Research Topics
Species | Jian KongSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Placebo analgesia: findings from brain imaging studies and emerging hypothesesJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA
Rev Neurosci 18:173-90. 2007..The literature suggests that multiple brain regions, including the anterior cingulate cortex, anterior insula, prefrontal cortex and periaqueductal grey, play a pivotal role in these processes...
Acupuncture de qi, from qualitative history to quantitative measurementJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Altern Complement Med 13:1059-70. 2007....
A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effectJian Kong
Department of Psychiatry, Massachusetts General Hospital, Massachusetts General Hospital, Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts 02215, USA
J Neurosci 28:13354-62. 2008..In conclusion, we found evidence that nocebo hyperalgesia may be predominantly produced through an affective-cognitive pain pathway (medial pain system), and the left hippocampus may play an important role in this process...- Functional connectivity of the frontoparietal network predicts cognitive modulation of painJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA Electronic address
Pain 154:459-67. 2013..We believe that these findings will shed new light on our understanding of variable cue/expectancy effects across individuals and how the intrinsic connectivity of the brain may influence expectancy-induced modulation of pain... - Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI studyJian Kong
Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, Charlestown, MA 02129, USA
Behav Brain Res 211:215-9. 2010..We believe eluciation of this intrinsic PAG network during the resting state will enhance our physiological and pathological understandings of the development and maintenance of chronic pain states... - Exploring the brain in pain: activations, deactivations and their relationJian Kong
Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, Charlestown, MA 02129, USA
Pain 148:257-67. 2010..Our results illustrate the absence of a linear relationship between pain activations and deactivations, and therefore suggest that these brain signal changes underlie different aspects of the pain experience... - An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatmentJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 47:1066-76. 2009..We hypothesize that as a peripheral-central modulation, acupuncture needle stimulation may inhibit incoming noxious stimuli; while as a top-down modulation, expectancy (placebo) may work through the emotional circuit... - Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesiaJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 45:940-9. 2009..Our results also suggest that the brain network involved in expectancy may vary under different treatment situations (verum and sham acupuncture treatment)... - A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methodsJian Kong
Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing, People s Republic of China
J Altern Complement Med 8:411-9. 2002..To characterize the brain activation patterns evoked by manual and electroacupuncture on normal human subjects... - Functional neuroanatomical investigation of vision-related acupuncture point specificity--a multisession fMRI studyJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Hum Brain Mapp 30:38-46. 2009..Given the complexity of acupuncture systems and brain activity, additional work is required to determine whether functional neuroanatomical correlates of acupoint specificity can be validated by means of brain imaging tools... - The neural substrate of arithmetic operations and procedure complexityJian Kong
Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Brain Res Cogn Brain Res 22:397-405. 2005..Our results suggest that the network activated by the simplest calculation serves as a common basis, to which more regions are recruited for more difficult problems or different arithmetic operations... - Test-retest study of fMRI signal change evoked by electroacupuncture stimulationJian Kong
Department of Psychiatry, Massachusetts General Hospital MGH, MA, USA
Neuroimage 34:1171-81. 2007.... - Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imagingJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurosci 26:381-8. 2006..Our results suggest that placebo analgesia may be configured through multiple brain pathways and mechanisms... - Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensityJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Hum Brain Mapp 27:715-21. 2006..We hypothesize that these two regions play a crucial role in bridging the encoding of pain sensation and the cognitive processing of sensory input... - Imaging the functional connectivity of the Periaqueductal Gray during genuine and sham electroacupuncture treatmentCarolyn E Zyloney
Department of Psychiatry, Massachusetts General Hospital, Charlestown, USA
Mol Pain 6:80. 2010..Given the PAG's important role in mediating acupuncture analgesia, in this study we investigated functional connectivity with the area of the PAG we previously identified and how that connectivity was affected by genuine and sham EA... - Psychophysical outcomes from a randomized pilot study of manual, electro, and sham acupuncture treatment on experimentally induced thermal painJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
J Pain 6:55-64. 2005..This suggests that switching acupuncture mode may be a treatment option for unresponsive patients... - A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesiaDarin D Dougherty
Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, MA 02129, USA
Behav Brain Res 193:63-8. 2008..These findings include brain regions within both the lateral and medial pain networks... - Sex similarities and differences in pain-related periaqueductal gray connectivityClas Linnman
P A I N Group, McLean Hospital, Belmont, MA, USA
Pain 153:444-54. 2012..Our results emphasize the importance of including both male and female subjects when studying basic mechanisms of pain processing, and point toward a possible sex difference in endogenous pain inhibition... - The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuliMarco L Loggia
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e27764. 2011..These findings may help explain the inconsistencies in reported findings of the impact of COMT in pain regulation... - The impact of placebo, psychopathology, and expectations on the response to acupuncture needling in patients with chronic low back painAjay Darsh Wasan
Department of Anesthesiology, Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Pain 11:555-63. 2010..Using a blinded, crossover design, we report that it does not predict outcome, nor does it seem to modify the effect of expectancy (a known predictor) on acupuncture response... - Nonconscious activation of placebo and nocebo pain responsesKarin B Jensen
Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 109:15959-64. 2012..This is a unique experimental verification of the influence of nonconscious conditioned stimuli on placebo/nocebo effects and the results challenge the exclusive role of awareness and conscious cognitions in placebo responses... - Default mode network connectivity encodes clinical pain: an arterial spin labeling studyMarco L Loggia
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School HMS, Boston, MA, USA
Pain 154:24-33. 2013..Our results support the use of arterial spin labeling to evaluate clinical pain, and the use of resting DMN connectivity as a potential neuroimaging biomarker for chronic pain perception... - Neural correlates of chronic low back pain measured by arterial spin labelingAjay D Wasan
Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Anesthesiology 115:364-74. 2011..Arterial spin labeling is a perfusion-based imaging technique allowing the absolute quantification of regional cerebral blood flow, which is a surrogate measure of neuronal activity... - Sham acupuncture devices--practical advice for researchersClaire A McManus
Harvard Medical School, Boston, MA, USA
Acupunct Med 25:36-40. 2007..We also report our experience with the sham needle in neuroimaging experiments where the magnetic machinery poses considerable challenges for acupuncture research... - The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulationJiliang Fang
Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Hum Brain Mapp 30:1196-206. 2009.... - For placebo effects in medicine, seeing is believingRandy L Gollub
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Sci Transl Med 3:70ps5. 2011.... - The effects of acupuncture on the brain networks for emotion and cognition: an observation of gender differencesWei Qiao Qiu
Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, USA
Brain Res 1362:56-67. 2010..Our study suggests that brains with sex dimorphism may process the acupuncture stimulation differently between women and men... - Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory networkKarin B Jensen
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Mol Pain 8:32. 2012..The seed coordinates were based on the findings from our previous study, comparing the fMRI signal during calibrated pressure pain in FM and HC: the rostral anterior cingulate cortex (rACC) and thalamus... - The effect of body temperature on the murine electroretinogramJian Kong
Department of Ophthalmology, Columbia University, New York, NY 10032, USA
Doc Ophthalmol 106:239-42. 2003..CONCLUSION: The murine ERG is very sensitive to changes in temperature. In order to monitor the ERG accurately over time, continuous recording of body temperature is essential... - [Some misunderstandings of deqi phenomenon: from historic review to experimental study]Tao Huang
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
Zhongguo Zhen Jiu 28:105-9. 2008..The two states will be detected by fMRI in experimental studies, so as to have indexes to be followed for deqi or needling sensation... - Retinal degeneration and RPE transplantation in Rpe65(-/-) micePeter Gouras
Department of Ophthalmology, Columbia University, New York, New York 10032, USA
Invest Ophthalmol Vis Sci 43:3307-11. 2002..To determine whether transplanting normal retinal pigment epithelium (RPE) into the subretinal space influences photoreceptor function and degeneration in Rpe65(-/-) mice...
Research Grants
- Study of individual variability in acupuncture and placebo analgesiaJian Kong; Fiscal Year: 2007..This integrated program of training and research will yield new tools for studying acupuncture and placebo treatment and provide the candidate with the skills needed to achieve independence in a highly complex field. ..