David Kokel

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Using the zebrafish photomotor response for psychotropic drug screening
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Methods Cell Biol 105:517-24. 2011
  2. pmc Photochemical activation of TRPA1 channels in neurons and animals
    David Kokel
    Department of Medicine, Cardiovascular Research Center and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Chem Biol 9:257-63. 2013
  3. pmc Identification of nonvisual photomotor response cells in the vertebrate hindbrain
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 33:3834-43. 2013
  4. pmc Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Brief Funct Genomic Proteomic 7:483-90. 2008
  5. doi request reprint An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action
    Shan Jin
    Massachusetts General Hospital, Harvard Medical School, Department of Medicine, Charlestown, MA, USA
    J Biomol Screen 18:108-15. 2013
  6. ncbi request reprint cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish
    Jolijn W Groeneweg
    Vincent Center for Reproductive Biology, MGH Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Mol Reprod Dev 78:22-32. 2011
  7. pmc Live imaging of apoptotic cells in zebrafish
    Tjakko J van Ham
    Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FASEB J 24:4336-42. 2010
  8. pmc Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Trends Biotechnol 30:421-5. 2012
  9. pmc Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment
    Tjakko J van Ham
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Curr Biol 22:830-6. 2012

Collaborators

Detail Information

Publications10

  1. pmc Using the zebrafish photomotor response for psychotropic drug screening
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Methods Cell Biol 105:517-24. 2011
    ....
  2. pmc Photochemical activation of TRPA1 channels in neurons and animals
    David Kokel
    Department of Medicine, Cardiovascular Research Center and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Chem Biol 9:257-63. 2013
    ..These studies identify a light-based strategy for controlling endogenous TRPA1 receptors in vivo, with potential clinical and research applications in nontransgenic animals, including humans...
  3. pmc Identification of nonvisual photomotor response cells in the vertebrate hindbrain
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 33:3834-43. 2013
    ..Pharmacological inhibition of the visual cycle blocks PMR behaviors, suggesting that opsin-based photoreceptors control this behavior. These data represent the first known light-sensing circuit in the vertebrate hindbrain...
  4. pmc Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Brief Funct Genomic Proteomic 7:483-90. 2008
    ..Thus, behaviour-based chemical screens in the zebrafish may improve our understanding of neurobiology and accelerate the pace of psychiatric drug discovery...
  5. doi request reprint An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action
    Shan Jin
    Massachusetts General Hospital, Harvard Medical School, Department of Medicine, Charlestown, MA, USA
    J Biomol Screen 18:108-15. 2013
    ..These findings suggest that zebrafish screens might be a broadly applicable approach for discovering compounds that counteract the toxic effects of accidental or malicious poisonous exposures...
  6. ncbi request reprint cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish
    Jolijn W Groeneweg
    Vincent Center for Reproductive Biology, MGH Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Mol Reprod Dev 78:22-32. 2011
    ..Collectively, these data suggest that cables1 is important for neural differentiation during embryogenesis, in a mechanism that likely involves interactions with the Cdk5/p35 kinase pathway...
  7. pmc Live imaging of apoptotic cells in zebrafish
    Tjakko J van Ham
    Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FASEB J 24:4336-42. 2010
    ..We use this fluorescent probe to characterize patterns of apoptosis in living zebrafish larvae and to visualize neuronal cell death at single-cell resolution in vivo...
  8. pmc Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Trends Biotechnol 30:421-5. 2012
    ..Here, we review behavioral barcoding, a process by which complex behavioral assays are reduced to a string of numeric features, facilitating analysis and comparison within and across datasets...
  9. pmc Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment
    Tjakko J van Ham
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Curr Biol 22:830-6. 2012
    ..These findings suggest that clearance of apoptotic cells in living vertebrates is accomplished by the combined actions of apoptotic cell migration and elmo1-dependent macrophage engulfment...