Erin E Kershaw

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Adipose tissue as an endocrine organ
    Erin E Kershaw
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 89:2548-56. 2004
  2. pmc Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity
    Erin E Kershaw
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 54:1023-31. 2005
  3. pmc Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin
    Erin E Kershaw
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Diabetes 55:148-57. 2006
  4. pmc PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo
    Erin E Kershaw
    Div of Endocrinology and Metabolism, Dept of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 293:E1736-45. 2007
  5. pmc Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    Janice M Zabolotny
    Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 283:14230-41. 2008
  6. pmc Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
    Mahesh K Basantani
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 52:318-29. 2011
  7. pmc Transcriptional control of adipose lipid handling by IRF4
    Jun Eguchi
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cell Metab 13:249-59. 2011

Collaborators

Detail Information

Publications7

  1. ncbi Adipose tissue as an endocrine organ
    Erin E Kershaw
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 89:2548-56. 2004
    ..A better understanding of the endocrine function of adipose tissue will likely lead to more rational therapy for these increasingly prevalent disorders. This review presents an overview of the endocrine functions of adipose tissue...
  2. pmc Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity
    Erin E Kershaw
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 54:1023-31. 2005
    ..These data suggest that reduction of active GCs exclusively in adipose tissue is an important determinant of a favorable metabolic phenotype with respect to energy homeostasis and the metabolic syndrome...
  3. pmc Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin
    Erin E Kershaw
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Diabetes 55:148-57. 2006
    ..These data suggest that murine ATGL but not adiponutrin contributes to net adipocyte lipolysis and that ATGL and adiponutrin are oppositely regulated by insulin both in vitro and in vivo...
  4. pmc PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo
    Erin E Kershaw
    Div of Endocrinology and Metabolism, Dept of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 293:E1736-45. 2007
    ..Thus, PPARgamma positively regulates ATGL mRNA and protein expression in mature adipocytes in vitro and in adipose tissue in vivo, suggesting a role for ATGL in mediating PPARgamma's effects on lipid metabolism...
  5. pmc Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    Janice M Zabolotny
    Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 283:14230-41. 2008
    ..Our data suggest that PTP1B overexpression in multiple tissues in obesity is regulated by inflammation and that PTP1B may be a target of anti-inflammatory therapies...
  6. pmc Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
    Mahesh K Basantani
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 52:318-29. 2011
    ..Together these data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice...
  7. pmc Transcriptional control of adipose lipid handling by IRF4
    Jun Eguchi
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cell Metab 13:249-59. 2011
    ..Mice lacking adipocyte IRF4 exhibit increased adiposity and deficient lipolysis. These studies establish a link between IRF4 and the disposition of calories in adipose tissue, with consequences for systemic metabolic homeostasis...

Research Grants5

  1. Adipocyte-specific glucocorticoid metabolism: 11betaHSDs
    ERIN KERSHAW; Fiscal Year: 2007
    ..The ultimate goal is for the applicant to become an independent investigator. ..
  2. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2007
    ..Evaluating the role of ATGL-mediated fat breakdown in skeletal muscle will provide important insights into the pathophysiology and treatment of obesity, insulin resistance, and related metabolic disorders. ..