A Kaur

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDS
    Amitinder Kaur
    Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 77:5749-58. 2003
  2. ncbi request reprint Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection
    A Kaur
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Immunol 164:934-43. 2000
  3. pmc Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection
    A Kaur
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 74:8413-24. 2000
  4. ncbi request reprint Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infection
    A Kaur
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Eur J Immunol 31:3207-17. 2001
  5. pmc Decreased frequency of cytomegalovirus (CMV)-specific CD4+ T lymphocytes in simian immunodeficiency virus-infected rhesus macaques: inverse relationship with CMV viremia
    Amitinder Kaur
    Division of Immunolog, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 76:3646-58. 2002
  6. pmc Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus
    Amitinder Kaur
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Virology 357:199-214. 2007
  7. pmc Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus
    Amitinder Kaur
    Division of Immunology, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    J Virol 82:1084-93. 2008
  8. pmc Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus
    R P Johnson
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 71:7711-8. 1997
  9. pmc Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection
    Mareike Meythaler
    Divisions of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 83:572-83. 2009
  10. pmc Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease
    Roland C Zahn
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 115:3070-8. 2010

Collaborators

Detail Information

Publications34

  1. pmc Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDS
    Amitinder Kaur
    Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 77:5749-58. 2003
    ..The underlying mechanism may be a dysfunction of memory B and CD8(+) T lymphocytes associated with SIV-induced impairment of CMV-specific CD4(+) T-cell help...
  2. ncbi request reprint Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection
    A Kaur
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Immunol 164:934-43. 2000
    ..Longitudinal studies of viral load and sequence variation in CTL epitopes may provide useful information on the role of CTL in control or persistence of SIV infection in sooty mangabeys...
  3. pmc Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection
    A Kaur
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 74:8413-24. 2000
    ..Thus, divergent patterns of proliferation and activation are exhibited by CD4(+) and CD8(+) T lymphocytes in early SIV infection and may determine how these cells are differentially affected in AIDS...
  4. ncbi request reprint Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infection
    A Kaur
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Eur J Immunol 31:3207-17. 2001
    ..These results document the occurrence of CTL escape in a host that does not develop AIDS, and adds to the growing body of evidence that CTL exert significant selective pressure in SIV infection...
  5. pmc Decreased frequency of cytomegalovirus (CMV)-specific CD4+ T lymphocytes in simian immunodeficiency virus-infected rhesus macaques: inverse relationship with CMV viremia
    Amitinder Kaur
    Division of Immunolog, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 76:3646-58. 2002
    ..Future longitudinal studies with these techniques will facilitate the study of CMV pathogenesis in AIDS...
  6. pmc Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus
    Amitinder Kaur
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Virology 357:199-214. 2007
    ..05) and peak neutralizing antibody titers pre-challenge (P value 0.06). These findings support continued study of recombinant herpesviruses as a vaccine approach for AIDS...
  7. pmc Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus
    Amitinder Kaur
    Division of Immunology, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    J Virol 82:1084-93. 2008
    ....
  8. pmc Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus
    R P Johnson
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 71:7711-8. 1997
    ....
  9. pmc Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection
    Mareike Meythaler
    Divisions of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 83:572-83. 2009
    ..Thus, species-specific differences in the early innate immune response appear to be an important factor contributing to differential immune activation in natural and nonnatural hosts of SIV infection...
  10. pmc Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease
    Roland C Zahn
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 115:3070-8. 2010
    ..Thus, adaptive immune responses in natural hosts appear to be less critical for viral containment than in HIV infection...
  11. pmc Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes
    Iole Macchia
    New England Primate Research Center, Department of Immunology, Harvard Medical School, Southborough, MA 01772, and Infectious Disease Unit and Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA
    Immunology 119:232-42. 2006
    ..Taken together, these data suggest that CD4+ T cells expressing CD8alpha represent an effector/memory subset of CD4+ T cells and that this cell population can be depleted during the course of SIV infection...
  12. pmc Th-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys
    Zichun Wang
    Division of Immunology, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, Massachusetts 01772, USA
    J Virol 80:2771-83. 2006
    ....
  13. pmc Flow cytometric detection of degranulation reveals phenotypic heterogeneity of degranulating CMV-specific CD8+ T lymphocytes in rhesus macaques
    Kenneth S Chan
    Department of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Immunol Methods 325:20-34. 2007
    ..Our findings suggest that the composition of rhCMV-specific CD8+ T lymphocytes with regards to CD107a+IFN-gamma- responders may be an important determinant of their ability to control CMV replication...
  14. ncbi request reprint Experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for Epstein-Barr virus pathogenesis in the immunosuppressed host
    Pierre Rivailler
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Blood 104:1482-9. 2004
    ..These studies demonstrate the potential for lymphomagenesis in an experimental model system for EBV infection and underscore the strength and depth of immune control in limiting LCV-induced lymphoproliferative disease...
  15. pmc Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys
    Jörn E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 5:e1000691. 2009
    ..However, the maintenance of a disease-free course of SIV infection in AGM likely depends on a number of mechanisms including non-adaptive immune mechanisms...
  16. ncbi request reprint Optimization of intracellular cytokine staining for the quantitation of antigen-specific CD4+ T cell responses in rhesus macaques
    Marie Claire Gauduin
    New England Primate Research Center, Harvard Medical School, Division of Immunology, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    J Immunol Methods 288:61-79. 2004
    ..The use of more sensitive techniques such as ICS permits delineation of antigen-specific cells at the single cell level and should provide new insights into pathogen-specific immune responses in the rhesus macaque model...
  17. pmc Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative Natural Killer T cell subsets in sooty mangabeys
    Namita Rout
    New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
    J Med Primatol 39:224-34. 2010
    ..To investigate differences in the two NKT cell subsets, we compared the phenotype and function of sooty mangabey CD8(+) and DN NKT cells...
  18. pmc Kinetics of T lymphocyte apoptosis and the cellular immune response in SIVmac239-infected rhesus macaques
    Mareike Meythaler
    Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
    J Med Primatol 37:33-45. 2008
    ..Although increased apoptosis is a central feature of AIDS, little is known about its kinetics or relationship to the early host response in acute HIV/SIV infection...
  19. ncbi request reprint Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Transplant 3:1057-64. 2003
    ..GCV and other antiviral agents have limited activities against PCMV in vitro. Breeding of PCMV-free xenograft donors may be necessary to prevent PCMV infections in clinical trials...
  20. pmc Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2
    M Quinn DeGottardi
    Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 82:3139-46. 2008
    ..Thus, selective major histocompatibility complex class I downregulation is a conserved mechanism of immune evasion for pathogenic SIV infection of rhesus macaques and nonpathogenic SIV infection of sooty mangabeys...
  21. pmc Genomic sequence of rhesus cytomegalovirus 180.92: insights into the coding potential of rhesus cytomegalovirus
    Pierre Rivailler
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 80:4179-82. 2006
    ..Like hCMV, understanding of the complete coding capacity of rhCMV is complicated by genomic instability and may require comparisons with additional isolates in vitro and in vivo...
  22. pmc The CD8+ T-cell response to an Epstein-Barr virus-related gammaherpesvirus infecting rhesus macaques provides evidence for immune evasion by the EBNA-1 homologue
    Mark H Fogg
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Virol 79:12681-91. 2005
    ..Thus, the rhLCV animal model can be used to analyze the immune responses important for control of persistent LCV infection and the role of the EBNA-1 GAR for immune evasion in vivo...
  23. ncbi request reprint The BZLF1 homolog of an Epstein-Barr-related gamma-herpesvirus is a frequent target of the CTL response in persistently infected rhesus macaques
    Mark H Fogg
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:3391-401. 2006
    ..These data underscore the utility of the rhLCV-macaque model for studies of EBV pathogenesis...
  24. pmc Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis
    Shari N Gordon
    University of Pennsylvania School of Medicine, 705 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19143, USA
    J Virol 82:3725-35. 2008
    ....
  25. pmc Activation of cytomegalovirus in pig-to-primate organ xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Virol 76:4734-40. 2002
    ..The observation of graft injury by PCMV demonstrates that CMV will be an important pathogen in immunosuppressed xenograft recipients. Strategies must be developed to exclude CMV from porcine organ donors...
  26. pmc Immunogenicity and protective efficacy of DNA vaccines expressing rhesus cytomegalovirus glycoprotein B, phosphoprotein 65-2, and viral interleukin-10 in rhesus macaques
    Yujuan Yue
    Center for Comparative Medicine, University of California Davis, County Rd 98 and Hutchison Dr, Davis, CA 95616, USA
    J Virol 81:1095-109. 2007
    ..These data demonstrated that DNA vaccines targeting the RhCMV homologues of HCMV gB and pp65 altered the course of acute and persistent RhCMV infection in a primate host...
  27. pmc Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts
    Ivona Pandrea
    Tulane National Primate Research Center, Covington, LA 70433, USA
    Blood 109:1069-76. 2007
    ..Beneficial effects of low CCR5 expression on CD4+ T cells may include the reduction of target cells for viral replication and a decreased homing of activated CD4+ T cells to inflamed tissue...
  28. ncbi request reprint Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and H
    Rebecca Elkington
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Australia
    Eur J Immunol 34:3216-26. 2004
    ..In addition, they also provide a functional basis for the conservation of MHC class II lineages between humans and Old World primates and open the possibility for the use of such primate models in vaccine development against HCMV...
  29. ncbi request reprint Characterization and immunological analysis of the rhesus cytomegalovirus homologue (Rh112) of the human cytomegalovirus UL83 lower matrix phosphoprotein (pp65)
    Yujuan Yue
    Center for Comparative Medicine, University of California, Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
    J Gen Virol 87:777-87. 2006
    ..Thus, the rhesus macaque model of HCMV persistence and pathogenesis should be relevant for addressing pp65-based vaccine modalities...
  30. ncbi request reprint HIV: viral blitzkrieg
    R Paul Johnson
    Nature 434:1080-1. 2005
  31. ncbi request reprint Kuru experiments triggered the emergence of pathogenic SIVmac
    Cristian Apetrei
    Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    AIDS 20:317-21. 2006
  32. pmc Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstm
    Cristian Apetrei
    Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Virol 79:8991-9005. 2005
    ..The genetic variability of SIVsm strains among PCs may influence the diagnosis and monitoring of SIVsm infection and, consequently, may bias the results of pathogenesis studies...
  33. ncbi request reprint Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population
    Tonia Woodberry
    Partners AIDS Research Center, Massachusetts General Hospital, Boston 02129, USA
    J Immunol 175:4355-62. 2005
    ....
  34. ncbi request reprint Isolation of viable antigen-specific CD4 T cells by CD40L surface trapping
    George B Cohen
    Department of Biochemistry and Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    J Immunol Methods 302:103-15. 2005
    ....

Research Grants17

  1. INTERACTIONS BETWEEN CMV AND SIV IN RHESUS MACAQUES
    Amitinder Kaur; Fiscal Year: 2007
    ..Specific Aim #3: To examine mechanisms of restoration of CMV-specific immunity in SIV-infected macaques treated with HAART. ..
  2. INTERACTIONS BETWEEN CMV AND SIV IN RHESUS MACAQUES
    Amitinder Kaur; Fiscal Year: 2006
    ..Specific Aim #3: To examine mechanisms of restoration of CMV-specific immunity in SIV-infected macaques treated with HAART. ..
  3. Cell immune responses in SIV-infected sooty mangabeys
    Amitinder Kaur; Fiscal Year: 2004
    ..abstract_text> ..
  4. INTERACTIONS BETWEEN CMV AND SIV IN RHESUS MACAQUES
    Amitinder Kaur; Fiscal Year: 2001
    ..The elucidation of mechanisms underlying interactions between CMV and SIV should help in the design of effective antiviral or immune-based therapeutic strategies to control the morbidity associated with CMV infection in AIDS. ..
  5. Modulation of the early host response to SIV in pathogenic infection
    Amitinder Kaur; Fiscal Year: 2010
    ..Differences in the early innate and adaptive host response to SIV will be studied in SIV infected and vaccinated sooty mangabeys and rhesus macaques. ..