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Genomes and Genes | D L KasperSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccineD L Kasper
Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Clin Invest 98:2308-14. 1996....- Effects of chain length on the immunogenicity in rabbits of group B Streptococcus type III oligosaccharide-tetanus toxoid conjugatesL C Paoletti
Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts
J Clin Invest 89:203-9. 1992..These opposing trends may account for the optimal immunogenicity of an intermediate-size group B Streptococcus type III oligosaccharide conjugate vaccine... 
Synthesis and preclinical evaluation of glycoconjugate vaccines against group B Streptococcus types VI and VIIIL C Paoletti
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Infect Dis 180:892-5. 1999..GBS types VI and VIII conjugate vaccines of the design presented may be important components of a multivalent GBS vaccine for use in regions where these serotypes predominate...- Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccinesH K Guttormsen
Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 67:6375-84. 1999..Comparable results were obtained with pathway antagonists. These data suggest that MHC class II Ag-TCR, B7-CD28, and CD40-CD40L interactions are critical for immune responses to glycoconjugate vaccines in vivo... - Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis lociM J Coyne
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 68:6176-81. 2000..Although purified PS B can induce abscesses, removal of this polysaccharide does not attenuate the organism's ability to induce abscesses... - Ozonolytic depolymerization of polysaccharides in aqueous solutionY Wang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Carbohydr Res 319:141-7. 1999..The ozonolysis method described herein provides a convenient, inexpensive, and controllable means for generating small polysaccharides or large oligosaccharide fragments... - Maternal antibody transfer in baboons and mice vaccinated with a group B streptococcal polysaccharide conjugateL C Paoletti
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Infect Dis 181:653-8. 2000..These preclinical studies provide further evidence for effective immunogenicity of GBS conjugate vaccine and efficient transport of functionally active maternal antibody... - Protection against experimental intraabdominal sepsis by two polysaccharide immunomodulatorsA O Tzianabos
Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Infect Dis 178:200-6. 1998.... - Cellular mechanism of intraabdominal abscess formation by Bacteroides fragilisF C Gibson
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 160:5000-6. 1998..These results illustrated the role of the CPC in promoting adhesion of B. fragilis to the peritoneal wall and coordinating the cellular events leading to the development of abscesses associated with experimental intraabdominal sepsis... - Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer modelH K Guttormsen
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 66:2026-32. 1998.... - T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteriaA O Tzianabos
Channing Laboratory, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115, USA
J Biol Chem 275:6733-40. 2000..These studies demonstrate that bacterial polysaccharides with a distinct charge motif activate T cells and that this activity confers immunity to a distinct pathologic response to bacterial infection... - Functional analysis in type Ia group B Streptococcus of a cluster of genes involved in extracellular polysaccharide production by diverse species of streptococciM J Cieslewicz
Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 276:139-46. 2001..We conclude that CpsA to -D are not required for polysaccharide repeating unit biosynthesis but rather that they direct the coordinated polymerization and export of high molecular weight polysaccharide... - Extensive surface diversity of a commensal microorganism by multiple DNA inversionsC M Krinos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 414:555-8. 2001.... - IL-2 mediates protection against abscess formation in an experimental model of sepsisA O Tzianabos
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 163:893-7. 1999..These data demonstrate that PS A-mediated protection against abscess formation is dependent upon a CD4+ T cell-dependent response, and that IL-2 is essential to this immune mechanism... - Antibody responses in invasive group B streptococcal infection in adultsM R Wessels
Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
J Infect Dis 178:569-72. 1998.... - Structural properties of group B streptococcal type III polysaccharide conjugate vaccines that influence immunogenicity and efficacyM R Wessels
Channing Laboratory, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 66:2186-92. 1998..We conclude that conjugate size, polysaccharide size, and degree of polysaccharide-protein cross-linking influence the immunogenicity and protective efficacy of III-TT conjugate vaccines... - Effects of alum adjuvant or a booster dose on immunogenicity during clinical trials of group B streptococcal type III conjugate vaccinesL C Paoletti
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 69:6696-701. 2001.... - Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilisY Wang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 97:13478-83. 2000..The three-dimensional structure of PS A2 explicitly suggests mechanisms of interaction between zwitterionic polysaccharides and proteins... - Structure of an antigenic teichoic acid shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faeciumY Wang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 5804, USA
Carbohydr Res 316:155-60. 1999..It was composed of glucose, glycerol, and phosphate as determined by chemical and GC-MS analysis. The repeating-unit structure was elucidated by a series of 1H, 13C, and 31P NMR spectroscopy to be the following: [formula: see text].. - Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strainW M Kalka-Moll
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 69:2339-44. 2001..Relationships among structural components of the zwitterionic polysaccharides and their molecular biosynthesis loci were identified... - Immunogenicity and protective efficacy of the alpha C protein of group B streptococci are inversely related to the number of repeatsC Gravekamp
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 65:5216-21. 1997.... - Serotypes VI and VIII predominate among group B streptococci isolated from pregnant Japanese womenC S Lachenauer
Division of Infectious Diseases, Children s Hospital, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Infect Dis 179:1030-3. 1999..These data show that type VI and VIII GBS strains are common vaginal isolates in pregnant Japanese women and that one or more laddering proteins are present in most GBS strains... - Genetic diversity of the capsular polysaccharide C biosynthesis region of Bacteroides fragilisL E Comstock
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 68:6182-8. 2000..The data suggest that the synthesis of polysaccharides that have zwitterionic characteristics rendering them able to induce abscesses is common in B. fragilis... - Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilisM J Coyne
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 69:4342-50. 2001..Conservation of these genes suggests that this sugar is present in the PS A of all serotypes and may explain the abscessogenic nature of B. fragilis... - Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilisL E Comstock
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 67:3525-32. 1999..fragilis 9343. The virulence of the polysaccharide B-deficient mutant was comparable to that of the wild type in terms of its ability to induce abscesses in a rat model of intra-abdominal infection... - Interstrain variation of the polysaccharide B biosynthesis locus of Bacteroides fragilis: characterization of the region from strain 638RL E Comstock
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Bacteriol 181:6192-6. 1999..fragilis NCTC 9343. Two genes of the region, wcgD and wcgC, are shown by complementation to encode a UDP-N-acetylglucosamine 2-epimerase and a UDP-N-acetylmannosamine dehydrogenase, respectively... - Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococciJ L Michel
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA
Proc Natl Acad Sci U S A 89:10060-4. 1992..The large region of identical repeating units in bca defines protective epitopes and may play a role in generating phenotypic and genotypic diversity of the alpha antigen...