Alon Keinan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants
    George Ayodo
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 81:234-42. 2007
  2. pmc Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans
    Alon Keinan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:1251-5. 2007
  3. pmc Accelerated genetic drift on chromosome X during the human dispersal out of Africa
    Alon Keinan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 41:66-70. 2009
  4. pmc The history of African gene flow into Southern Europeans, Levantines, and Jews
    Priya Moorjani
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001373. 2011
  5. pmc Integrating common and rare genetic variation in diverse human populations
    David M Altshuler
    Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02138, USA
    Nature 467:52-8. 2010
  6. pmc Detecting natural selection by empirical comparison to random regions of the genome
    Fuli Yu
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 18:4853-67. 2009
  7. pmc Human population differentiation is strongly correlated with local recombination rate
    Alon Keinan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000886. 2010
  8. pmc Demographic history and rare allele sharing among human populations
    Simon Gravel
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Proc Natl Acad Sci U S A 108:11983-8. 2011
  9. pmc Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation
    Jeffrey M Kidd
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 91:660-71. 2012

Detail Information

Publications9

  1. pmc Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants
    George Ayodo
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 81:234-42. 2007
    ..This empirically demonstrates that combining association analysis with evidence of natural selection can increase power to detect risk variants by orders of magnitude--up to P=.000018 for HBB and P=.00043 for CD36...
  2. pmc Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans
    Alon Keinan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:1251-5. 2007
    ..Our analysis shows that East Asian and northern European ancestors shared the same population bottleneck expanding out of Africa but that both also experienced more recent genetic drift, which was greater in East Asians...
  3. pmc Accelerated genetic drift on chromosome X during the human dispersal out of Africa
    Alon Keinan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 41:66-70. 2009
    ..We conclude that a sex-biased process that reduced the female effective population size, or an episode of natural selection unusually affecting chromosome X, was associated with the founding of non-African populations...
  4. pmc The history of African gene flow into Southern Europeans, Levantines, and Jews
    Priya Moorjani
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001373. 2011
    ..For the Jewish admixture, we obtain an average estimated date of about 72 generations. This may reflect descent of these groups from a common ancestral population that already had some African ancestry prior to the Jewish Diasporas...
  5. pmc Integrating common and rare genetic variation in diverse human populations
    David M Altshuler
    Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02138, USA
    Nature 467:52-8. 2010
    ....
  6. pmc Detecting natural selection by empirical comparison to random regions of the genome
    Fuli Yu
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 18:4853-67. 2009
    ..Our study also provides a prototype for how empirical scans for ancient selection can be carried out once many genomes are sequenced...
  7. pmc Human population differentiation is strongly correlated with local recombination rate
    Alon Keinan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000886. 2010
    ....
  8. pmc Demographic history and rare allele sharing among human populations
    Simon Gravel
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Proc Natl Acad Sci U S A 108:11983-8. 2011
    ..Our results emphasize that replication of disease association for specific rare genetic variants across diverged populations must overcome both reduced statistical power because of rarity and higher population divergence...
  9. pmc Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation
    Jeffrey M Kidd
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 91:660-71. 2012
    ....