Research Topics
Genomes and Genes
Species | D KarasikSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham StudyKathryn L Lunetta
The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S13. 2007..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...- Genome-wide association with bone mass and geometry in the Framingham Heart StudyDouglas P Kiel
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
BMC Med Genet 8:S14. 2007..There have been no genome-wide association and linkage studies for these traits using high-density genotyping platforms... - Genetics of the musculoskeletal system: a pleiotropic approachDavid Karasik
Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02131, USA
J Bone Miner Res 23:788-802. 2008.... 
Evidence for pleiotropic factors in genetics of the musculoskeletal systemDavid Karasik
Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
Bone 46:1226-37. 2010..This may translate into new approaches to reduce the burden of both conditions, which are prevalent in the elderly population...- A genome wide linkage scan of metacarpal size and geometry in the Framingham StudyDavid Karasik
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts 02131, USA
Am J Hum Biol 20:663-70. 2008..Genes in these regions may regulate bone geometry via effects on body size. Identification and subsequent characterization of loci for bone geometry can further elucidate the genetic contributions to bone's resistance to stress... - Contribution of gender-specific genetic factors to osteoporosis riskD Karasik
Hebrew SeniorLife IFAR and Harvard Medical School, Boston, MA 02131, USA
Ann Hum Genet 72:696-714. 2008..We conclude that there is need to consider gender-specific genetic and environmental factors in the planning of future association studies on the etiology of osteoporosis and other complex diseases prevalent in the general population... - Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHAReDavid Karasik
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
Bone 46:1114-21. 2010..Subsequent focus on the spectrum of genetic polymorphisms in these refined regions may contribute to finding variants predisposing to osteoporosis... - How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of agingDavid Karasik
Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
Age (Dordr) 33:49-62. 2011..Comprehensive databases on biomarkers of musculoskeletal aging in multiple large cohort studies, along with information on various health outcomes, are needed to validate the proposed measure of biological aging... - Osteoporosis: an evolutionary perspectiveDavid Karasik
Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
Hum Genet 124:349-56. 2008..The answer to the above questions will help us to identify causes of the current epidemic of osteoporosis and to pin-point a tailored treatment... - Bivariate linkage study of proximal hip geometry and body size indices: the Framingham studyD Karasik
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
Calcif Tissue Int 81:162-73. 2007.... - Proximal hip geometry is linked to several chromosomal regions: genome-wide linkage results from the Framingham Osteoporosis StudyS Demissie
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Bone 40:743-50. 2007..The purpose of this study was to evaluate heritability (h(2)) of geometric indices of the proximal hip and to perform whole-genome linkage analyses of these traits, adjusted for body size... 
Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: the Framingham StudyD Karasik
Hebrew Rehabilitation Center for Aged and Harvard Medical School, Boston, Massachusetts 02131, USA
J Bone Miner Res 17:1718-27. 2002..92 at 14q21.3 with lumbar spine BMD. This largest genome screen to date for genes underlying normal variation in BMD, adjusted for a large number of covariates, will help to identify new positional candidate genes, otherwise unrecognized...- Age, gender, and body mass effects on quantitative trait loci for bone mineral density: the Framingham StudyD Karasik
Hebrew Rehabilitation Center for Aged Research and Training Institute and Harvard Medical School, Division on Aging, Boston, MA 02131, USA
Bone 33:308-16. 2003..Evaluation of family members stratified in homogeneous groups may be warranted in genetic studies of bone mass... - Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humansK Cho
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Bone 42:53-60. 2008..Thus, NOS3 genetic variation does not appear to be a major contributor to adult bone density/ultrasound and geometry in our sample... - Genome screen for a combined bone phenotype using principal component analysis: the Framingham studyD Karasik
Harvard Medical School Division on Aging, Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, MA 02131, USA
Bone 34:547-56. 2004.... - Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysisD Karasik
Hebrew Rehabilitation Center for Aged and Harvard Medical School, Boston, MA 02131, USA
Osteoporos Int 13:796-802. 2002..In conclusion, our results suggest that there may be genetic determinants for BUA on 1p36.3. These results should encourage further investigations of the genetic source of QUS variability and candidate polymorphisms in this region... - Abdominal aortic calcification and exostoses at the hand and lumbar spine: the Framingham StudyD Karasik
Hebrew SeniorLife and Harvard Medical School, Boston, MA, USA
Calcif Tissue Int 78:1-8. 2006..In conclusion, in this cross-sectional study, anterior lumbar osteophytes and AAC occurred in the same individuals after adjustment for age and other covariates. In general, hand exostoses were not associated with aortic calcification... - Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hipElizabeth J Samelson
Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
J Clin Endocrinol Metab 93:1789-95. 2008..We conducted a cross-sectional study to evaluate the association between plasma OPG and femoral neck (FN) bone density (BMD) and geometry in a large cohort of women and men... - Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham StudyDavid Karasik
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
J Bone Miner Res 25:1555-63. 2010..Most of the similarity between the quantitative bone phenotypes may be attributed to pleiotropic effects of genes. This knowledge may prove helpful in defining the best phenotypes to be used in genetic studies of osteoporosis... - Hip structural geometry in old and old-old age: similarities and differences between men and womenLaurel B Yates
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
Bone 41:722-32. 2007.... - Genetic contribution to biological aging: the Framingham StudyDavid Karasik
Hebrew Rehabilitation Center for Aged, and Harvard Medical School, Boston, MA 02131, USA
J Gerontol A Biol Sci Med Sci 59:218-26. 2004..In conclusion, the variation in BA measured by radiography was strongly governed by genetic factors in a sample of American adults... - Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate statusRobert R McLean
Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 01702, USA
J Bone Miner Res 19:410-8. 2004..Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status... - Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham studyDavid Karasik
Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA
J Bone Miner Res 24:710-8. 2009..Identification and subsequent characterization of these shared loci may further elucidate the genetic contributions to both osteoporosis and sarcopenia... - Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measuresDavid Karasik
Hebrew Rehabilitation Center for Aged, Research and Training Institute, 1200 Centre Street, Boston, MA 02131, USA
J Gerontol A Biol Sci Med Sci 60:574-87. 2005..The aim of this review is twofold: first, to summarize growing consensus on reliable methods of biological age assessment, and second, to demonstrate validity of this phenotype for research in the genetics of aging in humans... - Bone geometry and skeletal fragilityMary L Bouxsein
Orthopedic Biomechanics Laboratory, RN115, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Curr Osteoporos Rep 4:49-56. 2006..Additional studies that incorporate three-dimensional imaging are needed to better define the relationship between bone geometry and skeletal fragility, and to establish the clinical utility of bone geometry measurements... - Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in menDouglas P Kiel
Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA
Bone 40:587-96. 2007..These observations suggest that Wnt-LRP5 may play a role in the adaptation of bone to mechanical load in humans, and may explain some gender-related differences in bone mass... - Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and womenD Karasik
Hebrew Rehabilitation Center for Aged, Research and Training Institute and Harvard Medical School Division on Aging, Boston, MA, USA
Calcif Tissue Int 71:323-8. 2002..No other associations were observed for BMD at any other site. Further study is necessary for elucidation of the gender differences in the possible influence of IGF system components on bone mass... - An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traitsYi Hsiang Hsu
Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts, USA
PLoS Genet 6:e1000977. 2010.... - Common genetic determinants of vitamin D insufficiency: a genome-wide association studyThomas J Wang
Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Lancet 376:180-8. 2010..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency... - Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart StudyA D Coviello
Sections of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston University School of Public Health, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 96:E1491-5. 2011..However, little is known about the genetic contribution to their circulating concentrations in women, and their heritability in women is not well established... - PPARG by dietary fat interaction influences bone mass in mice and humansCheryl L Ackert-Bicknell
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
J Bone Miner Res 23:1398-408. 2008..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene... - Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosisJoyce B J van Meurs
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
JAMA 299:1277-90. 2008..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population... - Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone massJohn P A Ioannidis
Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
J Bone Miner Res 22:173-83. 2007..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner... - Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham StudyAmanda M Shearman
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
J Bone Miner Res 19:773-81. 2004..This was investigated in 723 men and 795 women from the Framingham study. Results show association of variation in this gene with BMD in both women and men... - Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis StudySerge L Ferrari
Division of Bone Diseases and WHO Collaborating Center for Osteoporosis, Departments of Geriatrics and Internal Medicine, Geneva University Hospital, Geneva, Switzerland
J Bone Miner Res 19:552-9. 2004..Hence, association of IL-6 polymorphisms with BMD may be limited to discrete population subgroups... - Complex segregation analysis of the radiographic phalanges bone mineral density and their age-related changesGregory Livshits
Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
J Bone Miner Res 17:152-61. 2002..We suppose that if the rate of age-related changes in phalangeal BMD is genetically determined, then these are not the same genes as those affecting the BMD baseline levels...
Research Grants
- GENETIC OF BONE GEOMETRY: FRAMINGHAM COHORTSDavid Karasik; Fiscal Year: 2005..Elucidation of genetic and molecular mechanisms underlying bone strength will ultimately lead to the identification of the individuals at highest risk of osteoporotic fractures who can be targeted for therapeutic interventions. ..
- GENETIC OF BONE STRUCTURAL GEOMETRY: FRAMINGHAM COHORTSDavid Karasik; Fiscal Year: 2006..Linkage analysis will also be combined with family based tests of association with candidate genes that lie under the peak, with additional mapping with single nucleotide polyrnorphisms. ..
- NEW WAYS TO FIND HUMAN BMD GENES USING MOUSE QTL MAPPINGDavid Karasik; Fiscal Year: 2007..This integrated bioinformatic approach ultimately can be extended to gene identification for other complex diseases. ..
- Unraveling Musculoskeletal Pleiotropy Using Genome-Wide AssociationDavid Karasik; Fiscal Year: 2009..The above will improve substantially quality of life and decrease health care costs for millions of middle-aged and elderly Americans. ..
- Unraveling Musculoskeletal Pleiotropy Using Genome-Wide AssociationDavid Karasik; Fiscal Year: 2010..The above will improve substantially quality of life and decrease health care costs for millions of middle-aged and elderly Americans. ..