Peter Kraft

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17142. 2011
  2. pmc Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R18. 2007
  3. pmc A Bayesian latent class analysis for whole-genome association analyses: an illustration using the GAW15 simulated rheumatoid arthritis dense scan data
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Kresge Building, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    BMC Proc 1:S112. 2007
  4. pmc Exhaustive screens for disease susceptibility loci incorporating statistical interaction of genotypes: a comparison of likelihood-ratio-based and Akaike and Bayesian information criteria-based methods
    Fangyi Gu
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Building 2, Room 9, Boston, Massachusetts 02115 USA
    BMC Proc 1:S25. 2007
  5. pmc Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
  6. ncbi request reprint Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 28:261-72. 2005
  7. ncbi request reprint Curses--winner's and otherwise--in genetic epidemiology
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 19:649-51; discussion 657-8. 2008
  8. pmc Integrating epidemiology and genetic association: the challenge of gene-environment interaction
    Peter Kraft
    Departments of Epidemiology and Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Philos Trans R Soc Lond B Biol Sci 360:1609-16. 2005
  9. doi request reprint Beyond odds ratios--communicating disease risk based on genetic profiles
    Peter Kraft
    Harvard School of Public Health, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Genet 10:264-9. 2009
  10. ncbi request reprint Exploiting gene-environment interaction to detect genetic associations
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Hered 63:111-9. 2007

Collaborators

Detail Information

Publications135 found, 100 shown here

  1. pmc Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17142. 2011
    ..While these SNPs represent new independent risk factors for prostate cancer, we saw little evidence for effect modification by other SNPs or by the environmental factors examined...
  2. pmc Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R18. 2007
    ....
  3. pmc A Bayesian latent class analysis for whole-genome association analyses: an illustration using the GAW15 simulated rheumatoid arthritis dense scan data
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Kresge Building, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    BMC Proc 1:S112. 2007
    ..Overall, Bayesian latent class analyses provided no obvious improvement over maximum-likelihood estimation. However, our results may not be able to be generalized due to the large effect simulated in the human leukocyte antigen-DR locus...
  4. pmc Exhaustive screens for disease susceptibility loci incorporating statistical interaction of genotypes: a comparison of likelihood-ratio-based and Akaike and Bayesian information criteria-based methods
    Fangyi Gu
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Building 2, Room 9, Boston, Massachusetts 02115 USA
    BMC Proc 1:S25. 2007
    ..Algorithms incorporating gene x gene interaction to prioritize markers for follow-up will require further development...
  5. pmc Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
    ..004) and ttth1-ttth4 (p = 0.004) phenotype(s). We find that both univariate- and multivariate-based screening techniques are powerful tools for detecting an association...
  6. ncbi request reprint Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 28:261-72. 2005
    ..An application to progesterone-receptor haplotypes and endometrial cancer further illustrates that the performance of all these methods depends on how well the observed haplotypes "tag" the unobserved causal variant...
  7. ncbi request reprint Curses--winner's and otherwise--in genetic epidemiology
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 19:649-51; discussion 657-8. 2008
    ..Epidemiologists need to be aware of these potential problems: as authors, to avoid or minimize them, and as readers, to detect them...
  8. pmc Integrating epidemiology and genetic association: the challenge of gene-environment interaction
    Peter Kraft
    Departments of Epidemiology and Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Philos Trans R Soc Lond B Biol Sci 360:1609-16. 2005
    ..Such collaborations also ensure a common approach to measuring variation at a genetic locus, avoiding a problem that has led to difficulties when comparing results from genetic association studies...
  9. doi request reprint Beyond odds ratios--communicating disease risk based on genetic profiles
    Peter Kraft
    Harvard School of Public Health, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Genet 10:264-9. 2009
    ..We argue that other measures--such as sensitivity, specificity, and positive and negative predictive values--are more useful when proposing a genetic profile for risk prediction...
  10. ncbi request reprint Exploiting gene-environment interaction to detect genetic associations
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Hered 63:111-9. 2007
    ..This makes the joint test an attractive tool for large-scale association scans where the true gene-environment interaction model is unknown...
  11. ncbi request reprint Case-sibling gene-association studies for diseases with variable age at onset
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Stat Med 23:3697-712. 2004
    ....
  12. pmc Multivariate variance-components analysis of longitudinal blood pressure measurements from the Framingham Heart Study
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    BMC Genet 4:S55. 2003
    ..2 and 2.4, respectively). In this study, multivariate analysis provides no increase in power; this is likely due to the strong positive correlation in systolic blood pressure measured at different ages...
  13. ncbi request reprint RHD maternal-fetal genotype incompatibility and schizophrenia: extending the MFG test to include multiple siblings and birth order
    Peter Kraft
    Department of Epidemiology and Biostatistics, Harvard School of Public Health, University of California, Los Angeles, USA
    Eur J Hum Genet 12:192-8. 2004
    ..7, consistent with earlier estimates. Our extension of the MFG test has general application to family-based studies of maternal-genotype and MFG interaction effects...
  14. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  15. pmc Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 22:2948-59. 2013
    ..0 × 10(-8); P = 6.6 × 10(-7) in the discovery set and P = 3.0 × 10(-3) in the replication set) and rs8015138 upstream of GNG2 (P = 6.6 × 10(-8); P = 5.3 × 10(-7) in the discovery set and P = 0.01 in the replication set). ..
  16. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color...
  17. pmc A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians
    Fredrick R Schumacher
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 19:3089-101. 2010
    ....
  18. pmc Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
    Hongmei Nan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 125:909-17. 2009
    ..Our study provides evidence for the contribution of pigmentation genetic variants, in addition to the MC1R variants, to variation in human pigmentary phenotypes and possibly the development of skin cancer...
  19. pmc A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 95:E121-7. 2010
    ..A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes...
  20. pmc Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer
    Fangyi Gu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:2877-87. 2010
    ..Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins...
  21. pmc Hyperglycemia, insulin resistance, impaired pancreatic β-cell function, and risk of pancreatic cancer
    Brian M Wolpin
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 105:1027-35. 2013
    ..Hemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of peripheral insulin resistance, and the proinsulin to insulin ratio marks pancreatic β-cell dysfunction...
  22. pmc Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
    ..Nonetheless, the data are consistent with the hypothesis that IGF-1- and IL-6-related gene variation influences susceptibility to multiple myeloma and warrant confirmation in larger populations...
  23. pmc Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:3140-9. 2010
    ..We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk...
  24. ncbi request reprint Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Yen Ching Chen
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1973-81. 2007
    ..Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis...
  25. pmc Prediagnostic body mass index and pancreatic cancer survival
    Chen Yuan
    Chen Yuan, Shuji Ogino, Kimmie Ng, Zhi Rong Qian, Douglas A Rubinson, and Brian M Wolpin, Dana Farber Cancer Institute Ying Bao, Shuji Ogino, Kimmie Ng, Meir J Stampfer, Edward L Giovannucci, and Brian M Wolpin, Brigham and Women s Hospital, Harvard Medical School and Chen Wu, Peter Kraft, Shuji Ogino, Meir J Stampfer, and Edward L Giovannucci, Harvard School of Public Health, Boston, MA
    J Clin Oncol 31:4229-34. 2013
    ..Although obesity is associated with increased incidence of pancreatic cancer, studies have not prospectively evaluated prediagnostic body mass index (BMI) and survival...
  26. ncbi request reprint CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Veronica Wendy Setiawan
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007
    ..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility...
  27. pmc Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies
    Sara Lindstrom
    Department of Epidemiology, Harvard School of Public Health, Building 2, Room 249B, 655 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:873-6. 2010
    ..Genetic variation in two members of the Toll-like receptor family, TLR4 and the gene cluster TLR6-1-10, has been implicated in prostate cancer in several studies but the associated alleles have not been consistent across reports...
  28. pmc Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma
    Fangyi Gu
    Department of aEpidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Melanoma Res 18:330-5. 2008
    ..93 to 1.03. We did not find significant results for the SNPs in the other four genes. These data suggest the involvement of IL-6R in melanoma development. Further studies are needed to confirm these findings...
  29. pmc Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 20:2673-9. 2011
    ..5 × 10(-6)) and in primary melanoma (P = 4.6 × 10(-4)) compared with the normal skin...
  30. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  31. pmc Common genetic variants in prostate cancer risk prediction--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 21:437-44. 2012
    ..In this study, we evaluated the discriminative and predictive ability for prostate cancer risk models incorporating 25 common prostate cancer genetic markers, family history of prostate cancer, and age...
  32. pmc Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Mol Genet 19:1856-62. 2010
    ..Our findings indicate that the genetic variants at ABO locus affect plasma sE-selectin levels and diabetes risk. The genetic associations with diabetes risk were independent of sE-selectin levels...
  33. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
    ..42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits...
  34. pmc A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 3:604-10. 2010
    ..Additionally, the association of selenium with PCa mortality was modified by a variant, suggesting the possibility that some men with PCa may benefit more from selenium than others, depending on their genotype...
  35. pmc Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:3718-24. 2011
    ..21 (1.02-1.44); P= 0.03], were associated with an increased risk of SCC. These two variants were not associated with melanoma risk. We conclude that 6p25 and 13q32 are novel loci conferring susceptibility to non-melanoma skin cancer...
  36. pmc Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk
    Genevieve M Monsees
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Breast Cancer Res Treat 125:207-14. 2011
    ..85. Common variation alone in DNA repair genes plays at most a small role in determining postmenopausal breast cancer risk among women of European ancestry...
  37. pmc Plasma carotenoid- and retinol-weighted multi-SNP scores and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Sara J Hendrickson
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 22:927-36. 2013
    ..We determined associations between variants in BCMO1 and breast cancer risk in a large cohort consortium...
  38. pmc Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 18:4677-87. 2009
    ..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP...
  39. pmc Common genetic variation of the calcium-sensing receptor and lethal prostate cancer risk
    Irene M Shui
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 22:118-26. 2013
    ..We assessed whether (i) common genetic variation in CaSR was associated with PCa risk and (ii) these associations varied by calcium intake or plasma 25-hydroxyvitamin D [25(OH)D] levels...
  40. pmc Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study
    Irene M Shui
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
    J Natl Cancer Inst 104:690-9. 2012
    ..The association of vitamin D status with prostate cancer is controversial; no association has been observed for overall incidence, but there is a potential link with lethal disease...
  41. pmc Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality
    Irene M Shui
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Prostate 72:209-16. 2012
    ..Common genetic variants in the Toll-like receptor 4 (TLR4), which is involved in inflammation and immune response pathways, may be important for prostate cancer...
  42. pmc Breast cancer susceptibility loci and mammographic density
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Breast Cancer Res 10:R66. 2008
    ....
  43. pmc Replication of five prostate cancer loci identified in an Asian population--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)
    Sara Lindstrom
    Department of Epidemiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 21:212-6. 2012
    ..In this study, we attempt to replicate these five loci in a series of nested prostate cancer case-control studies of European ancestry...
  44. pmc Genome-wide association scans for secondary traits using case-control samples
    Genevieve M Monsees
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 33:717-28. 2009
    ....
  45. pmc Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
    Eric J Jacobs
    Department of Epidemiology, American Cancer Society, Atlanta, GA, USA
    Int J Cancer 127:1421-8. 2010
    ..47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study...
  46. pmc Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 57:3145-51. 2008
    ..To examine the longitudinal association of fat mass-and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse...
  47. pmc Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 19:1846-55. 2010
    ..These data provide novel evidence revealing the role of polymorphisms in LEPR in modulating plasma levels of sOB-R and may further our understanding of the complex relationships among leptin, leptin receptor and diabetes-related traits...
  48. ncbi request reprint Physical activity and risk of endometrial adenocarcinoma in the Nurses' Health Study
    Mengmeng Du
    Department of Epidemiology, University of Washington School of Public Health, Seattle, WA Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Int J Cancer 134:2707-16. 2014
    ..Greater recent physical activity, including activity of moderate duration and intensity such as walking, may reduce endometrial adenocarcinoma risk. This relation is largely mediated or confounded by body mass index...
  49. pmc Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium
    Mia M Gaudet
    Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Epidemiol Biomarkers Prev 18:1610-6. 2009
    ....
  50. pmc Genome-wide association study of survival in patients with pancreatic adenocarcinoma
    Chen Wu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Gut 63:152-60. 2014
    ..We conducted a two-stage genome-wide association study (GWAS) to identify germline variants associated with survival in patients with pancreatic adenocarcinoma...
  51. pmc Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the Nurses' Health Study
    Mengmeng Du
    Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, United States of America
    PLoS ONE 8:e52240. 2013
    ..We therefore examined whether genetic predisposition to higher BMI or T2D was associated with shortened leukocyte telomere length (LTL)...
  52. ncbi request reprint A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes
    Hugues Aschard
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Genet Epidemiol 37:323-33. 2013
    ..We demonstrate the potential utility of our method on real data by analyzing mammographic density genome-wide data from the Nurses' Health Study...
  53. ncbi request reprint One thousand genomes imputation in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium aggressive prostate cancer genome-wide association study
    Mitchell J Machiela
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Prostate 73:677-89. 2013
    ....
  54. pmc A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts
    Ying Bao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 105:95-103. 2013
    ..Although development of pancreatic cancer is associated with states of insulin resistance and chronic inflammation, the mechanistic basis of the associations is poorly understood...
  55. pmc Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women
    Jennifer Prescott
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e37815. 2012
    ..Our results suggest that the small magnitude of difference in hormone levels associated with common genetic variants is likely insufficient to detectably contribute to breast cancer risk...
  56. pmc Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex diseases
    Hugues Aschard
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 90:962-72. 2012
    ..We show that the inclusion of G-G and G-E interaction effects in risk-prediction models is unlikely to dramatically improve the discrimination ability of these models...
  57. pmc Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 70:1015-23. 2010
    ..68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk...
  58. pmc Artifact due to differential error when cases and controls are imputed from different platforms
    Jennifer A Sinnott
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Genet 131:111-9. 2012
    ..Every SNP found with genome-wide significance should be validated on another platform to verify that its significance is not an artifact of study design...
  59. pmc Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Genet 131:615-23. 2012
    ..08). Based on the evidence of biological functions of the JAK-STAT pathway on oncogenesis, it is plausible that this pathway is involved in BCC pathogenesis...
  60. pmc Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
    ..We compare the results from the PBAT analysis to that of quantitative linkage analysis on chromosome 4 using the Collaborative Study on the Genetics of Alcoholism data, as released through Genetic Analysis Workshop 14...
  61. pmc Common variants of FUT2 are associated with plasma vitamin B12 levels
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA
    Nat Genet 40:1160-2. 2008
    ..This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels...
  62. pmc ABO blood group and the risk of pancreatic cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 101:424-31. 2009
    ..ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies...
  63. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  64. pmc TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 89:1256-62. 2009
    ..Dietary factors that increase the insulin demand might enhance the risk of T2D associated with TCF7L2 variants...
  65. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
    ..We sought to identify the common genetic variants associated with IL-18 levels...
  66. doi request reprint Evaluation of polygenic risk scores for predicting breast and prostate cancer risk
    Mitchell J Machiela
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Genet Epidemiol 35:506-14. 2011
    ..53 for breast and 0.57 for prostate). We found no significant evidence that PRS using common variants improved risk prediction for BCa and PCa over replicated SNP scores...
  67. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  68. pmc ASIP genetic variants and the number of non-melanoma skin cancers
    Wen Lin
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 22:495-501. 2011
    ..32; 95% CI, 1.07-1.63). The OR increased to 1.45(1.18-1.78) for those with 2-4 NMSCs and 1.84(1.34-2.53) for those with at least five. The findings suggest that ASIP locus is associated with the number of NMSCs...
  69. ncbi request reprint Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer
    Yen Ching Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1982-9. 2007
    ..We assessed if genetic polymorphisms of this gene cluster were associated with the risk of prostate cancer in a U.S. population...
  70. pmc Informed conditioning on clinical covariates increases power in case-control association studies
    Noah Zaitlen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1003032. 2012
    ..This suggests that applying our method to existing and future association studies of these diseases may identify novel disease loci...
  71. pmc The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women
    Jennifer H Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e42079. 2012
    ..It is possible that the CYP19A1 gene which alters sex hormones production may influence HGF levels. We examined the association between the CYP19A1 gene variants and plasma HGF concentrations...
  72. pmc Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium
    Mitchell J Machiela
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 176:1121-9. 2012
    ..These data suggest a shared genetic component between T2D and PCa and add to the evidence for an interrelation between these diseases...
  73. pmc Genome-wide association study identifies new prostate cancer susceptibility loci
    Fredrick R Schumacher
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Hum Mol Genet 20:3867-75. 2011
    ..72 and P= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes...
  74. pmc Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 32:853-9. 2011
    ..Understanding the mechanism by which genetic variation in KLK3 affects prostate cancer risk has important implications for study of the biological role of PSA in prostate tumorigenesis...
  75. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci...
  76. pmc Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women
    Jessica K Paulus
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Lung Cancer 71:258-63. 2011
    ..Our findings indicate that ESR2 is not associated with risk of lung cancer in women...
  77. ncbi request reprint Quantification of the power of Hardy-Weinberg equilibrium testing to detect genotyping error
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Hered 61:10-4. 2006
    ..While these methods are fairly reliable, they are also costly and time consuming...
  78. pmc The impact of gene-environment dependence and misclassification in genetic association studies incorporating gene-environment interactions
    Sara Lindstrom
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    Hum Hered 68:171-81. 2009
    ....
  79. pmc Genetic variation in the HSD17B1 gene and risk of prostate cancer
    Peter Kraft
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 1:e68. 2005
    ..These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites...
  80. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
    ..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...
  81. pmc Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer
    David G Cox
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Breast Cancer Res 7:R171-5. 2005
    ..Truncation mutations in the BRCA1 gene cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population and account for little of the overall incidence of sporadic breast cancer...
  82. pmc Estrogen and progesterone-related gene variants and colorectal cancer risk in women
    Jennifer H Lin
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 12:78. 2011
    ..Inherited variation in the sex-hormone genes may be one mechanism by which sex hormones affect colorectal cancer, although data are limited...
  83. pmc Toll-like receptor signaling pathway variants and prostate cancer mortality
    Jennifer R Stark
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1859-63. 2009
    ..No significant associations were observed for common haplotypes and PCa mortality. This study highlights the importance of studies of PCa mortality because risk factors for incidence and mortality may differ...
  84. ncbi request reprint CYP19 (aromatase) haplotypes and endometrial cancer risk
    Randi A Paynter
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 116:267-74. 2005
    ..Our data suggest that there is a high-frequency CYP19 haplotype related to higher estrogen to androgen ratios and increased risk of endometrial cancer and that this association may primarily pertain to postmenopausal women...
  85. pmc Sequence variants of elaC homolog 2 (Escherichia coli) (ELAC2) gene and susceptibility to prostate cancer in the Health Professionals Follow-Up Study
    Yen Ching Chen
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Carcinogenesis 29:999-1004. 2008
    ..43, snp3: OR = 0.69, hap1: OR = 1.47, hap2: OR = 0.72, hap4: OR = 1.51; global P-value for all common haplotypes = 0.11). Common SNPs and haplotypes of ELAC2 were associated with risk of aggressive prostate cancer...
  86. ncbi request reprint Quantifying bias due to allele misclassification in case-control studies of haplotypes
    Usha S Govindarajulu
    Department of Biostatistics, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Genet Epidemiol 30:590-601. 2006
    ..Here, we considered the impact of SNP allele misclassification on haplotype odds ratio estimates from case-control studies of unrelated individuals...
  87. pmc Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality
    Jennifer Rider Stark
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 124:2683-9. 2009
    ..02). Adjusted hazard ratios were 1.73 (95% CI: 0.86, 3.51) comparing the highest to lowest IL-6 level. Our study suggests that IL-6 may potentially be involved in the development or progression of prostate cancer...
  88. ncbi request reprint Effect of apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica
    Yadong Yang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Hum Biol 79:637-47. 2007
    ....
  89. ncbi request reprint Ala12 variant of the peroxisome proliferator-activated receptor-gamma gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction
    Edward A Ruiz-Narváez
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:1238-42. 2007
    ..The Ala12 allele of the peroxisome proliferator-activated receptor-gamma gene (PPARG) decreases the lipolysis of triacylglycerols in adipose tissue, which results in the accumulation of fatty acids in adipocytes...
  90. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
    ..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation...
  91. pmc Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Mol Diagn 9:305-14. 2007
    ..In conclusion, a panel of markers including at least RUNX3, CACNA1G, IGF2, and MLH1 can serve as a sensitive and specific marker panel for CIMP-high...
  92. ncbi request reprint Drinking from the fire hose--statistical issues in genomewide association studies
    David J Hunter
    Harvard School of Public Health, Boston, USA
    N Engl J Med 357:436-9. 2007
  93. pmc Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart Study
    Terri Kang
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    BMC Genet 4:S43. 2003
    ..This suggests that if missingness patterns are correlated within families, then imputation methods that do not allow this correlation can yield biased results...
  94. ncbi request reprint Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 28:1510-9. 2007
    ..Further investigation is required to validate the association of the polymorphisms in the one-carbon metabolic genes and risk of colorectal adenoma...
  95. ncbi request reprint Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer
    Yen Ching Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Res 65:11771-8. 2005
    ..02). Two common haplotypes were statistically significantly associated with altered risk of prostate cancer. Inherited polymorphisms of the innate immune gene TLR4 are associated with risk of prostate cancer...
  96. doi request reprint Association between genetic polymorphisms of macrophage scavenger receptor 1 gene and risk of prostate cancer in the health professionals follow-up study
    Yen Ching Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:1001-3. 2008
    ..Association studies assessing the relationship between sequence variants of MSR1 and prostate cancer are inconsistent. We hypothesized that sequence variants of MSR1 were associated with prostate cancer risk...
  97. pmc The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk
    Annamaria Pezzotti
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5356. 2009
    ....
  98. pmc A prospective study of relative telomere length and postmenopausal breast cancer risk
    Immaculata De Vivo
    Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1152-6. 2009
    ..07). Our results provide little support for an important role of telomere length, as measured in peripheral blood leukocytes, as a biomarker of breast cancer risk...
  99. ncbi request reprint Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2408-17. 2006
    ..Our results corroborate previous findings for MTHFR Ala(222)Val and suggest that other genes involved in one-carbon metabolism, particularly those that affect DNA methylation, may be associated with colorectal cancer risk...
  100. ncbi request reprint XPA, haplotypes, and risk of basal and squamous cell carcinoma
    Katie L Miller
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 27:1670-5. 2006
    ..The common G allele of the A23G polymorphism was associated with an increased risk of BCC and SCC and this polymorphism appeared to be the determining polymorphism in XPA that alters cancer susceptibility...
  101. ncbi request reprint Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Crit Care Med 35:893-8. 2007
    ..Inhibitor kappaB-alpha (NFKBIA) inhibits NF-kappaB and controls its activities. The objective was to determine whether polymorphisms in NFKBIA gene would be associated with ARDS development...