Douglas P Kiel

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Effects of beer, wine, and liquor intakes on bone mineral density in older men and women
    Katherine L Tucker
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1188-96. 2009
  2. pmc Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal health
    Douglas P Kiel
    Institute for Aging Research, Boston, MA, USA
    Clin Trials 7:354-67. 2010
  3. pmc Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Douglas P Kiel
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S14. 2007
  4. ncbi request reprint Efficacy of a hip protector to prevent hip fracture in nursing home residents: the HIP PRO randomized controlled trial
    Douglas P Kiel
    Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, Boston, Massachusetts 02131, USA
    JAMA 298:413-22. 2007
  5. pmc Impact of Tai Chi exercise on multiple fracture-related risk factors in post-menopausal osteopenic women: a pilot pragmatic, randomized trial
    Peter M Wayne
    Harvard Medical School, Boston, MA, USA
    BMC Complement Altern Med 12:7. 2012
  6. ncbi request reprint Associations between vitamin K biochemical measures and bone mineral density in men and women
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:4904-9. 2004
  7. pmc Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study
    Shivani Sahni
    Dietary Assessment and Epidemiology Research Program and the Antioxidants Research Laboratory, Jean Mayer US Department of Agriculture, HNRCA, Tufts University, Boston, MA 02111 1524, USA
    Am J Clin Nutr 89:416-24. 2009
  8. pmc Competing risk of death: an important consideration in studies of older adults
    Sarah D Berry
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 58:783-7. 2010
  9. pmc Survival of aged nursing home residents with hip fracture
    Sarah D Berry
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 64:771-7. 2009
  10. pmc Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study
    Jane A Driver
    Geriatric Research Education and Clinical Center and Boston VA Medical Center, Boston, MA 02130, USA
    BMJ 344:e1442. 2012

Research Grants

  1. RISK FACTORS FOR AGED RELATED BONE LOSS
    Douglas P Kiel; Fiscal Year: 2010
  2. RISK FACTORS FOR AGED RELATED BONE LOSS
    Douglas P Kiel; Fiscal Year: 2010
  3. Low Magnitude Mechanical Stimulation to Improve BMD
    Douglas P Kiel; Fiscal Year: 2010

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. pmc Effects of beer, wine, and liquor intakes on bone mineral density in older men and women
    Katherine L Tucker
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1188-96. 2009
    ..Moderate intake of alcohol has been reported to have beneficial effects on bone. However, different classes of alcoholic beverages have not been investigated...
  2. pmc Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal health
    Douglas P Kiel
    Institute for Aging Research, Boston, MA, USA
    Clin Trials 7:354-67. 2010
    ..Alternatives to pharmacologic treatment are needed for older adults. Nonpharmacologic treatment with low magnitude, high frequency mechanical stimulation has been shown to prevent bone loss in animal and human studies...
  3. pmc Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Douglas P Kiel
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S14. 2007
    ..There have been no genome-wide association and linkage studies for these traits using high-density genotyping platforms...
  4. ncbi request reprint Efficacy of a hip protector to prevent hip fracture in nursing home residents: the HIP PRO randomized controlled trial
    Douglas P Kiel
    Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, Boston, Massachusetts 02131, USA
    JAMA 298:413-22. 2007
    ..Past studies of the efficacy of hip protectors to prevent hip fracture in nursing home residents have had conflicting results, possibly due to potential biases from clustered randomization designs and modest adherence to intervention...
  5. pmc Impact of Tai Chi exercise on multiple fracture-related risk factors in post-menopausal osteopenic women: a pilot pragmatic, randomized trial
    Peter M Wayne
    Harvard Medical School, Boston, MA, USA
    BMC Complement Altern Med 12:7. 2012
    ..Few randomized trials have simultaneously evaluated TC's potential to reduce bone loss and improve fall-predictive balance parameters in osteopenic women...
  6. ncbi request reprint Associations between vitamin K biochemical measures and bone mineral density in men and women
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:4904-9. 2004
    ..Clinical trials are required to isolate any putative effects of vitamin K on rates of bone loss. The target population in these trials, particularly in regard to estrogen use, may be critical, as suggested by the findings of this study...
  7. pmc Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study
    Shivani Sahni
    Dietary Assessment and Epidemiology Research Program and the Antioxidants Research Laboratory, Jean Mayer US Department of Agriculture, HNRCA, Tufts University, Boston, MA 02111 1524, USA
    Am J Clin Nutr 89:416-24. 2009
    ..Few studies have examined the association between carotenoid intake (other than beta-carotene) and bone mineral density (BMD)...
  8. pmc Competing risk of death: an important consideration in studies of older adults
    Sarah D Berry
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 58:783-7. 2010
    ..Use of a competing risk approach is critical to accurately determining disease risk for elderly individuals and therefore best inform clinical decision-making...
  9. pmc Survival of aged nursing home residents with hip fracture
    Sarah D Berry
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 64:771-7. 2009
    ..This study examined the effect of pre-fracture characteristics, hospital complications, and post-fracture complications on mortality in residents with hip fracture...
  10. pmc Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study
    Jane A Driver
    Geriatric Research Education and Clinical Center and Boston VA Medical Center, Boston, MA 02130, USA
    BMJ 344:e1442. 2012
    ..To relate cancer since entry into the Framingham Heart Study with the risk of incident Alzheimer's disease and to estimate the risk of incident cancer among participants with and without Alzheimer's disease...
  11. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
    ..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...
  12. ncbi request reprint Metacarpal cortical area and risk of coronary heart disease: the Framingham Study
    Elizabeth J Samelson
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, 1200 Center Street, Boston, MA 02131, USA
    Am J Epidemiol 159:589-95. 2004
    ..53, 1.00; p(trend) = 0.03). In contrast, no association was present in men (highest vs. lowest quartile of metacarpal cortical area: hazard ratio = 1.14, 95% confidence interval: 0.84, 1.56; p(trend) = 0.55)...
  13. ncbi request reprint Bone mineral density and the risk of Alzheimer disease
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02215, USA
    Arch Neurol 62:107-11. 2005
    ..Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration...
  14. ncbi request reprint Homocysteine as a predictive factor for hip fracture in older persons
    Robert R McLean
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, USA
    N Engl J Med 350:2042-9. 2004
    ..We examined the association between the total homocysteine concentration and the risk of hip fracture in men and women enrolled in the Framingham Study...
  15. pmc Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study
    Ching Ti Liu
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    J Bone Miner Res 27:954-8. 2012
    ....
  16. pmc Tai Chi for osteopenic women: design and rationale of a pragmatic randomized controlled trial
    Peter M Wayne
    Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, The Landmark Center, Suite 22 A, Boston, MA 02215, USA
    BMC Musculoskelet Disord 11:40. 2010
    ....
  17. pmc Poor adherence to medications may be associated with falls
    Sarah D Berry
    MD Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 65:553-8. 2010
    ....
  18. ncbi request reprint Vitamin K intake and bone mineral density in women and men
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 77:512-6. 2003
    ..Low dietary vitamin K intake has been associated with an increased risk of hip fracture in men and women. Few data exist on the association between dietary vitamin K intake and bone mineral density (BMD)...
  19. pmc Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHARe
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
    Bone 46:1114-21. 2010
    ..Subsequent focus on the spectrum of genetic polymorphisms in these refined regions may contribute to finding variants predisposing to osteoporosis...
  20. pmc High vitamin C intake is associated with lower 4-year bone loss in elderly men
    Shivani Sahni
    Dietary Assessment and Epidemiology Research Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:1931-8. 2008
    ..Null associations were observed among women. These results suggest a possible protective role of vitamin C for bone health in older men...
  21. pmc Calcium intake is not associated with increased coronary artery calcification: the Framingham Study
    Elizabeth J Samelson
    Department of Medicine, Harvard Medical School and Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA
    Am J Clin Nutr 96:1274-80. 2012
    ..Adequate calcium intake is known to protect the skeleton. However, studies that have reported adverse effects of calcium supplementation on vascular events have raised widespread concern...
  22. pmc Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Clin Endocrinol Metab 93:2206-12. 2008
    ..Elevated homocysteine is a strong risk factor for osteoporotic fractures among elders, yet it may be a marker for low B-vitamin status...
  23. ncbi request reprint Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 84:936-42. 2006
    ..In addition to displacing healthier beverages, colas contain caffeine and phosphoric acid (H3PO4), which may adversely affect bone...
  24. pmc Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
    J Bone Miner Res 25:1555-63. 2010
    ..Most of the similarity between the quantitative bone phenotypes may be attributed to pleiotropic effects of genes. This knowledge may prove helpful in defining the best phenotypes to be used in genetic studies of osteoporosis...
  25. pmc Optimizing the tracking of falls in studies of older participants: comparison of quarterly telephone recall with monthly falls calendars in the MOBILIZE Boston Study
    Marian T Hannan
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131 1097, USA
    Am J Epidemiol 171:1031-6. 2010
    ..Retrospective 3-month recall of falls resulted in underreporting of falls by as much as 25% compared with daily calendars. Calendars should be considered the preferred method of ascertaining falls in longitudinal studies...
  26. pmc Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study
    Shivani Sahni
    Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, Boston, MA 02131, USA
    Arch Osteoporos 8:119. 2013
    ....
  27. pmc New loop diuretic prescriptions may be an acute risk factor for falls in the nursing home
    Sarah D Berry
    Hebrew SeniorLife Institute for Aging Research and Beth Israel Deaconess Medical Center Division of Gerontology, Boston, MA 02131, USA
    Pharmacoepidemiol Drug Saf 21:560-3. 2012
    ..We evaluated the relationship between change in a diuretic prescription (new prescription or increased dose) and the occurrence of documented falls among nursing home residents...
  28. pmc Hip geometry variation is associated with bone mineralization pathway gene variants: The Framingham Study
    Ching Lung Cheung
    Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, MA, USA
    J Bone Miner Res 25:1564-71. 2010
    ..The alteration of a binding site of the deregulator of extracellular matrix HOXA7 warrants further investigation...
  29. ncbi request reprint Long-term effects of serum cholesterol on bone mineral density in women and men: the Framingham Osteoporosis Study
    Elizabeth J Samelson
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, MA 02131, USA
    Bone 34:557-61. 2004
    ..73, 0.72, 0.72, 0.70 g/cm2, lowest to highest quartile, P for trend=0.02. Cholesterol levels in women and men from young adulthood to middle age years do not appear to have long-term clinical implications for osteoporosis later in life...
  30. pmc Subsequent fracture in nursing home residents with a hip fracture: a competing risks approach
    Sarah D Berry
    Hebrew SeniorLife, Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 56:1887-92. 2008
    ..To determine the incidence and predictors of subsequent fracture in nursing home residents with a hip fracture, accounting for the competing risk of death...
  31. pmc Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults
    Emily K Farina
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 141:1146-53. 2011
    ..04-0.96). No significant associations were observed among intakes of EPA, DHA, EPA+DHA, or fish. These findings suggest dietary ALA may reduce hip fracture risk in women and men and dietary AA may reduce hip fracture risk in men...
  32. pmc Chronic musculoskeletal pain and the occurrence of falls in an older population
    Suzanne G Leveille
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    JAMA 302:2214-21. 2009
    ..Chronic pain is a major contributor to disability in older adults; however, the potential role of chronic pain as a risk factor for falls is poorly understood...
  33. pmc Self-reported adherence with the use of a device in a clinical trial as validated by electronic monitors: the VIBES study
    Brianne A Jeffrey
    Hebrew SeniorLife Institute for Aging Research, Musculoskeletal Research Center, Boston, MA, USA
    BMC Med Res Methodol 12:171. 2012
    ..The purpose of this study was to determine whether real time self-reported adherence is an accurate measurement of device usage during a clinical trial by comparing it to electronic recording...
  34. pmc Cross-calibration and comparison of variability in 2 bone densitometers in a research setting: the framingham experience
    David R Gagnon
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    J Clin Densitom 13:210-8. 2010
    ....
  35. ncbi request reprint Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status
    Robert R McLean
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 01702, USA
    J Bone Miner Res 19:410-8. 2004
    ..Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status...
  36. ncbi request reprint Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study
    Katherine L Tucker
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Bone Miner Res 20:152-8. 2005
    ..Men with plasma B12 < 148 pM had significantly lower BMD at the hip, and women at the spine, relative to those with higher B12, and trends were similar for both at all sites. Low vitamin B12 may be a risk factor for low BMD...
  37. ncbi request reprint Dihydrophylloquinone intake is associated with low bone mineral density in men and women
    Lisa M Troy
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 86:504-8. 2007
    ..Poor diet may affect bone status by displacing nutrients involved in bone health. Dihydrophylloquinone, a form of vitamin K present in foods made with partially hydrogenated fat, is a potential marker of a low-quality dietary pattern...
  38. pmc Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men
    Douglas P Kiel
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA
    Bone 40:587-96. 2007
    ..These observations suggest that Wnt-LRP5 may play a role in the adaptation of bone to mechanical load in humans, and may explain some gender-related differences in bone mass...
  39. pmc Plasma phosphatidylcholine concentrations of polyunsaturated fatty acids are differentially associated with hip bone mineral density and hip fracture in older adults: the Framingham Osteoporosis Study
    Emily K Farina
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Bone Miner Res 27:1222-30. 2012
    ..00). Opposing effects of PC DHA on FN-BMD loss observed in women and men need further clarification. Bone loss associated with PC LA may be confounded by BMI. High PC AA concentrations may be associated with reduced hip fracture risk...
  40. pmc Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
    J Bone Miner Res 27:319-30. 2012
    ....
  41. pmc Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA
    J Bone Miner Res 24:710-8. 2009
    ..Identification and subsequent characterization of these shared loci may further elucidate the genetic contributions to both osteoporosis and sarcopenia...
  42. pmc Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hip
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Clin Endocrinol Metab 93:1789-95. 2008
    ..We conducted a cross-sectional study to evaluate the association between plasma OPG and femoral neck (FN) bone density (BMD) and geometry in a large cohort of women and men...
  43. pmc Thyroid function and the risk of Alzheimer disease: the Framingham Study
    Zaldy S Tan
    Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, 110 Francis St, LMOB 1A, Boston, MA 02215, USA
    Arch Intern Med 168:1514-20. 2008
    ..Clinical hypothyroidism and hyperthyroidism are recognized causes of reversible dementia, but previous studies relating thyrotropin levels to cognitive performance in clinically euthyroid persons have yielded inconsistent results...
  44. pmc Identification of homogeneous genetic architecture of multiple genetically correlated traits by block clustering of genome-wide associations
    Mayetri Gupta
    Department of Biostatistics, Boston University, Boston, MA, USA
    J Bone Miner Res 26:1261-71. 2011
    ..This knowledge may prove helpful in identifying novel genes and pathways that underlie several correlated phenotypes, as well as in deciphering genetic and phenotypic modularity underlying osteoporosis risk...
  45. pmc Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study
    Emily K Farina
    Friedman School of Nutrition Science and Policy, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02115, USA
    Am J Clin Nutr 93:1142-51. 2011
    ..Polyunsaturated fatty acids and fish may influence bone health...
  46. pmc Protective effect of high protein and calcium intake on the risk of hip fracture in the Framingham offspring cohort
    Shivani Sahni
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA
    J Bone Miner Res 25:2770-6. 2010
    ..Calcium intake modifies the association of protein intake and the risk of hip fracture in this cohort and may explain the lack of concordance seen in previous studies...
  47. pmc Dietary acid load is not associated with lower bone mineral density except in older men
    Robert R McLean
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
    J Nutr 141:588-94. 2011
    ..These results suggest that, with a possible exception of older men, dietary acid load does not have a measureable negative effect on bone health, regardless of total calcium intake...
  48. pmc Vascular calcification in middle age and long-term risk of hip fracture: the Framingham Study
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Bone Miner Res 22:1449-54. 2007
    ..This study examined the relation between severity of aortic calcification in middle-age years and subsequent risk of hip fracture in women and men in the population-based Framingham Study...
  49. ncbi request reprint A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study
    Kerry E Broe
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 55:234-9. 2007
    ..To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents...
  50. ncbi request reprint Incidence and risk factors for vertebral fracture in women and men: 25-year follow-up results from the population-based Framingham study
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
    J Bone Miner Res 21:1207-14. 2006
    ..Incidence was 24% in women and 10% in men. Few factors in middle-aged persons, except prevalent (moderate) fracture and alcohol consumption (in men), predicted long-term incidence of vertebral fracture...
  51. pmc Height loss predicts subsequent hip fracture in men and women of the Framingham Study
    Marian T Hannan
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131 1097, USA
    J Bone Miner Res 27:146-52. 2012
    ..14, 2.09; 1.03, 1.42, respectively). Adult height loss predicted hip fracture risk in men in our study. Recent height loss in elderly men and women predicted risk of hip fracture...
  52. pmc Correlations of clinical and laboratory measures of balance in older men and women
    Uyen Sa D T Nguyen
    Boston University School of Medicine, Boston, MA, USA
    Arthritis Care Res (Hoboken) 64:1895-902. 2012
    ..We examined the associations among 4 types of measures of laboratory- and clinic-based balance in a large population-based cohort of older adults...
  53. pmc QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
    J Bone Miner Res 27:654-63. 2012
    ..Our study confirms the importance of evaluating determinants of vertebral strength in both the thoracic and lumbar spine and in both women and men to understand mechanisms underlying the structural failure of vertebral bodies with aging...
  54. pmc A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study
    Natalie E Cusano
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Calcif Tissue Int 90:96-107. 2012
    ..Identification of genes that influence human height may lead to a better understanding of the processes involved in growth and development...
  55. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  56. ncbi request reprint Bone mass and the risk of prostate cancer: the Framingham Study
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, Boston, University School of Medicine, Massachusetts 02118, USA
    Am J Med 113:734-9. 2002
    ..To examine the relation of bone mass-a potential biologic marker for cumulative exposure to androgens, insulin-like growth factors, and calcium intake-to subsequent development of prostate cancer...
  57. pmc Issues in conducting epidemiologic research among elders: lessons from the MOBILIZE Boston Study
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Am J Epidemiol 168:1444-51. 2008
    ..It is hoped that this paper will encourage and inform future epidemiologic research in this important segment of the population...
  58. ncbi request reprint Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study
    Shreyasee Amin
    Boston University Clinical Epidemiology Research and Training Unit, Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Am J Med 119:426-33. 2006
    ..We examined whether low estradiol increases the risk for future hip fracture among men and explored whether testosterone levels influence this risk...
  59. pmc Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis
    Blaine A Christiansen
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Bone Miner Res 26:974-83. 2011
    ..This differential bone loss explains, in part, a greater decline in bone strength in women and may contribute to the higher incidence of vertebral fractures among women than men...
  60. pmc Genetic contribution to biological aging: the Framingham Study
    David Karasik
    Hebrew Rehabilitation Center for Aged, and Harvard Medical School, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 59:218-26. 2004
    ..In conclusion, the variation in BA measured by radiography was strongly governed by genetic factors in a sample of American adults...
  61. pmc Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures
    David Karasik
    Hebrew Rehabilitation Center for Aged, Research and Training Institute, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 60:574-87. 2005
    ..The aim of this review is twofold: first, to summarize growing consensus on reliable methods of biological age assessment, and second, to demonstrate validity of this phenotype for research in the genetics of aging in humans...
  62. pmc A genome wide linkage scan of metacarpal size and geometry in the Framingham Study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts 02131, USA
    Am J Hum Biol 20:663-70. 2008
    ..Genes in these regions may regulate bone geometry via effects on body size. Identification and subsequent characterization of loci for bone geometry can further elucidate the genetic contributions to bone's resistance to stress...
  63. pmc Hip structural geometry in old and old-old age: similarities and differences between men and women
    Laurel B Yates
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Bone 41:722-32. 2007
    ....
  64. ncbi request reprint Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:245-52. 2002
    ..Several nutrients are known to affect bone mineral density (BMD). However, these nutrients occur together in foods and dietary patterns, and the overall effects of dietary choices are not well understood...
  65. pmc Low acceptance of treatment in the elderly for the secondary prevention of osteoporotic fracture in the acute rehabilitation setting
    Sarah D Berry
    Institute for Aging Research, Hebrew SeniorLife, MA 02131, USA
    Aging Clin Exp Res 22:231-7. 2010
    ..We also described differences in baseline characteristics between study participants and non-participants...
  66. pmc An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits
    Yi Hsiang Hsu
    Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 6:e1000977. 2010
    ....
  67. ncbi request reprint Bone marrow lesions in the knee are associated with increased local bone density
    Grace H Lo
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 52:2814-21. 2005
    ..Therefore, we hypothesized that a higher M:L BMD ratio would be associated with medial bone marrow lesions, and that lower ratios would be associated with lateral bone marrow lesions...
  68. pmc Antidepressant prescriptions: an acute window for falls in the nursing home
    Sarah D Berry
    Hebrew Rehabilitation Center, IFAR, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 66:1124-30. 2011
    ....
  69. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  70. ncbi request reprint Second hip fracture in older men and women: the Framingham Study
    Sarah D Berry
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Arch Intern Med 167:1971-6. 2007
    ..Older persons with hip fractures remain at increased risk of subsequent hip fractures. However, little is known about the frequency and characteristics of persons who sustain a second hip fracture...
  71. pmc The MOBILIZE Boston Study: design and methods of a prospective cohort study of novel risk factors for falls in an older population
    Suzanne G Leveille
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    BMC Geriatr 8:16. 2008
    ....
  72. ncbi request reprint Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 86:1780-90. 2007
    ..The role of total calcium intake in the prevention of hip fracture risk has not been well established...
  73. ncbi request reprint Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis
    Heike A Bischoff-Ferrari
    Clinical Epidemiology Unit, Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 53:821-6. 2005
    ..To describe the association between serum 25-hydroxyvitamin D (25[OH]D) level and bone mineral density (BMD) in persons with primary knee osteoarthritis (OA)...
  74. pmc Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study
    Shivani Sahni
    Dietary Assessment and Epidemiology Research Program, Jean Mayer USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    J Bone Miner Res 24:1086-94. 2009
    ..10). No significant associations were observed with alpha-carotene, beta-cryptoxanthin, or lutein + zeaxanthin. These results suggest a protective role of several carotenoids for bone health in older adults...
  75. ncbi request reprint Dietary and nondietary determinants of vitamin K biochemical measures in men and women
    Nicola M McKeown
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:1329-34. 2002
    ..Despite these caveats, these findings support the use of a FFQ for a relative assessment of vitamin K status in population-based studies...
  76. ncbi request reprint Establishing the compliance in elderly women for use of a low level mechanical stress device in a clinical osteoporosis study
    Marian T Hannan
    Research and Training Institute, Hebrew Rehabilitation Center for Aged and Harvard Medical School Division on Aging, Boston, Mass, USA
    Osteoporos Int 15:918-26. 2004
    ..Larger randomized controlled trials should evaluate the long-term efficacy of vibrating platform devices for treatment of low bone mass and osteoporosis in elderly individuals...
  77. ncbi request reprint Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Boston, MA, USA
    Arch Intern Med 163:1053-7. 2003
    ..We examined the impact of baseline and lifetime plasma total cholesterol levels averaged across many years on the risk for AD in a large, population-based cohort...
  78. doi request reprint Evidence for pleiotropic factors in genetics of the musculoskeletal system
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Bone 46:1226-37. 2010
    ..This may translate into new approaches to reduce the burden of both conditions, which are prevalent in the elderly population...
  79. ncbi request reprint The effects of Tai Chi on bone mineral density in postmenopausal women: a systematic review
    Peter M Wayne
    New England School of Acupuncture, Watertown, MA, USA
    Arch Phys Med Rehabil 88:673-80. 2007
    ..To evaluate the evidence for Tai Chi as an intervention to reduce rate of bone loss in postmenopausal women...
  80. pmc Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of randomized controlled trials
    Dae Hyun Kim
    Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Geriatr Soc 59:1019-31. 2011
    ..To evaluate the effect of cholinesterase inhibitors (ChEIs) and memantine on the risk of falls, syncope, and related events, defined as fracture and accidental injury...
  81. pmc Genetics of the musculoskeletal system: a pleiotropic approach
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02131, USA
    J Bone Miner Res 23:788-802. 2008
    ....
  82. pmc Effect of birth cohort on risk of hip fracture: age-specific incidence rates in the Framingham Study
    Elizabeth J Samelson
    Boston University Arthritis Center, Boston, Mass, USA
    Am J Public Health 92:858-62. 2002
    ..This study examined the effect of birth cohort on incidence rates of hip fracture among women and men in the Framingham Study...
  83. ncbi request reprint Reduced risk of back pain following teriparatide treatment: a meta-analysis
    Michael C Nevitt
    University of California San Francisco, San Francisco, CA, USA
    Osteoporos Int 17:273-80. 2006
    ..In conclusion, patients randomized to teriparatide had a reduced risk of new or worsening back pain compared to patients randomized to placebo, hormone replacement therapy or alendronate...
  84. pmc PPARG by dietary fat interaction influences bone mass in mice and humans
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 23:1398-408. 2008
    ..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene...
  85. ncbi request reprint Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: the Framingham Heart Study
    Craig R Walsh
    Framingham Heart Study, Framingham, Mass 01702, USA
    Am Heart J 144:733-9. 2002
    ..We sought to determine the association of aortic atherosclerosis, detected by calcific deposits in the abdominal aorta seen on lateral lumbar radiographs, with risk for congestive heart failure (CHF)...
  86. ncbi request reprint To treat or not to treat, that is the question: proceedings of the Quebec Symposium for the Treatment of Osteoporosis in Long-term Care Institutions, Saint-Hyacinthe, Quebec, November 5, 2004
    Gustavo Duque
    Division of Geriatric Medicine, McGill University Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, Quebec, Canada
    J Am Med Dir Assoc 7:435-41. 2006
    ..Management strategies include both nonpharmacological and pharmacological interventions for the prevention and treatment of osteoporotic fractures in very frail older subjects...
  87. ncbi request reprint Evidence for heritability of abdominal aortic calcific deposits in the Framingham Heart Study
    Christopher J O'Donnell
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 106:337-41. 2002
    ..Little is known about the heritability of aortic calcification...
  88. ncbi request reprint Effects of atorvastatin on bone in postmenopausal women with dyslipidemia: a double-blind, placebo-controlled, dose-ranging trial
    Henry G Bone
    Michigan Bone and Mineral Clinic, 22201 Moross Road, Suite 260, Detroit, Michigan 48236 2175, USA
    J Clin Endocrinol Metab 92:4671-7. 2007
    ..Observational studies and secondary analyses from lipid-lowering trials have yielded inconsistent results regarding the effect of these agents on bone mineral density and fracture risk...
  89. ncbi request reprint Calcifications in the abdominal aorta predict fractures in men: MINOS study
    Pawel Szulc
    INSERM Research Unit 831 and University of Lyon, Lyon, France
    J Bone Miner Res 23:95-102. 2008
    ..In a cohort of 781 men >or=50 yr of age followed up for 10 yr, extended calcifications in the abdominal aorta were associated with a 2- to 3-fold increase in the risk of osteoporotic fractures regardless of BMD and falls...
  90. doi request reprint Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographs
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 101:326-31. 2008
    ..AAC appears to be useful for risk stratification in patients at intermediate CHD risk...
  91. ncbi request reprint Abdominal aortic calcification detected on lateral spine images from a bone densitometer predicts incident myocardial infarction or stroke in older women
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
    J Bone Miner Res 23:409-16. 2008
    ....
  92. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  93. ncbi request reprint To treat or not to treat, that is the question: proceedings of the Quebec symposium for the treatment of osteoporosis in long-term care institutions, Saint-Hyacinthe, Quebec, November 5, 2004
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada
    J Am Med Dir Assoc 8:e67-73. 2007
    ..Management strategies include both nonpharmacological and pharmacological interventions for the prevention and treatment of osteoporotic fractures in very frail older subjects...
  94. ncbi request reprint Vertebral deformity, back symptoms, and functional limitations among older women: the Framingham Study
    Susan L Edmond
    University of Medicine and Dentistry New Jersey, SHRP PT, 65 Bergen Street, Newark, NJ 07101 1709, USA
    Osteoporos Int 16:1086-95. 2005
    ..Efforts to prevent and treat back pain, independent of vertebral deformity status, might help to reduce functional limitations in older women...
  95. ncbi request reprint Comparison of weekly treatment of postmenopausal osteoporosis with alendronate versus risedronate over two years
    Sydney Bonnick
    Clinical Research Center of North Texas, 2921 Country Club Road, Suite 101, Denton, Texas 76210, USA
    J Clin Endocrinol Metab 91:2631-7. 2006
    ..A 1-yr extension of the Fosamax Actonel Comparison Trial was completed to compare changes in bone mineral density (BMD), bone turnover, and upper gastrointestinal tolerability over 2 yr of treatment...
  96. ncbi request reprint Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Bone Miner Res 19:773-81. 2004
    ..This was investigated in 723 men and 795 women from the Framingham study. Results show association of variation in this gene with BMD in both women and men...
  97. ncbi request reprint Detection of abdominal aortic calcification with lateral spine imaging using DXA
    John T Schousboe
    Park Nicollet Health Services, Minneapolis, MN 55416, USA
    J Clin Densitom 9:302-8. 2006
    ..Lateral imaging of the spine with DXA intended to detect vertebral fracture is a promising technology for the simultaneous assessment of a risk factor for cardiovascular disease incidence and death...
  98. ncbi request reprint Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort
    Ravin Jugdaohsingh
    Gastrointestinal Laboratory, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    J Bone Miner Res 19:297-307. 2004
    ....
  99. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
    ..Matrix Gla protein (MGP) is an inhibitor of calcification in vivo. However, little is known regarding the distribution of circulating MGP and its associations with CHD risk factors or with CAC in humans...
  100. ncbi request reprint Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
    John P A Ioannidis
    Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
    J Bone Miner Res 22:173-83. 2007
    ..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner...
  101. ncbi request reprint Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study
    Serge L Ferrari
    Division of Bone Diseases and WHO Collaborating Center for Osteoporosis, Departments of Geriatrics and Internal Medicine, Geneva University Hospital, Geneva, Switzerland
    J Bone Miner Res 19:552-9. 2004
    ..Hence, association of IL-6 polymorphisms with BMD may be limited to discrete population subgroups...

Research Grants3

  1. RISK FACTORS FOR AGED RELATED BONE LOSS
    Douglas P Kiel; Fiscal Year: 2010
    ..Second it will identify genes as well as nutritional factors such as the B-vitamins and dietary fat that work together to increase the risk for osteoporosis. ..
  2. RISK FACTORS FOR AGED RELATED BONE LOSS
    Douglas P Kiel; Fiscal Year: 2010
    ..Ultimately this could lead to the development of new treatments for osteoporosis. ..
  3. Low Magnitude Mechanical Stimulation to Improve BMD
    Douglas P Kiel; Fiscal Year: 2010
    ..The significance of the study is that it will test the efficacy of this unique intervention to improve multiple components of the musculoskeletal system that contribute to fracture risk. ..