Dan Kawamori

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Adv Exp Med Biol 654:421-45. 2010
  2. pmc Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice
    Charlotte Hinault
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 60:1210-22. 2011
  3. pmc Soluble factors secreted by T cells promote β-cell proliferation
    Ercument Dirice
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA
    Diabetes 63:188-202. 2014
  4. pmc Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young)
    Helge Ræder
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60229. 2013
  5. pmc Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states
    Abdelfattah El Ouaamari
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 3:401-10. 2013
  6. pmc The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells
    Chong Wee Liew
    Section of Islet Cell and Regenerative Medicine, Department of Medicine, Harvard Medical School, Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Clin Invest 120:2876-88. 2010
  7. doi request reprint Insulin modulation of glucagon secretion: the role of insulin and other factors in the regulation of glucagon secretion
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA USA
    Islets 1:276-9. 2009
  8. pmc Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
    Chong Wee Liew
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:217-26. 2013
  9. pmc Insulin signaling in alpha cells modulates glucagon secretion in vivo
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 9:350-61. 2009
  10. pmc Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells
    Chong Wee Liew
    Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612
    Proc Natl Acad Sci U S A 111:E2319-28. 2014

Collaborators

Detail Information

Publications10

  1. doi request reprint Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Adv Exp Med Biol 654:421-45. 2010
    ..Therefore, understanding the molecular mechanism of how glucagon secretion is regulated is critical for treating the alpha-cell dysfunction observed in diabetes...
  2. pmc Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice
    Charlotte Hinault
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 60:1210-22. 2011
    ....
  3. pmc Soluble factors secreted by T cells promote β-cell proliferation
    Ercument Dirice
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA
    Diabetes 63:188-202. 2014
    ..These data suggest that soluble factors secreted from T cells are potential therapeutic candidates to enhance β-cell proliferation in efforts to prevent and/or delay the onset of type 1 diabetes. ..
  4. pmc Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young)
    Helge Ræder
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60229. 2013
    ..We therefore aimed to create and phenotype a mouse model specifically over-expressing mutated CEL in the pancreas...
  5. pmc Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states
    Abdelfattah El Ouaamari
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 3:401-10. 2013
    ..These data implicate the liver as a critical source of β cell growth factor(s) in insulin-resistant states...
  6. pmc The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells
    Chong Wee Liew
    Section of Islet Cell and Regenerative Medicine, Department of Medicine, Harvard Medical School, Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Clin Invest 120:2876-88. 2010
    ..These data link a missense polymorphism in human TRB3 to impaired insulin exocytosis and thus increased risk for T2DM...
  7. doi request reprint Insulin modulation of glucagon secretion: the role of insulin and other factors in the regulation of glucagon secretion
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, MA USA
    Islets 1:276-9. 2009
    ....
  8. pmc Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
    Chong Wee Liew
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:217-26. 2013
    ....
  9. pmc Insulin signaling in alpha cells modulates glucagon secretion in vivo
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 9:350-61. 2009
    ..Together, these data indicate a significant role for intraislet insulin signaling in the regulation of alpha cell function in both normo- and hypoglycemic conditions...
  10. pmc Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells
    Chong Wee Liew
    Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612
    Proc Natl Acad Sci U S A 111:E2319-28. 2014
    ....