Research Topics
Species | S J KhourySummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Multiple sclerosis: what have we learned from magnetic resonance imaging studies?S J Khoury
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Mass 02115, USA
Arch Intern Med 158:565-73. 1998..More advanced applications of magnetic resonance imaging and their use in multiple sclerosis is addressed later in the article...- Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosisS J Khoury
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard School of Public Health, Boston, MA 02115, USA
Neurology 53:758-64. 1999..To study the change in serum levels of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble tumor necrosis factor receptors (sTNF-Rs) in MS patients in relation to clinical disease activity and changes on brain MRI... - Changes in activated T cells in the blood correlate with disease activity in multiple sclerosisS J Khoury
Center for Neurologic Diseases, 77 Ave Louis Pasteur, Boston, MA 02115, USA
Arch Neurol 57:1183-9. 2000..To determine whether changes in activation markers on peripheral blood T cells correlate with disease activity in patients with multiple sclerosis... 
Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cellsP Kivisakk
Center for Neurological Diseases, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Neurology 72:1922-30. 2009..The goal of this study was to characterize the effects of natalizumab treatment on cytokine production and expression of activation markers, costimulatory molecules, and trafficking determinants on CD4+ and CD8+ T cells...- Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosisD A Hafler
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Ann N Y Acad Sci 835:120-31. 1997.... 
HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal studyM Liguori
Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Genes Immun 12:183-90. 2011....- Daclizumab in treatment of multiple sclerosis patientsE N Ali
Partners MS Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Mult Scler 15:272-4. 2009..Our aim was to assess its safety and tolerability in our patient population... - Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis modelL Gallon
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 159:4212-6. 1997..Understanding the role and mechanisms of selective blockade of costimulatory molecules has implications for therapy of autoimmune disease... - Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitroM H Frank
Division of Nephrology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 166:2451-9. 2001..Our results define a novel role for P-gp in alloimmunity and thus raise the intriguing possibility that P-gp may represent a novel therapeutic target in allograft rejection... - Oral salbutamol decreases IL-12 in patients with secondary progressive multiple sclerosisK Makhlouf
Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
J Neuroimmunol 117:156-65. 2001..This first report on the use of salbutamol in MS shows that this drug has immunomodulatory properties both in vivo and in vitro, and may be beneficial in the treatment of MS... - Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosisB I Glanz
Department of Neurology, Brigam and Women s Hospital, Harvard Medical School, Boston, MA, USA
Mult Scler 13:1004-10. 2007..These findings suggest that cognitive impairment may predate the appearance of gross structural abnormalities on MRI and serve as an early marker of disease activity in MS... - CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trialV Viglietta
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Neurology 71:917-24. 2008..Autoreactive CD4(+) T cells play a critical role in initiating the immune response leading to the chronic inflammation and demyelination characteristic of multiple sclerosis (MS)... - Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosisZ Liptak
Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
AJNR Am J Neuroradiol 29:1465-70. 2008..The purpose of this study was to determine whether measurements of medulla oblongata volume (MOV) on routine brain MR imaging could serve as a biomarker of spinal cord damage and disability in MS... - Therapeutic strategies to prevent neurodegeneration and promote regeneration in multiple sclerosisT Chitnis
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Drug Targets Immune Endocr Metabol Disord 5:11-26. 2005..In addition, we will discuss potential molecular approaches to promote repair of CNS components in multiple sclerosis... - Predicting short-term disability in multiple sclerosisS A Gauthier
Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Brookline, MA 02445, USA
Neurology 68:2059-65. 2007..To develop covariate specific short-term disability curves to demonstrate the probability of progressing by Expanded Disability Status Scale (EDSS) at semiannual visits... - Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MSK Makhlouf
Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
J Neuroimmunol 119:145-9. 2001.... - Role of passive T-cell death in chronic experimental autoimmune encephalomyelitisS Issazadeh
Center for Neurologic Diseases, Boston, Massachusetts 02115, USA
J Clin Invest 105:1109-16. 2000..Our data indicate that the passive cell death pathway is important in the pathogenesis of chronic EAE. These findings have implications for understanding the pathogenesis of multiple sclerosis and other autoimmune diseases... - The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosisA Ceccarelli
Department of Neurology, Brigham and Women s Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA 02445, USA
AJNR Am J Neuroradiol 33:1579-85. 2012..DARTEL appears to improve registration versus the USM. Our aim was to compare the performance of VBM-DARTEL versus VBM-USM and the effect of LI in the regional analysis of GM atrophy in MS... - Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitisT Chitnis
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 108:739-47. 2001..In addition, adoptive transfer studies confirm the regulatory functions of a Th2 environment in vivo. These novel data indicate that STAT4 and STAT6 genes play a critical role in regulating the autoimmune response in EAE... - Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivoA M Waaga
Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
J Clin Invest 107:909-16. 2001..We suggest that self-restricted alloantigen-specific Th2 clones may regulate the alloimmune responses and promote long-term allograft survival and tolerance... - CD28-independent induction of experimental autoimmune encephalomyelitisT Chitnis
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 107:575-83. 2001..Our data show that EAE may develop in the absence of CD28 T-cell costimulation. These findings have implications for therapies aimed at blocking costimulatory signals in autoimmune diseases...