Affiliation: Harvard University
Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, et al
. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Sci Signal. 2014;7:ra106 pubmed publisher
Tanaka T, Ikegami Y, Nakazawa H, Kuriyama N, Oki M, Hanai J, et al
. Low-Dose Farnesyltransferase Inhibitor Suppresses HIF-1? and Snail Expression in Triple-Negative Breast Cancer MDA-MB-231 Cells In Vitro. J Cell Physiol. 2017;232:192-201 pubmed publisher
..These data suggest that FTIs may be capable of ameliorating the aggressive phenotype of TNBC by suppressing the HIF-1?-Snail pathway. J. Cell. Physiol. 232: 192-201, 2017. © 2016 Wiley Periodicals, Inc. ..
Kaneki M, Fukushima Y, Shinozaki S, Fukaya M, Habiro M, Shimizu N, et al
. iNOS inhibitor, L-NIL, reverses burn-induced glycogen synthase kinase-3? activation in skeletal muscle of rats. Metabolism. 2013;62:341-6 pubmed publisher
..These findings suggest that iNOS may contribute to burn injury-induced metabolic derangements, in part, by activating GSK-3?. ..
Nakazawa H, Ikeda K, Shinozaki S, Kobayashi M, Ikegami Y, Fu M, et al
. Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1Î± and mTORC1: Role of protein farnesylation. Sci Rep. 2017;7:6618 pubmed publisher