Margaret James Koziel

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Translational research in liver disease
    Margaret James Koziel
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Hepatology 48:1028-9. 2008
  2. ncbi Viral hepatitis in HIV infection
    Margaret James Koziel
    Division of Infectious Disease, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 356:1445-54. 2007
  3. ncbi Influence of HIV co-infection on hepatitis C immunopathogenesis
    Margaret James Koziel
    Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Rm 223a, 330 Brookline Ave, Boston, MA 02215 5321, USA
    J Hepatol 44:S14-8. 2006
  4. ncbi Cellular immune responses against hepatitis C virus
    Margaret James Koziel
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02215, USA
    Clin Infect Dis 41:S25-31. 2005
  5. ncbi Relationships between cellular immune responses and treatment outcomes with interferon and ribavirin in HIV/hepatitis C virus co-infection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    AIDS 20:345-51. 2006
  6. ncbi Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    AIDS 19:767-73. 2005
  7. ncbi Immune responses during acute and chronic infection with hepatitis C virus
    Shigeaki Ishii
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Clin Immunol 128:133-47. 2008
  8. ncbi CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection
    Nadia Alatrakchi
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 191:702-9. 2005
  9. ncbi Differential expression of toll-like receptor mRNA in treatment non-responders and sustained virologic responders at baseline in patients with chronic hepatitis C
    Qi He
    Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Liver Int 26:1100-10. 2006
  10. ncbi Viral factors associated with cytokine expression during HCV/HIV co-infection
    Jason T Blackard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Interferon Cytokine Res 27:263-9. 2007

Research Grants

  1. T Lymphocyte Apoptosis in Hepatitis C Persistence
    Margaret Koziel; Fiscal Year: 2006
  2. Natural Killer T Cells in an animal model of hepatitis C
    Margaret Koziel; Fiscal Year: 2006

Detail Information

Publications32

  1. ncbi Translational research in liver disease
    Margaret James Koziel
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Hepatology 48:1028-9. 2008
  2. ncbi Viral hepatitis in HIV infection
    Margaret James Koziel
    Division of Infectious Disease, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 356:1445-54. 2007
  3. ncbi Influence of HIV co-infection on hepatitis C immunopathogenesis
    Margaret James Koziel
    Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Rm 223a, 330 Brookline Ave, Boston, MA 02215 5321, USA
    J Hepatol 44:S14-8. 2006
    ..Neither CD4(+) nor CD8(+) responses correlate with the peripheral CD4 count...
  4. ncbi Cellular immune responses against hepatitis C virus
    Margaret James Koziel
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02215, USA
    Clin Infect Dis 41:S25-31. 2005
    ....
  5. ncbi Relationships between cellular immune responses and treatment outcomes with interferon and ribavirin in HIV/hepatitis C virus co-infection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    AIDS 20:345-51. 2006
    ..To test the hypothesis that hepatitis C virus (HCV)-specific interferon (IFN)gamma immune responses are correlated with HCV virological response following treatment in subjects with HIV-1 and HCV co-infection...
  6. ncbi Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    AIDS 19:767-73. 2005
    ..To test the hypothesis that antigen-specific interferon (IFN)gamma responses are correlated with milder liver disease in subjects coinfected with HIV-1 and hepatitis C virus (HCV)...
  7. ncbi Immune responses during acute and chronic infection with hepatitis C virus
    Shigeaki Ishii
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Clin Immunol 128:133-47. 2008
    ..Resolution of these outstanding questions is important to the development of a prophylactic vaccine as well as improving therapeutic options for those with chronic infection...
  8. ncbi CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection
    Nadia Alatrakchi
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 191:702-9. 2005
    ..We sought to determine whether T cell responses were present in the liver of patients with human immunodeficiency virus (HIV) and HCV coinfection...
  9. ncbi Differential expression of toll-like receptor mRNA in treatment non-responders and sustained virologic responders at baseline in patients with chronic hepatitis C
    Qi He
    Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Liver Int 26:1100-10. 2006
    ..The aim of this study was to explore the relationship of the toll-like receptor (TLR) expression with the outcome of antiviral therapy in hepatitis C viral infection...
  10. ncbi Viral factors associated with cytokine expression during HCV/HIV co-infection
    Jason T Blackard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Interferon Cytokine Res 27:263-9. 2007
    ..Further studies are warranted to identify noninvasive markers of liver disease for the clinical management of HCV disease, particularly when liver biopsies have not been performed or are contraindicated...
  11. ncbi Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses
    Nadia Alatrakchi
    Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    J Virol 81:5882-92. 2007
    ..In conclusion, blockade of TGF-beta secretion could enhance peripheral HCV-specific T-cell responses even in the presence of HIV coinfection...
  12. ncbi Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis
    Sanaa M Kamal
    Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Hepatology 43:771-9. 2006
    ..In conclusion, serial cytokine and fibrosis markers can accurately determine the rate at which fibrosis is progressing, identifying both those with rapid fibrosis and those with stable disease...
  13. ncbi Effect of exposure to injection drugs or alcohol on antigen-specific immune responses in HIV and hepatitis C virus coinfection
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA
    J Infect Dis 195:847-56. 2007
    ..We wanted to determine whether IDU or alcohol affected immune responses in HCV-infected and human immunodeficiency virus (HIV)/HCV coinfected subjects...
  14. ncbi Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV
    Camilla S Graham
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Hepatology 40:125-32. 2004
    ..In conclusion, subjects with coinfection have an alteration of intrahepatic HCV-specific IL-10 cytokine response that may have implications for HCV-related disease progression...
  15. ncbi Cellular immune responses in seronegative sexual contacts of acute hepatitis C patients
    Sanaa M Kamal
    Department of Infectious Diseases, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    J Virol 78:12252-8. 2004
    ..This finding has important implications for HCV vaccine and therapeutic development...
  16. ncbi Effects of HCV treatment on cytokine expression during HCV/HIV coinfection
    Jason T Blackard
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Interferon Cytokine Res 26:834-8. 2006
    ....
  17. ncbi Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction
    Khadija Iken
    Division of Infectious Disease, Beth Israel Deaconess Hospital, HIM 223a, 330 Brookline Ave, Boston, MA 02115, USA
    Virology 346:363-72. 2006
    ..Increased apoptosis of activated T cells induced by HCV structural proteins could amplify the ability of the liver to down-modulate T cell responses, leading to attenuation of anti-viral responses and facilitating viral persistence...
  18. ncbi To be or not to be NKT: natural killer T cells in the liver
    Mark A Exley
    Division of Hematology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Hepatology 40:1033-40. 2004
    ..Although there is an abundance of literature on the phenotype, distribution, and function of these cells in mice, much less is known about them in human health or liver diseases...
  19. ncbi Pegylated interferon alpha therapy in acute hepatitis C: relation to hepatitis C virus-specific T cell response kinetics
    Sanaa M Kamal
    Department of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Hepatology 39:1721-31. 2004
    ....
  20. ncbi A tale of two viruses: hepatitis C in the age of HAART
    Nadia Alatrakchi
    Infectious Disease Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Lancet 362:1687-8. 2003
  21. ncbi Health-related quality of life of patients with HIV disease: impact of hepatitis C coinfection
    Catherine A Fleming
    Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Clin Infect Dis 38:572-8. 2004
    ..These findings underscore the importance of a multidisciplinary approach to the treatment of these patient populations...
  22. ncbi HIV and liver disease forum: conference proceedings
    Kenneth E Sherman
    Division of Digestive Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Hepatology 45:1566-77. 2007
  23. ncbi Hepatitis C and alcohol: fundamental and translational research directions
    Timothy R Morgan
    Department of Medicine, Veterans Adminstration Medical Center, Long Beach, California, USA
    Alcohol Clin Exp Res 27:726-31. 2003
    ..This article summarizes the panel's deliberations and their recommendations for future research on alcohol and hepatitis C...
  24. ncbi Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C
    Chihiro Morishima
    Department of Laboratory Medicine and Pediatrics, University of Washington, Seattle, USA
    J Infect Dis 193:931-40. 2006
    ..Thus, in patients with advanced hepatic fibrosis due to HCV infection, pretreatment HCV-specific immune responses and increased QS variability appear to hinder viral clearance by pegylated IFN- alpha 2a and ribavirin combination therapy...
  25. ncbi NK cells: natural born killers in the conflict between humans and HCV
    Margaret James Koziel
    Hepatology 43:395-7. 2006
  26. ncbi Antiviral T-cell responses and therapy in chronic hepatitis B
    Nadia Alatrakchi
    J Hepatol 39:631-4. 2003
  27. ncbi Impact of hepatitis C virus on immune restoration in HIV-infected patients who start highly active antiretroviral therapy: a meta-analysis
    Melissa Farmer Miller
    Division of Cancer Prevention, Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, Maryland, USA
    Clin Infect Dis 41:713-20. 2005
    ..Future research should examine whether an impaired immunologic response corresponds with meaningful virologic and clinical outcomes...
  28. ncbi Prediction of relapse following treatment for hepatitis C: is whole blood more than the sum of its parts?
    Norah Shire
    Clin Infect Dis 39:1761-3. 2004
  29. ncbi HCV quasispecies evolution: association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV
    Hongxing Qin
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Blood 105:533-41. 2005
    ..Evolution patterns differ for progressors and nonprogressors. Further understanding of these mechanisms may help identify factors related to progression rate and treatment response...
  30. ncbi First things first: balancing hepatitis C and human immunodeficiency virus
    Camilla S Graham
    Clin Infect Dis 36:368-9. 2003
  31. ncbi Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C
    Alan Lee Rothman
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 41:617-25. 2005
    ....
  32. ncbi Natural killer cells and hepatitis C: is losing inhibition the key to clearance?
    Rachel Baden Herman
    Clin Gastroenterol Hepatol 2:1061-3. 2004

Research Grants10

  1. T Lymphocyte Apoptosis in Hepatitis C Persistence
    Margaret Koziel; Fiscal Year: 2006
    ..abstract_text> ..
  2. Natural Killer T Cells in an animal model of hepatitis C
    Margaret Koziel; Fiscal Year: 2006
    ....