Hernan D Kopcow

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Human decidual NK cells form immature activating synapses and are not cytotoxic
    Hernan D Kopcow
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:15563-8. 2005
  2. ncbi TGF-β affects development and differentiation of human natural killer cell subsets
    David S J Allan
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Eur J Immunol 40:2289-95. 2010
  3. ncbi TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells
    Derin B Keskin
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:3378-83. 2007
  4. ncbi JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity
    Changlin Li
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:3017-22. 2008
  5. ncbi T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1
    Hernan D Kopcow
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:18472-7. 2008
  6. ncbi Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
    Louise A Koopman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 198:1201-12. 2003
  7. ncbi Angiogenic factors and natural killer (NK) cells in the pathogenesis of preeclampsia
    Hernan D Kopcow
    Department of Molecular and Cell Biology, Harvard University, Boston, MA, USA
    J Reprod Immunol 76:23-9. 2007

Detail Information

Publications7

  1. ncbi Human decidual NK cells form immature activating synapses and are not cytotoxic
    Hernan D Kopcow
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:15563-8. 2005
    ..However, in contrast to peripheral NK cells, they failed to polarize their microtubule organizing centers and perforin-containing granules to the synapse, accounting for their lack of cytotoxicity...
  2. ncbi TGF-β affects development and differentiation of human natural killer cell subsets
    David S J Allan
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Eur J Immunol 40:2289-95. 2010
    ....
  3. ncbi TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells
    Derin B Keskin
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:3378-83. 2007
    ..These progenitors also produced NK cells when cultured in conditioned medium from decidual stromal cells supplemented with IL-15 and stem cell factor...
  4. ncbi JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity
    Changlin Li
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:3017-22. 2008
    ..Thus, activation of two MAP kinase pathways is required for cytotoxic granule and MTOC polarization and for cytotoxicity of human NK cells when NKG2D is ligated...
  5. ncbi T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1
    Hernan D Kopcow
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:18472-7. 2008
    ..Thus, secretion of gal1 by dNKs and other decidual cells contributes to the generation of an immune-privileged environment at the maternal-fetal interface...
  6. ncbi Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
    Louise A Koopman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 198:1201-12. 2003
    ..Additionally, two secreted proteins, galectin-1 and progestagen-associated protein 14, known to have immunomodulatory functions, were selectively expressed in dNK cells...
  7. ncbi Angiogenic factors and natural killer (NK) cells in the pathogenesis of preeclampsia
    Hernan D Kopcow
    Department of Molecular and Cell Biology, Harvard University, Boston, MA, USA
    J Reprod Immunol 76:23-9. 2007
    ..This review summarizes our current understanding of the role of angiogenic factors and NK cells in the pathogenesis of preeclampsia...