D L Kasper

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine
    D L Kasper
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 98:2308-14. 1996
  2. pmc Effects of chain length on the immunogenicity in rabbits of group B Streptococcus type III oligosaccharide-tetanus toxoid conjugates
    L C Paoletti
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts
    J Clin Invest 89:203-9. 1992
  3. ncbi request reprint Synthesis and preclinical evaluation of glycoconjugate vaccines against group B Streptococcus types VI and VIII
    L C Paoletti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Infect Dis 180:892-5. 1999
  4. pmc Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines
    H K Guttormsen
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 67:6375-84. 1999
  5. pmc Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci
    M J Coyne
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 68:6176-81. 2000
  6. ncbi request reprint Ozonolytic depolymerization of polysaccharides in aqueous solution
    Y Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carbohydr Res 319:141-7. 1999
  7. ncbi request reprint Maternal antibody transfer in baboons and mice vaccinated with a group B streptococcal polysaccharide conjugate
    L C Paoletti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Infect Dis 181:653-8. 2000
  8. ncbi request reprint Protection against experimental intraabdominal sepsis by two polysaccharide immunomodulators
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 178:200-6. 1998
  9. ncbi request reprint Cellular mechanism of intraabdominal abscess formation by Bacteroides fragilis
    F C Gibson
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 160:5000-6. 1998
  10. pmc Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model
    H K Guttormsen
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 66:2026-32. 1998

Collaborators

Detail Information

Publications27

  1. pmc Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine
    D L Kasper
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 98:2308-14. 1996
    ....
  2. pmc Effects of chain length on the immunogenicity in rabbits of group B Streptococcus type III oligosaccharide-tetanus toxoid conjugates
    L C Paoletti
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts
    J Clin Invest 89:203-9. 1992
    ..These opposing trends may account for the optimal immunogenicity of an intermediate-size group B Streptococcus type III oligosaccharide conjugate vaccine...
  3. ncbi request reprint Synthesis and preclinical evaluation of glycoconjugate vaccines against group B Streptococcus types VI and VIII
    L C Paoletti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Infect Dis 180:892-5. 1999
    ..GBS types VI and VIII conjugate vaccines of the design presented may be important components of a multivalent GBS vaccine for use in regions where these serotypes predominate...
  4. pmc Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines
    H K Guttormsen
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 67:6375-84. 1999
    ..Comparable results were obtained with pathway antagonists. These data suggest that MHC class II Ag-TCR, B7-CD28, and CD40-CD40L interactions are critical for immune responses to glycoconjugate vaccines in vivo...
  5. pmc Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci
    M J Coyne
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 68:6176-81. 2000
    ..Although purified PS B can induce abscesses, removal of this polysaccharide does not attenuate the organism's ability to induce abscesses...
  6. ncbi request reprint Ozonolytic depolymerization of polysaccharides in aqueous solution
    Y Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carbohydr Res 319:141-7. 1999
    ..The ozonolysis method described herein provides a convenient, inexpensive, and controllable means for generating small polysaccharides or large oligosaccharide fragments...
  7. ncbi request reprint Maternal antibody transfer in baboons and mice vaccinated with a group B streptococcal polysaccharide conjugate
    L C Paoletti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Infect Dis 181:653-8. 2000
    ..These preclinical studies provide further evidence for effective immunogenicity of GBS conjugate vaccine and efficient transport of functionally active maternal antibody...
  8. ncbi request reprint Protection against experimental intraabdominal sepsis by two polysaccharide immunomodulators
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 178:200-6. 1998
    ....
  9. ncbi request reprint Cellular mechanism of intraabdominal abscess formation by Bacteroides fragilis
    F C Gibson
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 160:5000-6. 1998
    ..These results illustrated the role of the CPC in promoting adhesion of B. fragilis to the peritoneal wall and coordinating the cellular events leading to the development of abscesses associated with experimental intraabdominal sepsis...
  10. pmc Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model
    H K Guttormsen
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 66:2026-32. 1998
    ....
  11. ncbi request reprint T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria
    A O Tzianabos
    Channing Laboratory, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115, USA
    J Biol Chem 275:6733-40. 2000
    ..These studies demonstrate that bacterial polysaccharides with a distinct charge motif activate T cells and that this activity confers immunity to a distinct pathologic response to bacterial infection...
  12. ncbi request reprint Functional analysis in type Ia group B Streptococcus of a cluster of genes involved in extracellular polysaccharide production by diverse species of streptococci
    M J Cieslewicz
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:139-46. 2001
    ..We conclude that CpsA to -D are not required for polysaccharide repeating unit biosynthesis but rather that they direct the coordinated polymerization and export of high molecular weight polysaccharide...
  13. ncbi request reprint Extensive surface diversity of a commensal microorganism by multiple DNA inversions
    C M Krinos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:555-8. 2001
    ....
  14. ncbi request reprint IL-2 mediates protection against abscess formation in an experimental model of sepsis
    A O Tzianabos
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 163:893-7. 1999
    ..These data demonstrate that PS A-mediated protection against abscess formation is dependent upon a CD4+ T cell-dependent response, and that IL-2 is essential to this immune mechanism...
  15. ncbi request reprint Antibody responses in invasive group B streptococcal infection in adults
    M R Wessels
    Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 178:569-72. 1998
    ....
  16. pmc Structural properties of group B streptococcal type III polysaccharide conjugate vaccines that influence immunogenicity and efficacy
    M R Wessels
    Channing Laboratory, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 66:2186-92. 1998
    ..We conclude that conjugate size, polysaccharide size, and degree of polysaccharide-protein cross-linking influence the immunogenicity and protective efficacy of III-TT conjugate vaccines...
  17. pmc Effects of alum adjuvant or a booster dose on immunogenicity during clinical trials of group B streptococcal type III conjugate vaccines
    L C Paoletti
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 69:6696-701. 2001
    ....
  18. pmc Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis
    Y Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:13478-83. 2000
    ..The three-dimensional structure of PS A2 explicitly suggests mechanisms of interaction between zwitterionic polysaccharides and proteins...
  19. ncbi request reprint Structure of an antigenic teichoic acid shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium
    Y Wang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 5804, USA
    Carbohydr Res 316:155-60. 1999
    ..It was composed of glucose, glycerol, and phosphate as determined by chemical and GC-MS analysis. The repeating-unit structure was elucidated by a series of 1H, 13C, and 31P NMR spectroscopy to be the following: [formula: see text]..
  20. pmc Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strain
    W M Kalka-Moll
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 69:2339-44. 2001
    ..Relationships among structural components of the zwitterionic polysaccharides and their molecular biosynthesis loci were identified...
  21. pmc Immunogenicity and protective efficacy of the alpha C protein of group B streptococci are inversely related to the number of repeats
    C Gravekamp
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 65:5216-21. 1997
    ....
  22. ncbi request reprint Serotypes VI and VIII predominate among group B streptococci isolated from pregnant Japanese women
    C S Lachenauer
    Division of Infectious Diseases, Children s Hospital, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Infect Dis 179:1030-3. 1999
    ..These data show that type VI and VIII GBS strains are common vaginal isolates in pregnant Japanese women and that one or more laddering proteins are present in most GBS strains...
  23. pmc Genetic diversity of the capsular polysaccharide C biosynthesis region of Bacteroides fragilis
    L E Comstock
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 68:6182-8. 2000
    ..The data suggest that the synthesis of polysaccharides that have zwitterionic characteristics rendering them able to induce abscesses is common in B. fragilis...
  24. pmc Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis
    M J Coyne
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 69:4342-50. 2001
    ..Conservation of these genes suggests that this sugar is present in the PS A of all serotypes and may explain the abscessogenic nature of B. fragilis...
  25. pmc Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilis
    L E Comstock
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 67:3525-32. 1999
    ..fragilis 9343. The virulence of the polysaccharide B-deficient mutant was comparable to that of the wild type in terms of its ability to induce abscesses in a rat model of intra-abdominal infection...
  26. pmc Interstrain variation of the polysaccharide B biosynthesis locus of Bacteroides fragilis: characterization of the region from strain 638R
    L E Comstock
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 181:6192-6. 1999
    ..fragilis NCTC 9343. Two genes of the region, wcgD and wcgC, are shown by complementation to encode a UDP-N-acetylglucosamine 2-epimerase and a UDP-N-acetylmannosamine dehydrogenase, respectively...
  27. pmc Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci
    J L Michel
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 89:10060-4. 1992
    ..The large region of identical repeating units in bca defines protective epitopes and may play a role in generating phenotypic and genotypic diversity of the alpha antigen...