S A Kalams

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Latent infection of cells in HIV disease: abstract and commentary
    S A Kalams
    Massachusetts General Hospital, AIDS Research Center, Charlestown, USA
    JAMA 279:807-8. 1998
  2. pmc Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection
    S A Kalams
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:6715-20. 1999
  3. pmc Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy
    S A Kalams
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:6721-8. 1999
  4. pmc Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 74:5679-90. 2000
  5. pmc Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 193:181-94. 2001
  6. pmc Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 192:1819-32. 2000
  7. pmc Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences
    C Brander
    AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:10191-8. 1999
  8. pmc Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity
    P O Flores-Villanueva
    Dana-Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:5140-5. 2001
  9. pmc Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif
    M A Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Virol 75:1301-11. 2001
  10. pmc Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression
    S A Islam
    Partners AIDS Research Center and ID Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 75:4907-11. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Latent infection of cells in HIV disease: abstract and commentary
    S A Kalams
    Massachusetts General Hospital, AIDS Research Center, Charlestown, USA
    JAMA 279:807-8. 1998
  2. pmc Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection
    S A Kalams
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:6715-20. 1999
    ..These data linking the levels of HIV-specific CTL with virus-specific helper cell function during chronic viral infection provide cellular immunologic parameters to guide therapeutic and prophylactic vaccine development...
  3. pmc Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy
    S A Kalams
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:6721-8. 1999
    ....
  4. pmc Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 74:5679-90. 2000
    ..The fine focusing of dominant CTL responses to these few regions of high immunogenicity is of significance to vaccine design...
  5. pmc Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 193:181-94. 2001
    ..This finding is an important consideration in vaccine design and in the evaluation of vaccine candidates...
  6. pmc Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 192:1819-32. 2000
    ..These data together show that functionally inert CTLs do not play a significant role in chronic pediatric or adult HIV infection...
  7. pmc Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences
    C Brander
    AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:10191-8. 1999
    ..These data suggest that escape from this immunodominant CTL response is not frequently accomplished by changes in the epitope flanking sequences...
  8. pmc Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity
    P O Flores-Villanueva
    Dana-Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:5140-5. 2001
    ..We conclude that homozygosity for HLA-Bw4-bearing B alleles is associated with a significant advantage and that the HLA-Bw4 motif is important in AIDS pathogenesis...
  9. pmc Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif
    M A Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Virol 75:1301-11. 2001
    ....
  10. pmc Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression
    S A Islam
    Partners AIDS Research Center and ID Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 75:4907-11. 2001
    ..CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection...
  11. pmc Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles
    C L Day
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Virol 75:6279-91. 2001
    ..These data also provide a rationale for boosting both the breadth and the magnitude of HIV-1-specific CTL responses by immunotherapy in persons with chronic HIV-1 infection...
  12. ncbi request reprint Detection of HIV-1-specific CTLs in the semen of HIV-infected individuals
    A J Quayle
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:4406-10. 1998
    ..In summary, our results demonstrate the presence of a broad CTL response to HIV in the urogenital tract and provide a rationale for further studies of local enhancement of genital mucosal responses by anti-HIV immunization...
  13. ncbi request reprint Vpr is preferentially targeted by CTL during HIV-1 infection
    M Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 167:2743-52. 2001
    ..These findings will be important in evaluating the specificity and breadth of immune responses during acute and chronic infection, and in the design and testing of candidate HIV vaccines...