Jian Kong

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Placebo analgesia: findings from brain imaging studies and emerging hypotheses
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA
    Rev Neurosci 18:173-90. 2007
  2. doi request reprint Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
  3. pmc A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Massachusetts General Hospital, Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts 02215, USA
    J Neurosci 28:13354-62. 2008
  4. pmc S1 is associated with chronic low back pain: a functional and structural MRI study
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Harvard Medical School, 120 2nd Ave, Room 101, Charlestown, MA 02129, USA
    Mol Pain 9:43. 2013
  5. pmc Are all placebo effects equal? Placebo pills, sham acupuncture, cue conditioning and their association
    Jian Kong
    Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    PLoS ONE 8:e67485. 2013
  6. pmc Transcutaneous vagus nerve stimulation for the treatment of depression: a study protocol for a double blinded randomized clinical trial
    Pei jing Rong
    Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, 100700, China
    BMC Complement Altern Med 12:255. 2012
  7. pmc Functional connectivity of the frontoparietal network predicts cognitive modulation of pain
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA
    Pain 154:459-67. 2013
  8. ncbi request reprint A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods
    Jian Kong
    Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing, People s Republic of China
    J Altern Complement Med 8:411-9. 2002
  9. pmc Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 45:940-9. 2009
  10. pmc An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 47:1066-76. 2009

Detail Information

Publications36

  1. ncbi request reprint Placebo analgesia: findings from brain imaging studies and emerging hypotheses
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA
    Rev Neurosci 18:173-90. 2007
    ..The literature suggests that multiple brain regions, including the anterior cingulate cortex, anterior insula, prefrontal cortex and periaqueductal grey, play a pivotal role in these processes...
  2. doi request reprint Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
    ....
  3. pmc A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Massachusetts General Hospital, Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts 02215, USA
    J Neurosci 28:13354-62. 2008
    ..In conclusion, we found evidence that nocebo hyperalgesia may be predominantly produced through an affective-cognitive pain pathway (medial pain system), and the left hippocampus may play an important role in this process...
  4. pmc S1 is associated with chronic low back pain: a functional and structural MRI study
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Harvard Medical School, 120 2nd Ave, Room 101, Charlestown, MA 02129, USA
    Mol Pain 9:43. 2013
    ..Our results provide evidence of structural plasticity co-localized with areas exhibiting FC changes in S1 in cLBP patients...
  5. pmc Are all placebo effects equal? Placebo pills, sham acupuncture, cue conditioning and their association
    Jian Kong
    Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    PLoS ONE 8:e67485. 2013
    ..However, a significant association was found between the genuine and sham acupuncture treatments, implying that the non-specific effects of acupuncture may contribute to the analgesic effect observed in genuine acupuncture analgesia. ..
  6. pmc Transcutaneous vagus nerve stimulation for the treatment of depression: a study protocol for a double blinded randomized clinical trial
    Pei jing Rong
    Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, 100700, China
    BMC Complement Altern Med 12:255. 2012
    ....
  7. pmc Functional connectivity of the frontoparietal network predicts cognitive modulation of pain
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA
    Pain 154:459-67. 2013
    ..We believe that these findings will shed new light on our understanding of variable cue/expectancy effects across individuals and how the intrinsic connectivity of the brain may influence expectancy-induced modulation of pain...
  8. ncbi request reprint A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods
    Jian Kong
    Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing, People s Republic of China
    J Altern Complement Med 8:411-9. 2002
    ..To characterize the brain activation patterns evoked by manual and electroacupuncture on normal human subjects...
  9. pmc Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 45:940-9. 2009
    ..Our results also suggest that the brain network involved in expectancy may vary under different treatment situations (verum and sham acupuncture treatment)...
  10. pmc An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 47:1066-76. 2009
    ..We hypothesize that as a peripheral-central modulation, acupuncture needle stimulation may inhibit incoming noxious stimuli; while as a top-down modulation, expectancy (placebo) may work through the emotional circuit...
  11. pmc Exploring the brain in pain: activations, deactivations and their relation
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, Charlestown, MA 02129, USA
    Pain 148:257-67. 2010
    ..Our results illustrate the absence of a linear relationship between pain activations and deactivations, and therefore suggest that these brain signal changes underlie different aspects of the pain experience...
  12. pmc Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI study
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, Charlestown, MA 02129, USA
    Behav Brain Res 211:215-9. 2010
    ..We believe eluciation of this intrinsic PAG network during the resting state will enhance our physiological and pathological understandings of the development and maintenance of chronic pain states...
  13. ncbi request reprint Functional neuroanatomical investigation of vision-related acupuncture point specificity--a multisession fMRI study
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Hum Brain Mapp 30:38-46. 2009
    ..Given the complexity of acupuncture systems and brain activity, additional work is required to determine whether functional neuroanatomical correlates of acupoint specificity can be validated by means of brain imaging tools...
  14. ncbi request reprint The neural substrate of arithmetic operations and procedure complexity
    Jian Kong
    Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Brain Res Cogn Brain Res 22:397-405. 2005
    ..Our results suggest that the network activated by the simplest calculation serves as a common basis, to which more regions are recruited for more difficult problems or different arithmetic operations...
  15. ncbi request reprint Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Hum Brain Mapp 27:715-21. 2006
    ..We hypothesize that these two regions play a crucial role in bridging the encoding of pain sensation and the cognitive processing of sensory input...
  16. ncbi request reprint Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:381-8. 2006
    ..Our results suggest that placebo analgesia may be configured through multiple brain pathways and mechanisms...
  17. pmc Test-retest study of fMRI signal change evoked by electroacupuncture stimulation
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital MGH, MA, USA
    Neuroimage 34:1171-81. 2007
    ....
  18. doi request reprint Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia pain
    Karin B Jensen
    Massachusetts General Hospital, Harvard Medical School, and Athinoula A Martinos Center for Biomedical Imaging, Boston, Massachusetts
    Arthritis Rheum 65:3293-303. 2013
    ..The aim of the present study was to investigate the relationship between brain structure and function in patients with FM...
  19. pmc Imaging the functional connectivity of the Periaqueductal Gray during genuine and sham electroacupuncture treatment
    Carolyn E Zyloney
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, USA
    Mol Pain 6:80. 2010
    ..Given the PAG's important role in mediating acupuncture analgesia, in this study we investigated functional connectivity with the area of the PAG we previously identified and how that connectivity was affected by genuine and sham EA...
  20. pmc A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia
    Darin D Dougherty
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, MA 02129, USA
    Behav Brain Res 193:63-8. 2008
    ..These findings include brain regions within both the lateral and medial pain networks...
  21. pmc Default mode network connectivity encodes clinical pain: an arterial spin labeling study
    Marco L Loggia
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School HMS, Boston, MA, USA
    Pain 154:24-33. 2013
    ..Our results support the use of arterial spin labeling to evaluate clinical pain, and the use of resting DMN connectivity as a potential neuroimaging biomarker for chronic pain perception...
  22. ncbi request reprint Psychophysical outcomes from a randomized pilot study of manual, electro, and sham acupuncture treatment on experimentally induced thermal pain
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Pain 6:55-64. 2005
    ..This suggests that attributes of the deqi sensation may be useful clinical indicators of effective treatment...
  23. pmc Sex similarities and differences in pain-related periaqueductal gray connectivity
    Clas Linnman
    P A I N Group, McLean Hospital, Belmont, MA, USA
    Pain 153:444-54. 2012
    ..Our results emphasize the importance of including both male and female subjects when studying basic mechanisms of pain processing, and point toward a possible sex difference in endogenous pain inhibition...
  24. pmc The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli
    Marco L Loggia
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e27764. 2011
    ..These findings may help explain the inconsistencies in reported findings of the impact of COMT in pain regulation...
  25. pmc The impact of placebo, psychopathology, and expectations on the response to acupuncture needling in patients with chronic low back pain
    Ajay Darsh Wasan
    Department of Anesthesiology, Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Pain 11:555-63. 2010
    ..Psychiatric comorbidity does not significantly impact acupuncture or placebo acupuncture analgesia in CLBP. It does not affect the positive impact of expectations on reported pain relief from real acupuncture...
  26. pmc Nonconscious activation of placebo and nocebo pain responses
    Karin B Jensen
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 109:15959-64. 2012
    ..This is a unique experimental verification of the influence of nonconscious conditioned stimuli on placebo/nocebo effects and the results challenge the exclusive role of awareness and conscious cognitions in placebo responses...
  27. pmc Neural correlates of chronic low back pain measured by arterial spin labeling
    Ajay D Wasan
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 115:364-74. 2011
    ..Arterial spin labeling is a perfusion-based imaging technique allowing the absolute quantification of regional cerebral blood flow, which is a surrogate measure of neuronal activity...
  28. pmc The effects of acupuncture on the brain networks for emotion and cognition: an observation of gender differences
    Wei Qiao Qiu
    Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, USA
    Brain Res 1362:56-67. 2010
    ..Our study suggests that brains with sex dimorphism may process the acupuncture stimulation differently between women and men...
  29. ncbi request reprint Sham acupuncture devices--practical advice for researchers
    Claire A McManus
    Harvard Medical School, Boston, MA, USA
    Acupunct Med 25:36-40. 2007
    ..We also report our experience with the sham needle in neuroimaging experiments where the magnetic machinery poses considerable challenges for acupuncture research...
  30. doi request reprint The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation
    Jiliang Fang
    Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    Hum Brain Mapp 30:1196-206. 2009
    ....
  31. doi request reprint Functional network architecture predicts psychologically mediated analgesia related to treatment in chronic knee pain patients
    Javeria Ali Hashmi
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts 02129, Harvard Medical School, Boston, Massachusetts 02115, Department of Neurology and A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Program in Placebo Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215
    J Neurosci 34:3924-36. 2014
    ..This suggests a potential utility of network measures in predicting placebo response for clinical use. ..
  32. doi request reprint For placebo effects in medicine, seeing is believing
    Randy L Gollub
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Sci Transl Med 3:70ps5. 2011
    ....
  33. pmc Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network
    Karin B Jensen
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Mol Pain 8:32. 2012
    ..The seed coordinates were based on the findings from our previous study, comparing the fMRI signal during calibrated pressure pain in FM and HC: the rostral anterior cingulate cortex (rACC) and thalamus...
  34. ncbi request reprint The effect of body temperature on the murine electroretinogram
    Jian Kong
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Doc Ophthalmol 106:239-42. 2003
    ..To study the effect of body temperature on the murine electroretinogram (ERG)...
  35. ncbi request reprint Retinal degeneration and RPE transplantation in Rpe65(-/-) mice
    Peter Gouras
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 43:3307-11. 2002
    ..To determine whether transplanting normal retinal pigment epithelium (RPE) into the subretinal space influences photoreceptor function and degeneration in Rpe65(-/-) mice...
  36. ncbi request reprint [Some misunderstandings of deqi phenomenon: from historic review to experimental study]
    Tao Huang
    Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Zhongguo Zhen Jiu 28:105-9. 2008
    ..The two states will be detected by fMRI in experimental studies, so as to have indexes to be followed for deqi or needling sensation...

Research Grants1

  1. Study of individual variability in acupuncture and placebo analgesia
    Jian Kong; Fiscal Year: 2007
    ..This integrated program of training and research will yield new tools for studying acupuncture and placebo treatment and provide the candidate with the skills needed to achieve independence in a highly complex field. ..