Khashayarsha Khazaie

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer
    Khashayarsha Khazaie
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Semin Cancer Biol 16:124-36. 2006
  2. pmc Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
    Zhuyan Guo
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Blood 109:5463-72. 2007
  3. pmc c-Myc mediates pre-TCR-induced proliferation but not developmental progression
    Marei Dose
    Tufts New England Medical Center, 750 Washington St, Tufts NEMC no 5602, Boston, MA 02111, USA
    Blood 108:2669-77. 2006
  4. doi request reprint Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity
    Fay C Magnusson
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:1028-37. 2008
  5. ncbi request reprint Inducing and expanding regulatory T cell populations by foreign antigen
    Karsten Kretschmer
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1219-27. 2005
  6. ncbi request reprint Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Thorsten R Mempel
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 25:129-41. 2006
  7. pmc Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation
    Oksana B Serebrennikova
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 109:E1082-91. 2012
  8. pmc Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
    Xiaoyu Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:2851-61. 2008
  9. ncbi request reprint Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer
    Karsten Kretschmer
    Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunol Rev 212:163-9. 2006
  10. ncbi request reprint Loss of adenomatous polyposis coli gene function disrupts thymic development
    Fotini Gounari
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Nat Immunol 6:800-9. 2005

Research Grants

  1. Immunity in healthy and neoplastic gut mucosa
    Khashayarsha Khazaie; Fiscal Year: 2003
  2. Imaging proteolytic activity in colon cancer
    Khashayarsha Khazaie; Fiscal Year: 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer
    Khashayarsha Khazaie
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Semin Cancer Biol 16:124-36. 2006
    ....
  2. pmc Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
    Zhuyan Guo
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Blood 109:5463-72. 2007
    ..Thus, beta-catenin activation may provide a mechanism for the induction of T-cell-acute lymphoblastic leukemia (T-ALL) that does not depend on Notch activation...
  3. pmc c-Myc mediates pre-TCR-induced proliferation but not developmental progression
    Marei Dose
    Tufts New England Medical Center, 750 Washington St, Tufts NEMC no 5602, Boston, MA 02111, USA
    Blood 108:2669-77. 2006
    ....
  4. doi request reprint Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity
    Fay C Magnusson
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:1028-37. 2008
    ..To determine the contribution of antigen-specific CD8 and CD4 T cells to the breakdown of the EGC network, we studied specific autoimmune targeting of an ectopic antigen expressed by EGCs...
  5. ncbi request reprint Inducing and expanding regulatory T cell populations by foreign antigen
    Karsten Kretschmer
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1219-27. 2005
    ..The extrathymic generation and proliferation of regulatory T cells may contribute to self-tolerance as well as the poor immunogenicity of tumors and may be exploited clinically to prevent or reverse unwanted immunity...
  6. ncbi request reprint Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Thorsten R Mempel
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 25:129-41. 2006
    ..Thus, T(reg) cells reversibly suppress CTL-mediated immunity by allowing acquisition of full effector potential but withholding the license to kill...
  7. pmc Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation
    Oksana B Serebrennikova
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 109:E1082-91. 2012
    ..This may be because these mice have a higher intestinal polyp burden as a result of the enhancement of tumor initiation...
  8. pmc Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
    Xiaoyu Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:2851-61. 2008
    ..As judged by array-based comparative genomic hybridization (array CGH) and spectral karyotype (SKY) analysis, none of the tumors arise because of genomic instability...
  9. ncbi request reprint Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer
    Karsten Kretschmer
    Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunol Rev 212:163-9. 2006
    ..The precise mechanisms of suppression remain enigmatic, however, but may be further elucidated by the molecular analysis of suppressed versus non-suppressed T cells...
  10. ncbi request reprint Loss of adenomatous polyposis coli gene function disrupts thymic development
    Fotini Gounari
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Nat Immunol 6:800-9. 2005
    ..Thus, loss of APC in immature thymocytes has consequences distinct from those of deregulation of beta-catenin signaling and is essential for T cell differentiation...
  11. pmc Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo
    Mei Ling Chen
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:419-24. 2005
    ....
  12. ncbi request reprint Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe
    Wei Tsung Chen
    Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 92129, USA
    Mol Imaging 4:67-74. 2005
    ..2.2%), and confirmed the source of FFP-positive cells to be primarily an F4/80-positive macrophage subpopulation. Taken together, these results indicate that probe potentially can be used to image dysplastic intestinal adenomas in vivo...
  13. pmc In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
    Ludger Klein
    Harvard Medical School, Dana Farber Cancer Institute, 44 Binney Street, Smith 736, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:8886-91. 2003
    ..Our results reveal properties of regulatory T cells that were not predicted from in vitro studies...
  14. pmc Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage
    Julie Cabarrocas
    Institut National de la Sante et de la Recherche Medicale U563, Purpan Hospital, 31000 Toulouse, France
    Proc Natl Acad Sci U S A 103:8453-8. 2006
    ..Our data show that the promiscuous expression of the HA transgene in thymic epithelial cells is involved in the selective induction and/or expansion of HA-specific Foxp3(+) Treg thymic precursors as early as the double-positive stage...

Research Grants6

  1. Immunity in healthy and neoplastic gut mucosa
    Khashayarsha Khazaie; Fiscal Year: 2003
    ..abstract_text> ..
  2. Imaging proteolytic activity in colon cancer
    Khashayarsha Khazaie; Fiscal Year: 2007
    ..These preclinical studies will prepare the grounds for near future clinical trials. ..