Research Topics
| M J KaufmanSummaryAffiliation: Harvard Medical School Country: USA Publications
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Detail Information
Publications
Cocaine-induced cerebral vasoconstriction detected in humans with magnetic resonance angiographyM J Kaufman
Brain Imaging Center, McLean Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Belmont, Mass 02178, USA
JAMA 279:376-80. 1998..Clinical observations and case reports suggest that there are important cerebrovascular complications of cocaine use, but no studies have documented a direct link...- Cocaine decreases relative cerebral blood volume in humans: a dynamic susceptibility contrast magnetic resonance imaging studyM J Kaufman
Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA
Psychopharmacology (Berl) 138:76-81. 1998..These data suggest that DSC-MRI can detect cocaine-induced CBV reductions indicative of vasoconstriction, and that it may be useful for evaluating treatments designed to reduce the cerebrovascular effects of cocaine... - Cocaine administration induces human splenic constriction and altered hematologic parametersM J Kaufman
Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
J Appl Physiol 85:1877-83. 1998..These events may help to preserve or increase tissue oxygenation in periods of high oxygen demand and/or increased vascular resistance... - Cerebral phosphorus metabolite abnormalities in opiate-dependent polydrug abusers in methadone maintenanceM J Kaufman
Brain Imaging Center, McLean Hospital, MA 02478, USA
Psychiatry Res 90:143-52. 1999..The nearly normal metabolite profile in long-term MMT subjects suggests that prolonged MMT may be associated with improved neurochemistry... - Illicit cocaine use patterns in intravenous-naive cocaine users following investigational intravenous cocaine administrationM J Kaufman
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
Drug Alcohol Depend 58:35-42. 2000..These data suggest that illicit cocaine use frequencies and routes of administration are not altered following investigational intravenous cocaine administration to healthy, occasional cocaine users... - Cocaine-induced cerebral vasoconstriction differs as a function of sex and menstrual cycle phaseM J Kaufman
Brain Imaging Center, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
Biol Psychiatry 49:774-81. 2001..These findings imply that gonadal steroids or the factors they modulate merit study as possible therapeutic agents for reducing cocaine-induced cerebrovascular disorders... - Reduction in BOLD fMRI response to primary visual stimulation following alcohol ingestionJ M Levin
Laboratory for Cerebral Blood Flow, McLean Hospital, Belmont, MA 02178, USA
Psychiatry Res 82:135-46. 1998.... - Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effectsA J Siegel
Department of Medicine, McLean Hospital, Belmont, Mass 02478, USA
Arch Intern Med 159:1925-9. 1999..Mechanisms that mediate cocaine-induced cardiovascular events following vasoconstriction are incompletely understood... - Influence of baseline hematocrit and hemodilution on BOLD fMRI activationJ M Levin
Laboratory for Cerebral Blood Flow, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Magn Reson Imaging 19:1055-62. 2001..Finally, the robust agreement between predicted and empiric data serves to validate a semiquantitative approach to the analysis of BOLD fMRI data... - Brain kinetics of paroxetine and fluoxetine on the third day of placebo substitution: a fluorine MRS studyM E Henry
McLean Hospital, Belmont, MA 02478, USA
Am J Psychiatry 157:1506-8. 2000..This study tested whether a relationship exists between concentration and response following discontinuation of selective serotonin reuptake inhibitors... - Functional magnetic resonance imaging of human brain activation during cue-induced cocaine cravingL C Maas
Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA
Am J Psychiatry 155:124-6. 1998..Functional magnetic resonance imaging (MRI) was used to test whether brain activation was detectable in regions previously associated with cocaine cue-induced craving... - Test-retest reliability of DSC MRI CBV mapping in healthy volunteersM E Henry
Brain Imaging Center, McLean Hospital and The Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Neuroreport 12:1567-9. 2001..08, with a coefficient of variation of 12%. The correlation between scans was 0.84 (p < 0.0001). The data presented here support the hypothesis that DSC MRI CBV mapping has acceptable test-retest reliability... - Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brainB K Madras
Dept of Psychiatry, Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
Synapse 29:105-15. 1998..The selective binding of altropane to the dopamine-rich striatum within 30 min of i.v. administration indicates that it is uniquely suited for SPECT or PET imaging of the dopamine transporter and associated dopamine neurons... - Brain T2 relaxation times correlate with regional cerebral blood volumeC M Anderson
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
MAGMA 18:3-6. 2005..007;r = 0.782,p = 0.004, respectively). These correlations predict 9 +/- 3% and 10 +/- 3% rCBV changes, respectively, for each 1-msec change in T2. Consequently, brain T2 measurements may be useful for estimating steady-state rCBV...