Dennis Kasper

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
    Qun Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:2853-63. 2006
  2. pmc Kdo hydrolase is required for Francisella tularensis virulence and evasion of TLR2-mediated innate immunity
    Nihal A Okan
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    MBio 4:e00638-12. 2013
  3. pmc A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design
    Fikri Y Avci
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:1602-9. 2011
  4. pmc Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in salmonella infection
    Vincent L Chen
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e65405. 2013
  5. doi request reprint A paradigm for commensalism: the role of a specific microbial polysaccharide in health and disease
    Dennis L Kasper
    Channing Laboratory, Brigham and Women s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Nestle Nutr Workshop Ser Pediatr Program 64:1-8; discussion 8-10, 251-7. 2009
  6. ncbi request reprint Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice
    Olga Pozdnyakova
    Department of Pathology, Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:84-90. 2003
  7. ncbi request reprint CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism
    Doo Ryeon Chung
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:1958-63. 2003
  8. doi request reprint Novel tools for modulating immune responses in the host-polysaccharides from the capsule of commensal bacteria
    Suryasarathi Dasgupta
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 106:61-91. 2010
  9. ncbi request reprint A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides
    Yong Hoon Choi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 41:15144-51. 2002
  10. pmc Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation
    Christopher D Velez
    Department of Medicine, Channing Laboratory, Harvard Medical School, Boston, MA, USA
    Immunology 127:73-82. 2009

Research Grants

  1. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2007
  2. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2003
  3. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2000
  4. INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMS
    Dennis Kasper; Fiscal Year: 2007
  5. New England Regional Center of Excellence for Biodefense
    Dennis Kasper; Fiscal Year: 2007
  6. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2006
  7. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 1999
  8. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2001

Collaborators

Detail Information

Publications56

  1. pmc A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
    Qun Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:2853-63. 2006
    ..fragilis. Commensal bacteria, using molecules like PSA, potentially modulate the Th1/Th2 cell balance and the response to infection by coordinating both the innate and adaptive pathways...
  2. pmc Kdo hydrolase is required for Francisella tularensis virulence and evasion of TLR2-mediated innate immunity
    Nihal A Okan
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    MBio 4:e00638-12. 2013
    ..tularensis subsp. tularensis strain Schu S4. These findings suggest an important role for the Francisella Kdo hydrolase system in virulence and offer a novel mutant as a candidate vaccine...
  3. pmc A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design
    Fikri Y Avci
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:1602-9. 2011
    ....
  4. pmc Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in salmonella infection
    Vincent L Chen
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e65405. 2013
    ..LTi-like cells require IL-1R1 for production of protective cytokines and confer protection in infectious colitis, and their cell numbers in the colon depend upon having a microbiome...
  5. doi request reprint A paradigm for commensalism: the role of a specific microbial polysaccharide in health and disease
    Dennis L Kasper
    Channing Laboratory, Brigham and Women s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Nestle Nutr Workshop Ser Pediatr Program 64:1-8; discussion 8-10, 251-7. 2009
    ..Thus polysaccharides of the bacterial microbiota can mediate the critical balance between health and disease in the host. As evidence accumulates, this concept is being accepted as an important feature of the immune repertoire...
  6. ncbi request reprint Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice
    Olga Pozdnyakova
    Department of Pathology, Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:84-90. 2003
    ..The normal immune response in wild-type mice may require localization of polysaccharide to marginal zone B cells with subsequent transfer of the Ag to follicular dendritic cells...
  7. ncbi request reprint CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism
    Doo Ryeon Chung
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:1958-63. 2003
    ..These data delineate the specific T cell response necessary for the development of intra-abdominal abscesses and underscore the role of IL-17 in this disease process...
  8. doi request reprint Novel tools for modulating immune responses in the host-polysaccharides from the capsule of commensal bacteria
    Suryasarathi Dasgupta
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 106:61-91. 2010
    ..These molecules can be used to elucidate the basic biology of the mammalian intestine and have the potential for use in novel therapeutic regimens for various systemic or intestinal pathological conditions...
  9. ncbi request reprint A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides
    Yong Hoon Choi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 41:15144-51. 2002
    ..These results support our hypothesis that T-cell-activating ZPSs assume similar conformational and charge patterns that are recognized by specific receptors and that account for their common property as T-cell activators...
  10. pmc Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation
    Christopher D Velez
    Department of Medicine, Channing Laboratory, Harvard Medical School, Boston, MA, USA
    Immunology 127:73-82. 2009
    ....
  11. ncbi request reprint Zwitterionic capsular polysaccharides: the new MHCII-dependent antigens
    Brian A Cobb
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Cell Microbiol 7:1398-403. 2005
    ..In this review, we explore what is currently known about ZPS processing and presentation within antigen-presenting cells (APCs) and the immune response that follows...
  12. pmc Microbial carbohydrate depolymerization by antigen-presenting cells: deamination prior to presentation by the MHCII pathway
    Jinyou Duan
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:5183-8. 2008
    ..RNSs and ROSs may be involved in the presentation of glycopeptides by MHC molecules via the processing of other carbohydrate-containing antigens, such as bacterial or viral glycoproteins or glycoconjugate vaccines...
  13. ncbi request reprint IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection
    Rachel M McLoughlin
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:1323-32. 2008
    ..aureus pathogenesis by facilitating bacterial survival within the neutrophil. These findings suggest avenues for novel immunomodulatory approaches to control S. aureus infections...
  14. doi request reprint How bacterial carbohydrates influence the adaptive immune system
    Fikri Y Avci
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 28:107-30. 2010
    ....
  15. pmc Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma/delta T cells
    Jinyou Duan
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell Host Microbe 7:140-50. 2010
    ..Thus, commensals orchestrate the expansion of phenotypically distinct gammadelta T cells, and innate immunity is a three-way interaction between host, pathogens, and microbiota...
  16. ncbi request reprint An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    Sarkis K Mazmanian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:107-18. 2005
    ..These findings provide a molecular basis for host-bacterial symbiosis and reveal the archetypal molecule of commensal bacteria that mediates development of the host immune system...
  17. pmc Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 70:1724-38. 2002
    ..When present, these vaccine-induced cross-reacting antibodies conferred in vitro antibody-mediated opsonophagocytosis and killing of both GBS III and Pn14, two pathogens that cause invasive disease in young infants...
  18. ncbi request reprint Quantitative determination of immunoglobulin G specific for group B streptococcal beta C protein in human maternal serum
    Catherine S Lachenauer
    Channing Laboratory and Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Infect Dis 185:368-74. 2002
    ..This difference was not explained by a major difference in epitope specificity...
  19. ncbi request reprint Glycoconjugate vaccines to prevent group B streptococcal infections
    Lawrence C Paoletti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    Expert Opin Biol Ther 3:975-84. 2003
    ..Results from these preclinical and clinical studies strongly suggest that GBS conjugate vaccines will be effective in preventing diseases caused by GBS...
  20. ncbi request reprint Conjugate vaccines against group B Streptococcus types IV and VII
    Lawrence C Paoletti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 186:123-6. 2002
    ..If needed, types IV and VII CPS conjugate vaccines of the design described can be added to the formulation of a multivalent GBS vaccine...
  21. ncbi request reprint Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions
    Wiltrud M Kalka-Moll
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:6149-53. 2002
    ..These results indicate that MHC class II molecules expressing HLA-DR on professional APCs are required for ZPS-induced T cell activation. The implication is that binding of ZPS to HLA-DR may be required for T cell activation...
  22. ncbi request reprint Role of T cells in abscess formation
    Arthur O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Departments of Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Microbiol 5:92-6. 2002
    ..This work describes how zwitterionic polysaccharides on the surface of these organisms interact with the host immune system in general, and with T cells in particular, to coordinate this pathobiologic response...
  23. ncbi request reprint Induction of cross-reactive antibodies by immunization of healthy adults with types Ia and Ib group B streptococcal polysaccharide-tetanus toxoid conjugate vaccines
    Anne Karin Brigtsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 185:1277-84. 2002
    ..These results indicate that GBS Ia and Ib PSs should be included in a multivalent conjugate vaccine to prevent GBS disease...
  24. ncbi request reprint Construction of designer glycoconjugate vaccines with size-specific oligosaccharide antigens and site-controlled coupling
    Julia Y Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Vaccine 21:1112-7. 2003
    ..As an example, we synthesized and evaluated an oligosaccharide-based vaccine against type III group B Streptococcus...
  25. ncbi request reprint Biological chemistry of immunomodulation by zwitterionic polysaccharides
    Arthur Tzianabos
    Department of Medicine, Channing Laboratory, 181 Longwood Ave, Brigham and Women s Hospital, Boston, MA 02115, USA
    Carbohydr Res 338:2531-8. 2003
    ..This review will describe the biological and structural aspects of ZPSs that convey these activities...
  26. ncbi request reprint A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 177:583-92. 2006
    ..We suggest that this process contributes substantially to the serious morbidity associated with neonatal GBS meningitis and may provide a potential therapeutic target...
  27. pmc Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Institute for Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:5903-8. 2008
    ..Targeted chemical engineering of a carbohydrate to create a molecule less like host self may be a rational approach for improving other glycoconjugates...
  28. pmc Beneficial effects of Bacteroides fragilis polysaccharides on the immune system
    Erin B Troy
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Front Biosci (Landmark Ed) 15:25-34. 2010
    ..This review provides an overview of the immunologic properties of PSA including the mechanisms of immune system activation and the resulting immunomodulatory effects...
  29. pmc Orientations of the Bacteroides fragilis capsular polysaccharide biosynthesis locus promoters during symbiosis and infection
    Erin B Troy
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Bacteriol 192:5832-6. 2010
    ..fragilis-induced murine abscesses. Bacteria grown in vivo have greater variability in orientation of polysaccharide locus promoters than culture-grown organisms...
  30. pmc Polysaccharide processing and presentation by the MHCII pathway
    Brian A Cobb
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell 117:677-87. 2004
    ..Our observations begin to elucidate the mechanisms by which some carbohydrates induce important immunologic responses through T cell activation, suggesting a fundamental shift in the MHCII presentation paradigm...
  31. pmc CD4+ T cells regulate surgical and postinfectious adhesion formation
    Doo Ryeon Chung
    Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    J Exp Med 195:1471-8. 2002
    ....
  32. doi request reprint Symbiotic commensal bacteria direct maturation of the host immune system
    Sanna M Edelman
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Gastroenterol 24:720-4. 2008
    ..The present review summarizes recent findings in the field and describes new knowledge on the interplay of the innate and adaptive arms of the immune response induced by symbiotic bacterial carbohydrate antigens...
  33. pmc A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity
    Shite Sebastian
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Infect Immun 75:2591-602. 2007
    ..tularensis type B. Recognition and characterization of the pivotal role of O-PS in the virulence of this intracellular bacterial pathogen may have broad implications for the creation of a safe and efficacious vaccine...
  34. pmc 3-Deoxy-D-manno-octulosonic acid (Kdo) hydrolase identified in Francisella tularensis, Helicobacter pylori, and Legionella pneumophila
    Sabina Chalabaev
    Department of Microbiology and Molecular Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:34330-6. 2010
    ..The identification of this previously faceless enzyme will accelerate study of the biosynthetic basis and biologic impact for postbiosynthetic LPS structural modification...
  35. pmc Cellular and humoral immunity are synergistic in protection against types A and B Francisella tularensis
    Shite Sebastian
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Vaccine 27:597-605. 2009
    ..tularensis and provide important insight into the development of a safer vaccine effective against infections caused by clinical type A and B strains of F. tularensis...
  36. ncbi request reprint Bacterial glycans: key mediators of diverse host immune responses
    Laurie E Comstock
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 126:847-50. 2006
    ..Here, we discuss the diverse interactions between bacterial glycans and the host immune system...
  37. pmc Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Clin Immunol 130:264-71. 2009
    ..B1 cells were expanded in peritonium but not in spleen of MBL null mice. The mechanisms of heightened IgG response in MBL null mice were related to C3, and share the same pathway with IgM...
  38. pmc Modulation of surgical fibrosis by microbial zwitterionic polysaccharides
    Begonia Ruiz-Perez
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:16753-8. 2005
    ....
  39. pmc Regulation of virulence by a two-component system in group B streptococcus
    Sheng Mei Jiang
    Channing Laboratory, Brigham and Women s Hospital, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Bacteriol 187:1105-13. 2005
    ..Together, these results indicate that CsrRS regulates expression of multiple GBS virulence determinants and is likely to play an important role in GBS pathogenesis...
  40. ncbi request reprint Coming of age: carbohydrates and immunity
    Brian A Cobb
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur J Immunol 35:352-6. 2005
    ..With the common presence of carbohydrate molecules on eukaryotic, prokaryotic, and viral surfaces, the impact of carbohydrates on adaptive immunity is now indisputable...
  41. pmc Small molecule control of virulence gene expression in Francisella tularensis
    James C Charity
    Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 5:e1000641. 2009
    ..Through its responsiveness to ppGpp, the contact between PigR and the MglA-SspA complex allows the integration of nutritional cues into the regulatory network governing virulence gene expression...
  42. ncbi request reprint Case records of the Massachusetts General Hospital. Case 25-2005. A 40-year-old man with prolonged fever and weight loss
    Dennis L Kasper
    Department of Medicine, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 353:713-22. 2005
  43. pmc Anchors away: contribution of a glycolipid anchor to bacterial invasion of host cells
    Miriam J Baron
    The Channing Laboratory and the Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 115:2325-7. 2005
    ..The mechanism involved most likely relates to the gene product's role in synthesis of a glycolipid anchor for a bacterial cell-surface entity that interacts directly with host cells...
  44. ncbi request reprint Group A streptococcus epidemiology and vaccine implications
    Ronit Cohen-Poradosu
    Clin Infect Dis 45:863-5. 2007
  45. pmc Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae
    Herve Tettelin
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 99:12391-6. 2002
    ..agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms...
  46. ncbi request reprint Immune response of healthy women to 2 different group B streptococcal type V capsular polysaccharide-protein conjugate vaccines
    Carol J Baker
    Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 189:1103-12. 2004
    ..Infections caused by group B streptococcal (GBS) type V are increasingly common. Capsular polysaccharide (CPS)-protein conjugate GBS vaccines are immunogenic in healthy adults, but type V vaccines have not previously been tested...
  47. pmc Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation
    Tom Li Stephen
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Medical Center, Goldenfelsstr 19 21, 50935 Cologne, Germany
    Infect Immun 73:2184-9. 2005
    ..The implication is that activation of ZPS-specific T cells requires an orchestrated arrangement of both presenting and costimulatory molecules to form an immunological synapse...
  48. ncbi request reprint Role of lipoteichoic acid in the phagocyte response to group B streptococcus
    Philipp Henneke
    Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Immunol 174:6449-55. 2005
    ..In conclusion, LTA from GBS is a TLR2/TLR6 ligand that might contribute to secreted GBS activity, but does not contribute significantly to GBS cell wall mediated macrophage activation...
  49. pmc Identification of a universal Group B streptococcus vaccine by multiple genome screen
    Domenico Maione
    Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy
    Science 309:148-50. 2005
    ..Multigenome analysis and screening described here represent a powerful strategy for identifying potential vaccine candidates against highly variable pathogens...
  50. ncbi request reprint Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways
    Philipp Henneke
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 169:3970-7. 2002
    ..We conclude that the inflammatory, bactericidal, and phagocytic responses to GBS occur via parallel but independent processes...
  51. ncbi request reprint Safety and immunogenicity of a bivalent group B streptococcal conjugate vaccine for serotypes II and III
    Carol J Baker
    Sections of Infectious Diseases, Department of Pediatrics, and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 188:66-73. 2003
    ..These results support the feasibility of a multivalent vaccine for the 5 prevalent invasive disease-causing GBS CPS serotypes...
  52. ncbi request reprint The love-hate relationship between bacterial polysaccharides and the host immune system
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Mail Code 156 29, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Immunol 6:849-58. 2006
    ..This process seems to contribute to the overall health of the host by offering protection against various diseases and might provide supporting evidence at a molecular level for the 'hygiene hypothesis' of allergic immune disorders...
  53. pmc Regulation of surface architecture by symbiotic bacteria mediates host colonization
    Cui Hua Liu
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:3951-6. 2008
    ..These findings suggest a model whereby display of multiple capsular polysaccharides provides essential functions for bacterial colonization during host-symbiont mutualism...
  54. doi request reprint A microbial symbiosis factor prevents intestinal inflammatory disease
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 453:620-5. 2008
    ..Harnessing the immunomodulatory capacity of symbiosis factors such as PSA might potentially provide therapeutics for human inflammatory disorders on the basis of entirely novel biological principles...
  55. ncbi request reprint Zwitterionic polysaccharides stimulate T cells with no preferential V beta usage and promote anergy, resulting in protection against experimental abscess formation
    Francesca Stingele
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    J Immunol 172:1483-90. 2004
    ..Taken together, the data show that this class of polysaccharides interacts directly with T cells in a nonbiased manner to elicit an IL-2-dependent anergic response that confers protection against abscess formation...
  56. pmc Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome"
    Herve Tettelin
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 102:13950-5. 2005
    ..Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactiae pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes...

Research Grants14

  1. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2007
    ..abstract_text> ..
  2. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2003
    ..abstract_text> ..
  3. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2000
    ..One of the ultimate goals of this investigation is to understand how polysaccharides activate T cells, which might in turn lead to the design of the interventional strategies for potential new vaccines. ..
  4. INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMS
    Dennis Kasper; Fiscal Year: 2007
    ..Although only eight positions per year are supported by this grant, 175 postdoctoral trainees are currently being funded by our training program in the laboratories of the 39 participating research mentors. ..
  5. New England Regional Center of Excellence for Biodefense
    Dennis Kasper; Fiscal Year: 2007
    ..Thus, the NERCE will greatly improve the preparedness of the United States to resist and respond to attacks by infectious agents, whether their source is bioterrorism or nature. ..
  6. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2006
    ..abstract_text> ..
  7. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 1999
    ..One of the ultimate goals of this investigation is to understand how polysaccharides activate T cells, which might in turn lead to the design of the interventional strategies for potential new vaccines. ..
  8. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2001
    ..One of the ultimate goals of this investigation is to understand how polysaccharides activate T cells, which might in turn lead to the design of the interventional strategies for potential new vaccines. ..