Robert E Kingston
Affiliation: Harvard University
Lavigne M, Francis N, King I, Kingston R. Propagation of silencing; recruitment and repression of naive chromatin in trans by polycomb repressed chromatin. Mol Cell. 2004;13:415-25 pubmed
..Thus, repression and template bridging require different subunits of PcG complexes, suggesting that long-range effects may be mechanistically distinct from repression. ..
Kundu S, Ji F, Sunwoo H, Jain G, Lee J, Sadreyev R, et al
. Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol Cell. 2017;65:432-446.e5 pubmed publisher
..These domains have the potential to play a key role in transmitting epigenetic silencing of PcG targets by linking PRC1 to formation of a repressive higher-order structure. ..
Tchasovnikarova I, Kingston R. Beyond the Histone Code: A Physical Map of Chromatin States. Mol Cell. 2018;69:5-7 pubmed publisher
..In a recent issue of Molecular Cell, Becker et al. (2017) delineate chromatin states based on physical properties, thereby expanding our understanding of chromatin function. ..
Ray M, Wiskow O, King M, Ismail N, Ergun A, Wang Y, et al
. CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. J Biol Chem. 2016;291:19558-72 pubmed publisher
..We propose a model whereby PRC1 acts in concert with specific lncRNAs and that CAT7/cat7l represents convergent lncRNAs that independently evolved to tune PRC1 repression at individual loci. ..
Lau M, Schwartz M, Kundu S, Savol A, Wang P, Marr S, et al
. Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017;355:1081-1084 pubmed publisher
..We propose that CBX2-driven nucleosome compaction is a key mechanism by which PcG proteins maintain gene silencing during mouse development. ..
Bowman S, Deaton A, Domingues H, Wang P, Sadreyev R, Kingston R, et al
. H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex. elife. 2014;3:e02833 pubmed publisher
..These findings provide a molecular definition of the homeotic domains, and implicate precisely positioned H3K27 modifications as a central determinant of segment identity. ..
West J, Davis C, Sunwoo H, Simon M, Sadreyev R, Wang P, et al
. The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites. Mol Cell. 2014;55:791-802 pubmed publisher
Ardehali M, Anselmo A, Cochrane J, Kundu S, Sadreyev R, Kingston R. Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription. Mol Cell. 2017;68:872-884.e6 pubmed publisher
..We propose that PRC2 modulates transcription of a subset of low expression target genes in part via methylation of EloA. ..