Research Topics
| Jing KangSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acidsJohannes Nowak
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Carcinogenesis 28:1991-5. 2007..These results support a protective role of n-3 PUFA supplementation in the prevention of CRC...
Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cellsChengwei He
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Boston, MA, 02129, USA
Chin Med 7:11. 2012..abstract:..- Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cellsZhihong Chen
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
BMC Cancer 2:18. 2002..However, whether or not decreased levels of functional M6P/IGF2R directly contribute to the process of carcinogenesis needs to be further verified by functional studies... - Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acidJ X Kang
Medical Services, Massachusetts General Hospital East, 149 13th Street, Fourth Floor, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 94:13671-6. 1997.... - The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cellsJing X Kang
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Carcinogenesis 26:1934-9. 2005..The results of this study implicate huanglian as a promising herb for chemoprevention and chemotherapy of certain cancers... - Fat-1 transgenic mice: a new model for omega-3 researchJing X Kang
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Prostaglandins Leukot Essent Fatty Acids 77:263-7. 2007..The transgenic mice are now being used widely and are emerging as a new tool for studying the benefits of n-3 fatty acids and the molecular mechanisms of their action... - Achieving balance in the omega-6/omega-3 ratio through nutrigenomicsJing X Kang
Departments of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02129, USA
World Rev Nutr Diet 93:92-8. 2004 - Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acidsJing X Kang
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 427:504. 2004..As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs... - The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturaseJing X Kang
Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
World Rev Nutr Diet 92:23-36. 2003 
A transgenic mouse model for gene-nutrient interactionsJing X Kang
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
J Nutrigenet Nutrigenomics 1:172-7. 2008..The fat-1 mouse model allows carefully controlled studies to be performed in the absence of restricted diets, which can create confounding factors that limit studies of this nature...- Differential expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in human breast cancer cell lines of different invasive potentialSuqing Xie
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Med Sci Monit 8:BR293-300. 2002.... - Mannose 6-phosphate/insulin-like growth factor II receptor mediates the growth-inhibitory effects of retinoidsJ X Kang
Department of Medicine, Massachusetts General Hospital, Charlestown 02129 2000, USA
Cell Growth Differ 10:591-600. 1999.... - Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymesJ X Kang
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 95:13687-91. 1998..Therefore, our observations may have important implications for the understanding of the diverse biological effects of retinoids... - Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammationJian Bo Wan
Laboratory for Lipid Medicine and Technology, The Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Arterioscler Thromb Vasc Biol 30:2487-94. 2010..The fat-1 transgenic mouse model, expressing an n-3 fatty acid desaturase, is capable of producing n-3 PUFAs from n-6 PUFAs and thereby has a ratio of n-6/n-3 fatty acids close to 1:1 in tissues and organs... - Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cellsYinlin Ge
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Anticancer Res 22:537-43. 2002..These data also increase the understanding of the effects of n-3 fatty acids and the n-6/n-3 ratio on cancer prevention and treatment... - Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acidsShuhua Xia
Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 103:12499-504. 2006..These data demonstrate an anticancer (antimelanoma) effect of n-3 fatty acids through, at least in part, activation of PTEN pathway mediated by PGE(3)... - Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosisYinlin Ge
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Neurochem 82:1360-6. 2002..These results demonstrate that expression of the fat-1 gene can inhibit apoptotic cell death in neurons and suggest that the change in the n-6 : n-3 fatty acid ratio may play a key role in this protective effect... - Balance of omega-6/omega-3 essential fatty acids is important for health. The evidence from gene transfer studiesJing X Kang
Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
World Rev Nutr Diet 95:93-102. 2005 - Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genesShu-Hua Xia
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Carcinogenesis 26:779-84. 2005.... - Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cellsJing Liu
Departmement of Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4433, Charlestown, MA 02129, USA
Biochem Biophys Res Commun 378:174-8. 2009..Our results suggest that coptis extracts could be promising adjuvant to ER antagonists in ER positive breast cancer treatment through regulating expression of multiple genes... - Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesisKip M Connor
Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Med 13:868-73. 2007..Supplementing omega-3-PUFA intake may be of benefit in preventing retinopathy... - Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesionJian Bo Wan
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Agric Food Chem 57:6692-7. 2009..In conclusion, PNS has antiatherogenic activity through, at least in part, its lipid-lowering and antivascular inflammatory mechanisms... - Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokinesChristoph Schmöcker
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Hepatology 45:864-9. 2007..CONCLUSION: The results of this study offer evidence for an inflammation dampening effect of omega-3 polyunsaturated fatty acids in the context of liver inflammation... - Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitisChristian A Hudert
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 103:11276-81. 2006..They add insight into the molecular mechanisms of inflammation protection afforded by n-3 PUFA through formation of resolvins and protectins other than inhibition of n-6 PUFA-derived eicosanoid formation... - Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted dietArunabh Bhattacharya
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center, San Antonio, TX 78229, USA
Biochem Biophys Res Commun 349:925-30. 2006..These results suggest that n-3 lipids with moderate CR may confer protection in autoimmune and inflammatory diseases... - Modulation of inflammatory cytokines by omega-3 fatty acidsJing X Kang
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Subcell Biochem 49:133-43. 2008..This chapter focuses on the evidence from recent studies using new experimental models... - Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acidChengwei He
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 106:11370-5. 2009..These results together provide direct evidence for a promoting effect of DHA on neurogenesis and neuritogenesis and suggest that this effect may be a mechanism underlying its beneficial effect on behavioral performance... - Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesisMd Mizanur Rahman
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Cell Mol Med 13:1833-44. 2009..In conclusion, we offer further insight into the mechanisms involved in preventing the BMD loss in Ovx mice by n-3 FA using a Fat-1 transgenic mouse model... - Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitisKarsten H Weylandt
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Biochim Biophys Acta 1782:634-41. 2008..These results suggest a beneficial potential for n-3 PUFA supplementation in acute and particularly chronic pancreatitis... - Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cellsPiet Habbel
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
World J Gastroenterol 15:1079-84. 2009..To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth... - Prevention of sudden cardiac death by n-3 polyunsaturated fatty acidsAlexander Leaf
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Pharmacol Ther 98:355-77. 2003..An attempt to show the place of the PUFAs in human nutrition during the 2-4 million years of our evolution will conclude the review... - Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oilsAlexander Leaf
Departments of Medicine, Massachusetts General Hospital, Boston, Mass, USA
Circulation 107:2646-52. 2003 - Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytesZhihong Chen
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
BMC Cell Biol 5:15. 2004..However, involvement of M6P/IGF2R in the pathogenesis of these conditions has not been determined. Thus, the objective of this study was to determine the role of M6P/IGF2R in regulation of cardiac myocyte growth and apoptosis... - Fish oil fatty acids as cardiovascular drugsAlexander Leaf
Departments of Medicine, aMassachusetts General Hospital, Boston, MA, USA
Curr Vasc Pharmacol 6:1-12. 2008..The bold, underlined abbreviation will appear in the text to identify the fatty acid being discussed... - Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intakeAlexander Leaf
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Circulation 112:2762-8. 2005..Therefore, we hypothesized that these n-3 fatty acids might prevent potentially fatal ventricular arrhythmias in high-risk patients... - Omega-3 fatty acids and ventricular arrhythmiasAlexander Leaf
Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
World Rev Nutr Diet 94:129-38. 2005 - N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary glandDavid W L Ma
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
Lipids 41:35-9. 2006..Therefore, this newly developed mouse model may be highly useful for investigating molecular and cellular mechanisms by which n-3 PUFA prevents and inhibits breast cancer growth... - Generation of cloned transgenic pigs rich in omega-3 fatty acidsLiangxue Lai
Division of Animal Science, University of Missouri-Columbia, Columbia, Missouri 65211, USA
Nat Biotechnol 24:435-6. 2006..The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001)... - Activation of Stat5 and induction of a pregnancy-like mammary gland differentiation by eicosapentaenoic and docosapentaenoic omega-3 fatty acidsYiliang E Liu
Feinstein Institute for Medical Research, Department of Radiation Oncology, Long Island Jewish Medical Center, The Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA
FEBS J 274:3351-62. 2007..Thus, alternation of n-6/n-3 fatty acid compositional ratio in favor of n-3 PUFA, and particularly docosapentaenoic acid and eicosapentaenoic acid, is one of the underlying mechanisms of pregnancy-induced mammary differentiation... - Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acidsIsabelle M Berquin
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Clin Invest 117:1866-75. 2007..Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer... - Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acidsAmeer Y Taha
Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Canada
J Neurochem 105:380-8. 2008..05). These findings demonstrate that n-3 PUFA have anticonvulsant properties and suggest the possibility of a novel, non-drug dietary approach for the treatment of epilepsy... - Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic miceQian Jia
Department of Nutrition and Food Science, Intercollegiate Faculty of Nutrition, Texas A and M University, Houston, USA
Cancer Res 68:3985-91. 2008..05) CD3(+), CD4(+) T helper, and macrophage cell numbers per colon as compared with wt mice. These results suggest that the antitumorigenic effect of n-3 PUFA may be mediated, in part, via its anti-inflammatory properties... - Why the omega-3 piggy should go to marketJing X Kang
Nat Biotechnol 25:505-6; author reply 506. 2007 - Rethinking lipid mediatorsKarsten H Weylandt
Department of Gastroenterology and Hepatology, , Campus Virchow, 13353 Berlin, Germany
Lancet 366:618-20. 2005
Research Grants
- RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATIONJing Kang; Fiscal Year: 2002..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
- Omega-6/Omega-3 Fatty Acid Ratio and TumorigenesisJing Kang; Fiscal Year: 2007..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
- Omega-6/Omega-3 Fatty Acid Ratio and TumorigenesisJing Kang; Fiscal Year: 2009..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..