Research Topics
| A W KarchmerSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Nosocomial bloodstream infections: organisms, risk factors, and implicationsA W Karchmer
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Clin Infect Dis 31:S139-43. 2000..Therefore, newer, more effective antimicrobial therapies are needed to treat BSIs caused by gram-positive cocci are needed...- Infections of intracardiac devicesAdolf W Karchmer
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Kennedy 6, Boston, MA 02215, USA
Infect Dis Clin North Am 16:477-505, xii. 2002..This article reviews the epidemiology, microbiology, clinical presentation, and medical as well as surgical therapy of intracardiac device infections... - Infections of intracardiac devicesAdolf W Karchmer
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Cardiol Clin 21:253-71, vii. 2003..This article reviews the epidemiology, microbiology, clinical presentation, and medical as well as surgical therapy of intracardiac device infections... - Clinical effectiveness and cost-effectiveness of 2 management strategies for infected total hip arthroplasty in the elderlyD N Fisman
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, MA, USA
Clin Infect Dis 32:419-30. 2001..In the absence of prospective clinical trials, debridement and retention is a reasonable strategy for treatment of older persons with staphylococcal or streptococcal infection and a nonloosened prosthesis... 
Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patientsStephen G Weber
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Emerg Infect Dis 9:1415-22. 2003..4; p <0.0001; ciprofloxacin OR 2.5; p = 0.005) but not MSSA. Exposure to levofloxacin or ciprofloxacin is a significant risk factor for the isolation of MRSA, but not MSSA...- Outcomes with daptomycin versus standard therapy for osteoarticular infections associated with Staphylococcus aureus bacteraemiaT Lalani
Division of Infectious Diseases, Duke Clinical Research Institute, Durham, NC, USA
J Antimicrob Chemother 61:177-82. 2008..To evaluate the clinical characteristics, treatment and outcomes of patients with osteoarticular infections (OAIs) associated with Staphylococcus aureus bacteraemia (SAB)... - The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital chargesSara E Cosgrove
Division of Infectious Diseases, Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Infect Control Hosp Epidemiol 26:166-74. 2005..To evaluate the impact of methicillin resistance in Staphylococcus aureus on mortality, length of hospitalization, and hospital charges... - Preventing the influx of vancomycin-resistant enterococci into health care institutions, by use of a simple validated prediction ruleEvelina Tacconelli
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Clin Infect Dis 39:964-70. 2004..The goal of this study was to develop a validated prediction rule for identification of patients harboring vancomycin-resistant enterococci (VRE) at hospital admission... - Non-HACEK gram-negative bacillus endocarditisSusan Morpeth
Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27710, USA
Ann Intern Med 147:829-35. 2007.... - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-2004. A 75-year-old woman with acute onset of chest pain followed by feverAdolf W Karchmer
Division of Infectious Diseases, Beth Israel Deaconess Medical Center. Boston, USA
N Engl J Med 351:1240-8. 2004 - Increased antibiotic resistance in respiratory tract pathogens: PROTEKT US--an updateAdolf W Karchmer
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215 5399, USA
Clin Infect Dis 39:S142-50. 2004..The patterns of resistance detected by these major surveillance programs are a warning signal regarding the continued emergence of resistance among community-acquired respiratory tract pathogens... - Epidemiological comparison of true methicillin-resistant and methicillin-susceptible coagulase-negative staphylococcal bacteremia at hospital admissionEvelina Tacconelli
Beth Israel Deaconess Medical Center and Division of Infectious Diseases, Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Infect Dis 37:644-9. 2003.... - Methicillin-resistant Staphylococcus aureus: an evolving clinical challengeAdolf W Karchmer
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Clin Infect Dis 46:S342-3. 2008 - Detection of Staphylococcus aureus in peripheral blood stem cell cultures after sterilization of standard blood culturesMitchell J Schwaber
Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Clin Apher 18:37-9. 2003..Cultures of apheresis product may be more sensitive to the presence of bacteremia than standard blood cultures, and they should guide clinical decisions when the bacteria isolated are potential pathogens or suggest clinical infection... 
Risk factors for albicans and non-albicans candidemia in the intensive care unitJennifer K Chow
Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
Crit Care Med 36:1993-8. 2008..To determine risk factors for bloodstream infections (BSI) with Candida non-albicans (C-NA) species and Candida albicans (CA) among critically ill patients...- Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysisSara E Cosgrove
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
Clin Infect Dis 36:53-9. 2003..54-2.42; P<.001); significant heterogeneity was present. We explored the reasons for heterogeneity by means of subgroup analyses. MRSA bacteremia is associated with significantly higher mortality rate than is MSSA bacteremia... - Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureusVance G Fowler
Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 355:653-65. 2006..Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed... - Factors associated with candidemia caused by non-albicans Candida species versus Candida albicans in the intensive care unitJennifer K Chow
Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Clin Infect Dis 46:1206-13. 2008..We examined factors associated with BSIs due to non-albicans Candida species, compared with C. albicans BSIs, in an ICU patient population... - Prosthetic joint infectionsIrene G Sia
Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Infect Dis Clin North Am 19:885-914. 2005..If surgery is not possible, an alternative is long-term oral antimicrobial suppression to maintain a functioning prosthesis. Treatment must be individualized for a specific infection in a specific patient... - Diagnosis and treatment of diabetic foot infectionsBenjamin A Lipsky
Medical Service, Veterans Affairs Puget Sound Health Care System, and Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108-9804, USA
Clin Infect Dis 39:885-910. 2004 - Cardiology patient page. Bacterial endocarditis: the disease, treatment, and preventionChristopher H Cabell
Duke University School of Medicine and Duke Clinical Research Institute, Durham, NC, USA
Circulation 107:e185-7. 2003 - A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjectsJohn H Rex
Division of Infectious Diseases, University of Texas Medical School, Houston, TX 77030, USA
Clin Infect Dis 36:1221-8. 2003..02). In nonneutropenic subjects, the combination of fluconazole plus AmB was not antagonistic compared with fluconazole alone, and the combination trended toward improved success and more-rapid clearance from the bloodstream... - Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapyCarol L Addy
Department of Internal Medicine, Endocrinology-Hypertension Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 88:627-36. 2003..Thus, adiponectin replacement may be a potential treatment option to ameliorate the metabolic changes observed in this patient population... - Empirical fluconazole versus placebo for intensive care unit patients: a randomized trialMindy G Schuster
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 149:83-90. 2008..Invasive infection with Candida species is an important cause of morbidity and mortality in intensive care unit (ICU) patients. Optimal preventive strategies have not been clearly defined...