Christine Konradi

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways
    Christine Konradi
    Laboratory of Neuroplasticity, McLean Hospital, Harvard Medical School, MRC215, 115 Mill St, Belmont, MA 02478, USA
    Brain Res Mol Brain Res 115:157-61. 2003
  2. ncbi request reprint Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Pharmacol Ther 97:153-79. 2003
  3. ncbi request reprint Molecular evidence for mitochondrial dysfunction in bipolar disorder
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 61:300-8. 2004
  4. ncbi request reprint Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia
    Christine Konradi
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, MA 02478, USA
    Neurobiol Dis 17:219-36. 2004
  5. ncbi request reprint L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neurons
    Molly E Eaton
    Laboratory of Neuroplasticity, McLean Hospital, Harvard Medical School, MRC215, 115 Mill Street Belmont, MA 02478, USA
    Brain Res Mol Brain Res 131:65-72. 2004
  6. pmc Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors
    Frederick A Schroeder
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Neuropsychopharmacology 33:2981-92. 2008
  7. ncbi request reprint Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling
    Jianhong Li
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurochem 90:1117-31. 2004
  8. ncbi request reprint Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1
    Joshua T Dudman
    Laboratory of Neuroplacticity, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurochem 87:922-34. 2003
  9. pmc Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats
    Allison T Knoll
    Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 70:425-33. 2011
  10. ncbi request reprint Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School at McLean Hospital, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1003:368-71. 2003

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways
    Christine Konradi
    Laboratory of Neuroplasticity, McLean Hospital, Harvard Medical School, MRC215, 115 Mill St, Belmont, MA 02478, USA
    Brain Res Mol Brain Res 115:157-61. 2003
    ..This synchronization of second messenger pathways provides a coincidence mechanism that gates proenkephalin synthesis in striatal neurons, ensuring that levels are increased only in the presence of activated PKA and depolarization...
  2. ncbi request reprint Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Pharmacol Ther 97:153-79. 2003
    ..Here we discuss how the molecular aspects of glutamate malfunction can explain some of the neuropathology observed in schizophrenia, and how the available treatment intervenes through the glutamate system...
  3. ncbi request reprint Molecular evidence for mitochondrial dysfunction in bipolar disorder
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 61:300-8. 2004
    ..The disease mechanism of bipolar disorder remains unknown. Recent studies have provided evidence for abnormal gene expression in bipolar disorder...
  4. ncbi request reprint Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia
    Christine Konradi
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, MA 02478, USA
    Neurobiol Dis 17:219-36. 2004
    ..Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended ATP levels...
  5. ncbi request reprint L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neurons
    Molly E Eaton
    Laboratory of Neuroplasticity, McLean Hospital, Harvard Medical School, MRC215, 115 Mill Street Belmont, MA 02478, USA
    Brain Res Mol Brain Res 131:65-72. 2004
    ..We conclude that the D1 receptor signal transduction pathway depends on L-type Ca2+ channels to mediate CREB phosphorylation...
  6. pmc Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors
    Frederick A Schroeder
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Neuropsychopharmacology 33:2981-92. 2008
    ....
  7. ncbi request reprint Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling
    Jianhong Li
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurochem 90:1117-31. 2004
    ..Blockade of D2-like receptors induces H3 phospho-acetylation, H3pS10-acK14, through cAMP-dependent PKA, and post-synaptic NMDA receptor signaling...
  8. ncbi request reprint Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1
    Joshua T Dudman
    Laboratory of Neuroplacticity, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurochem 87:922-34. 2003
    ..The recruitment of the NMDA receptor signal transduction pathway by D1 receptors may provide a general mechanism for gene regulation that is fundamental for mechanisms of drug addiction and long-term memory...
  9. pmc Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats
    Allison T Knoll
    Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 70:425-33. 2011
    ..Here, we sought to identify neural circuits that mediate KOR system effects on fear and anxiety in rats...
  10. ncbi request reprint Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School at McLean Hospital, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1003:368-71. 2003
  11. pmc Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat
    Matthew L MacDonald
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 57:1041-51. 2005
    ..Molecular adaptations are believed to contribute to the mechanism of action of antipsychotic drugs (APDs). We attempted to establish common gene regulation patterns induced by chronic treatment with APDs...
  12. pmc Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue
    Elena H Chartoff
    Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Mol Pharmacol 75:704-12. 2009
    ....
  13. ncbi request reprint Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell
    Mark S Todtenkopf
    Behavioral Genetics, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:11665-9. 2006
    ..These data suggest that GluR1 and GluR2 in the NAc shell play opposing roles in the regulation of motivated behavior...
  14. ncbi request reprint Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stress
    Alipi V Naydenov
    Laboratory of Neuroplasticity and Schizophrenia and Bipolar Disorders Program, McLean Hospital, Belmont, MA, USA
    Arch Gen Psychiatry 64:555-64. 2007
    ..Bipolar disorder (BPD) is among the top 10 causes of disability worldwide. Recent findings on the etiology of the disease point to a disturbed mitochondrial energy metabolism in the brain of subjects with BPD...
  15. ncbi request reprint Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequences
    Rachael M Youngs
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:6031-9. 2006
    ..Our results indicate that Li administration to the normal brain has the potential for lasting adverse effects...
  16. ncbi request reprint Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder
    Matthew L MacDonald
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, MA 02478, USA
    Bipolar Disord 8:255-64. 2006
    ....
  17. ncbi request reprint Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence
    Yolanda D Black
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:9656-65. 2006
    ..These findings suggest that exposure to cocaine during adolescence has far-reaching molecular and behavioral consequences in the rat PFC that develop over time and endure long after drug administration has ceased...
  18. ncbi request reprint Hippocampal pathology in schizophrenia
    Stephan Heckers
    Department of Psychiatry, Vanderbilt University, 1601 23rd Avenue South, Room 3060, Nashville, TN 37212, USA
    Curr Top Behav Neurosci 4:529-53. 2010
    ..Taken together, this pattern of findings points to a disinhibition of hippocampal pyramidal cells and abnormal cortico-hippocampal interactions in schizophrenia...
  19. ncbi request reprint Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 87:107-18. 2003
    ..Furthermore, they are consistent with in vivo evidence suggesting that increased CREB activation in portions of the striatum (e.g. the NAc) is related to dysphoric states associated with drug withdrawal...
  20. ncbi request reprint Gene expression microarray studies in polygenic psychiatric disorders: applications and data analysis
    Christine Konradi
    Laboratory of Neuroplasticity, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Brain Res Brain Res Rev 50:142-55. 2005
    ..All results should be verified by independent means. This review is intended to help brain researchers who want to apply gene expression microarray technology to conceptualize research strategies and sample analysis...
  21. ncbi request reprint Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 47:47-60. 2004
    ..It may also identify periods of development during which administration of these agents is particularly safe or risky...
  22. ncbi request reprint Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors
    Jenny E Westin
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Sweden
    Biol Psychiatry 62:800-10. 2007
    ..We examined the activation pattern of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and its dependence on D1 versus D2 dopamine receptors in hemiparkinsonian rats treated with 3,4-dihydroxyphenyl-L-alanine (L-DOPA)...