RAYMOND KELLEHER

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice
    Michelle R Simpson-Abelson
    State University of New York, Department of Microbiology and Immunology and The Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY 14214, USA
    J Immunol 180:7009-18. 2008
  2. pmc High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism
    Raymond J Kelleher
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35003. 2012
  3. doi request reprint The autistic neuron: troubled translation?
    Raymond J Kelleher
    Center for Human Genetic Research, Harvard Partners Center for Genetics and Genomics, Massachusetts General Hospital, Program in Neuroscience and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 135:401-6. 2008
  4. pmc The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism
    Jie Shen
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:403-9. 2007
  5. ncbi request reprint Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
    Carlos A Saura
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 42:23-36. 2004
  6. pmc Indirect regulation of presenilins in CREB-mediated transcription
    Hirotaka Watanabe
    Center for Neurologic Diseases, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:13705-13. 2009
  7. pmc A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity
    Elizabeth A Heilig
    Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 285:22350-9. 2010
  8. pmc Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:9879-84. 2010

Research Grants

Collaborators

  • Jie Shen
  • Mark F Bear
  • W Xia
  • K Duff
  • Leonard D Shultz
  • Youren Tong
  • Elizabeth A Heilig
  • Hirotaka Watanabe
  • Michelle R Simpson-Abelson
  • Vassilios Beglopoulos
  • Carlos A Saura
  • Scott Boyle
  • Raphael Kopan
  • Hiroo Yamaguchi
  • Emilie Giaime
  • Miriam J Smith
  • Elizabeth Heilig
  • Sandra J Yokota
  • Richard B Bankert
  • Thomas F Conway
  • Hiroshi Takita
  • Maurice Barcos
  • Gregory F Sonnenberg
  • Dawei Zhang
  • Sumantra Chattarji
  • Se Young Choi
  • Eric R Kandel
  • Seema Malkani
  • Alfredo Kirkwood
  • B S Shankaranarayana Rao

Detail Information

Publications8

  1. ncbi request reprint Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice
    Michelle R Simpson-Abelson
    State University of New York, Department of Microbiology and Immunology and The Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY 14214, USA
    J Immunol 180:7009-18. 2008
    ..We conclude that the NOD-scid IL2Rgamma(null) tumor xenograft model provides an opportunity to study tumor and tumor-stromal cell interactions in situ for prolonged periods...
  2. pmc High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism
    Raymond J Kelleher
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35003. 2012
    ..Collectively, these findings suggest that altered signaling downstream of mGluRs contributes to the pathogenesis of non-syndromic autism...
  3. doi request reprint The autistic neuron: troubled translation?
    Raymond J Kelleher
    Center for Human Genetic Research, Harvard Partners Center for Genetics and Genomics, Massachusetts General Hospital, Program in Neuroscience and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 135:401-6. 2008
    ..We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognitive impairment and savant abilities...
  4. pmc The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism
    Jie Shen
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:403-9. 2007
    ..We also speculate that Abeta42 may act primarily to antagonize PS-dependent functions, possibly by operating as an active site-directed inhibitor of gamma-secretase...
  5. ncbi request reprint Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
    Carlos A Saura
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 42:23-36. 2004
    ..These results define essential roles and molecular targets of presenilins in synaptic plasticity, learning and memory, and neuronal survival in the adult cerebral cortex...
  6. pmc Indirect regulation of presenilins in CREB-mediated transcription
    Hirotaka Watanabe
    Center for Neurologic Diseases, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:13705-13. 2009
    ....
  7. pmc A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity
    Elizabeth A Heilig
    Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 285:22350-9. 2010
    ..Rather, our findings provide support for the hypothesis that pathogenic mutations cause a general loss of presenilin function...
  8. pmc Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:9879-84. 2010
    ....

Research Grants7

  1. MAP Kinases ERK1/2 in Synaptic Plasticity in Brain
    RAYMOND KELLEHER; Fiscal Year: 2003
    ..no abstract provided..
  2. Translational Control in Long-Term Synaptic Plasticity
    RAYMOND KELLEHER; Fiscal Year: 2007
    ..abstract_text> ..
  3. MicroRNAs in Synaptic Plasticity and Cognitive Function
    RAYMOND KELLEHER; Fiscal Year: 2007
    ..Accomplishment of the proposed studies should yield important insights into the role of miRNAs in brain function, and the possible involvement of altered miRNA-dependent processes in the pathogenesis of mental disorders. ..
  4. MicroRNAs in Synaptic Plasticity and Cognitive Function
    RAYMOND KELLEHER; Fiscal Year: 2009
    ..Accomplishment of the proposed studies should yield important insights into the role of miRNAs in brain function, and the possible involvement of altered miRNA-dependent processes in the pathogenesis of mental disorders. ..
  5. MicroRNAs in Synaptic Plasticity and Cognitive Function
    Raymond J Kelleher; Fiscal Year: 2010
    ..Accomplishment of the proposed studies should yield important insights into the role of miRNAs in brain function, and the possible involvement of altered miRNA-dependent processes in the pathogenesis of mental disorders. ..