Jing Kang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids
    Johannes Nowak
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Carcinogenesis 28:1991-5. 2007
  2. doi request reprint The role of the tissue omega-6/omega-3 fatty acid ratio in regulating tumor angiogenesis
    Jing X Kang
    Harvard Medical School, Boston, MA, USA
    Cancer Metastasis Rev 32:201-10. 2013
  3. pmc Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells
    Chengwei He
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Boston, MA, 02129, USA
    Chin Med 7:11. 2012
  4. pmc Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells
    Zhihong Chen
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    BMC Cancer 2:18. 2002
  5. pmc Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid
    J X Kang
    Medical Services, Massachusetts General Hospital East, 149 13th Street, Fourth Floor, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 94:13671-6. 1997
  6. pmc Fat-1 transgenic mice: a new model for omega-3 research
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Prostaglandins Leukot Essent Fatty Acids 77:263-7. 2007
  7. ncbi request reprint The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Carcinogenesis 26:1934-9. 2005
  8. ncbi request reprint Achieving balance in the omega-6/omega-3 ratio through nutrigenomics
    Jing X Kang
    Departments of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02129, USA
    World Rev Nutr Diet 93:92-8. 2004
  9. doi request reprint A transgenic mouse model for gene-nutrient interactions
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    J Nutrigenet Nutrigenomics 1:172-7. 2008
  10. ncbi request reprint Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 427:504. 2004

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids
    Johannes Nowak
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Carcinogenesis 28:1991-5. 2007
    ..These results support a protective role of n-3 PUFA supplementation in the prevention of CRC...
  2. doi request reprint The role of the tissue omega-6/omega-3 fatty acid ratio in regulating tumor angiogenesis
    Jing X Kang
    Harvard Medical School, Boston, MA, USA
    Cancer Metastasis Rev 32:201-10. 2013
    ..Furthermore, we recommend that clinical interventions should aim to both reduce n-6 metabolites and simultaneously increase n-3 FA intake...
  3. pmc Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells
    Chengwei He
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Boston, MA, 02129, USA
    Chin Med 7:11. 2012
    ..abstract:..
  4. pmc Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells
    Zhihong Chen
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    BMC Cancer 2:18. 2002
    ..However, whether or not decreased levels of functional M6P/IGF2R directly contribute to the process of carcinogenesis needs to be further verified by functional studies...
  5. pmc Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid
    J X Kang
    Medical Services, Massachusetts General Hospital East, 149 13th Street, Fourth Floor, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 94:13671-6. 1997
    ....
  6. pmc Fat-1 transgenic mice: a new model for omega-3 research
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Prostaglandins Leukot Essent Fatty Acids 77:263-7. 2007
    ..The transgenic mice are now being used widely and are emerging as a new tool for studying the benefits of n-3 fatty acids and the molecular mechanisms of their action...
  7. ncbi request reprint The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Carcinogenesis 26:1934-9. 2005
    ..The results of this study implicate huanglian as a promising herb for chemoprevention and chemotherapy of certain cancers...
  8. ncbi request reprint Achieving balance in the omega-6/omega-3 ratio through nutrigenomics
    Jing X Kang
    Departments of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02129, USA
    World Rev Nutr Diet 93:92-8. 2004
  9. doi request reprint A transgenic mouse model for gene-nutrient interactions
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    J Nutrigenet Nutrigenomics 1:172-7. 2008
    ..The fat-1 mouse model allows carefully controlled studies to be performed in the absence of restricted diets, which can create confounding factors that limit studies of this nature...
  10. ncbi request reprint Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 427:504. 2004
    ..As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs...
  11. ncbi request reprint The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase
    Jing X Kang
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    World Rev Nutr Diet 92:23-36. 2003
  12. ncbi request reprint Differential expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in human breast cancer cell lines of different invasive potential
    Suqing Xie
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Med Sci Monit 8:BR293-300. 2002
    ....
  13. ncbi request reprint Mannose 6-phosphate/insulin-like growth factor II receptor mediates the growth-inhibitory effects of retinoids
    J X Kang
    Department of Medicine, Massachusetts General Hospital, Charlestown 02129 2000, USA
    Cell Growth Differ 10:591-600. 1999
    ....
  14. pmc Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes
    J X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 95:13687-91. 1998
    ..Therefore, our observations may have important implications for the understanding of the diverse biological effects of retinoids...
  15. doi request reprint Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation
    Jian Bo Wan
    Laboratory for Lipid Medicine and Technology, The Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 30:2487-94. 2010
    ..The fat-1 transgenic mouse model, expressing an n-3 fatty acid desaturase, is capable of producing n-3 PUFAs from n-6 PUFAs and thereby has a ratio of n-6/n-3 fatty acids close to 1:1 in tissues and organs...
  16. ncbi request reprint Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells
    Yinlin Ge
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Anticancer Res 22:537-43. 2002
    ..Human cells usually have a very high n-6/n-3 fatty acid ratio because they cannot convert n-6 PUFAs to n-3 PUFAs due to lack of an n-3 desaturase found in C. elegans...
  17. pmc Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids
    Shuhua Xia
    Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:12499-504. 2006
    ..These data demonstrate an anticancer (antimelanoma) effect of n-3 fatty acids through, at least in part, activation of PTEN pathway mediated by PGE(3)...
  18. ncbi request reprint Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis
    Yinlin Ge
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neurochem 82:1360-6. 2002
    ..These results demonstrate that expression of the fat-1 gene can inhibit apoptotic cell death in neurons and suggest that the change in the n-6 : n-3 fatty acid ratio may play a key role in this protective effect...
  19. ncbi request reprint Balance of omega-6/omega-3 essential fatty acids is important for health. The evidence from gene transfer studies
    Jing X Kang
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    World Rev Nutr Diet 95:93-102. 2005
  20. ncbi request reprint Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes
    Shu Hua Xia
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Carcinogenesis 26:779-84. 2005
    ....
  21. pmc Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
    Christian A Hudert
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:11276-81. 2006
    ..They add insight into the molecular mechanisms of inflammation protection afforded by n-3 PUFA through formation of resolvins and protectins other than inhibition of n-6 PUFA-derived eicosanoid formation...
  22. pmc Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells
    Jing Liu
    Departmement of Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4433, Charlestown, MA 02129, USA
    Biochem Biophys Res Commun 378:174-8. 2009
    ..Our results suggest that coptis extracts could be promising adjuvant to ER antagonists in ER positive breast cancer treatment through regulating expression of multiple genes...
  23. ncbi request reprint Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines
    Christoph Schmöcker
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 45:864-9. 2007
    ..CONCLUSION: The results of this study offer evidence for an inflammation dampening effect of omega-3 polyunsaturated fatty acids in the context of liver inflammation...
  24. doi request reprint Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion
    Jian Bo Wan
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Agric Food Chem 57:6692-7. 2009
    ..In conclusion, PNS has antiatherogenic activity through, at least in part, its lipid-lowering and antivascular inflammatory mechanisms...
  25. ncbi request reprint Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis
    Kip M Connor
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 13:868-73. 2007
    ..Supplementing omega-3-PUFA intake may be of benefit in preventing retinopathy...
  26. pmc Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis
    Karsten H Weylandt
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Biochim Biophys Acta 1782:634-41. 2008
    ..These results suggest a beneficial potential for n-3 PUFA supplementation in acute and particularly chronic pancreatitis...
  27. pmc Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid
    Chengwei He
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:11370-5. 2009
    ..These results together provide direct evidence for a promoting effect of DHA on neurogenesis and neuritogenesis and suggest that this effect may be a mechanism underlying its beneficial effect on behavioral performance...
  28. doi request reprint Modulation of inflammatory cytokines by omega-3 fatty acids
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Subcell Biochem 49:133-43. 2008
    ..This chapter focuses on the evidence from recent studies using new experimental models...
  29. pmc Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis
    Md Mizanur Rahman
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Cell Mol Med 13:1833-44. 2009
    ..In conclusion, we offer further insight into the mechanisms involved in preventing the BMD loss in Ovx mice by n-3 FA using a Fat-1 transgenic mouse model...
  30. ncbi request reprint Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet
    Arunabh Bhattacharya
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 349:925-30. 2006
    ..These results suggest that n-3 lipids with moderate CR may confer protection in autoimmune and inflammatory diseases...
  31. pmc Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells
    Piet Habbel
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    World J Gastroenterol 15:1079-84. 2009
    ..To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth...
  32. ncbi request reprint Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils
    Alexander Leaf
    Departments of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    Circulation 107:2646-52. 2003
  33. ncbi request reprint Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Pharmacol Ther 98:355-77. 2003
    ..An attempt to show the place of the PUFAs in human nutrition during the 2-4 million years of our evolution will conclude the review...
  34. pmc Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes
    Zhihong Chen
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    BMC Cell Biol 5:15. 2004
    ..However, involvement of M6P/IGF2R in the pathogenesis of these conditions has not been determined. Thus, the objective of this study was to determine the role of M6P/IGF2R in regulation of cardiac myocyte growth and apoptosis...
  35. ncbi request reprint Fish oil fatty acids as cardiovascular drugs
    Alexander Leaf
    Departments of Medicine, aMassachusetts General Hospital, Boston, MA, USA
    Curr Vasc Pharmacol 6:1-12. 2008
    ..The bold, underlined abbreviation will appear in the text to identify the fatty acid being discussed...
  36. ncbi request reprint Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:2762-8. 2005
    ..Therefore, we hypothesized that these n-3 fatty acids might prevent potentially fatal ventricular arrhythmias in high-risk patients...
  37. ncbi request reprint Omega-3 fatty acids and ventricular arrhythmias
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    World Rev Nutr Diet 94:129-38. 2005
  38. pmc Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice
    Qian Jia
    Department of Nutrition and Food Science, Intercollegiate Faculty of Nutrition, Texas A and M University, Houston, USA
    Cancer Res 68:3985-91. 2008
    ..05) CD3(+), CD4(+) T helper, and macrophage cell numbers per colon as compared with wt mice. These results suggest that the antitumorigenic effect of n-3 PUFA may be mediated, in part, via its anti-inflammatory properties...
  39. pmc Generation of cloned transgenic pigs rich in omega-3 fatty acids
    Liangxue Lai
    Division of Animal Science, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Nat Biotechnol 24:435-6. 2006
    ..The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001)...
  40. ncbi request reprint Activation of Stat5 and induction of a pregnancy-like mammary gland differentiation by eicosapentaenoic and docosapentaenoic omega-3 fatty acids
    Yiliang E Liu
    Feinstein Institute for Medical Research, Department of Radiation Oncology, Long Island Jewish Medical Center, The Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA
    FEBS J 274:3351-62. 2007
    ..Thus, alternation of n-6/n-3 fatty acid compositional ratio in favor of n-3 PUFA, and particularly docosapentaenoic acid and eicosapentaenoic acid, is one of the underlying mechanisms of pregnancy-induced mammary differentiation...
  41. pmc Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Clin Invest 117:1866-75. 2007
    ..Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer...
  42. ncbi request reprint Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids
    Ameer Y Taha
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Canada
    J Neurochem 105:380-8. 2008
    ..05). These findings demonstrate that n-3 PUFA have anticonvulsant properties and suggest the possibility of a novel, non-drug dietary approach for the treatment of epilepsy...
  43. ncbi request reprint N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland
    David W L Ma
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Lipids 41:35-9. 2006
    ..Therefore, this newly developed mouse model may be highly useful for investigating molecular and cellular mechanisms by which n-3 PUFA prevents and inhibits breast cancer growth...
  44. ncbi request reprint Why the omega-3 piggy should go to market
    Jing X Kang
    Nat Biotechnol 25:505-6; author reply 506. 2007
  45. ncbi request reprint Rethinking lipid mediators
    Karsten H Weylandt
    Department of Gastroenterology and Hepatology, Charite University Hospital, Campus Virchow, 13353 Berlin, Germany
    Lancet 366:618-20. 2005

Research Grants8

  1. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  2. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2007
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  3. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..