Hannah C Kinney

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Serotonergic brainstem abnormalities in Northern Plains Indians with the sudden infant death syndrome
    Hannah C Kinney
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 62:1178-91. 2003
  2. pmc Late development of the GABAergic system in the human cerebral cortex and white matter
    Gang Xu
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 70:841-58. 2011
  3. pmc Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Brain Pathol 18:153-63. 2008
  4. pmc Thalamic damage in periventricular leukomalacia: novel pathologic observations relevant to cognitive deficits in survivors of prematurity
    Poonam Ligam
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 65:524-9. 2009
  5. ncbi request reprint The effect of maternal smoking and drinking during pregnancy upon (3)H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population
    Jhodie R Duncan
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Brain Pathol 18:21-31. 2008
  6. pmc The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, United States
    J Chem Neuroanat 41:182-99. 2011
  7. pmc Lack of association of the serotonin transporter polymorphism with the sudden infant death syndrome in the San Diego Dataset
    David S Paterson
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 68:409-13. 2010
  8. pmc Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia
    Tara M Desilva
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 508:238-48. 2008
  9. pmc Brainstem serotonergic deficiency in sudden infant death syndrome
    Jhodie R Duncan
    Department of Pathology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 303:430-7. 2010
  10. pmc The cerebral cortex overlying periventricular leukomalacia: analysis of pyramidal neurons
    Sarah E Andiman
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Mass, USA
    Brain Pathol 20:803-14. 2010

Detail Information

Publications75

  1. ncbi request reprint Serotonergic brainstem abnormalities in Northern Plains Indians with the sudden infant death syndrome
    Hannah C Kinney
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 62:1178-91. 2003
    ..011) and alcohol (p = 0.075), during the periconceptional period or throughout pregnancy. Prenatal exposure to cigarette smoke and/or alcohol may contribute to abnormal fetal medullary 5-HT development in SIDS infants...
  2. pmc Late development of the GABAergic system in the human cerebral cortex and white matter
    Gang Xu
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 70:841-58. 2011
    ..This period corresponds to the peak window of vulnerability to perinatal hypoxia-ischemia in which GABAergic neurons are potentially developmentally susceptible, including in the preterm infant...
  3. pmc Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Brain Pathol 18:153-63. 2008
    ..OL migration toward the "core" of injury may occur to replenish OL cell number. This study provides new insight into the cellular basis of the myelin deficits observed in survivors of PVL...
  4. pmc Thalamic damage in periventricular leukomalacia: novel pathologic observations relevant to cognitive deficits in survivors of prematurity
    Poonam Ligam
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 65:524-9. 2009
    ..01), with substantial involvement of the mediodorsal, and reticular nuclei in PVL. The prevention of thalamic damage may be required for the eradication of defects in survivors with PVL...
  5. ncbi request reprint The effect of maternal smoking and drinking during pregnancy upon (3)H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population
    Jhodie R Duncan
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Brain Pathol 18:21-31. 2008
    ..Future studies are needed to establish the role of adverse prenatal exposures in altered brainstem neurochemistry in SIDS...
  6. pmc The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, United States
    J Chem Neuroanat 41:182-99. 2011
    ..The delineation of the development and organization of the human caudal 5-HT system provides the critical foundation for the neuropathologic elucidation of its disorders directly in the human brain...
  7. pmc Lack of association of the serotonin transporter polymorphism with the sudden infant death syndrome in the San Diego Dataset
    David S Paterson
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 68:409-13. 2010
    ..These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS...
  8. pmc Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia
    Tara M Desilva
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 508:238-48. 2008
    ..The previously unrecognized up-regulation of EAAT2 in reactive astrocytes and its presence in macrophages in PVL reported here may reflect a response to either hypoxic-ischemic injury or inflammation...
  9. pmc Brainstem serotonergic deficiency in sudden infant death syndrome
    Jhodie R Duncan
    Department of Pathology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 303:430-7. 2010
    ..Abnormalities of serotonin (5-hydroxytryptamine [5-HT]) receptor binding in regions of the medulla oblongata involved in this control have been reported in infants dying from SIDS...
  10. pmc The cerebral cortex overlying periventricular leukomalacia: analysis of pyramidal neurons
    Sarah E Andiman
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Mass, USA
    Brain Pathol 20:803-14. 2010
    ..This study underscores the potential role of secondary cortical injury in the encephalopathy of prematurity...
  11. pmc Potential asphyxia and brainstem abnormalities in sudden and unexpected death in infants
    Bradley B Randall
    Department of Pathology, Enders Building Room 1112, Boston Children s Hospital, 61 Binney St, Boston, MA 02115
    Pediatrics 132:e1616-25. 2013
    ..g., supine), whereas infants with intermediate or borderline brainstem deficiencies require asphyxial stressors to precipitate death...
  12. pmc Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice
    Caitlin A Massey
    Department of Anesthesiology, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neurochem 126:749-57. 2013
    ..Thus, brainstem 5-HT(1A)-heteroreceptor-binding sites do not appear developmentally sensitive to reduced brain 5-HT levels...
  13. pmc Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medulla
    Kevin G Broadbelt
    Department of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
    Auton Neurosci 154:30-41. 2010
    ..The developmental profile of GABAergic markers changed dramatically relative to the 5-HT markers. These data provide baseline information for medullary studies of human pediatric disorders, such as sudden infant death syndrome...
  14. ncbi request reprint Serotonergic and glutamatergic neurons at the ventral medullary surface of the human infant: Observations relevant to central chemosensitivity in early human life
    David S Paterson
    Department of Pathology, Enders 1111, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, United States Harvard Medical School, Boston, MA 02115, USA
    Auton Neurosci 124:112-24. 2006
    ..These data are important towards delineating the role of the human Arc in modulation of homeostasis, and its dysfunction in brainstem-associated pathologies such as the sudden infant death syndrome...
  15. ncbi request reprint Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter
    Rebecca D Folkerth
    From Departments of Pathology Neuropathology, Children s Hospital, Boston, USA
    J Neuropathol Exp Neurol 63:990-9. 2004
    ..The previously unrecognized dissociation between the expression of the SODs and that of catalase and GPx in the fetal period has potential implications for future antioxidant therapy in PVL...
  16. ncbi request reprint Multiple serotonergic brainstem abnormalities in sudden infant death syndrome
    David S Paterson
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    JAMA 296:2124-32. 2006
    ..Previously, abnormalities in 5-HT receptor binding in the medullae of infants dying from sudden infant death syndrome (SIDS) were identified, suggesting that medullary 5-HT dysfunction may be responsible for a subset of SIDS cases...
  17. pmc Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome
    Kevin G Broadbelt
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Neuropathol Exp Neurol 70:799-810. 2011
    ..026). These data suggest that medullary GABAA receptors are abnormal in SIDS infants and that SIDS is a complex disorder of a homeostatic network in the medulla that involves deficits of the GABAergic and 5-HT systems...
  18. pmc Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome
    Kevin G Broadbelt
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Proteomics 11:M111.009530. 2012
    ..These data suggest a potential molecular defect in SIDS related to TPH2 regulation, as 14-3-3 is critical in this process...
  19. pmc Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin
    Robin L Haynes
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 63:656-61. 2008
    ..We conclude that diffuse axonal injury, as determined by apoptotic marker fractin, occurs in PVL and that its cause likely includes primary ischemia and trophic degeneration secondary to corticothalamic neuronal damage...
  20. doi request reprint Brainstem mechanisms underlying the sudden infant death syndrome: evidence from human pathologic studies
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Dev Psychobiol 51:223-33. 2009
    ..The possible fetal origin of brainstem defects in SIDS is reviewed, including evidence for adverse effects of prenatal exposure to maternal cigarette smoking and alcohol upon the postnatal development of human brainstem 5-HT pathways...
  21. ncbi request reprint The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter
    Tara M Desilva
    Neurobiology Program, Children s Hospital Boston, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 501:879-90. 2007
    ....
  22. pmc Disconnection of the ascending arousal system in traumatic coma
    Brian L Edlow
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    J Neuropathol Exp Neurol 72:505-23. 2013
    ..We propose that traumatic coma may be a subcortical disconnection syndrome related to the disconnection of specific brainstem arousal nuclei from the thalamus and basal forebrain...
  23. doi request reprint Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous
    Hannah C Kinney
    Department of Pathology, Boston Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Enders Building 1112, Boston, MA 02115, USA
    Forensic Sci Med Pathol 8:414-25. 2012
    ..Krous' far-reaching influence upon SIDS and SUDC research...
  24. pmc Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development
    Tara M Desilva
    Department of Neurology and the FM Kirby Neurobiology Center, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 520:3912-32. 2012
    ..In addition, by studying the expression of EAAT1 and EAAT2 glutamate transporters, it was possible to document the development of protoplasmic astrocytes...
  25. ncbi request reprint Lipid peroxidation during human cerebral myelination
    Robin L Haynes
    Department of Pathology, Children s Hospital Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 65:894-904. 2006
    ....
  26. ncbi request reprint Development of microglia in the cerebral white matter of the human fetus and infant
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, MA 02115, USA
    J Comp Neurol 497:199-208. 2006
    ..j...
  27. pmc The development of nicotinic receptors in the human medulla oblongata: inter-relationship with the serotonergic system
    Jhodie R Duncan
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Auton Neurosci 144:61-75. 2008
    ..This study indicates parallel dynamic and complex changes in the medullary nicotinic and 5-HT systems throughout early life, i.e., the period of risk for SIDS...
  28. pmc Sudden death, febrile seizures, and hippocampal and temporal lobe maldevelopment in toddlers: a new entity
    Hannah C Kinney
    Department of Pathology Neuropathology, Children s Hospital and Harvard Medical School, Enders Building, Room 1112, 300 Longwood Avenue, Boston, MA, 02115, USA
    Pediatr Dev Pathol 12:455-63. 2009
    ..This study mandates further research into the potential link between simple febrile seizures and death...
  29. ncbi request reprint Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: a case report
    Hannah C Kinney
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 64:689-94. 2005
    ..Replication of these findings in a large population may lead to the development of predictive cardiorespiratory assessment tools for future screening to identify infants with medullary 5-HT abnormalities and SIDS risk...
  30. pmc Neuron deficit in the white matter and subplate in periventricular leukomalacia
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 71:397-406. 2012
    ..We tested the hypothesis that the overall density of neurons in the white matter and subplate region is significantly lower in PVL cases compared to non-PVL controls...
  31. pmc Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: implications for sudden infant death syndrome
    Jhodie R Duncan
    Dept of Pathology, Enders 1112 1, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 107:1579-90. 2009
    ..Thus increased risk for SIDS due to maternal smoking may be partly related to the effects of nicotine on 5-HT and/or nicotinic receptors...
  32. pmc Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia
    Robin L Haynes
    Departments of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
    Acta Neuropathol 118:391-9. 2009
    ..This study supports an important role for iNOS-induced nitrosative stress in the reactive/inflammatory component of PVL...
  33. ncbi request reprint The development of the medullary serotonergic system in early human life
    Hannah C Kinney
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Auton Neurosci 132:81-102. 2007
    ..Thus, protracted changes occur from the prenatal period through infancy. These data provide a foundation for 5-HT neuronal analysis in pediatric brainstem disorders, as proposed in the sudden infant death syndrome...
  34. pmc Gray matter injury associated with periventricular leukomalacia in the premature infant
    Christopher R Pierson
    Department of Pathology, Children s Hospital Boston, Boston, MA, USA
    Acta Neuropathol 114:619-31. 2007
    ..Gray matter lesions occur in a third or more of PVL cases suggesting that white matter injury generally does not occur in isolation, and that the term "perinatal panencephalopathy" may better describe the scope of the neuropathology...
  35. pmc Witnessed sleep-related seizure and sudden unexpected death in infancy: a case report
    Hannah C Kinney
    Department of Pathology, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Forensic Sci Med Pathol 9:418-21. 2013
    ..This report alerts the forensic community to the possibility that sudden and unexplained death in infants may be due to seizures...
  36. pmc Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population
    Kevin G Broadbelt
    Department of Pathology, Enders Building Room 1111, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Res 66:631-5. 2009
    ..128-(191_192)dupA). The polymorphism seems to be a common, likely nonpathogenic, variant in the African-American population...
  37. ncbi request reprint Interferon-gamma expression in periventricular leukomalacia in the human brain
    Rebecca D Folkerth
    Department of Pathology Neuropathology, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Brain Pathol 14:265-74. 2004
    ..In PVL, IFN-gamma produced by macrophages and reactive astrocytes may play a role in cytokine-induced toxicity to premyelinating oligodendrocytes as part of a cytokine response stimulated by ischemia and/or infection...
  38. ncbi request reprint Is the late preterm infant more vulnerable to gray matter injury than the term infant?
    Saraid S Billiards
    Department of Pathology, Enders Building, Room 1109, Children s Hospital Boston, Boston, MA 02115, USA
    Clin Perinatol 33:915-33; abstract x-xi. 2006
    ..Future research involving closer examination of the late preterm period is essential to provide a greater understanding of the neuronal vulnerability in the face of hypoxic-ischemic injury...
  39. ncbi request reprint Axonal development in the cerebral white matter of the human fetus and infant
    Robin L Haynes
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 484:156-67. 2005
    ..These data suggest that immature axons are susceptible to damage in PVL and that the timing of axonal maturation must be considered toward establishing its pathology relative to the oligodendrocyte/myelin/axonal unit...
  40. pmc Interleukin-6 and the serotonergic system of the medulla oblongata in the sudden infant death syndrome
    Ingvar Jon Rognum
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Acta Neuropathol 118:519-30. 2009
    ..Aberrant interactions between IL-6 and the arcuate nucleus may contribute to impaired responses to hypercapnia generated by infection (hyper-metabolism) combined with rebreathing...
  41. ncbi request reprint Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction
    David S Paterson
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neuropathol Exp Neurol 64:1018-27. 2005
    ..These data suggest hypotheses concerning 5-HT modulation of vagal function for testing in MeCP2 knockout mice to understand mechanisms underlying autonomic dysfunction in patients with Rett syndrome...
  42. pmc Potential neuronal repair in cerebral white matter injury in the human neonate
    Robin L Haynes
    Departments of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 69:62-7. 2011
    ..e. 35-42 postconceptional weeks. These data provide the first evidence suggestive of an attempt at neuronal repair or regeneration in human neonatal white matter injury...
  43. pmc Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights
    Gang Xu
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cereb Cortex 24:579-92. 2014
    ..This study provides baseline information for interpreting radial coherence in tractography studies of the preterm brain in the assessment of the encephalopathy of prematurity. ..
  44. pmc The developing oligodendrocyte: key cellular target in brain injury in the premature infant
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:423-40. 2011
    ..The critical next step, i.e., clinical trials in the living infant, is now on the horizon...
  45. pmc Inheritance of febrile seizures in sudden unexplained death in toddlers
    Ingrid A Holm
    Division of Genetics, Program in Genomics, and Manton Center for Orphan Disease Research, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Neurol 46:235-9. 2012
    ..Future studies should develop markers (including genetic) to identify which patients with febrile seizures are at risk for sudden unexplained death in childhood, and to provide guidance for families and physicians...
  46. pmc Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders
    Brian L Edlow
    Department of Neurology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Neuropathol Exp Neurol 71:531-46. 2012
    ....
  47. ncbi request reprint The near-term (late preterm) human brain and risk for periventricular leukomalacia: a review
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, MA 02115, USA
    Semin Perinatol 30:81-8. 2006
    ....
  48. ncbi request reprint Hypoxic-ischemic brain injury in infants with congenital heart disease dying after cardiac surgery
    Hannah C Kinney
    Department of Pathology, Children s Hospital and Harvard Medical School, Enders 1112, 300 Longwood Avenue, Boston, MA 02115, USA
    Acta Neuropathol 110:563-78. 2005
    ....
  49. ncbi request reprint Human myelination and perinatal white matter disorders
    Hannah C Kinney
    Department of Neuroscience, Harvard Medical School Children s Hospital, Enders Building, Room 206, 300 Longwood Avenue, Boston, MA 02115, USA
    J Neurol Sci 228:190-2. 2005
  50. ncbi request reprint Sudden death in toddlers associated with developmental abnormalities of the hippocampus: a report of five cases
    Hannah C Kinney
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Pediatr Dev Pathol 10:208-23. 2007
    ..Future studies are needed to confirm these initial findings and to define the putative links between sudden death, hippocampal anomalies, and febrile seizures in toddlers...
  51. pmc The brainstem and serotonin in the sudden infant death syndrome
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Pathol 4:517-50. 2009
    ..These emerging data suggest an important underlying mechanism in SIDS that may help lead to identification of infants at risk and specific interventions to prevent death...
  52. ncbi request reprint Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesis
    Stephen A Back
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neuropathol Exp Neurol 61:197-211. 2002
    ....
  53. doi request reprint Neuropathologic studies of the encephalopathy of prematurity in the late preterm infant
    Robin L Haynes
    Department of Pathology, Boston Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA Electronic address
    Clin Perinatol 40:707-22. 2013
    ..Further research is needed to more clearly define developmental cellular susceptibilities in preterm populations. ..
  54. pmc Whole genome sequencing identifies SCN2A mutation in monozygotic twins with Ohtahara syndrome and unique neuropathologic findings
    Marlin Touma
    Division of Newborn Medicine, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Epilepsia 54:e81-5. 2013
    ..In conclusion, we have identified a de novo SCN2A mutation as the etiology for Ohtahara syndrome in monozygotic twins associated with a unique dentate-olivary dysplasia in the deceased twin...
  55. ncbi request reprint Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla
    David S Paterson
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 472:221-31. 2004
    ..This study provides important baseline data that serve as a foundation for future work in pediatric 5-HT brainstem disorders, including sudden infant death syndrome...
  56. ncbi request reprint Sudden death in toddlers with viral meningitis, massive cerebral edema, and neurogenic pulmonary edema and hemorrhage: report of two cases
    Henry F Krous
    Department of Pathology, Rady Children s Hospital San Diego, San Diego, CA, USA
    Pediatr Dev Pathol 10:463-9. 2007
    ..They also underscore the importance of a comprehensive autopsy, including detailed neuropathologic examination and viral testing, in determining of the cause of unexpected death in toddlers...
  57. ncbi request reprint Reprint of "The developing oligodendrocyte: key cellular target in brain injury in the premature infant"
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:565-82. 2011
    ..The critical next step, i.e., clinical trials in the living infant, is now on the horizon...
  58. ncbi request reprint Abnormalities of the brainstem serotonergic system in the sudden infant death syndrome: a review
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston, Enders Building 1112, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Pediatr Dev Pathol 8:507-24. 2005
  59. ncbi request reprint Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia
    Robin L Haynes
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 62:441-50. 2003
    ..Agents that prevent nitrosative and oxidative stress may play a key role in ameliorating PVL in premature infants in the intensive care nursery...
  60. ncbi request reprint Anatomic relationships of the human nucleus of the solitary tract in the medulla oblongata: a DiI labeling study
    Natasa Zec
    Department of Neurology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Enders Building 206, Boston, MA 02115, USA
    Auton Neurosci 105:131-44. 2003
    ....
  61. doi request reprint Structural abnormalities in the brainstem and cerebellum in congenital central hypoventilation syndrome: commentary on the article by Kumar et al. on page 275
    Hannah C Kinney
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 64:226-7. 2008
  62. ncbi request reprint Sudden Infant Death Syndrome: increased carotid-body dopamine and noradrenaline content
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston, 300 Longwood Avenue, Enders 1112, Boston, MA 02115, USA
    Pediatr Dev Pathol 8:258-67. 2005
  63. pmc The encephalopathy of prematurity: one pediatric neuropathologist's perspective
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Semin Pediatr Neurol 16:179-90. 2009
    ....
  64. pmc Modeling the encephalopathy of prematurity in animals: the important role of translational research
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Neurol Res Int 2012:295389. 2012
    ....
  65. ncbi request reprint Neuropathology associated with stillbirth
    Marjorie R Grafe
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0609, USA
    Semin Perinatol 26:83-8. 2002
    ..The fetal brain may be selectively vulnerable to various insults at specific stages of development...
  66. pmc Novel neuropathologic findings in the Haddad syndrome
    Nestor D Tomycz
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Acta Neuropathol 119:261-9. 2010
    ..This study implicates novel brain findings in Haddad syndrome mimicking those in murine Phox2b null mutants. This case suggests that abnormalities occur in CCHS in a network of sites critical to chemoreception...
  67. ncbi request reprint Risk factors for sudden infant death syndrome among northern plains Indians
    Solomon Iyasu
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 288:2717-23. 2002
    ..Sudden infant death syndrome (SIDS) is a leading cause of postneonatal mortality among American Indians, a group whose infant death rate is consistently above the US national average...
  68. ncbi request reprint The development of the medullary serotonergic system in the piglet
    Mary M Niblock
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03753, USA
    Auton Neurosci 110:65-80. 2004
    ..Therefore, the first 30 days of life represent a critical period in the development of the 5-HT system and the homeostatic functions it mediates...
  69. ncbi request reprint Comparative anatomical assessment of the piglet as a model for the developing human medullary serotonergic system
    Mary M Niblock
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Brain Res Brain Res Rev 50:169-83. 2005
    ..Collectively, when certain species differences are considered, these data support the use of the piglet as a model for the human infant medullary 5-HT system...
  70. ncbi request reprint Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO2
    Natalie C Taylor
    Department of Physiology, Dartmouth Medical Center, Borwell Bldg, Lebanon, NH 03756 000, USA
    J Appl Physiol (1985) 97:1763-73. 2004
    ..Chronic fluoxetine treatment in the medullary raphe increases the ventilatory response to hypercapnia in an unanesthetized rat model, an effect that may be due to facilitation of chemosensitive serotonergic neurons...
  71. ncbi request reprint The late preterm infant and the control of breathing, sleep, and brainstem development: a review
    Robert A Darnall
    Department of Physiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Perinatol 33:883-914; abstract x. 2006
    ..Research focused on this group of infants will not only further our understanding of brainstem maturation during this high risk period, but will help develop focused plans for their management...
  72. ncbi request reprint Sudden unexpected death in childhood associated with cardiac rhabdomyoma, involuting adrenal ganglioneuroma, and megalencephaly: another expression of tuberous sclerosis?
    Homeyra Masoumi
    Rady Children s Hospital and Health Center, San Diego, CA, USA
    Pediatr Dev Pathol 10:129-33. 2007
    ..The constellation of her autopsy findings suggested a diagnosis of tuberous sclerosis, for which there are gene defects that can be identified in surviving family members...
  73. ncbi request reprint Subacute combined degeneration of the spinal cord in cblC disorder despite treatment with B12
    Sharon E Smith
    Division of Genetics, Children s Hospital Boston, MA 02115, USA
    Mol Genet Metab 88:138-45. 2006
    ..This is especially important now that the presymptomatic detection of cblC disorder is possible through the expansion of newborn screening...
  74. doi request reprint Fetal mechanisms in neurodevelopmental disorders
    Susan L Connors
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Pediatr Neurol 38:163-76. 2008
    ..This research emphasizes the diversity of such prenatal mechanisms and the need to expand our understanding of how, when altered, they may lead to disordered development, the signs of which may not appear until long after birth...
  75. ncbi request reprint Mechanism of JCV entry into oligodendrocytes
    Sandro Santagata
    Science 309:381-2. 2005