Research Topics
Genomes and Genes
| Raghu KalluriSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
The role of epithelial-to-mesenchymal transition in renal fibrosisMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
J Mol Med 82:175-81. 2004..Such antagonism results in the repair of injured kidneys, suggesting that modulation of epithelial cell plasticity has therapeutic advantages...
Interstitial fluid: the overlooked component of the tumor microenvironment?Helge Wiig
Department of Biomedicine, University of Bergen, Bergen, Norway
Fibrogenesis Tissue Repair 3:12. 2010..Here we focus on the interstitial fluid phase of tumors, i.e., the fluid bathing the tumor and stromal cells. Novel knowledge on this compartment may provide important insight into how tumors develop and how they respond to therapy...- Possible mechanisms of kidney repairPaola Romagnani
Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
Fibrogenesis Tissue Repair 2:3. 2009.... - Waking up dormant tumorsJoyce C Tse
Harvard Medical School, Boston, MA 02115, USA
Breast Cancer Res 13:310. 2011.... - Proteinuria with and without renal glomerular podocyte effacementRaghu Kalluri
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
J Am Soc Nephrol 17:2383-9. 2006.... - Basement membranes: structure, assembly and role in tumour angiogenesisRaghu Kalluri
Center for Matrix Biology, Department of Medicine, Dana 514, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nat Rev Cancer 3:422-33. 2003..Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies... - The basics of epithelial-mesenchymal transitionRaghu Kalluri
Division of Matrix Biology, Beth Israel Deaconess Medical Center, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 119:1420-8. 2009..The identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions... - EMT: when epithelial cells decide to become mesenchymal-like cellsRaghu Kalluri
Division of Matrix Biology, Beth Israel Deaconess Medical Center, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 119:1417-9. 2009..Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences... - Epithelial-mesenchymal transition and its implications for fibrosisRaghu Kalluri
Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
J Clin Invest 112:1776-84. 2003..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors... 
Targeting TGF-beta and the extracellular matrix in Marfan's syndromeRaghu Kalluri
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Dev Cell 15:1-2. 2008..Brooke et al. (2008) now report that combining angiotensin II receptor blockade by losartan with beta-blocker treatment is an effective treatment combination therapy for this disorder...- Fibroblasts in cancerRaghu Kalluri
Center for Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Rev Cancer 6:392-401. 2006..Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies... - Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulusKeizo Kanasaki
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Dev Biol 313:584-93. 2008..Collectively, our studies demonstrate that podocyte beta1 integrin and ILK signaling is critical for postnatal development and function of the glomerular filtration apparatus... - Type IV collagen alpha6 chain-derived noncollagenous domain 1 (alpha6(IV)NC1) inhibits angiogenesis and tumor growthThomas M Mundel
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Int J Cancer 122:1738-44. 2008..Inhibition of tumor growth is associated with significantly diminished microvascular density. Collectively, our results demonstrate that alpha6NC1 is an endogenous inhibitor of angiogenesis and tumor growth... - Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific mannerLiang Xie
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 108:9939-44. 2011..The results demonstrate that EAIs are part of a balance mechanism regulating tumor angiogenesis, serving as intrinsic microenvironmental barriers to tumorigenesis... - Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressorPia Nyberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Exp Cell Res 314:3292-305. 2008..Collectively, this data sheds more light into the anti-angiogenic mechanism of arresten... - Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrinYuki Hamano
Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Cancer Cell 3:589-601. 2003..These results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth... - Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal diseaseValerie S LeBleu
Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Lab Invest 88:284-92. 2008.... - Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assemblyValerie LeBleu
Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 285:41874-85. 2010..This novel approach to explore the assembly type IV collagen in vivo offers novel insights in the specific role of the NC1 domain in the assembly and function of GBM during health and disease... - Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressorsMalin Sund
Center for Matrix Biology, Department of Medicine, and Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:2934-9. 2005..Collectively, our data suggest that physiological levels of endogenous inhibitors of angiogenesis can serve as endothelium-specific tumor suppressors... - An unusual case of pulmonary-renal syndrome associated with defects in type IV collagen composition and anti-glomerular basement membrane autoantibodiesDavid Charytan
Department of Medicine, Center for Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA
Am J Kidney Dis 45:743-8. 2005..Further investigation showed that this patient has decreased alpha3 and alpha5 chain expression in the GBM and defects in type IV collagen, resembling abnormalities in patients with Alport's syndrome... - Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transitionElisabeth M Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Am Soc Nephrol 19:2282-7. 2008..Collectively, our results demonstrate that EndMT contributes to the accumulation of activated fibroblasts and myofibroblasts in kidney fibrosis and suggest that targeting EndMT might have therapeutic potential... - Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factorsBing Wang
Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
J Biol Chem 281:6020-9. 2006.... - Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathwayVesselina G Cooke
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Cancer Cell 21:66-81. 2012..Collectively, our study suggests that pericytes within the primary tumor microenvironment likely serve as important gatekeepers against cancer progression and metastasis... - Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growthLiang Xie
Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Exp Biol Med (Maywood) 233:155-62. 2008..Additionally, degradation of basement membrane by cathepsin D liberates both fibulin-1 fragments and fibulin-5, which function to inhibit angiogenesis... - Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transitionMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts 02215, USA
J Biol Chem 282:23337-47. 2007..Furthermore, our findings suggest that EMT is a promising therapeutic target for the attenuation of liver fibrosis... - Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney diseaseMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
PLoS Med 3:e100. 2006..The pathological mechanisms by which such mutations lead to eventual kidney failure are not completely understood... - Animal models of renal fibrosisMichael Zeisberg
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Methods Mol Med 117:261-72. 2005..In this chapter, the mouse models of nephrotoxic serum nephritis, COL4A3-deficiency, and unilateral urethral obstruction, which all result reliably into renal fibrosis, are described... - Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesisHarikrishna Tanjore
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Dev Dyn 237:75-82. 2008..These results indicate that beta1 integrin expression on vascular endothelial cells is crucial for embryonic angiogenesis but dispensable for vasculogenesis... - Modification of kidney barrier function by the urokinase receptorChangli Wei
Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Nat Med 14:55-63. 2008..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability... - Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosisValerie S LeBleu
Department of Medicine, Beth Israel Deaconess Medical Center, Division of Matrix Biology, Boston, Massachusetts, USA
Nat Med 19:227-31. 2013..Collectively these studies suggest that HE4 is a potential biomarker of renal fibrosis and a new therapeutic target... - Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblastsElisabeth M Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Cancer Res 67:10123-8. 2007.... - Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activityHans Petter Eikesdal
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:15040-5. 2008.... - VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonizationJoyce T O'Connell
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:16002-7. 2011..Our study demonstrates a crucial role for local S100A4(+) fibroblasts in providing the permissive "soil" for metastatic colonization, a challenging step in the metastatic cascade... - Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuriaHikaru Sugimoto
Program in Matrix Biology, Division of Gastroenterology, Department of Medicine and the Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 278:12605-8. 2003..These studies suggest that down-regulation or neutralization of circulating VEGF may play an important role in the induction of proteinuria in various kidney diseases, some forms of cancer therapy and also in women with preeclampsia... - Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosisSarah N Flier
Division of Matrix Biology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 3 Blackfan Circle, Rm 11090, Boston, MA 02215, USA
J Biol Chem 285:20202-12. 2010.... - Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse modelsMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Am J Physiol Renal Physiol 285:F1060-7. 2003..Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology... - Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidneyMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 280:8094-100. 2005.... - De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membraneMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Mol Cell Biochem 283:181-9. 2006..These findings suggest that the composition of liver basement membrane is important for the maintenance of hepatocyte viability and provide anti-de-differentiation clues... - Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppressionYuki Hamano
Center for Matrix Biology, Department of Medicine and the Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Cancer Res 64:1570-4. 2004..This study also makes a strong case for TSP-1 expression levels as a potential predictive marker for the successful use of LDC in cancer patients... - Stem cell therapies benefit Alport syndromeValerie LeBleu
Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Am Soc Nephrol 20:2359-70. 2009..These data provide further support for testing cell-based therapies for Alport syndrome... - Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditionsSoo Bong Lee
Division of Matrix Biology, CLS 11086, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Am J Pathol 176:710-20. 2010..We demonstrate that low-oxygen conditions of the placenta are a critical co-stimulator along with 2-ME for the proper invasion of cytotrophoblasts to facilitate appropriate vascular development and oxygenation during pregnancy... - Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosisHikaru Sugimoto
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Nat Med 18:396-404. 2012..Our studies show that BMP signaling agonists constitute a new line of therapeutic agents with potential utility in the clinic to induce regeneration, repair and reverse established fibrosis... - Alpha-actinin-4 is required for normal podocyte adhesionSavita V Dandapani
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
J Biol Chem 282:467-77. 2007..These results suggest that alpha-actinin-4 interacts with integrins and strengthens the podocyte-GBM interaction thereby stabilizing glomerular architecture and preventing disease... - Mice deficient in alpha-actinin-4 have severe glomerular diseaseClaudine H Kos
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 111:1683-90. 2003..In addition, these genetic studies demonstrate that the nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement... - BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injuryMichael Zeisberg
Center for Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Med 9:964-8. 2003..Collectively, these results provide evidence of cross talk between BMP-7 and TGF-beta1 in the regulation of EMT in health and disease... - Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney diseaseHikaru Sugimoto
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 103:7321-6. 2006..This study demonstrates that BM-derived stem cells can offer a viable strategy for repairing basement membrane defects and conferring therapeutic benefit for patients with Alport syndrome... - The origin of fibroblasts and mechanism of cardiac fibrosisGuido Krenning
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Cell Physiol 225:631-7. 2010..Here, we review the function and origin of fibroblasts in cardiac fibrosis.NB. The information given is correct... - Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsiaKeizo Kanasaki
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 453:1117-21. 2008.... - Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitorsHikaru Sugimoto
Harvard Medical School, Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Diabetes 56:1825-33. 2007..Collectively, our results report a new mouse model for diabetic nephropathy with prominent interstitial inflammation and fibrosis and the selective inhibition of diabetic kidney disease by AGE inhibitors and BMP-7... - Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndromeBrian A Macdonald
Center for Matrix Biology, Boston, MA, USA
Blood 107:1908-15. 2006.... - The biology of preeclampsiaKeizo Kanasaki
Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Kidney Int 76:831-7. 2009.... - Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrinsAkulapalli Sudhakar
Program in Matrix Biology, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 100:4766-71. 2003..Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis... - VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formationSung Hee Chang
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Cancer Res 69:4537-44. 2009.... - Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytesM Carmen Iglesias-de la Cruz
Renal-Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104-4218, USA
Kidney Int 62:901-13. 2002..The HG-induced increases in alpha3(IV) collagen and VEGF proteins are mediated by the TGF-beta system. By increasing the expression of TbetaRII, high glucose may augment the response of the podocyte to ambient levels of TGF-beta1... - Endothelial-to-mesenchymal transition contributes to cardiac fibrosisElisabeth M Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Med 13:952-61. 2007..Our findings show that EndMT contributes to the progression of cardiac fibrosis and that rhBMP-7 can be used to inhibit EndMT and to intervene in the progression of chronic heart disease associated with fibrosis... - Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cellsMichael Zeisberg
Department of Medicine and the Liver Center, Program in Matrix Biology, Renal, and Gastroenterology Divisions, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Pathol 160:2001-8. 2002.... - Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signallingDamian Medici
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Biochem J 437:515-20. 2011..Expression of a mutant Snail protein that is resistant to GSK-3β-dependent inactivation also promotes EndMT. These results provide the foundation for understanding the roles of specific signalling pathways in mediating EndMT... - Allograft rejection and glomerular basement membrane antibodies in Alport's syndromeDavid Charytan
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Nephrol 17:431-5. 2004..When vascular rejection occurs in Alport patients, the presence of anti-GBM antibodies should be sought. Recombinant anti-GBM assays should be used if standard anti-GBM testing is equivocal... - Transcriptional regulation of epithelial-mesenchymal transitionYingqi Teng
Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 117:304-6. 2007..Collectively, their results suggest that this complex is an important regulator of the EMT transcriptome... - Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosisMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Front Biosci 13:6991-8. 2008..While knowledge regarding EMT was previously based on experimental rodent studies, in recent years the evolving evidence demonstrates a role for EMT in human kidney diseases with chronic fibrosis... - Cellular and molecular pathways that lead to progression and regression of renal fibrogenesisHirokazu Okada
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Curr Mol Med 5:467-74. 2005..This review highlights recent advances in our understanding of the cellular and molecular events leading to the progression of renal fibrosis... - Methylation determines fibroblast activation and fibrogenesis in the kidneyWibke Bechtel
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:544-50. 2010..These studies demonstrate that epigenetic modifications may provide a molecular basis for perpetuated fibroblast activation and fibrogenesis in the kidney... - BMP-7 functions as a novel hormone to facilitate liver regenerationHikaru Sugimoto
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
FASEB J 21:256-64. 2007..Collectively, our results argue for the role of BMP-7 as a kidney- and bone-produced endogenous regulator of hepatocyte health... - Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factorsChangqing Yang
Program in Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Gastroenterology 124:147-59. 2003..Additionally, our data provide strong evidence for MMPs in regulation of HSCs migration... - The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesisMalin Sund
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
APMIS 112:450-62. 2004..This review provides the reader with an appreciation of this newly evolved concept in the area of vascular biology... - Endogenous stimulators and inhibitors of angiogenesis in gastrointestinal cancers: basic science to clinical applicationMalin Sund
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02125, USA
Gastroenterology 129:2076-91. 2005.... - Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinomaFrancisco Ayala de la Peña
0Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 286:20778-87. 2011..Our studies identify a new mouse model for bladder cancer that can be used to study factors that determine progression to an invasive phenotype of bladder cancer... - Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFβ type II receptor independent mannerYingqi Teng
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Biochem Biophys Res Commun 407:633-9. 2011..Our results emphasize the importance of BMP signaling pathways in the maturation and function of certain lineages of chondrocytes and offer an insight into the heterogeneity of the chondrocyte population in the body... - Renal studies provide an insight into cardiac extracellular matrix remodeling during health and diseaseAlexandre Hertig
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
J Mol Cell Cardiol 48:497-503. 2010..In many aspects, the kidney and the heart share many common injury mechanisms. We envision that some of them will be accessible as common therapeutic targets in the future... - Parstatin, a novel protease-activated receptor 1-derived inhibitor of angiogenesisMichael B Duncan
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Mol Interv 9:168-70. 2009.... - A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary developmentThomas A Natoli
Department of Medicine and Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 13:2058-67. 2002..These results suggest that WT1 controls the expression of growth factors that regulate glomerular capillary development and that abnormal capillary development might lead to glomerular disease... - The role of the microenvironment in mammary gland development and cancerKornelia Polyak
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Cold Spring Harb Perspect Biol 2:a003244. 2010..In this article, we overview the importance of cellular interactions and microenvironmental signals in mammary gland development and cancer... - Resolved: EMT produces fibroblasts in the kidneyMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Am Soc Nephrol 21:1247-53. 2010..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate... - Biomarkers for epithelial-mesenchymal transitionsMichael Zeisberg
Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 119:1429-37. 2009.... - Mechanisms of tubulointerstitial fibrosisMichael Zeisberg
Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Am Soc Nephrol 21:1819-34. 2010..How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding... - The role of type IV collagen and basement membranes in cancer progression and metastasisHarikrishna Tanjore
Department of Medicine, Center for Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Am J Pathol 168:715-7. 2006 - Endothelial-mesenchymal transition as a novel mechanism for generating myofibroblasts during diabetic nephropathyAkane Kizu
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 175:1371-3. 2009..This Commentary provides perspective on epithelial-mesenchymal transition in diabetic nephropathy... - Twist: a new link from hypoxia to fibrosisWibke Bechtel
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Kidney Int 75:1255-6. 2009..This study provides clues as to how hypoxia and transforming growth factor-beta can collaborate to drive renal fibrogenesis... - Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironmentJoyce C Tse
Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Cell Biochem 101:816-29. 2007..Here we evaluate the diverse mechanisms of EMT and tumor microenvironment interactions in the progression of cancer, and construct a rational argument for targeting these pathways to control metastasis... - Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cellsMichael Zeisberg
Program in Matrix Biology, Renal and Gastroenterology Divisions, Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Biochem Biophys Res Commun 295:401-7. 2002.... - Type IV collagen-derived angiogenesis inhibitorsThomas M Mundel
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Microvasc Res 74:85-9. 2007..This review will particularly focus on the type IV collagen-derived angiogenesis inhibitors Arresten, Canstatin and Tumstatin... - Tumor stroma derived biomarkers in cancerMalin Sund
Division for Matrix Biology CLS 11087, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Cancer Metastasis Rev 28:177-83. 2009..Additionally, this further stresses the importance of including factors related to the tumor stroma into the diagnostic and therapeutic equation of cancer... - Recapitulation of kidney development paradigms by BMP-7 reverses chronic renal injuryHirokazu Okada
Center for Matrix Biology, Dana 514, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Clin Exp Nephrol 9:100-1. 2005 - Experimental strategies to reverse chronic renal diseaseMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Blood Purif 22:440-5. 2004..This review summarizes the recent therapeutic advances using experimental models that might translate into novel human therapies to prevent, or significantly delay, requirement of renal replacement therapy... - Tumstatin, the NC1 domain of alpha3 chain of type IV collagen, is an endogenous inhibitor of pathological angiogenesis and suppresses tumor growthYuki Hamano
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Biochem Biophys Res Commun 333:292-8. 2005..These findings suggest that tumstatin functions as an endogenous inhibitor of pathological angiogenesis and functions as a novel suppressor of proliferating endothelial cells and growth of tumors... - Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesisCorinne L Reimer
ILEX Oncology, Inc, 20 Overland Street, Boston, MA 02215, USA
Cancer Res 62:789-95. 2002..Taken together, these findings demonstrate that NM-3 is a well-tolerated angiogenesis inhibitor that significantly increases the efficacy of existing antineoplastic agents... - Cancer without diseaseJudah Folkman
Department of Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 427:787. 2004 - Drug resistance associated with antiangiogenesis therapyHans Petter Eikesdal
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Semin Cancer Biol 19:310-7. 2009..The knowledge regarding resistance mechanisms towards angiogenesis inhibitors is still evolving and here we propose some theories and in some cases provide experimental evidence... - Circulating TGF-beta1 as a reliable biomarker for chronic kidney disease progression in the African-American populationSoo Bong Lee
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Kidney Int 76:10-2. 2009..This study offers a possible explanation for the higher prevalence of end-stage renal disease in African Americans and highlights the need for a better therapeutic strategy for this population... - Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironmentChangqing Yang
Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 63:8312-7. 2003.... - Chapter 1. Molecular mechanism of type IV collagen-derived endogenous inhibitors of angiogenesisVesselina G Cooke
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Methods Enzymol 444:1-19. 2008..This chapter will discuss the molecular mechanisms of endogenous inhibitors derived from type IV collagen and review the in vitro and in vivo assays available to study their role in angiogenesis... - Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient miceParaskevi A Farazi
Department of Medical Oncology and Center for Applied Cancer Science, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cancer Res 66:6622-7. 2006..Thus, p53 deficiency, chronic bile duct injury/proliferation, and the fibrotic matrix microenvironment cooperate to induce intrahepatic CCA, highlighting the key role of the ECM microenvironment in this common liver cancer... - Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney diseaseMichael Zeisberg
Pediatr Nephrol 23:1395-8. 2008..Here we summarize recent insights into the role of BMP7 in acute and chronic kidney injury and discuss the implications for future directions of antifibrotic therapies... - Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformationFrank Strutz
Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
Kidney Int 61:1714-28. 2002.... - Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouseKyungmin Hahm
Department of Exploratory Biology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
Am J Pathol 170:110-25. 2007..These findings demonstrate that alpha v beta6 can contribute to the regulation of renal fibrosis and suggest this integrin as a potential therapeutic target... - Tumor microenvironment and angiogenesisPia Nyberg
Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Finland
Front Biosci 13:6537-53. 2008..Taken together, the tumor microenvironment is a complex unorganized tissue of various cell types and extracellular matrix that can regulate the pathological angiogenic switch... - Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsiaVesna D Garovic
Division of Nephrology and Hypertension Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Nephrol Dial Transplant 22:1136-43. 2007..We sought to test the hypothesis that proteinuria in preeclampsia is associated with dysregulated expression of the podocyte cytoskeleton and/or tight junction proteins... - Controlling angiogenesis in heart valvesRaghu Kalluri
Nat Med 12:1118-9. 2006 - The epithelial-mesenchymal transition: new insights in signaling, development, and diseaseJonathan M Lee
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
J Cell Biol 172:973-81. 2006..E.W. Thompson, and D.F. Newgreen. 2005. Cancer Res. 65:5996-6000; Thompson, E.W., D.F. Newgreen, and D. Tarin. 2005. Cancer Res. 65:5991-5995)... - Are there endogenous molecules that protect kidneys from injury? The case for bone morphogenic protein-7 (BMP-7)Michael Zeisberg
Nephrol Dial Transplant 19:759-61. 2004 - Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrinAkulapalli Sudhakar
Cell Signaling and Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
J Clin Invest 115:2801-10. 2005..Collectively, the above data indicate that alpha1(IV)NC1 is a potential therapeutic candidate for targeting tumor angiogenesis...
Research Grants
- Matrix Microenvironment and Liver FibrosisRaghu Kalluri; Fiscal Year: 2007..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
- Role of Fibroblasts in CancerRaghu Kalluri; Fiscal Year: 2010..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
- The Biology and Function of BMP-7 in the KidneyRaghu Kalluri; Fiscal Year: 2007..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
- Assembly of type IV collagen in health and diseaseRaghu Kalluri; Fiscal Year: 2007..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
- Assembly of type IV collagen in health and diseaseRaghu Kalluri; Fiscal Year: 2009..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
- Epigenetic Modifications in Renal FibrogenesisMichael Zeisberg; Fiscal Year: 2010..The reason why the fibrotic process fails to stop in some patients is not known. This application will elucidate the role of epigenetic changes, which are relatively stable modifications of DNA, in renal fibrosis. ..
- Role of Fibroblasts in CancerRaghu Kalluri; Fiscal Year: 2009..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
- Regulation of Angiogenesis by TumstatinRaghu Kalluri; Fiscal Year: 2006..abstract_text> ..
- ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASERaghu Kalluri; Fiscal Year: 2001..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
- TYPE IV COLLAGEN IN ALPORT SYNDROME PATHOGENESISRaghu Kalluri; Fiscal Year: 2002..A consideration of the differential sensitivity of GBM in XAS to degradation might perhaps at some point lead to therapeutic trials with new generation protease inhibitors now emerging for clinical use. ..
- International Meeting--Epithelial /Mesenchymal TranitionRaghu Kalluri; Fiscal Year: 2005..abstract_text> ..
- Role of Fibroblasts in CancerRaghu Kalluri; Fiscal Year: 2010..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..