ELIZABETH KLERMAN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 34:309-18. 2013
  2. pmc Analysis method and experimental conditions affect computed circadian phase from melatonin data
    Hadassa Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33836. 2012
  3. pmc Age-related reduction in the maximal capacity for sleep--implications for insomnia
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:1118-23. 2008
  4. ncbi request reprint On mathematical modeling of circadian rhythms, performance, and alertness
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 22:91-102. 2007
  5. ncbi request reprint Circadian phase resetting in older people by ocular bright light exposure
    E B Klerman
    Circadian, Neuroendocrine, and Sleep Disorders Section, Division of Endocrinology Hypertension, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass, USA
    J Investig Med 49:30-40. 2001
  6. pmc Interindividual variation in sleep duration and its association with sleep debt in young adults
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sleep 28:1253-9. 2005
  7. ncbi request reprint Clinical aspects of human circadian rhythms
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Rhythms 20:375-86. 2005
  8. ncbi request reprint Older people awaken more frequently but fall back asleep at the same rate as younger people
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sleep 27:793-8. 2004
  9. ncbi request reprint A statistical model of diurnal variation in human growth hormone
    Elizabeth B Klerman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 285:E1118-26. 2003
  10. ncbi request reprint Photic resetting of the human circadian pacemaker in the absence of conscious vision
    E B Klerman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 17:548-55. 2002

Research Grants

  1. Impact of Sleep Disruption on Menstrual Cycle Dynamics
    ELIZABETH KLERMAN; Fiscal Year: 2004
  2. Impact of Sleep Disruption on Menstrual Cycle Dynamics
    ELIZABETH KLERMAN; Fiscal Year: 2007

Detail Information

Publications26

  1. pmc Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 34:309-18. 2013
    ..Interventions to improve age-related sleep complaints should thus target this change in awakenings...
  2. pmc Analysis method and experimental conditions affect computed circadian phase from melatonin data
    Hadassa Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33836. 2012
    ..We conclude that melatonin data set characteristics, including amplitude and completeness of data collection, differentially affect the results depending on the melatonin analysis method used...
  3. pmc Age-related reduction in the maximal capacity for sleep--implications for insomnia
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:1118-23. 2008
    ..Thus, in the absence of social and circadian constraints, both daytime sleep propensity and the maximal capacity for sleep are reduced in older people. These data have important implications for understanding age-related insomnia...
  4. ncbi request reprint On mathematical modeling of circadian rhythms, performance, and alertness
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 22:91-102. 2007
    ..This article also presents several methods of testing and comparing these models, suggests different uses of the models, and discusses problems with current models...
  5. ncbi request reprint Circadian phase resetting in older people by ocular bright light exposure
    E B Klerman
    Circadian, Neuroendocrine, and Sleep Disorders Section, Division of Endocrinology Hypertension, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass, USA
    J Investig Med 49:30-40. 2001
    ....
  6. pmc Interindividual variation in sleep duration and its association with sleep debt in young adults
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sleep 28:1253-9. 2005
    ..To determine whether variation in sleep duration reflects variation in sleep need or self-imposed sleep restriction...
  7. ncbi request reprint Clinical aspects of human circadian rhythms
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Rhythms 20:375-86. 2005
    ..The clinical side effects of disruption of circadian rhythmicity, such as in shiftwork, including the public health implications of the disrupted alertness and performance, are also discussed...
  8. ncbi request reprint Older people awaken more frequently but fall back asleep at the same rate as younger people
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sleep 27:793-8. 2004
    ....
  9. ncbi request reprint A statistical model of diurnal variation in human growth hormone
    Elizabeth B Klerman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 285:E1118-26. 2003
    ..Our analysis paradigm suggests an approach to decomposing GH diurnal patterns that can be used to characterize the physiological properties of this hormone under normal and pathological conditions...
  10. ncbi request reprint Photic resetting of the human circadian pacemaker in the absence of conscious vision
    E B Klerman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 17:548-55. 2002
    ....
  11. ncbi request reprint Circadian rhythms of women with fibromyalgia
    E B Klerman
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 86:1034-9. 2001
    ..We suggest that abnormalities in circadian rhythmicity are not a primary cause of fibromyalgia or its symptoms...
  12. ncbi request reprint Comparisons of the variability of three markers of the human circadian pacemaker
    Elizabeth B Klerman
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Rhythms 17:181-93. 2002
    ....
  13. ncbi request reprint EEG delta activity during undisturbed sleep in the squirrel monkey
    E B Klerman
    Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA 02115, USA
    Sleep Res Online 3:113-9. 2000
    ..These results differ from predictions of a purely homeostatic model of sleep that would include maximal levels of delta activity at sleep onset...
  14. ncbi request reprint Absence of an increase in the duration of the circadian melatonin secretory episode in totally blind human subjects
    E B Klerman
    Circadian, Neuroendocrine, and Sleep Disorders Section, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 86:3166-70. 2001
    ..Healthy blind individuals after years without ocular light exposure do not have a longer duration of melatonin secretion than healthy sighted individuals...
  15. doi request reprint Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials
    Shantha Mw Rajaratnam
    Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Lancet 373:482-91. 2009
    ....
  16. pmc Taking the lag out of jet lag through model-based schedule design
    Dennis A Dean
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    PLoS Comput Biol 5:e1000418. 2009
    ..The method presented in this paper has direct implications for designing jet lag, shift-work, and non-24-hour schedules, including scheduling for extreme environments, such as in space, undersea, or in polar regions...
  17. pmc Uncovering residual effects of chronic sleep loss on human performance
    Daniel A Cohen
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sci Transl Med 2:14ra3. 2010
    ..Thus, extended wake during the circadian night reveals the cumulative detrimental effects of chronic sleep loss on performance, with potential adverse health and safety consequences...
  18. pmc A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker
    Melissa A St Hilaire
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Pineal Res 43:294-304. 2007
    ..This updated model has been incorporated into an existing mathematical model of the human circadian pacemaker and can be used to simulate experimental protocols under a number of conditions...
  19. pmc Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker
    Melissa A St Hilaire
    Analytic and Modeling Unit, Division of Sleep Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    J Theor Biol 247:583-99. 2007
    ..Further experiments are required to validate fully our model and to understand the exact effect of the sleep-wake cycle as a non-photic stimulus for the human circadian pacemaker...
  20. ncbi request reprint Developing mathematical models of neurobehavioral performance for the "real world"
    Dennis A Dean
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 22:246-58. 2007
    ..However, major progress has been made in using mathematical model outputs to inform those individuals making schedule decisions for their workers...
  21. ncbi request reprint Peak of circadian melatonin rhythm occurs later within the sleep of older subjects
    Jeanne F Duffy
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 282:E297-303. 2002
    ..In healthy older subjects, the relative timing of the melatonin rhythm with respect to sleep may not play a causal role in sleep disruption...
  22. pmc Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker
    Premananda Indic
    Biomathematical Modeling Unit, Division of Sleep Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Chronobiol Int 22:613-29. 2005
    ..Experiments derived from model predictions are proposed to test the influence of low amplitude recovery on the physiological and neurobehavioral functions...
  23. ncbi request reprint Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling
    Richard E Kronauer
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, Division of Applied Sciences, Harvard University, Cambridge, MA 02115, USA
    J Biol Rhythms 22:233-45. 2007
    ..A unifying theme was that it is important to have strong collaborative ties between experimental investigators and mathematical modelers, both for the design and conduct of experiments and for continued development of the models...
  24. pmc Elevated body temperature during sleep in orexin knockout mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Am J Physiol Regul Integr Comp Physiol 291:R533-40. 2006
    ..In addition, because heat loss is an essential aspect of sleep, the blunted fall in Tb of orexin KO mice may provide an explanation for the fragmented sleep of narcolepsy...
  25. ncbi request reprint Development of a two-dimension manifold to represent high dimension mathematical models of the intracellular Mammalian circadian clock
    Premananda Indic
    Biomathematical Modeling Unit, Division of Sleep Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    J Biol Rhythms 21:222-32. 2006
    ....
  26. pmc Measuring melatonin in humans
    Susan Benloucif
    Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
    J Clin Sleep Med 4:66-9. 2008
    ....

Research Grants5

  1. Impact of Sleep Disruption on Menstrual Cycle Dynamics
    ELIZABETH KLERMAN; Fiscal Year: 2004
    ..abstract_text> ..
  2. Impact of Sleep Disruption on Menstrual Cycle Dynamics
    ELIZABETH KLERMAN; Fiscal Year: 2007
    ....