D Karasik

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
  2. pmc Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Douglas P Kiel
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S14. 2007
  3. pmc Genetics of the musculoskeletal system: a pleiotropic approach
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02131, USA
    J Bone Miner Res 23:788-802. 2008
  4. pmc A genome wide linkage scan of metacarpal size and geometry in the Framingham Study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts 02131, USA
    Am J Hum Biol 20:663-70. 2008
  5. doi request reprint Contribution of gender-specific genetic factors to osteoporosis risk
    D Karasik
    Hebrew SeniorLife IFAR and Harvard Medical School, Boston, MA 02131, USA
    Ann Hum Genet 72:696-714. 2008
  6. doi request reprint Osteoporosis: an evolutionary perspective
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
    Hum Genet 124:349-56. 2008
  7. pmc Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHARe
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
    Bone 46:1114-21. 2010
  8. doi request reprint Evidence for pleiotropic factors in genetics of the musculoskeletal system
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Bone 46:1226-37. 2010
  9. pmc How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
    Age (Dordr) 33:49-62. 2011
  10. pmc Bivariate linkage study of proximal hip geometry and body size indices: the Framingham study
    D Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
    Calcif Tissue Int 81:162-73. 2007

Detail Information

Publications37

  1. pmc Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
    Kathryn L Lunetta
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S13. 2007
    ..Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span...
  2. pmc Genome-wide association with bone mass and geometry in the Framingham Heart Study
    Douglas P Kiel
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S14. 2007
    ..There have been no genome-wide association and linkage studies for these traits using high-density genotyping platforms...
  3. pmc Genetics of the musculoskeletal system: a pleiotropic approach
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02131, USA
    J Bone Miner Res 23:788-802. 2008
    ....
  4. pmc A genome wide linkage scan of metacarpal size and geometry in the Framingham Study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts 02131, USA
    Am J Hum Biol 20:663-70. 2008
    ..Genes in these regions may regulate bone geometry via effects on body size. Identification and subsequent characterization of loci for bone geometry can further elucidate the genetic contributions to bone's resistance to stress...
  5. doi request reprint Contribution of gender-specific genetic factors to osteoporosis risk
    D Karasik
    Hebrew SeniorLife IFAR and Harvard Medical School, Boston, MA 02131, USA
    Ann Hum Genet 72:696-714. 2008
    ..We conclude that there is need to consider gender-specific genetic and environmental factors in the planning of future association studies on the etiology of osteoporosis and other complex diseases prevalent in the general population...
  6. doi request reprint Osteoporosis: an evolutionary perspective
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
    Hum Genet 124:349-56. 2008
    ..The answer to the above questions will help us to identify causes of the current epidemic of osteoporosis and to pin-point a tailored treatment...
  7. pmc Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHARe
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
    Bone 46:1114-21. 2010
    ..Subsequent focus on the spectrum of genetic polymorphisms in these refined regions may contribute to finding variants predisposing to osteoporosis...
  8. doi request reprint Evidence for pleiotropic factors in genetics of the musculoskeletal system
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Bone 46:1226-37. 2010
    ..This may translate into new approaches to reduce the burden of both conditions, which are prevalent in the elderly population...
  9. pmc How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
    Age (Dordr) 33:49-62. 2011
    ..Comprehensive databases on biomarkers of musculoskeletal aging in multiple large cohort studies, along with information on various health outcomes, are needed to validate the proposed measure of biological aging...
  10. pmc Bivariate linkage study of proximal hip geometry and body size indices: the Framingham study
    D Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, 1200 Centre Street, Boston, MA 02131, USA
    Calcif Tissue Int 81:162-73. 2007
    ....
  11. pmc Proximal hip geometry is linked to several chromosomal regions: genome-wide linkage results from the Framingham Osteoporosis Study
    S Demissie
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Bone 40:743-50. 2007
    ..The purpose of this study was to evaluate heritability (h(2)) of geometric indices of the proximal hip and to perform whole-genome linkage analyses of these traits, adjusted for body size...
  12. ncbi request reprint Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: the Framingham Study
    D Karasik
    Hebrew Rehabilitation Center for Aged and Harvard Medical School, Boston, Massachusetts 02131, USA
    J Bone Miner Res 17:1718-27. 2002
    ..92 at 14q21.3 with lumbar spine BMD. This largest genome screen to date for genes underlying normal variation in BMD, adjusted for a large number of covariates, will help to identify new positional candidate genes, otherwise unrecognized...
  13. ncbi request reprint Age, gender, and body mass effects on quantitative trait loci for bone mineral density: the Framingham Study
    D Karasik
    Hebrew Rehabilitation Center for Aged Research and Training Institute and Harvard Medical School, Division on Aging, Boston, MA 02131, USA
    Bone 33:308-16. 2003
    ..Evaluation of family members stratified in homogeneous groups may be warranted in genetic studies of bone mass...
  14. ncbi request reprint Genome screen for a combined bone phenotype using principal component analysis: the Framingham study
    D Karasik
    Harvard Medical School Division on Aging, Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, MA 02131, USA
    Bone 34:547-56. 2004
    ....
  15. pmc Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans
    K Cho
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Bone 42:53-60. 2008
    ..Thus, NOS3 genetic variation does not appear to be a major contributor to adult bone density/ultrasound and geometry in our sample...
  16. ncbi request reprint Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis
    D Karasik
    Hebrew Rehabilitation Center for Aged and Harvard Medical School, Boston, MA 02131, USA
    Osteoporos Int 13:796-802. 2002
    ..In conclusion, our results suggest that there may be genetic determinants for BUA on 1p36.3. These results should encourage further investigations of the genetic source of QUS variability and candidate polymorphisms in this region...
  17. doi request reprint The heritability of circulating testosterone, oestradiol, oestrone and sex hormone binding globulin concentrations in men: the Framingham Heart Study
    T G Travison
    Research Program on Men s Health, Aging and Metabolism, Brigham and Women s Hospital, Boston, MA, USA
    Clin Endocrinol (Oxf) 80:277-82. 2014
    ....
  18. ncbi request reprint Abdominal aortic calcification and exostoses at the hand and lumbar spine: the Framingham Study
    D Karasik
    Hebrew SeniorLife and Harvard Medical School, Boston, MA, USA
    Calcif Tissue Int 78:1-8. 2006
    ..In conclusion, in this cross-sectional study, anterior lumbar osteophytes and AAC occurred in the same individuals after adjustment for age and other covariates. In general, hand exostoses were not associated with aortic calcification...
  19. pmc Hip structural geometry in old and old-old age: similarities and differences between men and women
    Laurel B Yates
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Bone 41:722-32. 2007
    ....
  20. pmc Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA
    J Bone Miner Res 25:1555-63. 2010
    ..Most of the similarity between the quantitative bone phenotypes may be attributed to pleiotropic effects of genes. This knowledge may prove helpful in defining the best phenotypes to be used in genetic studies of osteoporosis...
  21. pmc Genetic contribution to biological aging: the Framingham Study
    David Karasik
    Hebrew Rehabilitation Center for Aged, and Harvard Medical School, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 59:218-26. 2004
    ..In conclusion, the variation in BA measured by radiography was strongly governed by genetic factors in a sample of American adults...
  22. pmc Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study
    David Karasik
    Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, USA
    J Bone Miner Res 24:710-8. 2009
    ..Identification and subsequent characterization of these shared loci may further elucidate the genetic contributions to both osteoporosis and sarcopenia...
  23. ncbi request reprint Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status
    Robert R McLean
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 01702, USA
    J Bone Miner Res 19:410-8. 2004
    ..Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status...
  24. pmc Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures
    David Karasik
    Hebrew Rehabilitation Center for Aged, Research and Training Institute, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 60:574-87. 2005
    ..The aim of this review is twofold: first, to summarize growing consensus on reliable methods of biological age assessment, and second, to demonstrate validity of this phenotype for research in the genetics of aging in humans...
  25. pmc Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hip
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Clin Endocrinol Metab 93:1789-95. 2008
    ..We conducted a cross-sectional study to evaluate the association between plasma OPG and femoral neck (FN) bone density (BMD) and geometry in a large cohort of women and men...
  26. ncbi request reprint Bone geometry and skeletal fragility
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, RN115, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Curr Osteoporos Rep 4:49-56. 2006
    ..Additional studies that incorporate three-dimensional imaging are needed to better define the relationship between bone geometry and skeletal fragility, and to establish the clinical utility of bone geometry measurements...
  27. pmc Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men
    Douglas P Kiel
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA
    Bone 40:587-96. 2007
    ..These observations suggest that Wnt-LRP5 may play a role in the adaptation of bone to mechanical load in humans, and may explain some gender-related differences in bone mass...
  28. pmc An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits
    Yi Hsiang Hsu
    Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 6:e1000977. 2010
    ....
  29. ncbi request reprint Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women
    D Karasik
    Hebrew Rehabilitation Center for Aged, Research and Training Institute and Harvard Medical School Division on Aging, Boston, MA, USA
    Calcif Tissue Int 71:323-8. 2002
    ..No other associations were observed for BMD at any other site. Further study is necessary for elucidation of the gender differences in the possible influence of IGF system components on bone mass...
  30. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  31. pmc Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart Study
    A D Coviello
    Sections of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 96:E1491-5. 2011
    ..However, little is known about the genetic contribution to their circulating concentrations in women, and their heritability in women is not well established...
  32. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  33. ncbi request reprint Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
    John P A Ioannidis
    Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
    J Bone Miner Res 22:173-83. 2007
    ..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner...
  34. ncbi request reprint Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study
    Serge L Ferrari
    Division of Bone Diseases and WHO Collaborating Center for Osteoporosis, Departments of Geriatrics and Internal Medicine, Geneva University Hospital, Geneva, Switzerland
    J Bone Miner Res 19:552-9. 2004
    ..Hence, association of IL-6 polymorphisms with BMD may be limited to discrete population subgroups...
  35. pmc PPARG by dietary fat interaction influences bone mass in mice and humans
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 23:1398-408. 2008
    ..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene...
  36. ncbi request reprint Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Bone Miner Res 19:773-81. 2004
    ..This was investigated in 723 men and 795 women from the Framingham study. Results show association of variation in this gene with BMD in both women and men...
  37. ncbi request reprint Complex segregation analysis of the radiographic phalanges bone mineral density and their age-related changes
    Gregory Livshits
    Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    J Bone Miner Res 17:152-61. 2002
    ..We suppose that if the rate of age-related changes in phalangeal BMD is genetically determined, then these are not the same genes as those affecting the BMD baseline levels...

Research Grants9

  1. GENETIC OF BONE GEOMETRY: FRAMINGHAM COHORTS
    David Karasik; Fiscal Year: 2005
    ..Elucidation of genetic and molecular mechanisms underlying bone strength will ultimately lead to the identification of the individuals at highest risk of osteoporotic fractures who can be targeted for therapeutic interventions. ..
  2. GENETIC OF BONE STRUCTURAL GEOMETRY: FRAMINGHAM COHORTS
    David Karasik; Fiscal Year: 2006
    ..Linkage analysis will also be combined with family based tests of association with candidate genes that lie under the peak, with additional mapping with single nucleotide polyrnorphisms. ..
  3. NEW WAYS TO FIND HUMAN BMD GENES USING MOUSE QTL MAPPING
    David Karasik; Fiscal Year: 2007
    ..This integrated bioinformatic approach ultimately can be extended to gene identification for other complex diseases. ..
  4. Unraveling Musculoskeletal Pleiotropy Using Genome-Wide Association
    David Karasik; Fiscal Year: 2009
    ..The above will improve substantially quality of life and decrease health care costs for millions of middle-aged and elderly Americans. ..
  5. Unraveling Musculoskeletal Pleiotropy Using Genome-Wide Association
    David Karasik; Fiscal Year: 2010
    ..The above will improve substantially quality of life and decrease health care costs for millions of middle-aged and elderly Americans. ..