Raghu Kalluri

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi The role of epithelial-to-mesenchymal transition in renal fibrosis
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 82:175-81. 2004
  2. pmc The role of endothelial-to-mesenchymal transition in cancer progression
    S Potenta
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Br J Cancer 99:1375-9. 2008
  3. pmc Interstitial fluid: the overlooked component of the tumor microenvironment?
    Helge Wiig
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Fibrogenesis Tissue Repair 3:12. 2010
  4. pmc Possible mechanisms of kidney repair
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Fibrogenesis Tissue Repair 2:3. 2009
  5. pmc Waking up dormant tumors
    Joyce C Tse
    Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 13:310. 2011
  6. ncbi Fibroblasts in cancer
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Rev Cancer 6:392-401. 2006
  7. doi Targeting TGF-beta and the extracellular matrix in Marfan's syndrome
    Raghu Kalluri
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 15:1-2. 2008
  8. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
  9. ncbi Proteinuria with and without renal glomerular podocyte effacement
    Raghu Kalluri
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Am Soc Nephrol 17:2383-9. 2006
  10. ncbi Basement membranes: structure, assembly and role in tumour angiogenesis
    Raghu Kalluri
    Center for Matrix Biology, Department of Medicine, Dana 514, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Rev Cancer 3:422-33. 2003

Research Grants

  1. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2007
  2. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
  3. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2006
  4. International Meeting--Epithelial /Mesenchymal Tranition
    Raghu Kalluri; Fiscal Year: 2005
  5. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2005
  6. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2009
  7. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2006
  8. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2005
  9. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2004
  10. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2003

Detail Information

Publications108 found, 100 shown here

  1. ncbi The role of epithelial-to-mesenchymal transition in renal fibrosis
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 82:175-81. 2004
    ..Such antagonism results in the repair of injured kidneys, suggesting that modulation of epithelial cell plasticity has therapeutic advantages...
  2. pmc The role of endothelial-to-mesenchymal transition in cancer progression
    S Potenta
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Br J Cancer 99:1375-9. 2008
    ..These new findings suggest that targeting EndMT may be a novel therapeutic strategy, which is broadly applicable not only to cancer but also to various other disease states...
  3. pmc Interstitial fluid: the overlooked component of the tumor microenvironment?
    Helge Wiig
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Fibrogenesis Tissue Repair 3:12. 2010
    ..Here we focus on the interstitial fluid phase of tumors, i.e., the fluid bathing the tumor and stromal cells. Novel knowledge on this compartment may provide important insight into how tumors develop and how they respond to therapy...
  4. pmc Possible mechanisms of kidney repair
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Fibrogenesis Tissue Repair 2:3. 2009
    ....
  5. pmc Waking up dormant tumors
    Joyce C Tse
    Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 13:310. 2011
    ....
  6. ncbi Fibroblasts in cancer
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Rev Cancer 6:392-401. 2006
    ..Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies...
  7. doi Targeting TGF-beta and the extracellular matrix in Marfan's syndrome
    Raghu Kalluri
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 15:1-2. 2008
    ..Brooke et al. (2008) now report that combining angiotensin II receptor blockade by losartan with beta-blocker treatment is an effective treatment combination therapy for this disorder...
  8. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors...
  9. ncbi Proteinuria with and without renal glomerular podocyte effacement
    Raghu Kalluri
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Am Soc Nephrol 17:2383-9. 2006
    ....
  10. ncbi Basement membranes: structure, assembly and role in tumour angiogenesis
    Raghu Kalluri
    Center for Matrix Biology, Department of Medicine, Dana 514, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Rev Cancer 3:422-33. 2003
    ..Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies...
  11. pmc EMT: when epithelial cells decide to become mesenchymal-like cells
    Raghu Kalluri
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 119:1417-9. 2009
    ..Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences...
  12. pmc The basics of epithelial-mesenchymal transition
    Raghu Kalluri
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 119:1420-8. 2009
    ..The identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions...
  13. pmc Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus
    Keizo Kanasaki
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Dev Biol 313:584-93. 2008
    ..Collectively, our studies demonstrate that podocyte beta1 integrin and ILK signaling is critical for postnatal development and function of the glomerular filtration apparatus...
  14. ncbi Type IV collagen alpha6 chain-derived noncollagenous domain 1 (alpha6(IV)NC1) inhibits angiogenesis and tumor growth
    Thomas M Mundel
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Int J Cancer 122:1738-44. 2008
    ..Inhibition of tumor growth is associated with significantly diminished microvascular density. Collectively, our results demonstrate that alpha6NC1 is an endogenous inhibitor of angiogenesis and tumor growth...
  15. pmc Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner
    Liang Xie
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:9939-44. 2011
    ..The results demonstrate that EAIs are part of a balance mechanism regulating tumor angiogenesis, serving as intrinsic microenvironmental barriers to tumorigenesis...
  16. pmc Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 3:589-601. 2003
    ..These results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth...
  17. pmc Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor
    Pia Nyberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Exp Cell Res 314:3292-305. 2008
    ..Collectively, this data sheds more light into the anti-angiogenic mechanism of arresten...
  18. pmc Type XVIII collagen is essential for survival during acute liver injury in mice
    Michael B Duncan
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Dis Model Mech 6:942-51. 2013
    ..These findings demonstrate that type XVIII collagen is an important functional component of the liver matrix microenvironment and is crucial for hepatocyte survival during injury and stress. ..
  19. ncbi Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal disease
    Valerie S LeBleu
    Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Lab Invest 88:284-92. 2008
    ....
  20. pmc Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly
    Valerie LeBleu
    Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:41874-85. 2010
    ..This novel approach to explore the assembly type IV collagen in vivo offers novel insights in the specific role of the NC1 domain in the assembly and function of GBM during health and disease...
  21. pmc Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors
    Malin Sund
    Center for Matrix Biology, Department of Medicine, and Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:2934-9. 2005
    ..Collectively, our data suggest that physiological levels of endogenous inhibitors of angiogenesis can serve as endothelium-specific tumor suppressors...
  22. pmc Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway
    Vesselina G Cooke
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Cancer Cell 21:66-81. 2012
    ..Collectively, our study suggests that pericytes within the primary tumor microenvironment likely serve as important gatekeepers against cancer progression and metastasis...
  23. ncbi An unusual case of pulmonary-renal syndrome associated with defects in type IV collagen composition and anti-glomerular basement membrane autoantibodies
    David Charytan
    Department of Medicine, Center for Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA
    Am J Kidney Dis 45:743-8. 2005
    ..Further investigation showed that this patient has decreased alpha3 and alpha5 chain expression in the GBM and defects in type IV collagen, resembling abnormalities in patients with Alport's syndrome...
  24. ncbi Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors
    Bing Wang
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 281:6020-9. 2006
    ....
  25. pmc Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 19:2282-7. 2008
    ..Collectively, our results demonstrate that EndMT contributes to the accumulation of activated fibroblasts and myofibroblasts in kidney fibrosis and suggest that targeting EndMT might have therapeutic potential...
  26. doi Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth
    Liang Xie
    Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Exp Biol Med (Maywood) 233:155-62. 2008
    ..Additionally, degradation of basement membrane by cathepsin D liberates both fibulin-1 fragments and fibulin-5, which function to inhibit angiogenesis...
  27. ncbi Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts 02215, USA
    J Biol Chem 282:23337-47. 2007
    ..Furthermore, our findings suggest that EMT is a promising therapeutic target for the attenuation of liver fibrosis...
  28. pmc Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Med 3:e100. 2006
    ..The pathological mechanisms by which such mutations lead to eventual kidney failure are not completely understood...
  29. ncbi Animal models of renal fibrosis
    Michael Zeisberg
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Methods Mol Med 117:261-72. 2005
    ..In this chapter, the mouse models of nephrotoxic serum nephritis, COL4A3-deficiency, and unilateral urethral obstruction, which all result reliably into renal fibrosis, are described...
  30. ncbi Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008
    ..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability...
  31. ncbi Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis
    Harikrishna Tanjore
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Dev Dyn 237:75-82. 2008
    ..These results indicate that beta1 integrin expression on vascular endothelial cells is crucial for embryonic angiogenesis but dispensable for vasculogenesis...
  32. ncbi Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and the Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 64:1570-4. 2004
    ..This study also makes a strong case for TSP-1 expression levels as a potential predictive marker for the successful use of LDC in cancer patients...
  33. doi Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis
    Valerie S LeBleu
    Department of Medicine, Beth Israel Deaconess Medical Center, Division of Matrix Biology, Boston, Massachusetts, USA
    Nat Med 19:227-31. 2013
    ..Collectively these studies suggest that HE4 is a potential biomarker of renal fibrosis and a new therapeutic target...
  34. pmc Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
    Sarah N Flier
    Division of Matrix Biology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 3 Blackfan Circle, Rm 11090, Boston, MA 02215, USA
    J Biol Chem 285:20202-12. 2010
    ....
  35. pmc VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
    ..Our study demonstrates a crucial role for local S100A4(+) fibroblasts in providing the permissive "soil" for metastatic colonization, a challenging step in the metastatic cascade...
  36. ncbi Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Renal Physiol 285:F1060-7. 2003
    ..Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology...
  37. ncbi Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria
    Hikaru Sugimoto
    Program in Matrix Biology, Division of Gastroenterology, Department of Medicine and the Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:12605-8. 2003
    ..These studies suggest that down-regulation or neutralization of circulating VEGF may play an important role in the induction of proteinuria in various kidney diseases, some forms of cancer therapy and also in women with preeclampsia...
  38. pmc Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity
    Hans Petter Eikesdal
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:15040-5. 2008
    ....
  39. ncbi Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 67:10123-8. 2007
    ....
  40. pmc Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions
    Soo Bong Lee
    Division of Matrix Biology, CLS 11086, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Am J Pathol 176:710-20. 2010
    ..We demonstrate that low-oxygen conditions of the placenta are a critical co-stimulator along with 2-ME for the proper invasion of cytotrophoblasts to facilitate appropriate vascular development and oxygenation during pregnancy...
  41. pmc Stem cell therapies benefit Alport syndrome
    Valerie LeBleu
    Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 20:2359-70. 2009
    ..These data provide further support for testing cell-based therapies for Alport syndrome...
  42. ncbi De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biochem 283:181-9. 2006
    ..These findings suggest that the composition of liver basement membrane is important for the maintenance of hepatocyte viability and provide anti-de-differentiation clues...
  43. ncbi Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:8094-100. 2005
    ....
  44. pmc TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis
    Fernanda T Borges
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 24:385-92. 2013
    ..The results also inform potential utility of exosome-targeted therapies to control tissue fibrosis...
  45. pmc Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
    Hikaru Sugimoto
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 18:396-404. 2012
    ..Our studies show that BMP signaling agonists constitute a new line of therapeutic agents with potential utility in the clinic to induce regeneration, repair and reverse established fibrosis...
  46. pmc Mice deficient in alpha-actinin-4 have severe glomerular disease
    Claudine H Kos
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 111:1683-90. 2003
    ..In addition, these genetic studies demonstrate that the nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement...
  47. ncbi Alpha-actinin-4 is required for normal podocyte adhesion
    Savita V Dandapani
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    J Biol Chem 282:467-77. 2007
    ..These results suggest that alpha-actinin-4 interacts with integrins and strengthens the podocyte-GBM interaction thereby stabilizing glomerular architecture and preventing disease...
  48. pmc Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease
    Hikaru Sugimoto
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:7321-6. 2006
    ..This study demonstrates that BM-derived stem cells can offer a viable strategy for repairing basement membrane defects and conferring therapeutic benefit for patients with Alport syndrome...
  49. ncbi BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    Michael Zeisberg
    Center for Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 9:964-8. 2003
    ..Collectively, these results provide evidence of cross talk between BMP-7 and TGF-beta1 in the regulation of EMT in health and disease...
  50. pmc The origin of fibroblasts and mechanism of cardiac fibrosis
    Guido Krenning
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Physiol 225:631-7. 2010
    ..Here, we review the function and origin of fibroblasts in cardiac fibrosis.NB. The information given is correct...
  51. ncbi Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
    Keizo Kanasaki
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 453:1117-21. 2008
    ....
  52. ncbi Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors
    Hikaru Sugimoto
    Harvard Medical School, Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Diabetes 56:1825-33. 2007
    ..Collectively, our results report a new mouse model for diabetic nephropathy with prominent interstitial inflammation and fibrosis and the selective inhibition of diabetic kidney disease by AGE inhibitors and BMP-7...
  53. pmc Methylation determines fibroblast activation and fibrogenesis in the kidney
    Wibke Bechtel
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:544-50. 2010
    ..These studies demonstrate that epigenetic modifications may provide a molecular basis for perpetuated fibroblast activation and fibrogenesis in the kidney...
  54. pmc Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure
    Xueping Fan
    Renal Section, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Cell Rep 2:52-61. 2012
    ..These results suggest that Robo2 signaling acts as a negative regulator on nephrin to influence podocyte foot process architecture...
  55. ncbi Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes
    M Carmen Iglesias-de la Cruz
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104 4218, USA
    Kidney Int 62:901-13. 2002
    ..Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes...
  56. pmc Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
    Akulapalli Sudhakar
    Program in Matrix Biology, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:4766-71. 2003
    ..Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis...
  57. ncbi Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 13:952-61. 2007
    ..Our findings show that EndMT contributes to the progression of cardiac fibrosis and that rhBMP-7 can be used to inhibit EndMT and to intervene in the progression of chronic heart disease associated with fibrosis...
  58. pmc Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome
    Brian A Macdonald
    Center for Matrix Biology, Boston, MA, USA
    Blood 107:1908-15. 2006
    ....
  59. doi The biology of preeclampsia
    Keizo Kanasaki
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Kidney Int 76:831-7. 2009
    ....
  60. pmc VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation
    Sung Hee Chang
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 69:4537-44. 2009
    ....
  61. pmc Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells
    Michael Zeisberg
    Department of Medicine and the Liver Center, Program in Matrix Biology, Renal, and Gastroenterology Divisions, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Pathol 160:2001-8. 2002
    ....
  62. ncbi Allograft rejection and glomerular basement membrane antibodies in Alport's syndrome
    David Charytan
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Nephrol 17:431-5. 2004
    ..Anti-glomerular basement membrane (GBM) antibodies occasionally occur in Alport patients after renal allograft transplantation...
  63. ncbi Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Front Biosci 13:6991-8. 2008
    ..While knowledge regarding EMT was previously based on experimental rodent studies, in recent years the evolving evidence demonstrates a role for EMT in human kidney diseases with chronic fibrosis...
  64. doi Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling
    Damian Medici
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Biochem J 437:515-20. 2011
    ..Expression of a mutant Snail protein that is resistant to GSK-3β-dependent inactivation also promotes EndMT. These results provide the foundation for understanding the roles of specific signalling pathways in mediating EndMT...
  65. ncbi BMP-7 functions as a novel hormone to facilitate liver regeneration
    Hikaru Sugimoto
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    FASEB J 21:256-64. 2007
    ..Collectively, our results argue for the role of BMP-7 as a kidney- and bone-produced endogenous regulator of hepatocyte health...
  66. ncbi Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors
    Changqing Yang
    Program in Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Gastroenterology 124:147-59. 2003
    ..The normal basement membrane-like matrix present within the space of Disse converts to a matrix rich in fibril-forming collagens during fibrosis...
  67. ncbi Cellular and molecular pathways that lead to progression and regression of renal fibrogenesis
    Hirokazu Okada
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Mol Med 5:467-74. 2005
    ..This review highlights recent advances in our understanding of the cellular and molecular events leading to the progression of renal fibrosis...
  68. pmc Transcriptional regulation of epithelial-mesenchymal transition
    Yingqi Teng
    Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 117:304-6. 2007
    ..Collectively, their results suggest that this complex is an important regulator of the EMT transcriptome...
  69. pmc Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFβ type II receptor independent manner
    Yingqi Teng
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Biochem Biophys Res Commun 407:633-9. 2011
    ..Our results emphasize the importance of BMP signaling pathways in the maturation and function of certain lineages of chondrocytes and offer an insight into the heterogeneity of the chondrocyte population in the body...
  70. ncbi The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesis
    Malin Sund
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    APMIS 112:450-62. 2004
    ..This review provides the reader with an appreciation of this newly evolved concept in the area of vascular biology...
  71. pmc Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinoma
    Francisco Ayala de la Peña
    0Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 286:20778-87. 2011
    ..Our studies identify a new mouse model for bladder cancer that can be used to study factors that determine progression to an invasive phenotype of bladder cancer...
  72. ncbi Endogenous stimulators and inhibitors of angiogenesis in gastrointestinal cancers: basic science to clinical application
    Malin Sund
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02125, USA
    Gastroenterology 129:2076-91. 2005
    ....
  73. pmc The role of the microenvironment in mammary gland development and cancer
    Kornelia Polyak
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cold Spring Harb Perspect Biol 2:a003244. 2010
    ..In this article, we overview the importance of cellular interactions and microenvironmental signals in mammary gland development and cancer...
  74. pmc Parstatin, a novel protease-activated receptor 1-derived inhibitor of angiogenesis
    Michael B Duncan
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Interv 9:168-70. 2009
    ....
  75. ncbi A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development
    Thomas A Natoli
    Department of Medicine and Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 13:2058-67. 2002
    ..These results suggest that WT1 controls the expression of growth factors that regulate glomerular capillary development and that abnormal capillary development might lead to glomerular disease...
  76. doi Renal studies provide an insight into cardiac extracellular matrix remodeling during health and disease
    Alexandre Hertig
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Mol Cell Cardiol 48:497-503. 2010
    ..In many aspects, the kidney and the heart share many common injury mechanisms. We envision that some of them will be accessible as common therapeutic targets in the future...
  77. doi Resolved: EMT produces fibroblasts in the kidney
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 21:1247-53. 2010
    ..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate...
  78. doi Mechanisms of tubulointerstitial fibrosis
    Michael Zeisberg
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 21:1819-34. 2010
    ..How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding...
  79. pmc Biomarkers for epithelial-mesenchymal transitions
    Michael Zeisberg
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 119:1429-37. 2009
    ....
  80. pmc The role of type IV collagen and basement membranes in cancer progression and metastasis
    Harikrishna Tanjore
    Department of Medicine, Center for Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Pathol 168:715-7. 2006
  81. pmc Endothelial-mesenchymal transition as a novel mechanism for generating myofibroblasts during diabetic nephropathy
    Akane Kizu
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 175:1371-3. 2009
    ..This Commentary provides perspective on epithelial-mesenchymal transition in diabetic nephropathy...
  82. doi Twist: a new link from hypoxia to fibrosis
    Wibke Bechtel
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 75:1255-6. 2009
    ..This study provides clues as to how hypoxia and transforming growth factor-beta can collaborate to drive renal fibrogenesis...
  83. ncbi Cancer without disease
    Judah Folkman
    Department of Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 427:787. 2004
  84. ncbi Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment
    Joyce C Tse
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biochem 101:816-29. 2007
    ..Here we evaluate the diverse mechanisms of EMT and tumor microenvironment interactions in the progression of cancer, and construct a rational argument for targeting these pathways to control metastasis...
  85. ncbi Recapitulation of kidney development paradigms by BMP-7 reverses chronic renal injury
    Hirokazu Okada
    Center for Matrix Biology, Dana 514, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Clin Exp Nephrol 9:100-1. 2005
  86. ncbi Tumstatin, the NC1 domain of alpha3 chain of type IV collagen, is an endogenous inhibitor of pathological angiogenesis and suppresses tumor growth
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Biochem Biophys Res Commun 333:292-8. 2005
    ..These findings suggest that tumstatin functions as an endogenous inhibitor of pathological angiogenesis and functions as a novel suppressor of proliferating endothelial cells and growth of tumors...
  87. ncbi Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis
    Corinne L Reimer
    ILEX Oncology, Inc, 20 Overland Street, Boston, MA 02215, USA
    Cancer Res 62:789-95. 2002
    ..Taken together, these findings demonstrate that NM-3 is a well-tolerated angiogenesis inhibitor that significantly increases the efficacy of existing antineoplastic agents...
  88. ncbi Experimental strategies to reverse chronic renal disease
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Blood Purif 22:440-5. 2004
    ..This review summarizes the recent therapeutic advances using experimental models that might translate into novel human therapies to prevent, or significantly delay, requirement of renal replacement therapy...
  89. doi Circulating TGF-beta1 as a reliable biomarker for chronic kidney disease progression in the African-American population
    Soo Bong Lee
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 76:10-2. 2009
    ..This study offers a possible explanation for the higher prevalence of end-stage renal disease in African Americans and highlights the need for a better therapeutic strategy for this population...
  90. pmc Drug resistance associated with antiangiogenesis therapy
    Hans Petter Eikesdal
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Semin Cancer Biol 19:310-7. 2009
    ..The knowledge regarding resistance mechanisms towards angiogenesis inhibitors is still evolving and here we propose some theories and in some cases provide experimental evidence...
  91. ncbi Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells
    Michael Zeisberg
    Program in Matrix Biology, Renal and Gastroenterology Divisions, Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Biochem Biophys Res Commun 295:401-7. 2002
    ....
  92. pmc Type IV collagen-derived angiogenesis inhibitors
    Thomas M Mundel
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Microvasc Res 74:85-9. 2007
    ..This review will particularly focus on the type IV collagen-derived angiogenesis inhibitors Arresten, Canstatin and Tumstatin...
  93. doi Tumor stroma derived biomarkers in cancer
    Malin Sund
    Division for Matrix Biology CLS 11087, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Metastasis Rev 28:177-83. 2009
    ..Additionally, this further stresses the importance of including factors related to the tumor stroma into the diagnostic and therapeutic equation of cancer...
  94. doi Chapter 1. Molecular mechanism of type IV collagen-derived endogenous inhibitors of angiogenesis
    Vesselina G Cooke
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 444:1-19. 2008
    ..This chapter will discuss the molecular mechanisms of endogenous inhibitors derived from type IV collagen and review the in vitro and in vivo assays available to study their role in angiogenesis...
  95. ncbi Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment
    Changqing Yang
    Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 63:8312-7. 2003
    ....
  96. ncbi Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice
    Paraskevi A Farazi
    Department of Medical Oncology and Center for Applied Cancer Science, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 66:6622-7. 2006
    ..Thus, p53 deficiency, chronic bile duct injury/proliferation, and the fibrotic matrix microenvironment cooperate to induce intrahepatic CCA, highlighting the key role of the ECM microenvironment in this common liver cancer...
  97. pmc The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    Jonathan M Lee
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Cell Biol 172:973-81. 2006
    ..E.W. Thompson, and D.F. Newgreen. 2005. Cancer Res. 65:5996-6000; Thompson, E.W., D.F. Newgreen, and D. Tarin. 2005. Cancer Res. 65:5991-5995)...
  98. ncbi Controlling angiogenesis in heart valves
    Raghu Kalluri
    Nat Med 12:1118-9. 2006
  99. ncbi Tumor microenvironment and angiogenesis
    Pia Nyberg
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Finland
    Front Biosci 13:6537-53. 2008
    ..Taken together, the tumor microenvironment is a complex unorganized tissue of various cell types and extracellular matrix that can regulate the pathological angiogenic switch...
  100. doi Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease
    Michael Zeisberg
    Pediatr Nephrol 23:1395-8. 2008
    ..Here we summarize recent insights into the role of BMP7 in acute and chronic kidney injury and discuss the implications for future directions of antifibrotic therapies...
  101. ncbi Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 61:1714-28. 2002
    ....

Research Grants33

  1. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2007
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  2. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  3. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2006
    ..abstract_text> ..
  4. International Meeting--Epithelial /Mesenchymal Tranition
    Raghu Kalluri; Fiscal Year: 2005
    ..abstract_text> ..
  5. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2005
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  6. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2009
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  7. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2006
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  8. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2005
    ..abstract_text> ..
  9. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2004
    ..abstract_text> ..
  10. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2003
    ..abstract_text> ..
  11. TYPE IV COLLAGEN IN ALPORT SYNDROME PATHOGENESIS
    Raghu Kalluri; Fiscal Year: 2002
    ..A consideration of the differential sensitivity of GBM in XAS to degradation might perhaps at some point lead to therapeutic trials with new generation protease inhibitors now emerging for clinical use. ..
  12. Epigenetic Modifications in Renal Fibrogenesis
    Michael Zeisberg; Fiscal Year: 2010
    ..The reason why the fibrotic process fails to stop in some patients is not known. This application will elucidate the role of epigenetic changes, which are relatively stable modifications of DNA, in renal fibrosis. ..
  13. Assembly of type IV collagen in health and disease
    Raghu Kalluri; Fiscal Year: 2007
    ..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
  14. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 1999
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  15. Assembly of type IV collagen in health and disease
    Raghu Kalluri; Fiscal Year: 2007
    ..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
  16. Assembly of type IV collagen in health and disease
    Raghu Kalluri; Fiscal Year: 2009
    ..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
  17. Epigenetic Modifications in Renal Fibrogenesis
    Michael Zeisberg; Fiscal Year: 2009
    ..The reason why the fibrotic process fails to stop in some patients is not known. This application will elucidate the role of epigenetic changes, which are relatively stable modifications of DNA, in renal fibrosis. ..
  18. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2009
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  19. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2009
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  20. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2007
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  21. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  22. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2000
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  23. TYPE IV COLLAGEN IN ALPORT SYNDROME PATHOGENESIS
    Raghu Kalluri; Fiscal Year: 2000
    ..A consideration of the differential sensitivity of GBM in XAS to degradation might perhaps at some point lead to therapeutic trials with new generation protease inhibitors now emerging for clinical use. ..
  24. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  25. TYPE IV COLLAGEN IN ALPORT SYNDROME PATHOGENESIS
    Raghu Kalluri; Fiscal Year: 2001
    ..A consideration of the differential sensitivity of GBM in XAS to degradation might perhaps at some point lead to therapeutic trials with new generation protease inhibitors now emerging for clinical use. ..
  26. Assembly of type IV collagen in health and disease
    Raghu Kalluri; Fiscal Year: 2005
    ..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
  27. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2005
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  28. Assembly of type IV collagen in health and disease
    Raghu Kalluri; Fiscal Year: 2006
    ..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
  29. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2006
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  30. Assembly of type IV collagen in health and disease
    Raghu Kalluri; Fiscal Year: 2006
    ..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..