Anna M Krichevsky

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc RNAi functions in cultured mammalian neurons
    Anna M Krichevsky
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:11926-9. 2002
  2. pmc Specific microRNAs modulate embryonic stem cell-derived neurogenesis
    Anna M Krichevsky
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 24:857-64. 2006
  3. pmc Human glioma growth is controlled by microRNA-10b
    Galina Gabriely
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 71:3563-72. 2011
  4. pmc Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway
    Okay Saydam
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts 02129, USA
    Mol Cell Biol 29:5923-40. 2009
  5. pmc miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways
    Okay Saydam
    Department of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:852-61. 2011
  6. pmc miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells
    Thomas Wurdinger
    Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 14:382-93. 2008
  7. doi request reprint De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease
    Hon Kit Andus Wong
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Hum Mol Genet 22:3077-92. 2013
  8. pmc MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons
    Sabrina Absalon
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, Massachusetts 02115
    J Neurosci 33:14645-59. 2013
  9. pmc Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    Johan Skog
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Nat Cell Biol 10:1470-6. 2008
  10. pmc MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity
    Nadiya M Teplyuk
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neuro Oncol 14:689-700. 2012

Collaborators

Detail Information

Publications25

  1. pmc RNAi functions in cultured mammalian neurons
    Anna M Krichevsky
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:11926-9. 2002
    ..We report here an application of RNAi to postmitotic primary neuronal cultures. Synthetic siRNA can be readily introduced into neurons and effectively inhibit the expression of endogenous and transfected genes...
  2. pmc Specific microRNAs modulate embryonic stem cell-derived neurogenesis
    Anna M Krichevsky
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 24:857-64. 2006
    ..We conclude that distinct miRNAs play a functional role in the determination of neural fates in ES cell differentiation...
  3. pmc Human glioma growth is controlled by microRNA-10b
    Galina Gabriely
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 71:3563-72. 2011
    ..Altogether, our experiments validate an important role of miR-10b in gliomagenesis, reveal a novel mechanism of miR-10b-mediated regulation, and suggest the possibility of its future use as a therapeutic target in gliomas...
  4. pmc Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway
    Okay Saydam
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts 02129, USA
    Mol Cell Biol 29:5923-40. 2009
    ....
  5. pmc miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways
    Okay Saydam
    Department of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:852-61. 2011
    ..Our findings suggest miR-7 as a potential therapeutic molecule for schwannoma treatment, and they prompt clinical evaluation of drugs that can inhibit the EGFR, Pak1, and Ack1 signaling pathways to treat this tumor type...
  6. pmc miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells
    Thomas Wurdinger
    Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 14:382-93. 2008
    ..Furthermore, inhibition of miR-296 with antagomirs reduces angiogenesis in tumor xenografts in vivo...
  7. doi request reprint De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease
    Hon Kit Andus Wong
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Hum Mol Genet 22:3077-92. 2013
    ..These results indicate that the miR-132/miR-212/PTEN/FOXO3a signaling pathway contributes to AD neurodegeneration. ..
  8. pmc MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons
    Sabrina Absalon
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, Massachusetts 02115
    J Neurosci 33:14645-59. 2013
    ..Therefore, upregulation of miR-26b in neurons causes pleiotropic phenotypes that are also observed in AD. Elevated levels of miR-26b may thus contribute to the AD neuronal pathology. ..
  9. pmc Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    Johan Skog
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Nat Cell Biol 10:1470-6. 2008
    ..Thus, tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test...
  10. pmc MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity
    Nadiya M Teplyuk
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neuro Oncol 14:689-700. 2012
    ..This study demonstrates that microRNA-based detection of brain malignancies can be reliably performed and that microRNAs in CSF can serve as biomarkers of treatment response in brain cancers...
  11. pmc Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
    Oleg Butovsky
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 122:3063-87. 2012
    ..Our results suggest that recruitment of inflammatory monocytes plays an important role in disease progression and that modulation of these cells is a potential therapeutic approach...
  12. doi request reprint Context effect: microRNA-10b in cancer cell proliferation, spread and death
    Galina Gabriely
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Autophagy 7:1384-6. 2011
    ..Here, we discuss a unique role of miR-10b in cancer cell survival, in diverse tumor microenvironments...
  13. ncbi request reprint MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas
    Maarten F Corsten
    Center for Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Cancer Res 67:8994-9000. 2007
    ..Furthermore, our findings provide the basis for developing combination therapies using miRNA modulation and cytotoxic tumor therapies...
  14. pmc MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
    Galina Gabriely
    Center of Neurologic Diseases, Brigham and Women s Hospital, 4 Blackfan Circle, HIM 758, Boston, MA 02115, USA
    Mol Cell Biol 28:5369-80. 2008
    ....
  15. pmc Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology
    Filip Simunovic
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Brain 132:1795-809. 2009
    ..Our data provide a 'molecular fingerprint identity' of late-stage Parkinson's disease DA neurons that will advance our understanding of the molecular pathology of this disease...
  16. pmc MicroRNA profiling of the murine hematopoietic system
    Silvia Monticelli
    Department of Pathology, Harvard Medical School, and CBR Institute for Biomedical Research, Boston, MA 02115, USA
    Genome Biol 6:R71. 2005
    ..It is becoming clear that miRNAs play an important role in the regulation of gene expression during development. However, in mammals, expression data are principally based on whole tissue analysis and are still very incomplete...
  17. doi request reprint miR-21: a small multi-faceted RNA
    Anna M Krichevsky
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Cell Mol Med 13:39-53. 2009
    ....
  18. pmc A microRNA array reveals extensive regulation of microRNAs during brain development
    Anna M Krichevsky
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    RNA 9:1274-81. 2003
    ..Creating clusters of coexpressed miRNAs will contribute to understanding their regulation, functions, and discovery of mRNA targets...
  19. ncbi request reprint MicroRNA profiling: from dark matter to white matter, or identifying new players in neurobiology
    Anna M Krichevsky
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    ScientificWorldJournal 7:155-66. 2007
    ..To facilitate these emerging studies, I here review the basic principles of medium- and high-throughput technologies available for miRNA expression profiling...
  20. ncbi request reprint BACE1 suppression by RNA interference in primary cortical neurons
    Shih Chu Kao
    Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, Armenise Building, 200 Longwood Avenue, Boston, MA 02115, USA
    J Biol Chem 279:1942-9. 2004
    ..Our results indicate that BACE1 siRNA specifically impacts on beta-cleavage of APP and may be a potential therapeutic approach for treating AD...
  21. ncbi request reprint MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    Jennifer A Chan
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:6029-33. 2005
    ..Our data suggest that aberrantly expressed miR-21 may contribute to the malignant phenotype by blocking expression of critical apoptosis-related genes...
  22. pmc MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway
    Eugene D Ponomarev
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:64-70. 2011
    ..These findings identify miR-124 both as a key regulator of microglia quiescence in the central nervous system and as a previously unknown modulator of monocyte and macrophage activation...
  23. ncbi request reprint The message and the messenger: delivering RNA in neurons
    Kenneth S Kosik
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci STKE 2002:pe16. 2002
    ..Kosik and Krichevsky describe how a dynamic macromolecular structure, the RNA granule, may be a key element contributing to changes in protein production leading to synaptic plasticity...
  24. ncbi request reprint Teaching resources. A model for local regulation of translation near active synapses
    Kenneth S Kosik
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106 5060, USA
    Sci STKE 2005:tr25. 2005
    ....
  25. ncbi request reprint The Elegance of the MicroRNAs: A Neuronal Perspective
    Kenneth S Kosik
    Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106, USA
    Neuron 47:779-82. 2005
    ..This review examines the interface between an emerging biology of miRNAs and their role in nervous systems...