Maria Koulmanda

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response
    Zhigang Fan
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:718-22. 2010
  2. pmc The role of TNF-α in mice with type 1- and 2- diabetes
    Maria Koulmanda
    Department of Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33254. 2012
  3. pmc Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival
    Maria Koulmanda
    Harvard Medical School, Beth Israel Deaconess Medical Center BIDMC, Boston, MA, USA
    Proc Natl Acad Sci U S A 109:15443-8. 2012
  4. pmc Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term triple therapy
    M Koulmanda
    Harvard Medical School, Department of Surgery, Transplant Institute at Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 12:1296-302. 2012
  5. pmc Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts
    Maria Koulmanda
    Department of Surgery, Harvard Medical School, and Islet Transplantation Research Laboratory, Massachusetts General Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:13074-9. 2007
  6. pmc Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice
    Maria Koulmanda
    Departments of Surgery and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16242-7. 2008
  7. pmc Tissue expression of PD-L1 mediates peripheral T cell tolerance
    Mary E Keir
    Department of Pathology, Brigham and Women s Hospital and Children s Hospital Boston, MA 02115, USA
    J Exp Med 203:883-95. 2006
  8. ncbi request reprint Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
  9. doi request reprint Inflammation and the balance of Treg and Th17 cells in transplant rejection and tolerance
    Dusan Hanidziar
    Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Curr Opin Organ Transplant 15:411-5. 2010
  10. pmc Prediction of marginal mass required for successful islet transplantation
    Klearchos K Papas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Invest Surg 23:28-34. 2010

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response
    Zhigang Fan
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:718-22. 2010
    ..These results establish real-time cell tracking as a powerful means to probe the dynamic cellular interplay mediating immunologic rejection or transplant tolerance...
  2. pmc The role of TNF-α in mice with type 1- and 2- diabetes
    Maria Koulmanda
    Department of Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33254. 2012
    ....
  3. pmc Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival
    Maria Koulmanda
    Harvard Medical School, Beth Israel Deaconess Medical Center BIDMC, Boston, MA, USA
    Proc Natl Acad Sci U S A 109:15443-8. 2012
    ..The conclusions yielded by the systems-biology analysis were rigorously confirmed by QRT-PCR and immunohistology. These data suggest that short-term AAT treatment of human islet transplant recipients may be worthy of a clinical trial...
  4. pmc Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term triple therapy
    M Koulmanda
    Harvard Medical School, Department of Surgery, Transplant Institute at Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 12:1296-302. 2012
    ..Moreover slow progressive loss of islet function in some recipients was not associated with obvious pathologic evidence of rejection...
  5. pmc Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts
    Maria Koulmanda
    Department of Surgery, Harvard Medical School, and Islet Transplantation Research Laboratory, Massachusetts General Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:13074-9. 2007
    ..Thus, this triple-therapy regimen, possessing both tolerance-inducing and select antiinflammatory properties, may represent a prototype for therapies able to restore euglycemia and self-tolerance in T1DM...
  6. pmc Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice
    Maria Koulmanda
    Departments of Surgery and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16242-7. 2008
    ..Indeed, the functional mass of beta cells expands in AAT-treated diabetic NOD mice...
  7. pmc Tissue expression of PD-L1 mediates peripheral T cell tolerance
    Mary E Keir
    Department of Pathology, Brigham and Women s Hospital and Children s Hospital Boston, MA 02115, USA
    J Exp Med 203:883-95. 2006
    ..These data provide evidence that PD-L1 expression on parenchymal cells rather than hematopoietic cells protects against autoimmune diabetes and point to a novel role for PD-1-PD-L1 interactions in mediating tissue tolerance...
  8. ncbi request reprint Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
    ....
  9. doi request reprint Inflammation and the balance of Treg and Th17 cells in transplant rejection and tolerance
    Dusan Hanidziar
    Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Curr Opin Organ Transplant 15:411-5. 2010
    ..Hence, benefits of tilting Treg-Th17 equilibrium toward dominance of Tregs may promote transplant tolerance...
  10. pmc Prediction of marginal mass required for successful islet transplantation
    Klearchos K Papas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Invest Surg 23:28-34. 2010
    ..Because human clinical islet preparations in a previous study had OCR/DNA...
  11. ncbi request reprint Pig islet xenografts are resistant to autoimmune destruction by non-obese diabetic recipients after anti-CD4 treatment
    Maria Koulmanda
    Islet Transplantation Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 10:178-84. 2003
    ..The difficulty in obtaining indefinite islet xenograft survival in NOD recipients occurs independently from the development of destructive autoimmunity...
  12. pmc Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates
    Timothy Millington
    Massachusetts General Hospital Transplant Center, Massachusetts General Hospital, Boston, MA, USA
    J Heart Lung Transplant 31:427-35. 2012
    ..To tilt the immunologic balance toward tolerance and away from rejection, non-human primate recipients of cardiac allografts were treated with interleukin (IL)-2/Fc, mutant (m) antagonist type mIL-15/Fc, and sirolimus...
  13. ncbi request reprint A simple and cost-effective method for the isolation of islets from nonhuman primates
    John J O'Neil
    Joslin Diabetes Center, Boston, MA, USA
    Cell Transplant 12:883-90. 2003
    ..The technique yields sufficient numbers of pure and viable islets to support preclinical research to develop improved strategies to prevent the immune destruction of the transplanted islet graft...
  14. ncbi request reprint The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade
    Leila Makhlouf
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 51:3202-10. 2002
    ..Our results may have implications for the design of future clinical trials in islet transplantation...
  15. doi request reprint Towards cytoprotection in the peritransplant period
    Dusan Hanidziar
    Harvard Medical School, Department of Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, 330 Brookline Ave, E CLS Room 609, Boston, MA 02215, USA
    Semin Immunol 23:209-13. 2011
    ....
  16. pmc Cytokine related therapies for autoimmune disease
    Terry B Strom
    Harvard Medical School, Beth Israel Deaconess Medical Center, Center for Life Sciences Building, 3 Blackfan Circle, Boston, MA 02115, United States
    Curr Opin Immunol 20:676-81. 2008
    ..The ability of IFNgamma, IL-4, TNFalpha, and lymphotoxin to exert selective effects upon crucial lymphocyte subset populations in vivo may also enable translation into potent therapies...
  17. ncbi request reprint Recently discovered T cell subsets cannot keep their commitments
    Terry B Strom
    Departments of Medicine and Surgery, Harvard Medical School, Transplant Institute, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Am Soc Nephrol 20:1677-80. 2009
    ..Rather, Tregs and Th17(+) cells respond to cues provided by the inflammatory texture in which these cells reside. We review the important scientific and therapeutic implications of these differences herein...
  18. pmc Mechanisms underlying blockade of allograft acceptance by TLR ligands
    Paige M Porrett
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 181:1692-9. 2008
    ..Instead, graft destruction results from the ability of CpG to drive Th1 differentiation and interfere with immunoregulation established by alloreactive natural CD4(+)Foxp3(+) Tregs...
  19. pmc Creating transplant tolerance by taming adverse intragraft innate immunity
    Dusan Hanidziar
    Departments of Medicine and Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, E CLS 608 Boston, MA 02215 USA
    F1000 Biol Rep 2:83. 2010
    ..Hence, a reduction in adverse tissue inflammation may prove crucial in facilitating the induction and maintenance of a long-lasting state of transplant tolerance...
  20. ncbi request reprint Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model
    Weihua Gong
    Department of Surgery and Medicine, Transplant International Research Centre TIRC, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People s Republic of China Departments of Medicine, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA Electronic address
    Clin Immunol 153:8-16. 2014
    ..Utilization of MDSC subset particularly CD11b+Gr1(-low) might provide a novel insight into improving graft outcome under such clinical scenarios. ..
  21. ncbi request reprint CD46 protects pig islets from antibody but not cell-mediated destruction in the mouse
    Ian F C McKenzie
    The Austin Research Institute, Heidelberg, Victoria, Australia
    Xenotransplantation 10:615-21. 2003
    ....

Research Grants1

  1. Tolerance Induction for Primate Islet Transplantation
    Maria Koulmanda; Fiscal Year: 2006
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