-10 year earlier than current methods. ..
  7. Mapping Genes for End-Stage Renal Disease in Type 1 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2007
    ..4) Investigate the ESRD-associated haplo-blocks to identify ESRD susceptibility genes through bioinformatics and molecular genetics protocols. ..
  8. Mapping genes for proteinuria in type II diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2007
    ..Furthermore while the proposed study aims to limit genetic and phenotypic heterogeneity to increase effectiveness, the generalizability of the findings will be verified by examining multi-center collections such as GoKinD and FIND. ..
  9. The Urinary Proteome and Renal Function Loss in Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2007
    ..The proposed research on the mechanisms and determinants of early renal function decline is novel and will provide data for the development of effective methods of prevention of renal function loss in diabetes. ..
  10. NATURAL HISTORY OF MICROALBUMINURIA IN TYPE I DIABETICS
    ANDRZEJ KROLEWSKI; Fiscal Year: 2002
    ..We will test the hypothesis that polymorphisms in eNOS and ACE genes contribute to the onset of microalbuminuria and polymorphism in ApoE contributes to progression of microalbuminuria to overt proteinuria. ..
  11. MAPPING GENES FOR NEPHROPATHY IN IDDM
    ANDRZEJ KROLEWSKI; Fiscal Year: 2001
    ....
  12. IDENTIFICATION OF SUSCEPTIBILITY GENES FOR NIDDM
    ANDRZEJ KROLEWSKI; Fiscal Year: 2000
    ..These findings will provide the bases for investigations of specific molecular defects which underlie susceptibility to NIDDM. ..
  13. NATURAL HISTORY OF MICROALBUMINURIA IN TYPE I DIABETES
    ANDRZEJ KROLEWSKI; Fiscal Year: 1993
    ....