I J Koralnik

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Agnogene deletion in a novel pathogenic JC virus isolate impairs VP1 expression and virion production
    Laura C Ellis
    Division of Neurovirology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America Center for Virology and Vaccine Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America Harvard Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e80840. 2013
  2. pmc JC virus encephalopathy is associated with a novel agnoprotein-deletion JCV variant
    Xin Dang
    Division of Neurovirology, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35793. 2012
  3. pmc Metabolic profile of PML lesions in patients with and without IRIS: an observational study
    Sarah Gheuens
    Division of Neurovirology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 79:1041-8. 2012
  4. ncbi request reprint Progressive multifocal leukoencephalopathy revisited: Has the disease outgrown its name?
    Igor J Koralnik
    HIV Neurology Center, Department of Neurology, and Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Neurol 60:162-73. 2006
  5. ncbi request reprint New insights into progressive multifocal leukoencephalopathy
    Igor J Koralnik
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Neurol 17:365-70. 2004
  6. pmc Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals
    R A Du Pasquier
    Division of Viral Pathogenesis and Department of Neurology, Research East, Room 213B, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215
    J Virol 78:10206-10. 2004
  7. ncbi request reprint JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy
    R A Du Pasquier
    Department of Neurology and Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurovirol 7:318-22. 2001
  8. pmc Determinants of survival in progressive multifocal leukoencephalopathy
    A Marzocchetti
    Division of Viral Pathogenesis, BIDMC, Harvard Medical School, Boston, MA 02215, USA
    Neurology 73:1551-8. 2009
  9. pmc JC virus regulatory region tandem repeats in plasma and central nervous system isolates correlate with poor clinical outcome in patients with progressive multifocal leukoencephalopathy
    L A Pfister
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 75:5672-6. 2001
  10. pmc JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy
    I J Koralnik
    Department of Neurology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 75:3483-7. 2001

Collaborators

Detail Information

Publications58

  1. pmc Agnogene deletion in a novel pathogenic JC virus isolate impairs VP1 expression and virion production
    Laura C Ellis
    Division of Neurovirology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America Center for Virology and Vaccine Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America Harvard Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e80840. 2013
    ..Studying this naturally occurring pathogenic variant of JCV provides a valuable tool for understanding the functions of the agnogene and RR form in JCV replication. ..
  2. pmc JC virus encephalopathy is associated with a novel agnoprotein-deletion JCV variant
    Xin Dang
    Division of Neurovirology, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35793. 2012
    ..Productive and lytic infection of these cells, resulting in fulminant JCV encephalopathy and death may have been facilitated by the co-infection with a wild-type strain of JCV...
  3. pmc Metabolic profile of PML lesions in patients with and without IRIS: an observational study
    Sarah Gheuens
    Division of Neurovirology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 79:1041-8. 2012
    ....
  4. ncbi request reprint Progressive multifocal leukoencephalopathy revisited: Has the disease outgrown its name?
    Igor J Koralnik
    HIV Neurology Center, Department of Neurology, and Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Neurol 60:162-73. 2006
    ..Hopefully, this crisis will be instrumental in helping us define novel avenues of research, develop predictive tests for PML in populations at risk, and challenge us to find a treatment for this deadly disease...
  5. ncbi request reprint New insights into progressive multifocal leukoencephalopathy
    Igor J Koralnik
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Neurol 17:365-70. 2004
    ..This review covers recent developments in the clinical and pathological presentations of progressive multifocal leukoencephalopathy, and advances in the understanding of JC virus biology...
  6. pmc Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals
    R A Du Pasquier
    Division of Viral Pathogenesis and Department of Neurology, Research East, Room 213B, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215
    J Virol 78:10206-10. 2004
    ..These results show that a CD8+-T-cell response against JCV is commonly found in immunocompetent people and suggest that these cells might protect against the development of PML...
  7. ncbi request reprint JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy
    R A Du Pasquier
    Department of Neurology and Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurovirol 7:318-22. 2001
    ..As the quest for an effective treatment of PML continues, JCV-specific cellular immune response deserves further attention because it appears to play a crucial role in the prevention of disease progression...
  8. pmc Determinants of survival in progressive multifocal leukoencephalopathy
    A Marzocchetti
    Division of Viral Pathogenesis, BIDMC, Harvard Medical School, Boston, MA 02215, USA
    Neurology 73:1551-8. 2009
    ..We sought to characterize the role of immunologic, virologic, and radiologic determinants of survival in patients with progressive multifocal leukoencephalopathy (PML)...
  9. pmc JC virus regulatory region tandem repeats in plasma and central nervous system isolates correlate with poor clinical outcome in patients with progressive multifocal leukoencephalopathy
    L A Pfister
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 75:5672-6. 2001
    ..These data suggest that the presence of tandem repeats in plasma and CNS JCV RR clones is associated with poor clinical outcome in patients with PML...
  10. pmc JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy
    I J Koralnik
    Department of Neurology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 75:3483-7. 2001
    ..These data suggest that the JCV-specific cellular immune response may play a crucial role in the containment of PML. This finding may also prove useful as a favorable prognostic marker in the clinical management of these patients...
  11. ncbi request reprint Spinal cord lesions of progressive multifocal leukoencephalopathy in an acquired immunodeficiency syndrome patient
    F Bernal-Cano
    Department of Neurology, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Neurovirol 13:474-6. 2007
    ..Indeed, spinal cord lesions are frequent in MS. Therefore clinicians should be aware that in addition to the brain, PML may also affect the spinal cord white matter...
  12. pmc Clinical outcome of long-term survivors of progressive multifocal leukoencephalopathy
    M A Lima
    Department of Neurology, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, MA 02215, USA
    J Neurol Neurosurg Psychiatry 81:1288-91. 2010
    ..In absence of a specific treatment, immunotherapies aiming at boosting the cellular immune response against JCV may improve the prognosis of PML...
  13. ncbi request reprint A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy
    Renaud A Du Pasquier
    Division of ViralPathogenesis Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Brain 127:1970-8. 2004
    ..Fluctuations of JCV-specific CTL in the blood are associated with variation in disease manifestations. These results indicate that JCV-specific CTL are associated with the control of PML...
  14. ncbi request reprint Overview of the cellular immunity against JC virus in progressive multifocal leukoencephalopathy
    Igor J Koralnik
    Department of Neurology and Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurovirol 8:59-65. 2002
    ..02). This cellular immune response may therefore be crucial in the prevention of PML disease progression and the tetramer staining assay may be used as a prognostic marker in the clinical management of these patients...
  15. pmc Low frequency of cytotoxic T lymphocytes against the novel HLA-A*0201-restricted JC virus epitope VP1(p36) in patients with proven or possible progressive multifocal leukoencephalopathy
    Renaud A Du Pasquier
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:11918-26. 2003
    ..These data suggest that, although present in low numbers, JCV-specific CTL may be of central importance in the containment of JCV spread in immunosuppressed individuals...
  16. pmc The spectrum of neurological disorders in a Zambian tertiary care hospital
    Omar K Siddiqi
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Neurol Sci 290:1-5. 2010
    ..To define the spectrum of inpatient and outpatient neurological illness in a Zambian tertiary care facility where HIV is endemic...
  17. ncbi request reprint Association of prolonged survival in HLA-A2+ progressive multifocal leukoencephalopathy patients with a CTL response specific for a commonly recognized JC virus epitope
    Igor J Koralnik
    Neurology Department, Beth Israel Deaconess Medical Center, RE 213B, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215
    J Immunol 168:499-504. 2002
    ..These data suggest that the JCV-specific cellular immune response may be important in the containment of PML, and the tetramer-staining assay may provide a useful prognostic tool in the clinical management of these patients...
  18. ncbi request reprint Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy
    Rachel Katz-Brull
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 63:897-900. 2004
    ..Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression...
  19. pmc Simultaneous PML-IRIS after discontinuation of natalizumab in a patient with MS
    S Gheuens
    Division of Neurovirology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 78:1390-3. 2012
    ..We describe a patient with MS who presented with simultaneous PML-IRIS 2 months after stopping natalizumab for other reasons. CASE REPORT and..
  20. ncbi request reprint Remission of progressive multifocal leukoencephalopathy and primary central nervous system lymphoma in an HIV-infected patient
    M A Lima
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Eur J Neurol 14:598-602. 2007
    ....
  21. ncbi request reprint Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual
    R A Du Pasquier
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 61:775-82. 2003
    ..Sequence analysis of the JCV regulatory region from cerebellar virions showed a tandem repeat pattern also found in PML lesions of the frontal lobe WM...
  22. ncbi request reprint A granule cell neuron-associated JC virus variant has a unique deletion in the VP1 gene
    Xin Dang
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 213C, 330 Brookline Avenue, Boston, MA 02215, USA
    J Gen Virol 87:2533-7. 2006
    ..This deletion was not present in JCV(HWM), suggesting that this mutation may be instrumental in facilitating entry or replication of JCV into granule cell neurons...
  23. pmc Interplay of cellular and humoral immune responses against BK virus in kidney transplant recipients with polyomavirus nephropathy
    YiPing Chen
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Virol 80:3495-505. 2006
    ..A high degree of epitope cross-recognition was present between BKV and corresponding JCV-specific CTLs, which indicates that the same population of cells is functionally effective against these two closely related viruses...
  24. pmc Frequent infection of cerebellar granule cell neurons by polyomavirus JC in progressive multifocal leukoencephalopathy
    Christian Wuthrich
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Neuropathol Exp Neurol 68:15-25. 2009
    ..These results indicate that infection of GCNs is an important, previously overlooked, aspect of JCV pathogenesis in immunosuppressed individuals...
  25. ncbi request reprint New features of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy and natalizumab
    Marco A Lima
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Neurovirol 11:52-7. 2005
    ....
  26. ncbi request reprint Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses
    W Kempf
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Cutan Pathol 28:29-33. 2001
    ..Ultrastructural and clinical features of LyP suggest that it has a viral etiology. Human herpesviruses have been proposed as causative cofactors for LyP because of their oncogenic potential and their association with other lymphomas...
  27. pmc BKV and JCV large T antigen-specific CD8+ T cell response in HLA A*0201+ kidney transplant recipients with polyomavirus nephropathy and patients with progressive multifocal leukoencephalopathy
    YiPing Chen
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Clin Virol 42:198-202. 2008
    ..The large T-antigen (T-ag) is the main regulatory protein of polyomaviruses that is expressed early in the viral cycle...
  28. pmc Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy
    Angela Marzocchetti
    Div of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Virology 383:173-7. 2009
    ..JCV peptide-loaded DC elicited a stronger CTL expansion in 13/15 responders. DC can induce a potent JCV-specific CTL response in vitro, and may constitute a promising approach for PML immunotherapy...
  29. pmc Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy
    Sarah Gheuens
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, E CLS 1005, 330 Brookline Avenue, Boston, MA 02215, USA
    J Neurovirol 16:41-7. 2010
    ..Physicians may exercise caution in the use of immunomodulatory medications in patients whose genetic background is associated with an increased risk of PML...
  30. ncbi request reprint JC virus induces a vigorous CD8+ cytotoxic T cell response in multiple sclerosis patients
    Renaud A Du Pasquier
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, USA
    J Neuroimmunol 176:181-6. 2006
    ..These findings may shed a new light on the recent events related to the development of progressive multifocal leukoencephalopathy in three natalizumab-treated patients...
  31. ncbi request reprint JC virus granule cell neuronopathy: A novel clinical syndrome distinct from progressive multifocal leukoencephalopathy
    Igor J Koralnik
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Neurol 57:576-80. 2005
    ..We propose to call this novel syndrome JCV granule cell neuronopathy (JCV GCN)...
  32. ncbi request reprint Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells
    Christian Wuthrich
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurovirol 12:116-28. 2006
    ..These observations are discussed in the context of the recent evidence of PML in multiple sclerosis and Crohn's patients treated with natalizumab, underscoring the role of CD8(+) T lymphocytes in continued immunosurveillance of the CNS...
  33. ncbi request reprint BK virus-associated hemorrhagic cystitis in a Human Immunodeficiency Virus-infected patient
    Dan H Barouch
    Division of Infectious Diseases, Massachusetts General Hospital, and Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA, USA
    Clin Infect Dis 35:326-9. 2002
    ....
  34. ncbi request reprint Inflammatory reaction in progressive multifocal leukoencephalopathy: harmful or beneficial?
    Renaud A Du Pasquier
    Department of Neurology and Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurovirol 9:25-31. 2003
    ..Therefore clinicians should not disregard the diagnosis of PML in presence of contrast-enhancing brain lesions, and should use caution before treating these immunosuppressed individuals with steroids...
  35. pmc Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis
    Chen S Tan
    Division of Viral Pathogenesis, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Lancet Neurol 9:425-37. 2010
    ..The increasingly diverse populations at risk and the recent discovery of the presence of the JC virus in the grey matter invite us to reappraise the pathogenesis of this virus in the CNS...
  36. pmc Asymptomatic reactivation of JC virus in patients treated with natalizumab
    YiPing Chen
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 361:1067-74. 2009
    ..Most adults who are infected with the JC virus, the etiologic agent in PML, do not have symptoms. We sought to determine whether exposure to natalizumab causes subclinical reactivation and neurotropic transformation of JC virus...
  37. pmc Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons
    Christian Wuthrich
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Neurol 65:742-8. 2009
    ..This novel gray matter syndrome expands the scope of JCV clinical presentation and pathogenesis...
  38. pmc Rearrangement of simian virus 40 regulatory region is not required for induction of progressive multifocal leukoencephalopathy in immunosuppressed rhesus monkeys
    Xin Dang
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 213, 330 Brookline Ave, Boston, MA 02215, USA
    J Virol 79:1361-6. 2005
    ..These results indicate that unlike JCV in humans, rearrangements of SV40 RR are not required for brain disease induction in immunosuppressed monkeys...
  39. pmc Rearrangement of the JC virus regulatory region sequence in the bone marrow of a patient with rheumatoid arthritis and progressive multifocal leukoencephalopathy
    Angela Marzocchetti
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurovirol 14:455-8. 2008
    ..Further studies will be needed to determine the prevalence of JCV in bone marrow of immunosuppressed individuals at risk of PML and characterize the RR and phenotype of these JCV isolates...
  40. doi request reprint Progressive multifocal leukoencephalopathy in a patient with relapsed acute myelogenous leukemia
    Santosh Kesari
    Department of Neurology, Dana Farber Brigham and Women s Cancer Center, Center for Neuro Oncology, Boston, MA, USA
    J Clin Oncol 26:3804-7. 2008
  41. pmc Productive simian virus 40 infection of neurons in immunosuppressed Rhesus monkeys
    Xin Dang
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neuropathol Exp Neurol 67:784-92. 2008
    ..These findings shed new light on SV40 neurotropism and expand the host cell range of this virus...
  42. ncbi request reprint Atypical radiological presentation of progressive multifocal leukoencephalopathy following liver transplantation
    Marco A Lima
    Department of Neurology, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Neurovirol 11:46-50. 2005
    ..The authors report an atypical presentation of PML with contrast-enhancing lesions and mass effect on the MRI in a liver transplant recipient,who had a progressive course and fatal outcome...
  43. ncbi request reprint Seizures and their outcome in progressive multifocal leukoencephalopathy
    Marco A Lima
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 66:262-4. 2006
    ..Seizures usually responded well to treatment and did not affect survival. The presence of PML lesions immediately adjacent to the hemispheric cortex was the only risk factor associated with seizures in this population...
  44. pmc Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy
    Marco A Lima
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    J Virol 81:3361-8. 2007
    ..Immunotherapies aiming at increasing the cellular immune response against JCV may be valuable in the treatment of HIV+ individuals with PML...
  45. pmc Role of CD4+ and CD8+ T-cell responses against JC virus in the outcome of patients with progressive multifocal leukoencephalopathy (PML) and PML with immune reconstitution inflammatory syndrome
    Sarah Gheuens
    Division of Neurovirology, Beth Israel Deaconess Medical Center, E CLS 1005, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 85:7256-63. 2011
    ..ELISpot and ICS assays are useful prognostic markers of PML evolution and may help in the clinical management of these patients...
  46. pmc Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences
    John Y H Kim
    Division of Neuroscience, Department of Neurology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuro Oncol 4:165-70. 2002
    ..In contrast to childhood ependymomas and choroid plexus tumors, medulloblastomas and sPNETs infrequently express evidence of polyomavirus infection...
  47. ncbi request reprint Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin
    Werner Kempf
    Department of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
    Carcinogenesis 24:301-6. 2003
  48. pmc JC virus latency in the brain and extraneural organs of patients with and without progressive multifocal leukoencephalopathy
    Chen S Tan
    Division of Infectious Disease, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Virol 84:9200-9. 2010
    ..These results provide evidence of JCV latency in the brain prior to severe immunosuppression and suggest new paradigms in JCV latency, compartmentalization, and reactivation...
  49. pmc Detection of JC virus DNA and proteins in the bone marrow of HIV-positive and HIV-negative patients: implications for viral latency and neurotropic transformation
    Chen S Tan
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 199:881-8. 2009
    ....
  50. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 14-2004. A 66-year-old man with progressive neurologic deficits
    Igor J Koralnik
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, USA
    N Engl J Med 350:1882-93. 2004
  51. pmc Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression
    Sarah Gheuens
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Neurol Neurosurg Psychiatry 81:247-54. 2010
    ..The authors performed a review of the literature to find similar cases...
  52. ncbi request reprint Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera
    Susama Verma
    Department of Neurology, Mount Sinai Medical Center, New York, NY 10029, USA
    J Infect Dis 196:709-11. 2007
    ..We propose that mirtazapine should be investigated further for use in PML...
  53. ncbi request reprint Analysis of 15 novel full-length BK virus sequences from three individuals: evidence of a high intra-strain genetic diversity
    YiPing Chen
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 213B, 330 Brookline Avenue, Boston, MA 02215, USA
    J Gen Virol 85:2651-63. 2004
    ..55 % of sites, implying a rate of nucleotide substitution of approximately 5 x 10(-5) substitutions per site per year, which is two orders of magnitude faster than estimated for the other human polyomavirus, JC virus...
  54. ncbi request reprint Presence of JC virus-specific CTL in the cerebrospinal fluid of PML patients: rationale for immune-based therapeutic strategies
    Renaud A Du Pasquier
    Division of Viral Pathogenesis and Beth Israel Deaconess Medical Center, Boston Massachusetts 02215, USA
    AIDS 19:2069-76. 2005
    ..In addition, we studied the breadth of their T-cell receptor (TCR) repertoire, and sought to establish a reliable method to expand these cells in vitro...
  55. ncbi request reprint Meningoencephalitis and demyelination are pathologic manifestations of primary polyomavirus infection in immunosuppressed rhesus monkeys
    Michael K Axthelm
    Vaccine and Gene Therapy Institute, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    J Neuropathol Exp Neurol 63:750-8. 2004
    ..This observation suggests that a primary polyomavirus infection can be associated with an inflammatory CNS process. These data shed new light on the pathogenic mechanisms of primate polyomaviruses in the immunocompromised host...
  56. ncbi request reprint Progressive multifocal leukoencephalopathy as a complication of hepatitis C virus treatment in an HIV-negative patient
    Marco A Lima
    Clin Infect Dis 41:417-9. 2005
  57. ncbi request reprint Progressive multifocal leukoencephalopathy and natalizumab--unforeseen consequences
    Joseph R Berger
    N Engl J Med 353:414-6. 2005
  58. ncbi request reprint The evolving face of human immunodeficiency virus-related progressive multifocal leukoencephalopathy: defining a consensus terminology
    Paola Cinque
    Clinic of Infectious Diseases, San Raffaele Hospital, Milano, Italy
    J Neurovirol 9:88-92. 2003
    ..A standard patient classification would be helpful for clinical management of PML patients, for their inclusion in clinical studies, and also will increase our current knowledge of PML and its evolution in relation with HAART...

Research Grants24

  1. Role of Inflammation in Progressive Multifocal Leukoencephalopathy
    Igor J Koralnik; Fiscal Year: 2010
    ..The knowledge we will gain from these studies will greatly expand our understanding of JCV pathogenesis and will have a direct impact on patient care. ..
  2. CELLULAR IMMUNITY TO JC VIRUS IN AIDS ASSOCIATED PML
    Igor Koralnik; Fiscal Year: 2001
    ..complex staining and ELISPOT assays 6) define the cellular immune response to JCV in the cerebrospinal fluid 7) correlate the detection of JCV-specific CTL with the immune status and clinical course of patients with PML ..
  3. Inflammation /Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2006
    ..abstract_text> ..
  4. Inflammation /Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2005
    ..abstract_text> ..
  5. Cellular Immunity/JC Virus/AIDS/Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2009
    ....
  6. Role of Inflammation in Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2009
    ..The knowledge we will gain from these studies will greatly expand our understanding of JCV pathogenesis and will have a direct impact on patient care. ..
  7. Cellular Immunity/JC Virus/AIDS/Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2007
    ..class I alleles in PML outcome 2) Characterize the phenotype of JCV-specific CTL 3) Analyze the repertoire of JCV-specific CTL in blood and CSF 4) Perform preclinical studies of dendritic cell-based immunotherapy for PML ..
  8. Inflammation /Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2006
    ..abstract_text> ..
  9. Role of Inflammation in Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2009
    ..The knowledge we will gain from these studies will greatly expand our understanding of JCV pathogenesis and will have a direct impact on patient care. ..
  10. Cellular Immunity/JC Virus/AIDS/Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2007
    ....
  11. Inflammation in Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2007
    ..abstract_text> ..
  12. Cellular Immunity/JC Virus/AIDS/Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2006
    ....
  13. CELLULAR IMMUNITY TO JC VIRUS IN AIDS ASSOCIATED PML
    Igor Koralnik; Fiscal Year: 2002
    ..complex staining and ELISPOT assays 6) define the cellular immune response to JCV in the cerebrospinal fluid 7) correlate the detection of JCV-specific CTL with the immune status and clinical course of patients with PML ..
  14. CELLULAR IMMUNITY TO JC VIRUS IN AIDS ASSOCIATED PML
    Igor Koralnik; Fiscal Year: 2003
    ..complex staining and ELISPOT assays 6) define the cellular immune response to JCV in the cerebrospinal fluid 7) correlate the detection of JCV-specific CTL with the immune status and clinical course of patients with PML ..
  15. CELLULAR IMMUNITY TO JC VIRUS IN AIDS ASSOCIATED PML
    Igor Koralnik; Fiscal Year: 2004
    ..complex staining and ELISPOT assays 6) define the cellular immune response to JCV in the cerebrospinal fluid 7) correlate the detection of JCV-specific CTL with the immune status and clinical course of patients with PML ..
  16. AIDS-assoc Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2004
    ..We expect that these hybrid viruses will produce a disease more closely resembling PML. The availability of an animal model of PML will allow new therapeutic interventions for this incurable disease. ..
  17. Inflammation /Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2004
    ..abstract_text> ..
  18. Cellular Immunity/JC Virus/AIDS/Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2005
    ....
  19. Role of Inflammation in Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2009
    ..The knowledge we will gain from these studies will greatly expand our understanding of JCV pathogenesis and will have a direct impact on patient care. ..
  20. CELLULAR IMMUNITY TO JC VIRUS IN AIDS ASSOCIATED PML
    Igor Koralnik; Fiscal Year: 2001
    ..complex staining and ELISPOT assays 6) define the cellular immune response to JCV in the cerebrospinal fluid 7) correlate the detection of JCV-specific CTL with the immune status and clinical course of patients with PML ..
  21. Granule cell neuron-tropic JC virus variant
    Igor Koralnik; Fiscal Year: 2006
    ....