Research Topics
| I KissinSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: a preliminary study on pain memoryRustam Yukhananov
Neurogenomic Laboratory Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
BMC Neurosci 9:32. 2008..This objective was undertaken with the understanding that the long-lasting imprint of acute pain in the central nervous system may contribute to the transition of acute pain to chronicity...
Perineural resiniferatoxin prevents hyperalgesia in a rat model of postoperative painIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Anesth Analg 100:774-80, table of contents. 2005..We conclude that RTX provides a type of neural blockade when postoperative pain is abolished and that nonpainful sensations and motor functions are preserved...- Memory of pain: the effect of perineural resiniferatoxinIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anesth Analg 103:721-8. 2006..Thus, pain memory can be preempted by selective and prolonged blockade of C-fibers... - Perineural resiniferatoxin prevents the development of hyperalgesia produced by loose ligation of the sciatic nerve in ratsIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anesth Analg 104:1210-6, tables of contents. 2007..In the present study, we tested the hypothesis that perineural resiniferatoxin (RTX) can prevent the development of hyperalgesia caused by placing loosely constrictive ligatures around the sciatic nerve... - Sciatic nerve block with resiniferatoxin: an electron microscopic study of unmyelinated fibers in the ratIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Anesth Analg 105:825-31. 2007..In the present study, we sought to determine whether RTX-induced reversible sciatic nerve block results in the degenerative changes of unmyelinated fibers... - Time course characteristics of acute tolerance development to continuously infused alfentanil in ratsI Kissin
Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Anesth Analg 83:600-5. 1996.... - Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicityIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anesth Analg 107:271-81. 2008..These promising results should be confirmed by experiments in species other than rodents (pigs, sheep). Taken together, the data indicate possible clinical applicability of vanilloid-induced conduction analgesia... 
Patient-controlled-analgesia analgesimetry and its problemsIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, MRB611, Boston, MA 02115, USA
Anesth Analg 108:1945-9. 2009..Knowledge of the pitfalls of PCA analgesimetry should decrease the risk of errors in its use...- The development of new analgesics over the past 50 years: a lack of real breakthrough drugsIgor Kissin
Brigham and Women s Hospital, 75 Francis St, Anesthesia MRB, Boston, MA 02115, USA
Anesth Analg 110:780-9. 2010..The present assessment reveals the lack of real breakthroughs in analgesic drug development despite intense research efforts. Possible factors contributing to the apparent drought of novel analgesics are discussed... - Preemptive analgesia: problems with assessment of clinical significanceIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Methods Mol Biol 617:475-82. 2010.... - Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trialsIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Curr Top Med Chem 11:2159-70. 2011..In this review, we argue that resiniferatoxin is an attractive alternative to capsaicin in that it achieves lasting desensitization without the side effects that complicate capsaicin therapy... - Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivityIgor Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anesth Analg 94:1253-8, table of contents. 2002..Applied to the sciatic and saphenous nerves, it completely prevented pain hypersensitivity caused by prolonged inflammatory process (injection of carrageenan into the paw)... - Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesiaI Kissin
Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Anesthesiology 88:224-32. 1998..The authors examined whether a tonicaine nerve block lasting for 12 to 16 h could prevent late inflammatory hyperalgesia... - Effect of midazolam on development of acute tolerance to alfentanil: the role of pharmacokinetic interactionsI Kissin
Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Anesth Analg 85:182-7. 1997..The results confirm that midazolam attenuates the development of acute tolerance to the analgesic effect of alfentanil and indicate that this interaction is not pharmacokinetic... - Can inflammatory pain prevent the development of acute tolerance to alfentanil?I Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Anesth Analg 92:1296-300. 2001..We found that acute tolerance to the analgesic effect of alfentanil, in the presence of constant pain caused by inflammation, develops as rapidly as without it... - The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?I Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anesth Analg 91:1483-8. 2000..Implications: Ketamine attenuated the development of acute tolerance to analgesia during alfentanil infusion and suppressed rebound hyperalgesia observed the day after the infusion... - Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systemsI Kissin
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Anesth Analg 91:110-6. 2000..Drugs that inhibit function of these systems attenuate tolerance development... - Hyperalgesia caused by nerve transection: long-lasting block prevents early hyperalgesia in the receptive field of the surviving nerveI Kissin
Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Anesth Analg 89:1475-81. 1999..IMPLICATIONS: A long-lasting nerve block can prevent early hyperalgesia caused by nerve transection... - Rapid development of tolerance to analgesia during remifentanil infusion in humansH R Vinik
Department of Anesthesiology, University of Alabama at Birmingham, USA
Anesth Analg 86:1307-11. 1998..The administration of opioids during anesthesia based on target-controlled infusions should include corrections for the development of tolerance... - Effect of subarachnoid bupivacaine block on anesthetic requirements for thiopental in ratsS Eappen
Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Anesthesiology 88:1036-42. 1998..The purpose of this study was to examine if local anesthetically induced lumbar intrathecal blockade would reduce thiopental requirements for blockade of motor responses to noxious and nonnoxious stimuli in rats... - Pharmacokinetic nature of tachyphylaxis to lidocaine: peripheral nerve blocks and infiltration anesthesia in ratsR H Choi
Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Life Sci 61:PL 177-84. 1997..Our data show that tachyphylaxis rapidly develops with both sciatic nerve blocks and infiltration anesthesia. The data also suggest that the mechanism is largely pharmacokinetic in nature... - Isobolographic analysis of propofol-thiopental hypnotic interaction in surgical patientsH R Vinik
Department of Anesthesiology, University of Alabama at Birmingham, USA
Anesth Analg 88:667-70. 1999..IMPLICATIONS: The propofol-thiopental hypnotic interaction is additive... - A high concentration of resiniferatoxin inhibits ion channel function in clonal neuroendocrine cellsKenji Sugimoto
Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Anesth Analg 107:318-24. 2008..RTX's effect could result from specific actions on TRPV1 channels, but might also arise from previously reported TRPV1-independent effects. We have tested whether exposure to RTX compromises ion channels in a TRPV1-independent manner... - Iatrogenic addiction in patients treated for acute or subacute pain: a systematic reviewAjay D Wasan
Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
J Opioid Manag 2:16-22. 2006..1 percent)... - The effects of intraarticular resiniferatoxin in experimental knee-joint arthritisEugene Y Kissin
Arthritis Center, Boston University School of Medicine, 715 Albany Street, E 5, Boston, MA 02118 2526, USA
Anesth Analg 101:1433-9. 2005..The experiments demonstrated that intraarticular RTX inhibits pain behavior in knee-joint arthritis and that this effect is dose-dependent. These results suggest a new direction for peripheral analgesia... - Study design to demonstrate clinical value of preemptive analgesia: is the commonly used approach valid?Igor Kissin
Reg Anesth Pain Med 27:242-4. 2002 - Effects of long-term nerve blockade in the spared nerve injury modelIgor Kissin
Anesthesiology 101:806-7. 2004 - Preemptive analgesia at the crossroadIgor Kissin
Anesth Analg 100:754-6. 2005
Research Grants
- Neural blockade with vanilloidsIgor Kissin; Fiscal Year: 2007..To study the specific aims of the project the effects of RTX will be examined in rats by behavioral methods; and whole cell voltage-clamp technique will be used to identify a mechanism for impulse failure induced by RTX. ..
- ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONSIgor Kissin; Fiscal Year: 2001....
- OPIOID-BENZODIAZEPINE INTERACTIONSIgor Kissin; Fiscal Year: 1993....