Dora Kovacs

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc BACE1 activity regulates cell surface contactin-2 levels
    Vivek Gautam
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 9:4. 2014
  2. pmc Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
    Manuel T Gersbacher
    Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 5:61. 2010

Collaborators

  • Vivek Gautam
  • Doo Yeon Kim
  • Manuel T Gersbacher
  • Matthias Hebisch
  • Carla D'Avanzo
  • Raja Bhattacharyya

Detail Information

Publications2

  1. pmc BACE1 activity regulates cell surface contactin-2 levels
    Vivek Gautam
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 9:4. 2014
    ..BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been characterized. Here we investigated BACE1-mediated cleavage of human contactin-2, a GPI-anchored cell adhesion molecule...
  2. pmc Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
    Manuel T Gersbacher
    Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 5:61. 2010
    ..abstract:..

Research Grants15

  1. Role of the g-secretase/PS1 complex in APP processing
    Dora Kovacs; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbe_ Face Page ....................................................................................................... Description, ..
  2. PS1 and BACE1 regulate processing and activity of voltage-gated sodium channels
    Dora M Kovacs; Fiscal Year: 2010
    ..Moreover, our preliminary data suggest that BACE1 and/or y-secretase inhibitors could affect VGSC function, and be beneficial in normalizing membrane excitability in AD patients with elevated BACE1 activity. ..
  3. PS1 and BACE1 regulate processing and activity of voltage-gated sodium channels
    Dora Kovacs; Fiscal Year: 2009
    ..Moreover, our preliminary data suggest that BACE1 and/or y-secretase inhibitors could affect VGSC function, and be beneficial in normalizing membrane excitability in AD patients with elevated BACE1 activity. ..
  4. Cholesterol distribution & regulation of AB generation
    Dora Kovacs; Fiscal Year: 2005
    ..These studies should provide a clearer understanding of the molecular and biochemicalevents involved in cholesterol-dependent regulation of Ab generation. ..
  5. Cholesterol distribution & regulation of AB generation
    Dora Kovacs; Fiscal Year: 2006
    ..These studies should provide a clearer understanding of the molecular and biochemicalevents involved in cholesterol-dependent regulation of Ab generation. ..
  6. ACAT inhibition regulates ERAD of APP and Abeta production
    Dora Kovacs; Fiscal Year: 2009
    ..These studies should further elucidate the prospects for employing ACAT inhibition as a novel therapeutic for AD. ..
  7. ACAT inhibition regulates ERAD of APP and Abeta production
    Dora Kovacs; Fiscal Year: 2007
    ..These studies should further elucidate the prospects for employing ACAT inhibition as a novel therapeutic for AD. ..
  8. Cholesterol distribution & regulation of AB generation
    Dora Kovacs; Fiscal Year: 2002
    ..These studies should provide a clearer understanding of the molecular and biochemicalevents involved in cholesterol-dependent regulation of Ab generation. ..
  9. Role of the g-secretase/PS1 complex in APP processing
    Dora Kovacs; Fiscal Year: 2006
    ..abstract_text> ..
  10. Cholesterol distribution & regulation of AB generation
    Dora Kovacs; Fiscal Year: 2004
    ..These studies should provide a clearer understanding of the molecular and biochemicalevents involved in cholesterol-dependent regulation of Ab generation. ..
  11. Cholesterol distribution & regulation of AB generation
    Dora Kovacs; Fiscal Year: 2003
    ..These studies should provide a clearer understanding of the molecular and biochemicalevents involved in cholesterol-dependent regulation of Ab generation. ..
  12. ACAT inhibition regulates ERAD of APP and Abeta production
    Dora M Kovacs; Fiscal Year: 2010
    ..These studies should further elucidate the prospects for employing ACAT inhibition as a novel therapeutic for AD. ..