EFI G contact KOKKOTOU

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Serum correlates of the placebo effect in irritable bowel syndrome
    E Kokkotou
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurogastroenterol Motil 22:285-e81. 2010
  2. pmc Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone
    Jutta M Nagel
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41914. 2012
  3. pmc Intestinal Upregulation of Melanin-Concentrating Hormone in TNBS-Induced Enterocolitis in Adult Zebrafish
    Brenda M Geiger
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e83194. 2013
  4. pmc Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis
    Dimitrios C Ziogas
    Beth Israel Deaconess Medical Center, Dana 501, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 304:G876-84. 2013
  5. pmc Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice
    E Kokkotou
    Division of Gastroenterology, Dana 501, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gut 58:34-40. 2009
  6. pmc Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    D S Ludwig
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Clin Invest 107:379-86. 2001
  7. ncbi request reprint Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus
    N A Tritos
    Elliot P Joslin Laboratory, Joslin Diabetes Center, Rm 653, One Joslin Place, Boston, MA 02215, USA
    Brain Res 895:160-6. 2001
  8. pmc Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease
    F Cremonini
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Aliment Pharmacol Ther 32:29-42. 2010

Collaborators

Detail Information

Publications8

  1. pmc Serum correlates of the placebo effect in irritable bowel syndrome
    E Kokkotou
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurogastroenterol Motil 22:285-e81. 2010
    ....
  2. pmc Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone
    Jutta M Nagel
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41914. 2012
    ..Given the link between chronic intestinal inflammation and colorectal cancer, in the present study we sought to investigate whether blocking MCH might have effects on intestinal tumorigenesis that are independent of inflammation...
  3. pmc Intestinal Upregulation of Melanin-Concentrating Hormone in TNBS-Induced Enterocolitis in Adult Zebrafish
    Brenda M Geiger
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e83194. 2013
    ..Zebrafish have emerged as a new animal model of IBD, although the majority of the reported studies concern zebrafish larvae. Regulation MCH expression in the adult zebrafish intestine remains unknown...
  4. pmc Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis
    Dimitrios C Ziogas
    Beth Israel Deaconess Medical Center, Dana 501, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 304:G876-84. 2013
    ..Thus, by virtue of combined anti-inflammatory and anti-fibrotic effects, blocking MCH might represent a compelling approach for treating IBD...
  5. pmc Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice
    E Kokkotou
    Division of Gastroenterology, Dana 501, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gut 58:34-40. 2009
    ..Based on previous paradigms and the presence of MCH in the intestine as well as in immune cells, its potential role in gut innate immune responses was examined...
  6. pmc Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    D S Ludwig
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Clin Invest 107:379-86. 2001
    ..Heterozygote C57BL/6J mice expressing the transgene showed increased body weight on a standard diet, confirming that MCH overexpression can lead to obesity...
  7. ncbi request reprint Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus
    N A Tritos
    Elliot P Joslin Laboratory, Joslin Diabetes Center, Rm 653, One Joslin Place, Boston, MA 02215, USA
    Brain Res 895:160-6. 2001
    ..This conclusion is further supported by the observation that orexin ablated mice have arousal and not feeding deficits...
  8. pmc Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease
    F Cremonini
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Aliment Pharmacol Ther 32:29-42. 2010
    ..Little is known about the determinants and the circumstances associated with placebo response in the treatment of gastro-oesophageal reflux disease (GERD)...

Research Grants7

  1. Omics and Variable Responses to Placebo and Acupuncture in Irritable Bowel Syndro
    EFI G contact KOKKOTOU; Fiscal Year: 2010
    ..Our findings will improve the design of clinical trials and contribute to the practice of "personalized" medicine. ..
  2. Melanin-Concentrating Hormone as a Novel Mediator of Intestinal Inflammation
    Efi Kokkotou; Fiscal Year: 2009
    ..Experiments outlined in this proposal will uncover the mechanisms by which MCH mediates intestinal inflammation and test an MCH antagonist as a novel approach to treat IBD and perhaps additional inflammatory conditions. ..
  3. Melanin-Concentrating Hormone as a Novel Mediator of Intestinal Inflammation
    Efi G Kokkotou; Fiscal Year: 2010
    ..Experiments outlined in this proposal will uncover the mechanisms by which MCH mediates intestinal inflammation and test an MCH antagonist as a novel approach to treat IBD and perhaps additional inflammatory conditions. ..
  4. Omics and Variable Responses to Placebo and Acupuncture in Irritable Bowel Syndro
    EFI G contact KOKKOTOU; Fiscal Year: 2010
    ..Our findings will improve the design of clinical trials and contribute to the practice of "personalized" medicine. ..