Khashayarsha Khazaie

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer
    Khashayarsha Khazaie
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Semin Cancer Biol 16:124-36. 2006
  2. pmc Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
    Zhuyan Guo
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Blood 109:5463-72. 2007
  3. pmc c-Myc mediates pre-TCR-induced proliferation but not developmental progression
    Marei Dose
    Tufts New England Medical Center, 750 Washington St, Tufts NEMC no 5602, Boston, MA 02111, USA
    Blood 108:2669-77. 2006
  4. doi request reprint Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity
    Fay C Magnusson
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:1028-37. 2008
  5. ncbi request reprint Inducing and expanding regulatory T cell populations by foreign antigen
    Karsten Kretschmer
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1219-27. 2005
  6. ncbi request reprint Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Thorsten R Mempel
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 25:129-41. 2006
  7. pmc Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation
    Oksana B Serebrennikova
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 109:E1082-91. 2012
  8. pmc Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
    Xiaoyu Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:2851-61. 2008
  9. ncbi request reprint Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer
    Karsten Kretschmer
    Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunol Rev 212:163-9. 2006
  10. pmc Loss of adenomatous polyposis coli gene function disrupts thymic development
    Fotini Gounari
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Nat Immunol 6:800-9. 2005

Research Grants

  1. Immunity in healthy and neoplastic gut mucosa
    Khashayarsha Khazaie; Fiscal Year: 2003
  2. Imaging proteolytic activity in colon cancer
    Khashayarsha Khazaie; Fiscal Year: 2008

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer
    Khashayarsha Khazaie
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Semin Cancer Biol 16:124-36. 2006
    ....
  2. pmc Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
    Zhuyan Guo
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Blood 109:5463-72. 2007
    ..Thus, beta-catenin activation may provide a mechanism for the induction of T-cell-acute lymphoblastic leukemia (T-ALL) that does not depend on Notch activation...
  3. pmc c-Myc mediates pre-TCR-induced proliferation but not developmental progression
    Marei Dose
    Tufts New England Medical Center, 750 Washington St, Tufts NEMC no 5602, Boston, MA 02111, USA
    Blood 108:2669-77. 2006
    ....
  4. doi request reprint Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity
    Fay C Magnusson
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:1028-37. 2008
    ..To determine the contribution of antigen-specific CD8 and CD4 T cells to the breakdown of the EGC network, we studied specific autoimmune targeting of an ectopic antigen expressed by EGCs...
  5. ncbi request reprint Inducing and expanding regulatory T cell populations by foreign antigen
    Karsten Kretschmer
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1219-27. 2005
    ..The extrathymic generation and proliferation of regulatory T cells may contribute to self-tolerance as well as the poor immunogenicity of tumors and may be exploited clinically to prevent or reverse unwanted immunity...
  6. ncbi request reprint Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Thorsten R Mempel
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 25:129-41. 2006
    ..Thus, T(reg) cells reversibly suppress CTL-mediated immunity by allowing acquisition of full effector potential but withholding the license to kill...
  7. pmc Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation
    Oksana B Serebrennikova
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 109:E1082-91. 2012
    ..This may be because these mice have a higher intestinal polyp burden as a result of the enhancement of tumor initiation...
  8. pmc Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
    Xiaoyu Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:2851-61. 2008
    ..As judged by array-based comparative genomic hybridization (array CGH) and spectral karyotype (SKY) analysis, none of the tumors arise because of genomic instability...
  9. ncbi request reprint Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer
    Karsten Kretschmer
    Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunol Rev 212:163-9. 2006
    ..The precise mechanisms of suppression remain enigmatic, however, but may be further elucidated by the molecular analysis of suppressed versus non-suppressed T cells...
  10. pmc Loss of adenomatous polyposis coli gene function disrupts thymic development
    Fotini Gounari
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Nat Immunol 6:800-9. 2005
    ..Thus, loss of APC in immature thymocytes has consequences distinct from those of deregulation of beta-catenin signaling and is essential for T cell differentiation...
  11. pmc Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo
    Mei Ling Chen
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:419-24. 2005
    ....
  12. ncbi request reprint Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe
    Wei Tsung Chen
    Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 92129, USA
    Mol Imaging 4:67-74. 2005
    ..2.2%), and confirmed the source of FFP-positive cells to be primarily an F4/80-positive macrophage subpopulation. Taken together, these results indicate that probe potentially can be used to image dysplastic intestinal adenomas in vivo...
  13. pmc In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
    Ludger Klein
    Harvard Medical School, Dana Farber Cancer Institute, 44 Binney Street, Smith 736, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:8886-91. 2003
    ..Our results reveal properties of regulatory T cells that were not predicted from in vitro studies...
  14. pmc Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage
    Julie Cabarrocas
    Institut National de la Sante et de la Recherche Medicale U563, Purpan Hospital, 31000 Toulouse, France
    Proc Natl Acad Sci U S A 103:8453-8. 2006
    ..Our data show that the promiscuous expression of the HA transgene in thymic epithelial cells is involved in the selective induction and/or expansion of HA-specific Foxp3(+) Treg thymic precursors as early as the double-positive stage...

Research Grants2

  1. Immunity in healthy and neoplastic gut mucosa
    Khashayarsha Khazaie; Fiscal Year: 2003
    ..abstract_text> ..
  2. Imaging proteolytic activity in colon cancer
    Khashayarsha Khazaie; Fiscal Year: 2008
    ..These preclinical studies will prepare the grounds for near future clinical trials. ..