Dora Kovacs

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint BACE1 activity regulates cell surface contactin-2 levels
    Vivek Gautam
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 9:4. 2014
  2. pmc Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
    Manuel T Gersbacher
    Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 5:61. 2010

Collaborators

  • Vivek Gautam
  • Doo Yeon Kim
  • Manuel T Gersbacher
  • Matthias Hebisch
  • Carla D'Avanzo
  • Raja Bhattacharyya

Detail Information

Publications2

  1. doi request reprint BACE1 activity regulates cell surface contactin-2 levels
    Vivek Gautam
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 9:4. 2014
    ..BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been characterized. Here we investigated BACE1-mediated cleavage of human contactin-2, a GPI-anchored cell adhesion molecule...
  2. pmc Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
    Manuel T Gersbacher
    Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 5:61. 2010
    ..abstract:..

Research Grants15

  1. Role of the g-secretase/PS1 complex in APP processing
    Dora Kovacs; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbe_ Face Page ....................................................................................................... Description, ..
  2. PS1 and BACE1 regulate processing and activity of voltage-gated sodium channels
    Dora M Kovacs; Fiscal Year: 2010
    ..Moreover, our preliminary data suggest that BACE1 and/or y-secretase inhibitors could affect VGSC function, and be beneficial in normalizing membrane excitability in AD patients with elevated BACE1 activity. ..
  3. Cholesterol distribution & regulation of AB generation
    Dora Kovacs; Fiscal Year: 2006
    ..These studies should provide a clearer understanding of the molecular and biochemicalevents involved in cholesterol-dependent regulation of Ab generation. ..
  4. ACAT inhibition regulates ERAD of APP and Abeta production
    Dora Kovacs; Fiscal Year: 2007
    ..These studies should further elucidate the prospects for employing ACAT inhibition as a novel therapeutic for AD. ..
  5. Role of the g-secretase/PS1 complex in APP processing
    Dora Kovacs; Fiscal Year: 2006
    ..abstract_text> ..
  6. ACAT inhibition regulates ERAD of APP and Abeta production
    Dora M Kovacs; Fiscal Year: 2010
    ..These studies should further elucidate the prospects for employing ACAT inhibition as a novel therapeutic for AD. ..