Research Topics
| A KaurSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDSAmitinder Kaur
Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 77:5749-58. 2003..The underlying mechanism may be a dysfunction of memory B and CD8(+) T lymphocytes associated with SIV-induced impairment of CMV-specific CD4(+) T-cell help...
Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infectionA Kaur
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
J Immunol 164:934-43. 2000..Longitudinal studies of viral load and sequence variation in CTL epitopes may provide useful information on the role of CTL in control or persistence of SIV infection in sooty mangabeys...- Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infectionA Kaur
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 74:8413-24. 2000..Thus, divergent patterns of proliferation and activation are exhibited by CD4(+) and CD8(+) T lymphocytes in early SIV infection and may determine how these cells are differentially affected in AIDS... - Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infectionA Kaur
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Eur J Immunol 31:3207-17. 2001..These results document the occurrence of CTL escape in a host that does not develop AIDS, and adds to the growing body of evidence that CTL exert significant selective pressure in SIV infection... - Decreased frequency of cytomegalovirus (CMV)-specific CD4+ T lymphocytes in simian immunodeficiency virus-infected rhesus macaques: inverse relationship with CMV viremiaAmitinder Kaur
Division of Immunolog, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 76:3646-58. 2002..Future longitudinal studies with these techniques will facilitate the study of CMV pathogenesis in AIDS... - Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virusAmitinder Kaur
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
Virology 357:199-214. 2007..05) and peak neutralizing antibody titers pre-challenge (P value 0.06). These findings support continued study of recombinant herpesviruses as a vaccine approach for AIDS... - Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virusAmitinder Kaur
Division of Immunology, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
J Virol 82:1084-93. 2008.... - Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virusR P Johnson
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 71:7711-8. 1997.... - Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infectionMareike Meythaler
Divisions of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 83:572-83. 2009..Thus, species-specific differences in the early innate immune response appear to be an important factor contributing to differential immune activation in natural and nonnatural hosts of SIV infection... - Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce diseaseRoland C Zahn
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Blood 115:3070-8. 2010..Thus, adaptive immune responses in natural hosts appear to be less critical for viral containment than in HIV infection... - Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytesIole Macchia
New England Primate Research Center, Department of Immunology, Harvard Medical School, Southborough, MA 01772, and Infectious Disease Unit and Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA
Immunology 119:232-42. 2006..Taken together, these data suggest that CD4+ T cells expressing CD8alpha represent an effector/memory subset of CD4+ T cells and that this cell population can be depleted during the course of SIV infection... - Th-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeysZichun Wang
Division of Immunology, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, Massachusetts 01772, USA
J Virol 80:2771-83. 2006.... - Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaquesKenneth S Chan
Department of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
J Immunol Methods 325:20-34. 2007..Our findings suggest that the composition of rhCMV-specific CD8+ T lymphocytes with regards to CD107a+IFN-gamma- responders may be an important determinant of their ability to control CMV replication... - Experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for Epstein-Barr virus pathogenesis in the immunosuppressed hostPierre Rivailler
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Blood 104:1482-9. 2004..These studies demonstrate the potential for lymphomagenesis in an experimental model system for EBV infection and underscore the strength and depth of immune control in limiting LCV-induced lymphoproliferative disease... - Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeysJörn E Schmitz
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
PLoS Pathog 5:e1000691. 2009..However, the maintenance of a disease-free course of SIV infection in AGM likely depends on a number of mechanisms including non-adaptive immune mechanisms... - Optimization of intracellular cytokine staining for the quantitation of antigen-specific CD4+ T cell responses in rhesus macaquesMarie Claire Gauduin
New England Primate Research Center, Harvard Medical School, Division of Immunology, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
J Immunol Methods 288:61-79. 2004..The use of more sensitive techniques such as ICS permits delineation of antigen-specific cells at the single cell level and should provide new insights into pathogen-specific immune responses in the rhesus macaque model... - Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative Natural Killer T cell subsets in sooty mangabeysNamita Rout
New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
J Med Primatol 39:224-34. 2010..To investigate differences in the two NKT cell subsets, we compared the phenotype and function of sooty mangabey CD8(+) and DN NKT cells... - Kinetics of T lymphocyte apoptosis and the cellular immune response in SIVmac239-infected rhesus macaquesMareike Meythaler
Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
J Med Primatol 37:33-45. 2008..Although increased apoptosis is a central feature of AIDS, little is known about its kinetics or relationship to the early host response in acute HIV/SIV infection... - Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantationNicolas J Mueller
Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Transplant 3:1057-64. 2003..GCV and other antiviral agents have limited activities against PCMV in vitro. Breeding of PCMV-free xenograft donors may be necessary to prevent PCMV infections in clinical trials... - Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2M Quinn DeGottardi
Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
J Virol 82:3139-46. 2008..Thus, selective major histocompatibility complex class I downregulation is a conserved mechanism of immune evasion for pathogenic SIV infection of rhesus macaques and nonpathogenic SIV infection of sooty mangabeys... - Genomic sequence of rhesus cytomegalovirus 180.92: insights into the coding potential of rhesus cytomegalovirusPierre Rivailler
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 80:4179-82. 2006..Like hCMV, understanding of the complete coding capacity of rhCMV is complicated by genomic instability and may require comparisons with additional isolates in vitro and in vivo... - The CD8+ T-cell response to an Epstein-Barr virus-related gammaherpesvirus infecting rhesus macaques provides evidence for immune evasion by the EBNA-1 homologueMark H Fogg
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Virol 79:12681-91. 2005..Thus, the rhLCV animal model can be used to analyze the immune responses important for control of persistent LCV infection and the role of the EBNA-1 GAR for immune evasion in vivo... - The BZLF1 homolog of an Epstein-Barr-related gamma-herpesvirus is a frequent target of the CTL response in persistently infected rhesus macaquesMark H Fogg
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 176:3391-401. 2006..These data underscore the utility of the rhLCV-macaque model for studies of EBV pathogenesis... - Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesisShari N Gordon
University of Pennsylvania School of Medicine, 705 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19143, USA
J Virol 82:3725-35. 2008.... - Activation of cytomegalovirus in pig-to-primate organ xenotransplantationNicolas J Mueller
Infectious Diseases Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Virol 76:4734-40. 2002..The observation of graft injury by PCMV demonstrates that CMV will be an important pathogen in immunosuppressed xenograft recipients. Strategies must be developed to exclude CMV from porcine organ donors... - Immunogenicity and protective efficacy of DNA vaccines expressing rhesus cytomegalovirus glycoprotein B, phosphoprotein 65-2, and viral interleukin-10 in rhesus macaquesYujuan Yue
Center for Comparative Medicine, University of California Davis, County Rd 98 and Hutchison Dr, Davis, CA 95616, USA
J Virol 81:1095-109. 2007..These data demonstrated that DNA vaccines targeting the RhCMV homologues of HCMV gB and pp65 altered the course of acute and persistent RhCMV infection in a primate host... - Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hostsIvona Pandrea
Tulane National Primate Research Center, Covington, LA 70433, USA
Blood 109:1069-76. 2007..Beneficial effects of low CCR5 expression on CD4+ T cells may include the reduction of target cells for viral replication and a decreased homing of activated CD4+ T cells to inflamed tissue... - Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and HRebecca Elkington
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Australia
Eur J Immunol 34:3216-26. 2004..In addition, they also provide a functional basis for the conservation of MHC class II lineages between humans and Old World primates and open the possibility for the use of such primate models in vaccine development against HCMV... - Characterization and immunological analysis of the rhesus cytomegalovirus homologue (Rh112) of the human cytomegalovirus UL83 lower matrix phosphoprotein (pp65)Yujuan Yue
Center for Comparative Medicine, University of California, Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
J Gen Virol 87:777-87. 2006..Thus, the rhesus macaque model of HCMV persistence and pathogenesis should be relevant for addressing pp65-based vaccine modalities... - HIV: viral blitzkriegR Paul Johnson
Nature 434:1080-1. 2005 - Kuru experiments triggered the emergence of pathogenic SIVmacCristian Apetrei
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
AIDS 20:317-21. 2006 - Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstmCristian Apetrei
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 79:8991-9005. 2005..The genetic variability of SIVsm strains among PCs may influence the diagnosis and monitoring of SIVsm infection and, consequently, may bias the results of pathogenesis studies... - Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL populationTonia Woodberry
Partners AIDS Research Center, Massachusetts General Hospital, Boston 02129, USA
J Immunol 175:4355-62. 2005.... - Isolation of viable antigen-specific CD4 T cells by CD40L surface trappingGeorge B Cohen
Department of Biochemistry and Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454, USA
J Immunol Methods 302:103-15. 2005....
Research Grants
- INTERACTIONS BETWEEN CMV AND SIV IN RHESUS MACAQUESAmitinder Kaur; Fiscal Year: 2007..Specific Aim #3: To examine mechanisms of restoration of CMV-specific immunity in SIV-infected macaques treated with HAART. ..
- INTERACTIONS BETWEEN CMV AND SIV IN RHESUS MACAQUESAmitinder Kaur; Fiscal Year: 2006..Specific Aim #3: To examine mechanisms of restoration of CMV-specific immunity in SIV-infected macaques treated with HAART. ..
- Cell immune responses in SIV-infected sooty mangabeysAmitinder Kaur; Fiscal Year: 2004..abstract_text> ..
- INTERACTIONS BETWEEN CMV AND SIV IN RHESUS MACAQUESAmitinder Kaur; Fiscal Year: 2001..The elucidation of mechanisms underlying interactions between CMV and SIV should help in the design of effective antiviral or immune-based therapeutic strategies to control the morbidity associated with CMV infection in AIDS. ..
- Modulation of the early host response to SIV in pathogenic infectionAmitinder Kaur; Fiscal Year: 2010..Differences in the early innate and adaptive host response to SIV will be studied in SIV infected and vaccinated sooty mangabeys and rhesus macaques. ..