George King

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia
    In Kyung Jeong
    Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea
    Diabetes Metab J 35:8-11. 2011
  2. pmc Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes
    Akira Mima
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Diabetes 61:2967-79. 2012
  3. pmc Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy
    Akira Mima
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 26:2963-74. 2012
  4. pmc Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice
    Christian Rask-Madsen
    Research Division, Joslin Diabetes Center, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 32:1124-31. 2012
  5. ncbi request reprint Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice
    Yuzuru Ohshiro
    Research Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:3112-20. 2006
  6. doi request reprint The role of inflammatory cytokines in diabetes and its complications
    George L King
    Section on Vascular Cell Biology, Joslin Diabetes Center and Clinic, One Joslin Place, Boston, MA 02215, USA
    J Periodontol 79:1527-34. 2008
  7. pmc Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study
    Jennifer K Sun
    Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 34:968-74. 2011
  8. ncbi request reprint Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain
    Konstantinos B Sotiropoulos
    Research Division, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    FASEB J 20:1203-5. 2006
  9. ncbi request reprint Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes
    William C Hsu
    Asian American Diabetes Initiative and the Center for Innovation in Diabetes Education, Joslin Diabetes Center, One Joslin Place, Boston MA 02215, USA
    Diabetes Care 29:415-6. 2006
  10. ncbi request reprint B-cell signaling: protein kinase Cdelta puts the brakes on
    Diane Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Curr Biol 12:R554-6. 2002

Detail Information

Publications61

  1. pmc New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia
    In Kyung Jeong
    Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea
    Diabetes Metab J 35:8-11. 2011
    ..This review outlines some of the evidence supporting the importance of enhancing endogenous regenerative factors...
  2. pmc Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes
    Akira Mima
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Diabetes 61:2967-79. 2012
    ....
  3. pmc Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy
    Akira Mima
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 26:2963-74. 2012
    ..Hyperglycemia and diabetes can cause glomerular podocyte apoptosis and endothelial dysfunction partly due to increased PKCδ/p38 MAPK activation and the expression of SHP-1 to cause VEGF resistance, independent of NF-κB activation...
  4. pmc Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice
    Christian Rask-Madsen
    Research Division, Joslin Diabetes Center, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 32:1124-31. 2012
    ..To determine the contribution of hyperinsulinemia to atherosclerosis development...
  5. ncbi request reprint Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice
    Yuzuru Ohshiro
    Research Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:3112-20. 2006
    ..Lack of PKC-beta can protect against diabetes-induced renal dysfunction, fibrosis, and increased expressions of Nox2 and -4, ET-1, VEGF, TGF-beta, CTGF, and oxidant production...
  6. doi request reprint The role of inflammatory cytokines in diabetes and its complications
    George L King
    Section on Vascular Cell Biology, Joslin Diabetes Center and Clinic, One Joslin Place, Boston, MA 02215, USA
    J Periodontol 79:1527-34. 2008
    ..Further research is required to confirm the role of inflammation and the onset of diabetes, microvascular diseases, and periodontal pathologies...
  7. pmc Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study
    Jennifer K Sun
    Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 34:968-74. 2011
    ..Characterization of a complication-free subgroup in this cohort would suggest that some individuals are protected from diabetes complications and allow identification of endogenous protective factors...
  8. ncbi request reprint Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain
    Konstantinos B Sotiropoulos
    Research Division, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    FASEB J 20:1203-5. 2006
    ..control mice. Thus, thiazolidinedione's effects on edema and wt are partially due to an adipose tissue-selective activation of PKC and vascular permeability that may be prevented by PKCbeta inhibition...
  9. ncbi request reprint Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes
    William C Hsu
    Asian American Diabetes Initiative and the Center for Innovation in Diabetes Education, Joslin Diabetes Center, One Joslin Place, Boston MA 02215, USA
    Diabetes Care 29:415-6. 2006
  10. ncbi request reprint B-cell signaling: protein kinase Cdelta puts the brakes on
    Diane Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Curr Biol 12:R554-6. 2002
    ..The result is a state of non-responsiveness, termed anergy, that represents one form of immunological self-tolerance...
  11. ncbi request reprint Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance
    Keiko Naruse
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:691-8. 2006
    ....
  12. pmc p38 MAPK is a major regulator of MafA protein stability under oxidative stress
    Takuma Kondo
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 23:1281-90. 2009
    ..Therefore, preventing p38 MAPK-mediated degradation of MafA represents a novel approach to improve beta-cell function...
  13. ncbi request reprint Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats
    Emi Arikawa
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 56:1410-20. 2007
    ..Thus, PKCbeta or ACE inhibitors may ameliorate cardiac metabolism and function in diabetes partly by normalization of fuel metabolic gene expression directly in the myocardium...
  14. pmc Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
    Pedro Geraldes
    Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Boston, Massachusetts, USA
    Nat Med 15:1298-306. 2009
    ..These findings elucidate a new signaling pathway by which hyperglycemia can induce PDGF resistance and increase vascular cell apoptosis to cause diabetic vascular complications...
  15. ncbi request reprint The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients
    Panayiotis A Economides
    Microcirculation Laboratory, Palmer 317, BIDMC West, 1 Deaconess Rd, Boston, MA 02215, USA
    Diabetes 54:204-11. 2005
    ..Because vitamin E-treated patients had a worsening in some vascular reactivity measurements when compared with control subjects, the use of high dosages of vitamin E cannot be recommended...
  16. ncbi request reprint Oxidative stress and antioxidant treatment in diabetes
    Joshua A Scott
    Research Division, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Ann N Y Acad Sci 1031:204-13. 2004
    ..Furthermore, it appears that oxidative stress is only one factor contributing to diabetic complications; thus, antioxidant treatment would most likely be more effective if it were coupled with other treatments for diabetic complications...
  17. pmc Activation of protein kinase C isoforms and its impact on diabetic complications
    Pedro Geraldes
    Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Harvard Medical School, Boston, MA, USA
    Circ Res 106:1319-31. 2010
    ..This article reviews present understanding of how PKC isoforms cause vascular dysfunctions and pathologies in diabetes...
  18. ncbi request reprint Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation
    Toru Abiko
    Research Division, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:829-37. 2003
    ..Moreover, treatment with PKC beta inhibition is effective to normalize diabetes or hyperglycemia-induced PKC beta-isoform activation and oxidative stress...
  19. ncbi request reprint Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes
    Kerrie J Way
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 51:2709-18. 2002
    ..CTGF could act independently or together with other cytokines to induce cardiac fibrosis and dysfunction...
  20. ncbi request reprint Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue
    Eva Chou
    Research Division, Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts, USA
    Circulation 105:373-9. 2002
    ..Insulin treatment of diabetic rats normalized changes in both cardiac and microvascular tissues. Insulin increased VEGF mRNA expression in cultured rat neonatal cardiac myocytes...
  21. ncbi request reprint Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes
    Tamotsu Yokota
    Research Division, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:838-45. 2003
    ..The novel demonstration of elevated expression of PDGF-B and its induction by PKC activation identifies a potential new molecular step in the pathogenesis of diabetic retinopathy...
  22. ncbi request reprint Molecular targets of diabetic cardiovascular complications
    Fatima K Ahmad
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Curr Drug Targets 6:487-94. 2005
    ..However, clinical studies using these treatments have mainly yielded inconclusive results. The pathogenesis of diabetic vascular complications and results from animal studies and key clinical studies are reviewed here...
  23. ncbi request reprint Microvascular complications of diabetes
    Zhiheng He
    Section on Vascular Cell Biology and Complications, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Endocrinol Metab Clin North Am 33:215-38, xi-xii. 2004
  24. pmc Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
    Kiyoshi Suzuma
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:721-6. 2002
    ..The potential functional consequences of PKC beta-induced retinoblastoma phosphorylation could include enhanced E2 promoter binding factor transcriptional activity and increased VEGF-induced endothelial cell proliferation...
  25. ncbi request reprint Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications
    Tatsuya Kuroki
    Vascular Cell Biology and Complications, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 14:S216-20. 2003
  26. ncbi request reprint Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium
    Zhiheng He
    Research Division, Joslin Diabetes Center, Harvard Medical School and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    J Biol Chem 280:15719-26. 2005
    ....
  27. ncbi request reprint Hyperglycemia-induced oxidative stress in diabetic complications
    George L King
    Section on Vascular Cell Biology and Complications, Joslin Diabetes Center, Boston, Massachusetts, USA
    Histochem Cell Biol 122:333-8. 2004
    ..The focus of this review will be on the role of oxidative stress in the etiology of diabetic complications...
  28. ncbi request reprint Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology and Section on Vascular Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:3680-5. 2002
    ..These results suggest that at least some of the reduction of insulin gene transcription found in the diabetic state is mediated by PKC beta2 regulation of c-myc expression...
  29. ncbi request reprint Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 279:30369-74. 2004
    ..These studies implicate reduced thioredoxin activity through interaction with Txnip as an important mechanism for vascular oxidative stress in diabetes mellitus...
  30. ncbi request reprint Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications
    Yizhen Xu
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Room 4504, Boston, MA 02215, USA
    Curr Diab Rep 5:91-7. 2005
    ....
  31. ncbi request reprint Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways
    Takashi Minami
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:6976-84. 2003
    ..Taken together, these data suggest that the endothelial cell-specific effect of thrombin on VCAM-1 expression involves the coordinate activity of PKC-delta-NF-kappaB and PKC-zeta-GATA signaling pathways...
  32. pmc Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function
    Debra L Rigor
    Cardiovascular Division, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, Rm 910, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 296:H566-72. 2009
    ....
  33. pmc Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway
    Pedro Geraldes
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    J Biol Chem 283:34327-36. 2008
    ....
  34. ncbi request reprint Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes
    Gang Xu
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 56:1551-8. 2007
    ..Taken together, GLP-1 and GIP receptor expression is decreased with chronic hyperglycemia, and this decrease likely contributes to the impaired incretin effects found in diabetes...
  35. ncbi request reprint Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways
    Izumi Suzuma
    Research Division and Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:1047-57. 2002
    ..This mechanism may play a role in the well documented association of concomitant hypertension with clinical exacerbation of neovascularization and vascular permeability...
  36. ncbi request reprint Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes
    Christian Rask-Madsen
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02120, USA
    Nat Clin Pract Endocrinol Metab 3:46-56. 2007
    ..The clinical utility of endothelial function testing and future therapeutic targets is also discussed...
  37. ncbi request reprint Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells
    Xianjin Yi
    Howard Hughes Medical Institute, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neurosci 25:1240-8. 2005
    ....
  38. pmc The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
    David Vicent
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 111:1373-80. 2003
    ....
  39. doi request reprint Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 7:125-34. 2008
    ..Thus, insulin resistance at the level of the liver is sufficient to produce the dyslipidemia and increased risk of atherosclerosis associated with the metabolic syndrome...
  40. pmc Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study
    Hillary A Keenan
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 59:2846-53. 2010
    ..To evaluate the extent of pancreatic β-cell function in a large number of insulin-dependent diabetic patients with a disease duration of 50 years or longer (Medalists)...
  41. ncbi request reprint Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance
    Christian Rask-Madsen
    Joslin Diabetes Center, Harvard Medical School, Boston, Mass 02120, USA
    Arterioscler Thromb Vasc Biol 25:487-96. 2005
    ....
  42. ncbi request reprint Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy
    Yuji Hiramatsu
    Section on Cellular and Molecular Physiology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 51:2804-10. 2002
    ..These data indicate that hyperglycemia just before organogenesis activates the DAG-PKC cascade and is correlated with congenital defects...
  43. pmc Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice
    Christian Rask-Madsen
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Cell Metab 11:379-89. 2010
    ..Therefore, improving insulin sensitivity in the endothelium of patients with insulin resistance or type 2 diabetes may prevent cardiovascular complications...
  44. pmc Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells
    Keiji Isshiki
    Research Division, Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 74:1434-43. 2008
    ..Insulin deficiency may contribute to the mesangial expansion found in diabetes through reduced STAT5/SOCS2 expression...
  45. pmc Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
    Tatsuya Kondo
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 111:1835-42. 2003
    ..These data indicate that both insulin and IGF-1 signaling in endothelium play a role in retinal neovascularization through the expression of vascular mediators, with the effect of insulin being most important in this process...
  46. ncbi request reprint Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study
    Hillary A Keenan
    Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes Care 30:1995-7. 2007
  47. ncbi request reprint Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis
    Zhen Y Jiang
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:31964-71. 2003
    ..The in vivo results provide direct evidence that insulin can modulate hypoxia-induced angiogenesis via reduction in VEGF expression in vivo...
  48. ncbi request reprint Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia
    Zhiheng He
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 26:787-93. 2006
    ..This study characterized the role of insulin receptors and resistance on vascular endothelial growth factor (VEGF) expression and myocardial vascularization in physiological conditions and after ischemia...
  49. ncbi request reprint Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases
    Zhiheng He
    Circulation 110:7-9. 2004
  50. ncbi request reprint The role of protein kinase C activation and the vascular complications of diabetes
    Net Das Evcimen
    Ankara University, Pharmacy Faculty, Biochemistry Department, 06100 Ankara, Turkey
    Pharmacol Res 55:498-510. 2007
    ..PKC isoform selective inhibitors are likely new therapeutics, which can delay the onset or stop the progression of diabetic vascular disease with very little side effects...
  51. pmc Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications
    Zongzhong Tong
    Department of Ophthalmology and Visual Sciences, Eccles Institute of Human Genetics
    Proc Natl Acad Sci U S A 105:6998-7003. 2008
    ..These results suggest that rs1617640 in the EPO promoter is significantly associated with PDR and ESRD. This study identifies a disease risk-associated gene and potential pathway mediating severe diabetic microvascular complications...
  52. ncbi request reprint Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes
    Andras Treszl
    Diabetes Care 27:2769-70. 2004
  53. ncbi request reprint Retinopathy in diabetes
    Donald S Fong
    Diabetes Care 27:S84-7. 2004
  54. ncbi request reprint Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation
    Seigo Itoh
    Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:24135-42. 2005
    ..LY333,531, a specific PKCbeta inhibitor, inhibited both p90RSK and cTnI (Ser(23/24)) phosphorylation by H2O2. Taken together, our data support a new redox-sensitive mechanism regulating cTnI phosphorylation in cardiomyocytes...
  55. ncbi request reprint Applications of inhibitors for protein kinase C and their isoforms
    Garry X Shen
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Methods Mol Biol 233:397-422. 2003
  56. ncbi request reprint Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients?
    Zhiheng He
    Diabetes Care 28:2803-5. 2005
  57. ncbi request reprint Molecular understanding of hyperglycemia's adverse effects for diabetic complications
    Matthew J Sheetz
    Lilly Research Laboratories, Indianapolis, Ind, USA
    JAMA 288:2579-88. 2002
    ..This article summarizes these theories and the potential therapeutic interventions that may prevent diabetic complications in the presence of hyperglycemia, control of which is often difficult with current therapeutic options...
  58. ncbi request reprint Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin
    Janet B McGill
    Washington University School of Medicine, 660 S Euclid, Campus Box 8127, St Louis, MO 63110, USA
    Expert Opin Drug Saf 5:835-45. 2006
    ..In controlled, randomised clinical trials, RBX had an adverse event profile comparable to placebo, and was well tolerated...
  59. ncbi request reprint Summary statement IV: Obesity and diabetes: opportunities for translation of basic research
    Michael M Engelgau
    Division of Diabetes Translation, NCCD PHP, CoCHP, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Vascul Pharmacol 46:324-6. 2007
    ..Identification of new biological markers and better measures of current biological marker will both be critical in understanding and addressing the ongoing epidemic of chronic diseases...
  60. ncbi request reprint Diabetic retinopathy
    Donald S Fong
    Diabetes Care 26:S99-S102. 2003

Research Grants56

  1. Cell Biology of Diabetic Microvascular Complications
    George L King; Fiscal Year: 2010
    ....
  2. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2010
    ....
  3. Monocyte VEGF & PKC, Markers for Diabetic Complications
    George King; Fiscal Year: 2003
    ..These data can provide definitive evidence to determine whether further studies are needed to establish these two parameters in the circulating monocyte as surrogate markers of diabetic microvascular diseases. ..
  4. Retinal imaging tests for microvascular functions
    George King; Fiscal Year: 2003
    ..These studies should provide us with information on whether retinal neural and vascular imaging function tests can be related to peripheral neural and microvascular dysfunctions and pathologies in diabetic patients. ..
  5. PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
    George King; Fiscal Year: 2003
    ..3) Characterize the molecular and functional differences in the myocardium of transgenic mice overexpression PKCB2 and delta isoform in diabetic and non-diabetic states. ..
  6. Enhanced Program for Human Subject Protection
    George King; Fiscal Year: 2002
    ..III. To provide secure record storage facilities within existing research space by renovating currently unusable space. ..
  7. PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
    George King; Fiscal Year: 2002
    ..3) Characterize the molecular and functional differences in the myocardium of transgenic mice overexpression PKCB2 and delta isoform in diabetic and non-diabetic states. ..
  8. CELL BIOLOGY APPROACH TO DIABETIC RETINOPATHY
    George King; Fiscal Year: 2001
    ..The results from the use of LY333531 and the transgenic mice models will provide direct evidence to determine the roles of PKC beta isoform activation in the development of vascular complications of diabetes. ..
  9. PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
    George King; Fiscal Year: 2001
    ..3) Characterize the molecular and functional differences in the myocardium of transgenic mice overexpression PKCB2 and delta isoform in diabetic and non-diabetic states. ..
  10. ENDOTHELIN EFFECTS ON RETINAL CELLS AND BLOOD FLOW
    George King; Fiscal Year: 2001
    ....
  11. PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
    George King; Fiscal Year: 2000
    ..3) Characterize the molecular and functional differences in the myocardium of transgenic mice overexpression PKCB2 and delta isoform in diabetic and non-diabetic states. ..
  12. CELL BIOLOGY APPROACH TO DIABETIC RETINOPATHY
    George King; Fiscal Year: 2000
    ..The results from the use of LY333531 and the transgenic mice models will provide direct evidence to determine the roles of PKC beta isoform activation in the development of vascular complications of diabetes. ..
  13. SELECTIVE INSULIN RESISTANCE--DIABETIC VASCULAR DISEASE
    George King; Fiscal Year: 2000
    ..4) To determine in the vascular stromal tissues from fat of non-insulin resistant, insulin resistant and diabetic patients to determine whether the selective insulin resistance are occurring in clinical settings. ..
  14. Selective Insulin Resistance - Diabetic Vascular Disease
    George King; Fiscal Year: 2004
    ..These studies will provide information on the molecular interactions between PKC activation and insulin and VEGF activation of IRS-PI3 kinase-eNOS pathway in the cardiovascular tissues. ..
  15. ANIMAL RESOURCES FACILITY EQUIPMENT IMPROVED PROJECT
    George King; Fiscal Year: 2004
    ..Not only will the requested improvements impact animal welfare, but they will also benefit the efficiency of the research animal program. ..
  16. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George King; Fiscal Year: 2009
    ....
  17. PKC Activation and Cardiovascular Disease in Diabetes
    George King; Fiscal Year: 2007
    ..We will crossbreed PKC beta 2 M-Tg mice with apoE KO mice to determine its effect on the development of atherosclerosis. ..
  18. Cell Biology of Diabetic Microvascular Complications
    George King; Fiscal Year: 2007
    ....
  19. PKC Activation and Cardiovascular Disease in Diabetes
    George King; Fiscal Year: 2006
    ..We will crossbreed PKC beta 2 M-Tg mice with apoE KO mice to determine its effect on the development of atherosclerosis. ..
  20. Selective Insulin Resistance - Diabetic Vascular Disease
    George King; Fiscal Year: 2007
    ..These studies will provide information on the molecular interactions between PKC activation and insulin and VEGF activation of IRS-PI3 kinase-eNOS pathway in the cardiovascular tissues. ..
  21. PKC Activation and Cardiovascular Disease in Diabetes
    George King; Fiscal Year: 2006
    ..We will crossbreed PKC beta 2 M-Tg mice with apoE KO mice to determine its effect on the development of atherosclerosis. ..
  22. PKC Activation and Cardiovascular Disease in Diabetes
    George King; Fiscal Year: 2005
    ..We will crossbreed PKC beta 2 M-Tg mice with apoE KO mice to determine its effect on the development of atherosclerosis. ..
  23. PKC Activation and Cardiovascular Disease in Diabetes
    George King; Fiscal Year: 2004
    ..We will crossbreed PKC beta 2 M-Tg mice with apoE KO mice to determine its effect on the development of atherosclerosis. ..
  24. Selective Insulin Resistance - Diabetic Vascular Disease
    George King; Fiscal Year: 2005
    ..These studies will provide information on the molecular interactions between PKC activation and insulin and VEGF activation of IRS-PI3 kinase-eNOS pathway in the cardiovascular tissues. ..
  25. ENDOTHELIN EFFECTS ON RETINAL CELLS AND BLOOD FLOW
    George King; Fiscal Year: 2000
    ....
  26. ENDOTHELIN'S EFFECTS ON RETINAL CELLS AND BLOOD FLOW
    George King; Fiscal Year: 1993
    ....
  27. ENDOTHELIN EFFECTS ON RETINAL CELLS AND BLOOD FLOW
    George King; Fiscal Year: 1999
    ....
  28. CELL BIOLOGY APPROACH TO DIABETIC RETINOPATHY
    George King; Fiscal Year: 1999
    ..The results from the use of LY333531 and the transgenic mice models will provide direct evidence to determine the roles of PKC beta isoform activation in the development of vascular complications of diabetes. ..
  29. SELECTIVE INSULIN RESISTANCE--DIABETIC VASCULAR DISEASE
    George King; Fiscal Year: 1999
    ..4) To determine in the vascular stromal tissues from fat of non-insulin resistant, insulin resistant and diabetic patients to determine whether the selective insulin resistance are occurring in clinical settings. ..
  30. CELL BIOLOGY IN DIABETIC RETINOPATHY STUDY
    George King; Fiscal Year: 1991
    ....
  31. CELL BIOLOGY IN DIABETIC RETINOPATHY STUDY
    George King; Fiscal Year: 1990
    ....
  32. ENDOTHELIN'S EFFECTS ON RETINAL CELLS AND BLOOD FLOW
    George King; Fiscal Year: 1992
    ....
  33. CELL BIOLOGY APPROACH TO DIABETIC RETINOPATHY
    George King; Fiscal Year: 1993
    ..The new proposal will be to characterize and fully sequence these new genes and determine their expression in vascular tissue of diabetic animals...
  34. CELL BIOLOGY IN DIABETIC RETINOPATHY STUDY
    George King; Fiscal Year: 1992
    ....
  35. Cell Biology of Diabetic Microvascular Complications
    George King; Fiscal Year: 2009
    ....
  36. Selective Insulin Resistance - Diabetic Vascular Disease
    George King; Fiscal Year: 2006
    ..These studies will provide information on the molecular interactions between PKC activation and insulin and VEGF activation of IRS-PI3 kinase-eNOS pathway in the cardiovascular tissues. ..
  37. PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
    George King; Fiscal Year: 2004
    ..3) Characterize the molecular and functional differences in the myocardium of transgenic mice overexpression PKCB2 and delta isoform in diabetic and non-diabetic states. ..