Alec C Kimmelman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Metabolic Dependencies in RAS-Driven Cancers
    Alec C Kimmelman
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
    Clin Cancer Res 21:1828-34. 2015
  2. pmc Targeting autophagy addiction in cancer
    Joseph D Mancias
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA
    Oncotarget 2:1302-6. 2011
  3. pmc Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response
    Ying hua Li
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 7:e39588. 2012
  4. pmc The dynamic nature of autophagy in cancer
    Alec C Kimmelman
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:1999-2010. 2011
  5. pmc Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    Jaekyoung Son
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Nature 496:101-5. 2013
  6. pmc PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network
    Haoqiang Ying
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Cancer Discov 1:158-69. 2011
  7. pmc Pancreatic cancers require autophagy for tumor growth
    Shenghong Yang
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:717-29. 2011
  8. pmc PARI overexpression promotes genomic instability and pancreatic tumorigenesis
    Kevin W O'Connor
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Cancer Res 73:2529-39. 2013
  9. pmc Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
    Joseph D Mancias
    1 Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA 2 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA 3 Harvard Radiation Oncology Program, Boston, Massachusetts 02115, USA 4 Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 509:105-9. 2014
  10. ncbi request reprint A critical role for autophagy in pancreatic cancer
    Shenghong Yang
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Autophagy 7:912-3. 2011

Collaborators

  • Nabeel Bardeesy
  • Wei Wang
  • John M Asara
  • Lewis C Cantley
  • Cristina R Ferrone
  • Jason W Locasale
  • Jason B Fleming
  • Sarah P Thayer
  • Dipanjan Chowdhury
  • Giovanni Tonon
  • Marcia Haigis
  • ALAN D D'ANDREA
  • Shannon J Turley
  • Andrea Viale
  • Haoqiang Ying
  • Joseph D Mancias
  • Xiaoxu Wang
  • Shenghong Yang
  • Jaekyoung Son
  • Ronald A Depinho
  • Kevin W O'Connor
  • Costas A Lyssiotis
  • Sujun Hua
  • Ying hua Li
  • Aram F Hezel
  • Y Alan Wang
  • Samuel R Perry
  • Yonghong Xiao
  • Carol Lim
  • Gerald C Chu
  • Eliot Fletcher-Sananikone
  • Haiyan Yan
  • Hongwu Zheng
  • Hailei Zhang
  • Lynda Chin
  • Ji Hye Paik
  • Steven P Gygi
  • J Wade Harper
  • Edouard Mullarky
  • Claudia M Nicolae
  • Matteo Ligorio
  • Rushika M Perera
  • Ng Shyh-Chang
  • George Lucian Moldovan
  • Donniphat Dejsuphong
  • Ya an Kang
  • Eunmi Park
  • Shujuan Chen
  • Jonathan L Coloff
  • Jeffery Chang
  • Yunfeng Pan
  • Dong Hyun Lee
  • Alexander R Guimaraes
  • Ralph Weissleder
  • Boyi Gan
  • Eric S Martin
  • Jian Hu
  • Alexei Protopopov
  • Anant Vinjamoori
  • Alexandra Bause
  • Ergun Sahin
  • Giacomo Dell'antonio
  • Kutlu G Elpek
  • Josef Mautner
  • Brian Malinn
  • Simona Colla
  • Xiaojia Ren
  • Marc Liesa
  • Orian S Shirihai
  • Yinghua Li
  • Gianmarco Contino
  • Yingchun Liu
  • Stephanie M Zimmerman
  • Shan Jiang
  • Jayne M Stommel
  • Claudio Doglioni

Detail Information

Publications11

  1. doi request reprint Metabolic Dependencies in RAS-Driven Cancers
    Alec C Kimmelman
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
    Clin Cancer Res 21:1828-34. 2015
    ..Clin Cancer Res; 21(8); 1828-34. ©2015 AACR. See all articles in this CCR Focus section, "Targeting RAS-Driven Cancers." ..
  2. pmc Targeting autophagy addiction in cancer
    Joseph D Mancias
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA
    Oncotarget 2:1302-6. 2011
    ....
  3. pmc Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response
    Ying hua Li
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 7:e39588. 2012
    ..Together, these findings support the incorporation of NHEJ inhibition into PDAC therapeutic approaches, either alone, or in combination with DNA damaging therapies such as radiation...
  4. pmc The dynamic nature of autophagy in cancer
    Alec C Kimmelman
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:1999-2010. 2011
    ..While much needs to be learned about the regulation and context-dependent biological functions of autophagy, it seems clear that modulation of this process will be an attractive avenue for future cancer therapeutic approaches...
  5. pmc Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    Jaekyoung Son
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Nature 496:101-5. 2013
    ..The essentiality of this pathway in PDAC and the fact that it is dispensable in normal cells may provide novel therapeutic approaches to treat these refractory tumours...
  6. pmc PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network
    Haoqiang Ying
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Cancer Discov 1:158-69. 2011
    ..Thus, PTEN/phosphoinositide 3-kinase (PI3K) pathway alteration is a common event in PDAC development and functions in part to strongly activate the NF-κB network, which may serve to shape the PDAC tumor microenvironment...
  7. pmc Pancreatic cancers require autophagy for tumor growth
    Shenghong Yang
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:717-29. 2011
    ....
  8. pmc PARI overexpression promotes genomic instability and pancreatic tumorigenesis
    Kevin W O'Connor
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Cancer Res 73:2529-39. 2013
    ..Taken together, our findings offered a preclinical proof-of-concept for PARI as candidate therapeutic target to treat PDAC...
  9. pmc Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
    Joseph D Mancias
    1 Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA 2 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA 3 Harvard Radiation Oncology Program, Boston, Massachusetts 02115, USA 4 Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 509:105-9. 2014
    ....
  10. ncbi request reprint A critical role for autophagy in pancreatic cancer
    Shenghong Yang
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Autophagy 7:912-3. 2011
    ..These two, seemingly disparate functions can be reconciled by a possible temporal role of autophagy during tumor development, initially suppressing tumor initiation yet supporting tumor growth at later stages...
  11. pmc Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    Haoqiang Ying
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02215, USA Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Cell 149:656-70. 2012
    ..Together, this work provides in vivo mechanistic insights into how oncogenic Kras promotes metabolic reprogramming in native tumors and illuminates potential metabolic targets that can be exploited for therapeutic benefit in PDAC...