JEAN PIERRE M KINET

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial
    François Piette
    Hopital Charles Foix, Service de Medecine, Bâtiment Louis Ramond, 7 avenue de la Republique, 94205 Ivry sur Seine, France
    Alzheimers Res Ther 3:16. 2011
  2. ncbi The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology
    J P Kinet
    Harvard Medical School, Boston, Massachusetts, USA
    Annu Rev Immunol 17:931-72. 1999
  3. ncbi The essential role of mast cells in orchestrating inflammation
    Jean-Pierre Kinet
    Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, HIM-945, Boston, MA 02215, USA
    Immunol Rev 217:5-7. 2007
  4. ncbi Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses
    D Dombrowicz
    Laboratory of Allergy and Immunology, Beth Israel Deaconess Medical Center, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 8:517-29. 1998
  5. ncbi CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
    M Vig
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 312:1220-3. 2006
  6. ncbi Essential role for Gab2 in the allergic response
    H Gu
    Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 412:186-90. 2001
  7. ncbi Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
    I Miyajima
    Department of Pathology, Beth Israel Deaconess Medical Center East and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 99:901-14. 1997
  8. ncbi ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
    A L Perraud
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 411:595-9. 2001
  9. ncbi Minimal requirements for IgE-mediated regulation of surface Fc epsilon RI
    T A Borkowski
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 167:1290-6. 2001
  10. ncbi LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability
    M J Nadler
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 411:590-5. 2001

Research Grants

  1. Mechanisms of FcR-Mediated Inflammatory Responses
    Jean Pierre Kinet; Fiscal Year: 2009
  2. Role of the IgE-FceRI network in allergic inflammation
    Jean Pierre Kinet; Fiscal Year: 2005
  3. Calcium influx pathways in lymphocytes and mast cells
    Jean Pierre Kinet; Fiscal Year: 2007
  4. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    Jean Pierre Kinet; Fiscal Year: 2007
  5. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    Jean Pierre Kinet; Fiscal Year: 2003
  6. CALCIUM INFLUX PATHWAYS IN ALLERGY
    Jean Pierre Kinet; Fiscal Year: 2002
  7. MOLECULAR ANALYSIS OF FCERI SIGNALING PATHWAYS
    Jean Pierre Kinet; Fiscal Year: 1999
  8. Mechanism of IgE Mediated FceRI Regulation
    Jean Pierre Kinet; Fiscal Year: 2001
  9. Store operated calcium influx in cells of the immune system
    JEAN PIERRE M KINET; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. ncbi Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial
    François Piette
    Hopital Charles Foix, Service de Medecine, Bâtiment Louis Ramond, 7 avenue de la Republique, 94205 Ivry sur Seine, France
    Alzheimers Res Ther 3:16. 2011
    ..As the brain is rich in mast cells, the therapeutic potential of masitinib as an adjunct therapy to standard care was investigated...
  2. ncbi The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology
    J P Kinet
    Harvard Medical School, Boston, Massachusetts, USA
    Annu Rev Immunol 17:931-72. 1999
    ....
  3. ncbi The essential role of mast cells in orchestrating inflammation
    Jean-Pierre Kinet
    Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, HIM-945, Boston, MA 02215, USA
    Immunol Rev 217:5-7. 2007
  4. ncbi Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses
    D Dombrowicz
    Laboratory of Allergy and Immunology, Beth Israel Deaconess Medical Center, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 8:517-29. 1998
    ....
  5. ncbi CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
    M Vig
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 312:1220-3. 2006
    ..Although overexpression of CRACM1 did not affect CRAC currents, RNAi-mediated knockdown disrupted its activation. CRACM1 could be the CRAC channel itself, a subunit of it, or a component of the CRAC signaling machinery...
  6. ncbi Essential role for Gab2 in the allergic response
    H Gu
    Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 412:186-90. 2001
    ..Gab2 and/or its associated signalling molecules may be new targets for developing drugs to treat allergy...
  7. ncbi Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
    I Miyajima
    Department of Pathology, Beth Israel Deaconess Medical Center East and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 99:901-14. 1997
    ....
  8. ncbi ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
    A L Perraud
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 411:595-9. 2001
    ..These results indicate that intracellular ADPR regulates calcium entry into cells that express LTRPC2...
  9. ncbi Minimal requirements for IgE-mediated regulation of surface Fc epsilon RI
    T A Borkowski
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 167:1290-6. 2001
    ..It is possible that in vivo additional factors contribute to modulate the basic regulatory mechanism described here...
  10. ncbi LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability
    M J Nadler
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 411:590-5. 2001
    ..Our data indicate that LTRPC7, by virtue of its sensitivity to physiological Mg.ATP levels, may be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell...
  11. ncbi Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk
    K Saito
    Division of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:16201-6. 2001
    ..Thus, the Btk-PtdIns-3,4,5-P(3) interaction serves to translocate Btk to the membrane and directly regulate its signaling function...
  12. ncbi Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
    J C Laporte
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 164:141-8. 2001
    ..We propose that these direct effect of IL-13 on HASM cells may contribute at least in part to the airway narrowing observed in patients with asthma...

Research Grants35

  1. Mechanisms of FcR-Mediated Inflammatory Responses
    Jean Pierre Kinet; Fiscal Year: 2009
    ..Moreover, they will provide the proof of concept for the therapeutic use of these antibodies in the context of MC-associated diseases. ..
  2. Role of the IgE-FceRI network in allergic inflammation
    Jean Pierre Kinet; Fiscal Year: 2005
    ..abstract_text> ..
  3. Calcium influx pathways in lymphocytes and mast cells
    Jean Pierre Kinet; Fiscal Year: 2007
    ..All together, the proposed experiments will provide a comprehensive characterization of a new TRPM family member and an assessment of a new mechanism that impacts calcium entry in lymphocytes and mast cells. ..
  4. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    Jean Pierre Kinet; Fiscal Year: 2007
    ..All together, the proposed experiments will provide a comprehensive characterization of PI3KC2beta and its sphingosine kinase activity, and define its role in mast cell physiology. ..
  5. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    Jean Pierre Kinet; Fiscal Year: 2003
    ..He will investigate 1) whether there are differences between individuals in the betaWT/betaT ratio, and 2) whether these differences correlate with allergic status. ..
  6. CALCIUM INFLUX PATHWAYS IN ALLERGY
    Jean Pierre Kinet; Fiscal Year: 2002
    ....
  7. MOLECULAR ANALYSIS OF FCERI SIGNALING PATHWAYS
    Jean Pierre Kinet; Fiscal Year: 1999
    ..The answers to these questions will provide a molecular dissection of FcepsilonRI function which will be relevant to the understanding of other multi-subunit antigen receptors. ..
  8. Mechanism of IgE Mediated FceRI Regulation
    Jean Pierre Kinet; Fiscal Year: 2001
    ..Taken together, these analyses will provide significant insights into the process and molecular parameters that control the IgE-mediated regulation of FceRI expression. ..
  9. Store operated calcium influx in cells of the immune system
    JEAN PIERRE M KINET; Fiscal Year: 2010
    ..2 (Aim 2) and CaV1.3 (Aim 3) interact and modulate CRAC channels. These studies will yield new insights into the molecular regulation of SOCE within T cells, enabling the development new approaches to treat autoimmune diseases. ..