Affiliation: Harvard University
Kural C, Akatay A, Gaudin R, Chen B, Legant W, Betzig E, et al
. Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells. Mol Biol Cell. 2015;26:2044-53 pubmed publisher
..These observations support a previously proposed model that invokes net membrane deposition at the leading edge due to an imbalance between the endocytic and exocytic membrane flow at the front of a migrating cell. ..
Chou Y, Cuevas C, Carocci M, Stubbs S, Ma M, Cureton D, et al
. Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol. 2016;90:4494-4510 pubmed publisher
..Moreover, we show that ZCL278 also functions in vivo, thereby preventing Junin virus replication in a mouse model, opening the possibility for the discovery of ZCL278 derivatives of therapeutic potential. ..
Cocucci E, Gaudin R, Kirchhausen T. Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit. Mol Biol Cell. 2014;25:3595-609 pubmed publisher
..We discuss how these results restrict models for the mechanism of dynamin-mediated membrane scission. ..
Aguet F, Upadhyayula S, Gaudin R, Chou Y, Cocucci E, He K, et al
. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 2016;27:3418-3435 pubmed
..These applications demonstrate the advantage of lattice light-sheet microscopy and enable a new standard for imaging membrane dynamics in single cells and multicellular assemblies. ..
Kirchhausen T. Three ways to make a vesicle. Nat Rev Mol Cell Biol. 2000;1:187-98 pubmed
..A general model to explain the formation of coated vesicles is starting to emerge but the picture is more complex than we had imagined. ..
Kirchhausen T. Adaptors for clathrin-mediated traffic. Annu Rev Cell Dev Biol. 1999;15:705-32 pubmed
..This review focuses on the most recent advances dealing with the molecular basis for sorting by clathrin adaptors...
Kirchhausen T. Clathrin. Annu Rev Biochem. 2000;69:699-727 pubmed
..This review summarizes and illustrates the recent structural results and outlines what is known about coated-vesicle assembly in the context of this information. ..
Massol R, Boll W, Griffin A, Kirchhausen T. A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc Natl Acad Sci U S A. 2006;103:10265-10270 pubmed publisher
Kirchhausen T. Bending membranes. Nat Cell Biol. 2012;14:906-8 pubmed publisher
..The second reports that membrane crowding, driven by protein-protein interactions, can also drive membrane bending, even in the absence of any protein insertion into the bilayer...