Olivier N Kocher

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1
    Gabriel Birrane
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53819. 2013
  2. pmc Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice
    Ayce Yesilaltay
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 4:e8103. 2009
  3. pmc Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Lipidol 20:236-41. 2009
  4. ncbi request reprint Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:52820-5. 2003
  5. pmc Influence of PDZK1 on lipoprotein metabolism and atherosclerosis
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Biochim Biophys Acta 1782:310-6. 2008
  6. pmc Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional binding site for the C terminus of the high density lipoprotein receptor scavenger receptor class B type I
    Olivier Kocher
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 286:25171-86. 2011
  7. ncbi request reprint The thymus: a comprehensive review
    Mizuki Nishino
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Radiographics 26:335-48. 2006
  8. pmc In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1
    Olivier Kocher
    Department of Pathology, Center for Vascular Biology Research, Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215
    J Biol Chem 285:34999-5010. 2010
  9. ncbi request reprint Ligneous (pseudomembranous) inflammation involving the female genital tract associated with type-1 plasminogen deficiency
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Int J Gynecol Pathol 23:292-5. 2004
  10. pmc Targeted disruption of the PDZK1 gene by homologous recombination
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:1175-80. 2003

Research Grants

Collaborators

  • M Krieger
  • Susumu Kobayashi
  • Jianzhu Chen
  • Alex Toker
  • Y Rebecca Chin
  • Songwen Zhang
  • Mizuki Nishino
  • V Schuster
  • Clyde Crumpacker
  • Liron Pantanowitz
  • Jielin Zhang
  • U Steidl
  • Arturo Bravo-Nuevo
  • I J Koralnik
  • J H Schiller
  • A Rigotti
  • Mark Bedford
  • Balazs Halmos
  • Daniel G Tenen
  • Rinku Pal
  • Gabriel Birrane
  • Shiva Kazerounian
  • Karen B O'Brien
  • Ayce Yesilaltay
  • Jilin Cheng
  • Laura E Benjamin
  • Elena Levantini
  • Daniel B Costa
  • Shigeto Kubo
  • Azita Djalilvand
  • YiPing Chen
  • Louis K Sussman
  • Lawrence F Brown
  • James B DuHadaway
  • Carole Perruzzi
  • Thuy L Phung
  • B Therese Kinsella
  • Minzhou Huang
  • Jacob Pourat
  • Ningning Zheng
  • Stephanie McNamara
  • Eamon P Mulvaney
  • Damien Gerald
  • Rebekah K O'Donnell
  • George C Prendergast
  • Durga Udayakumar
  • Lee Mangiante
  • Sharon Shechter
  • Meritxell Alberich-Jordà
  • Manoj Bhasin
  • Alexander Ebralidze
  • Natasha J L Sng
  • Annalisa Diruscio
  • Daehoon Kim
  • Gang Huang
  • Neelu Yadav
  • Tyler Caron
  • Scott J Rodig
  • James P Morgan
  • Kathleen Daniels
  • Haibin Wang
  • Zhuang Jin
  • Qingen Ke
  • David H Johnson
  • Richard H Feins
  • Steven M Keller
  • Sigui Li
  • Masaya Takahashi
  • Donald Antonioli
  • Mary Fowkes
  • Paul M Sharp
  • Harvey Goldman
  • Jeffrey T Joseph
  • Jan Nalinee Upalakalin
  • Mark J Roberts
  • Katalin Ferenczi
  • Claudia S Huettner
  • Daniel D Karp

Detail Information

Publications19

  1. pmc Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1
    Gabriel Birrane
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53819. 2013
    ....
  2. pmc Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice
    Ayce Yesilaltay
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 4:e8103. 2009
    ....
  3. pmc Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Lipidol 20:236-41. 2009
    ....
  4. ncbi request reprint Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:52820-5. 2003
    ..The PDZK1-dependent regulation of hepatic SR-BI and, thus, lipoprotein metabolism supports the proposal that this adaptor may represent a new target for therapeutic intervention in cardiovascular disease...
  5. pmc Influence of PDZK1 on lipoprotein metabolism and atherosclerosis
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Biochim Biophys Acta 1782:310-6. 2008
    ..They also define PDZK1 as a member of the family of proteins that is instrumental in preventing cardiovascular disease by maintaining normal lipoprotein metabolism...
  6. pmc Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional binding site for the C terminus of the high density lipoprotein receptor scavenger receptor class B type I
    Olivier Kocher
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 286:25171-86. 2011
    ....
  7. ncbi request reprint The thymus: a comprehensive review
    Mizuki Nishino
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Radiographics 26:335-48. 2006
    ....
  8. pmc In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1
    Olivier Kocher
    Department of Pathology, Center for Vascular Biology Research, Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215
    J Biol Chem 285:34999-5010. 2010
    ..The results suggest that there may be an additional site(s) within PDZK1 that bind(s) SR-BI and mediate(s) productive SR-BI-PDZK1 interaction previously attributed exclusively to the canonical binding of the C-terminal SR-BI to PDZ1...
  9. ncbi request reprint Ligneous (pseudomembranous) inflammation involving the female genital tract associated with type-1 plasminogen deficiency
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Int J Gynecol Pathol 23:292-5. 2004
    ..We present a patient with ligneous inflammation of her genital, middle ear, and oral mucosa that was associated with type-1 homozygous plasminogen deficiency due to a novel missense mutation in the plasminogen gene...
  10. pmc Targeted disruption of the PDZK1 gene by homologous recombination
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:1175-80. 2003
    ....
  11. pmc Cytomegalovirus infection causes an increase of arterial blood pressure
    Jilin Cheng
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    PLoS Pathog 5:e1000427. 2009
    ..Viral persistent infection of EC may underlie the mechanism. Control of CMV infection can be developed to restrict hypertension and atherosclerosis in the cardiovascular system...
  12. doi request reprint RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis
    Shiva Kazerounian
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Cancer Res 73:50-61. 2013
    ..More generally, they illustrate how differential gene function effects on signaling pathways in the tumor stromal component can complicate the challenge of developing therapeutics to target cancer pathophysiology...
  13. ncbi request reprint Analysis of 15 novel full-length BK virus sequences from three individuals: evidence of a high intra-strain genetic diversity
    YiPing Chen
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 213B, 330 Brookline Avenue, Boston, MA 02215, USA
    J Gen Virol 85:2651-63. 2004
    ..55 % of sites, implying a rate of nucleotide substitution of approximately 5 x 10(-5) substitutions per site per year, which is two orders of magnitude faster than estimated for the other human polyomavirus, JC virus...
  14. ncbi request reprint Blood markers for vasculogenesis increase with tumor progression in patients with breast carcinoma
    Louis K Sussman
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Biol Ther 2:255-6. 2003
    ..Our data suggest increased circulating EPC markers in tumor patients, but further study of this cell population is needed to better define its role in tumor vasculogenesis...
  15. pmc CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells
    Karen B O'Brien
    Harvard Stem Cell Institute and Center for Life Sciences, Harvard Medical School, Boston, MA 02115, USA
    Development 137:2147-56. 2010
    ..These results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells...
  16. pmc Immunohistochemical analysis of C/EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: a correlative study of E3590
    Daniel B Costa
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA, United States
    Lung Cancer 56:97-103. 2007
    ..This is the first comprehensive study of this transcription factor in patients with NSCLC...
  17. ncbi request reprint Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice
    Shigeto Kubo
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, and Ireland Cancer Center, University Hospitals of Cleveland Case Western Reserve University, OH, USA
    Magn Reson Med 56:698-703. 2006
    ..This promising method is noninvasive and has the potential to eventually replace invasive histopathology because it obviates the need to kill groups of animals at multiple time points...
  18. ncbi request reprint Evaluation of p53 mutations in premalignant esophageal lesions and esophageal adenocarcinoma using laser capture microdissection
    Azita Djalilvand
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 17:1323-7. 2004
    ..Our results, using LCM, show that p53 gene mutations are relatively rare in esophageal preneoplastic and neoplastic conditions. Only point mutations were detected, but no deletions/insertions were identified...
  19. ncbi request reprint Down-regulation and antiproliferative role of C/EBPalpha in lung cancer
    Balazs Halmos
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 62:528-34. 2002
    ..Genetic analysis of the C/EBPalpha gene is in progress to fully evaluate its role as a novel tumor suppressor in lung cancer...

Research Grants5

  1. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2006
    ....
  2. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2007
    ....
  3. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2009
    ....
  4. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier N Kocher; Fiscal Year: 2010
    ....