I Kissin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc An early indicator of drug success: Top Journal Selectivity Index
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Drug Des Devel Ther 7:93-8. 2013
  2. pmc Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: a preliminary study on pain memory
    Rustam Yukhananov
    Neurogenomic Laboratory Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Neurosci 9:32. 2008
  3. doi request reprint Preemptive analgesia: problems with assessment of clinical significance
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 617:475-82. 2010
  4. ncbi request reprint Perineural resiniferatoxin prevents hyperalgesia in a rat model of postoperative pain
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesth Analg 100:774-80, table of contents. 2005
  5. ncbi request reprint Memory of pain: the effect of perineural resiniferatoxin
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 103:721-8. 2006
  6. ncbi request reprint Perineural resiniferatoxin prevents the development of hyperalgesia produced by loose ligation of the sciatic nerve in rats
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 104:1210-6, tables of contents. 2007
  7. ncbi request reprint Sciatic nerve block with resiniferatoxin: an electron microscopic study of unmyelinated fibers in the rat
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesth Analg 105:825-31. 2007
  8. ncbi request reprint Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Top Med Chem 11:2159-70. 2011
  9. pmc Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 107:271-81. 2008
  10. doi request reprint Patient-controlled-analgesia analgesimetry and its problems
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, MRB611, Boston, MA 02115, USA
    Anesth Analg 108:1945-9. 2009

Research Grants

  1. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
  2. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
  3. OPIOID-BENZODIAZEPINE INTERACTIONS
    Igor Kissin; Fiscal Year: 1993

Detail Information

Publications29

  1. pmc An early indicator of drug success: Top Journal Selectivity Index
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Drug Des Devel Ther 7:93-8. 2013
    ..The TJSI can be an indicator of a drug's potential for sustained use: a higher score increases the probability of continuing success...
  2. pmc Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: a preliminary study on pain memory
    Rustam Yukhananov
    Neurogenomic Laboratory Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Neurosci 9:32. 2008
    ..This objective was undertaken with the understanding that the long-lasting imprint of acute pain in the central nervous system may contribute to the transition of acute pain to chronicity...
  3. doi request reprint Preemptive analgesia: problems with assessment of clinical significance
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 617:475-82. 2010
    ....
  4. ncbi request reprint Perineural resiniferatoxin prevents hyperalgesia in a rat model of postoperative pain
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesth Analg 100:774-80, table of contents. 2005
    ..We conclude that RTX provides a type of neural blockade when postoperative pain is abolished and that nonpainful sensations and motor functions are preserved...
  5. ncbi request reprint Memory of pain: the effect of perineural resiniferatoxin
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 103:721-8. 2006
    ..Thus, pain memory can be preempted by selective and prolonged blockade of C-fibers...
  6. ncbi request reprint Perineural resiniferatoxin prevents the development of hyperalgesia produced by loose ligation of the sciatic nerve in rats
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 104:1210-6, tables of contents. 2007
    ..In the present study, we tested the hypothesis that perineural resiniferatoxin (RTX) can prevent the development of hyperalgesia caused by placing loosely constrictive ligatures around the sciatic nerve...
  7. ncbi request reprint Sciatic nerve block with resiniferatoxin: an electron microscopic study of unmyelinated fibers in the rat
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesth Analg 105:825-31. 2007
    ..In the present study, we sought to determine whether RTX-induced reversible sciatic nerve block results in the degenerative changes of unmyelinated fibers...
  8. ncbi request reprint Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Top Med Chem 11:2159-70. 2011
    ..In this review, we argue that resiniferatoxin is an attractive alternative to capsaicin in that it achieves lasting desensitization without the side effects that complicate capsaicin therapy...
  9. pmc Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 107:271-81. 2008
    ..These promising results should be confirmed by experiments in species other than rodents (pigs, sheep). Taken together, the data indicate possible clinical applicability of vanilloid-induced conduction analgesia...
  10. doi request reprint Patient-controlled-analgesia analgesimetry and its problems
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, MRB611, Boston, MA 02115, USA
    Anesth Analg 108:1945-9. 2009
    ..Knowledge of the pitfalls of PCA analgesimetry should decrease the risk of errors in its use...
  11. doi request reprint The development of new analgesics over the past 50 years: a lack of real breakthrough drugs
    Igor Kissin
    Brigham and Women s Hospital, 75 Francis St, Anesthesia MRB, Boston, MA 02115, USA
    Anesth Analg 110:780-9. 2010
    ..The present assessment reveals the lack of real breakthroughs in analgesic drug development despite intense research efforts. Possible factors contributing to the apparent drought of novel analgesics are discussed...
  12. ncbi request reprint Time course characteristics of acute tolerance development to continuously infused alfentanil in rats
    I Kissin
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesth Analg 83:600-5. 1996
    ....
  13. ncbi request reprint Hyperalgesia caused by nerve transection: long-lasting block prevents early hyperalgesia in the receptive field of the surviving nerve
    I Kissin
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesth Analg 89:1475-81. 1999
    ..As far as early hyperalgesia is concerned, the preventive effect of the N-butyl tetracaine was much longer than that of lidocaine and continued for approximately 1 wk...
  14. ncbi request reprint Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems
    I Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Anesth Analg 91:110-6. 2000
    ....
  15. ncbi request reprint The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    I Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 91:1483-8. 2000
    ..Implications: Ketamine attenuated the development of acute tolerance to analgesia during alfentanil infusion and suppressed rebound hyperalgesia observed the day after the infusion...
  16. ncbi request reprint Can inflammatory pain prevent the development of acute tolerance to alfentanil?
    I Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 92:1296-300. 2001
    ..We conclude that acute tolerance to the analgesic effect of opioids is profound and develops very rapidly, even in the presence of constant nociceptive input...
  17. ncbi request reprint Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia
    I Kissin
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 88:224-32. 1998
    ..The authors examined whether a tonicaine nerve block lasting for 12 to 16 h could prevent late inflammatory hyperalgesia...
  18. ncbi request reprint Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity
    Igor Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 94:1253-8, table of contents. 2002
    ..005). We suggest that the selective nature of the effect of vanilloid agonists on nociception could provide an opportunity for prolonged neural blockade when early mobilization and/or preservation of protective sensation are required...
  19. ncbi request reprint Effect of midazolam on development of acute tolerance to alfentanil: the role of pharmacokinetic interactions
    I Kissin
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesth Analg 85:182-7. 1997
    ..The results confirm that midazolam attenuates the development of acute tolerance to the analgesic effect of alfentanil and indicate that this interaction is not pharmacokinetic...
  20. ncbi request reprint Rapid development of tolerance to analgesia during remifentanil infusion in humans
    H R Vinik
    Department of Anesthesiology, University of Alabama at Birmingham, USA
    Anesth Analg 86:1307-11. 1998
    ..The administration of opioids during anesthesia based on target-controlled infusions should include corrections for the development of tolerance...
  21. ncbi request reprint Effect of subarachnoid bupivacaine block on anesthetic requirements for thiopental in rats
    S Eappen
    Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 88:1036-42. 1998
    ..The purpose of this study was to examine if local anesthetically induced lumbar intrathecal blockade would reduce thiopental requirements for blockade of motor responses to noxious and nonnoxious stimuli in rats...
  22. ncbi request reprint Pharmacokinetic nature of tachyphylaxis to lidocaine: peripheral nerve blocks and infiltration anesthesia in rats
    R H Choi
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Life Sci 61:PL 177-84. 1997
    ..Our data show that tachyphylaxis rapidly develops with both sciatic nerve blocks and infiltration anesthesia. The data also suggest that the mechanism is largely pharmacokinetic in nature...
  23. ncbi request reprint Isobolographic analysis of propofol-thiopental hypnotic interaction in surgical patients
    H R Vinik
    Department of Anesthesiology, University of Alabama at Birmingham, USA
    Anesth Analg 88:667-70. 1999
    ....
  24. doi request reprint A high concentration of resiniferatoxin inhibits ion channel function in clonal neuroendocrine cells
    Kenji Sugimoto
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesth Analg 107:318-24. 2008
    ..RTX's effect could result from specific actions on TRPV1 channels, but might also arise from previously reported TRPV1-independent effects. We have tested whether exposure to RTX compromises ion channels in a TRPV1-independent manner...
  25. ncbi request reprint Iatrogenic addiction in patients treated for acute or subacute pain: a systematic review
    Ajay D Wasan
    Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Opioid Manag 2:16-22. 2006
    ..1 percent)...
  26. pmc The effects of intraarticular resiniferatoxin in experimental knee-joint arthritis
    Eugene Y Kissin
    Arthritis Center, Boston University School of Medicine, 715 Albany Street, E 5, Boston, MA 02118 2526, USA
    Anesth Analg 101:1433-9. 2005
    ..The experiments demonstrated that intraarticular RTX inhibits pain behavior in knee-joint arthritis and that this effect is dose-dependent. These results suggest a new direction for peripheral analgesia...
  27. ncbi request reprint Study design to demonstrate clinical value of preemptive analgesia: is the commonly used approach valid?
    Igor Kissin
    Reg Anesth Pain Med 27:242-4. 2002
  28. ncbi request reprint Effects of long-term nerve blockade in the spared nerve injury model
    Igor Kissin
    Anesthesiology 101:806-7. 2004
  29. ncbi request reprint Preemptive analgesia at the crossroad
    Igor Kissin
    Anesth Analg 100:754-6. 2005

Research Grants14

  1. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..To study the specific aims of the project the effects of RTX will be examined in rats by behavioral methods; and whole cell voltage-clamp technique will be used to identify a mechanism for impulse failure induced by RTX. ..
  2. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ....
  3. OPIOID-BENZODIAZEPINE INTERACTIONS
    Igor Kissin; Fiscal Year: 1993
    ....