Barbara Kahn

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia
    Junji Kawashima
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e36335. 2012
  2. pmc A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
    Mark A Herman
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 484:333-8. 2012
  3. ncbi request reprint Leptin, GABA, and glucose control
    Barbara B Kahn
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA Electronic address
    Cell Metab 18:304-6. 2013
  4. pmc Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells
    Ann Hammarstedt
    The Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SE 413 45, Sweden
    Diabetol Metab Syndr 4:42. 2012
  5. pmc Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay
    Qin Yang
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, CLS 747, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 153:1519-27. 2012
  6. ncbi request reprint AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    Barbara B Kahn
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 1:15-25. 2005
  7. pmc AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
    Bingzhong Xue
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Research North 380C, Boston, MA 02215, USA
    J Physiol 574:73-83. 2006
  8. ncbi request reprint mTOR tells the brain that the body is hungry
    Barbara B Kahn
    Nat Med 12:615-7. 2006
  9. ncbi request reprint Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
    Timothy E Graham
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 354:2552-63. 2006
  10. ncbi request reprint Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance
    Bingzhong Xue
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 282:23829-40. 2007

Detail Information

Publications58

  1. pmc Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia
    Junji Kawashima
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e36335. 2012
    ..Importantly, activation of hypothalamic α1 and α2-AMPK by 2DG was not affected by ICV pre-administration of STO. In conclusion, activation of hypothalamic AMPK by 2DG-induced neuroglucopenia is not mediated by CaMKK...
  2. pmc A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
    Mark A Herman
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 484:333-8. 2012
    ..ChREBP-β expression in human adipose tissue predicts insulin sensitivity, indicating that it may be an effective target for treating diabetes...
  3. ncbi request reprint Leptin, GABA, and glucose control
    Barbara B Kahn
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA Electronic address
    Cell Metab 18:304-6. 2013
    ....
  4. pmc Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells
    Ann Hammarstedt
    The Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SE 413 45, Sweden
    Diabetol Metab Syndr 4:42. 2012
    ..abstract:..
  5. pmc Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay
    Qin Yang
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, CLS 747, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 153:1519-27. 2012
    ..Thus, qMSIA provides a novel tool for accurately measuring serum RBP4 levels as a biomarker for severity of insulin resistance and risk for type 2 diabetes and metabolic syndrome...
  6. ncbi request reprint AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    Barbara B Kahn
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 1:15-25. 2005
    ..Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes...
  7. pmc AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
    Bingzhong Xue
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Research North 380C, Boston, MA 02215, USA
    J Physiol 574:73-83. 2006
    ..The AMPK pathway in the hypothalamus and peripheral tissues coordinately integrates inputs from multiple hormones, peptides and nutrients to maintain energy homeostasis...
  8. ncbi request reprint mTOR tells the brain that the body is hungry
    Barbara B Kahn
    Nat Med 12:615-7. 2006
  9. ncbi request reprint Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
    Timothy E Graham
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 354:2552-63. 2006
    ..We also determined whether elevated serum RBP4 levels are associated with reduced expression of glucose transporter 4 (GLUT4) in adipocytes, an early pathological feature of insulin resistance...
  10. ncbi request reprint Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance
    Bingzhong Xue
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 282:23829-40. 2007
    ..Thus, even in the setting of high genetic risk for diabetes, reducing PTP1B is partially protective, further demonstrating its attractiveness as a target for prevention and treatment of type 2 diabetes...
  11. ncbi request reprint Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle
    Tonya L Martin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 281:18933-41. 2006
    ..Defective responses of AMPK to leptin may contribute to resistance to leptin action on food intake and energy expenditure in obese states...
  12. pmc Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism
    Young Bum Kim
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell Biol 25:9713-23. 2005
    ..This, combined with decreased glycogen phosphorylase activity, results in increased glycogen content in muscle in the fasted state when glucose transport is reduced...
  13. ncbi request reprint Role of Rho-kinase in regulation of insulin action and glucose homeostasis
    Noboru Furukawa
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 2:119-29. 2005
    ..These results strongly suggest that ROK regulates insulin-stimulated glucose transport in vitro and in vivo. Thus, ROK is an important regulator of insulin signaling and glucose metabolism...
  14. ncbi request reprint Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
    Kazuhisa Maeda
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell Metab 1:107-19. 2005
    ....
  15. ncbi request reprint Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling
    Anne Corbould
    Division of Women s Health, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 288:E1047-54. 2005
    ..These abnormalities differ from those reported in other insulin resistant states consistent with the hypothesis that PCOS is a genetically unique disorder conferring an increased risk for type 2 diabetes...
  16. pmc Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
    Mark A Herman
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:1767-75. 2006
    ..Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing...
  17. ncbi request reprint Neuronal PTP1B regulates body weight, adiposity and leptin action
    Kendra K Bence
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, NRB 1030, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 12:917-24. 2006
    ..Thus, PTP1B regulates body mass and adiposity primarily through actions in the brain. Furthermore, neuronal PTP1B regulates adipocyte leptin production and probably is essential for the development of leptin resistance...
  18. ncbi request reprint Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia
    Thierry Alquier
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, MA 02215, USA
    Endocrinology 148:1367-75. 2007
    ..Furthermore, impaired or delayed AMPK activation in specific hypothalamic regions may play a critical role in the etiology of HAAF...
  19. pmc Deletion of cd39/entpd1 results in hepatic insulin resistance
    Keiichi Enjyoji
    Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:2311-20. 2008
    ..CD39/ENTPD1 is the dominant vascular and immune cell ectoenzyme that hydrolyzes extracellular nucleotides to regulate purinergic signaling...
  20. pmc Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice
    Nimesh Mody
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 294:E785-93. 2008
    ..Lowering TTR levels or interfering with RBP4-TTR binding may enhance insulin sensitivity in obesity and type 2 diabetes...
  21. pmc Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    Janice M Zabolotny
    Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 283:14230-41. 2008
    ..Our data suggest that PTP1B overexpression in multiple tissues in obesity is regulated by inflammation and that PTP1B may be a target of anti-inflammatory therapies...
  22. pmc Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B
    Mirela Delibegovic
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 27:7727-34. 2007
    ..Therefore, combining PTP1B inhibition with thiazolidinediones should be more effective than either alone for treating insulin-resistant states...
  23. ncbi request reprint Cathepsin L activity controls adipogenesis and glucose tolerance
    Min Yang
    Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 9:970-7. 2007
    ..Increased levels of CatL in obese and diabetic patients suggest that this protease is a novel target for these metabolic disorders...
  24. pmc The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 104:12587-94. 2007
    ....
  25. ncbi request reprint The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance
    Qing Wu Yan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Diabetes 56:2533-40. 2007
    ..The purpose of this study was to determine how expression of Lcn2 is regulated in fat cells and to ascertain whether Lcn2 could be involved in metabolic dysregulation associated with obesity...
  26. pmc Regulation of gluconeogenesis by Krüppel-like factor 15
    Susan Gray
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 5:305-12. 2007
    ..Consistent with this observation, intraperitoneal injection of pyruvate, but not alanine, rescues fasting hypoglycemia in KLF15-/- mice. We conclude that KLF15 plays an important role in the regulation of gluconeogenesis...
  27. ncbi request reprint Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation
    Prabhakaran Balagopal
    Mayo Clinic College of Medicine, and Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    J Clin Endocrinol Metab 92:1971-4. 2007
    ..The role of RBP4 in pediatric obesity, its relationship with subclinical inflammation, and its response to lifestyle changes are not elucidated...
  28. ncbi request reprint Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    Qin Yang
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 436:356-62. 2005
    ..Thus, RBP4 is an adipocyte-derived 'signal' that may contribute to the pathogenesis of type 2 diabetes. Lowering RBP4 could be a new strategy for treating type 2 diabetes...
  29. ncbi request reprint Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle
    Eugenia Carvalho
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 289:E551-61. 2005
    ..This effect occurs even though AG4Tg-MG4KO mice have increased fat mass and low adiponectin and is associated with normalization of elevated resistin levels...
  30. ncbi request reprint GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase
    Eugenia Carvalho
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    J Biol Chem 279:21598-605. 2004
    ..Our results show that GLUT4 overexpression or deficiency affects the amount of other GLUT4-vesicle proteins including IRAP and VAMP2 and that GLUT4 sequestration is saturable...
  31. ncbi request reprint Leptin signaling in the central nervous system and the periphery
    Christian Bjørbaek
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Recent Prog Horm Res 59:305-31. 2004
    ..Recent progress in understanding central and peripheral leptin receptor signaling provides potential new targets for anti-obesity and anti-diabetes drug development...
  32. ncbi request reprint Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice
    Jake A Kushner
    Howard Hughes Medical Institute, Joslin Diabetes Center, and Division of Endocrinology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 53:61-6. 2004
    ..Our studies demonstrate a novel role for Ptp1b in regulating beta-cell homeostasis and indicate that Ptp1b deficiency can partially compensate for lack of Irs2...
  33. ncbi request reprint Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction
    Young Bum Kim
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Diabetes 52:1935-42. 2003
    ..In contrast to our previous data on Akt, reduced insulin-stimulated PKClambda/zeta activity could play a role in the pathogenesis of insulin resistance in muscle of obese and type 2 diabetic subjects...
  34. ncbi request reprint Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis
    Yasuhiko Minokoshi
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:33609-12. 2003
  35. pmc GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization
    Remy Burcelin
    Institute of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland
    J Clin Invest 111:1555-62. 2003
    ..These data demonstrate that the portal sensor induces glucose use and development of hypoglycemia independently of insulin action, but by a mechanism that requires activation of the AMPK and the presence of GLUT4...
  36. ncbi request reprint Extended longevity in mice lacking the insulin receptor in adipose tissue
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA, 02215 USA
    Science 299:572-4. 2003
    ..Thus, a reduction of fat mass without caloric restriction can be associated with increased longevity in mice, possibly through effects on insulin signaling...
  37. ncbi request reprint Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling
    Cheol S Choi
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9142, USA
    Am J Physiol Endocrinol Metab 283:E233-40. 2002
    ..In addition, lactate-induced insulin resistance was associated with impaired insulin signaling and decreased insulin-stimulated glucose transport in skeletal muscle...
  38. ncbi request reprint Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 3:25-38. 2002
    ....
  39. ncbi request reprint PTP1B regulates leptin signal transduction in vivo
    Janice M Zabolotny
    Division of Endocrinology and Metabolism, Division of Hematology and Oncology, Department of Medicine, Boston, MA, USA
    Dev Cell 2:489-95. 2002
    ..Our data indicate that PTP1B regulates leptin signaling in vivo, likely by targeting Jak2. PTP1B may be a novel target to treat leptin resistance in obesity...
  40. ncbi request reprint Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    Yasuhiko Minokoshi
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 415:339-43. 2002
    ..Blocking AMPK activation inhibits the phosphorylation of ACC stimulated by leptin. Our data identify AMPK as a principal mediator of the effects of leptin on fatty-acid metabolism in muscle...
  41. ncbi request reprint Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action
    Janice M Zabolotny
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:24844-51. 2004
    ..Lack of additive impairment of insulin signaling by PTP1B and LAR suggests that these PTPs have overlapping actions in causing insulin resistance in vivo...
  42. ncbi request reprint Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men
    Charles J Tanner
    Human Performance Laboratory, Diabetes Obesity Center, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol Endocrinol Metab 282:E147-53. 2002
    ..1 vs. 1.4 +/- 0.2-fold stimulation with insulin) with training. These data suggest that insulin action is enhanced with short-term exercise training via an adaptation distal to PI 3-kinase in middle-aged, insulin-resistant individuals...
  43. pmc Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP
    Sandra Galic
    Department of Biochemistry and Molecular Biology, P O Box 13D, Monash University, Victoria 3800, Australia
    Mol Cell Biol 25:819-29. 2005
    ..These results demonstrate that PTP1B and TCPTP are not redundant in insulin signaling and that they act to control both common as well as distinct insulin signaling pathways in the same cell...
  44. ncbi request reprint Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relativ
    Jean L Chan
    D Sc, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 90:1625-31. 2005
    ..Further studies are warranted to assess the implications of acquired relative hypoleptinemia and/or r-metHuLeptin administration on the immunosuppression associated with energy- and leptin-deficient states in humans...
  45. pmc Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue
    Christine Kurlawalla-Martinez
    Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Mol Cell Biol 25:2498-510. 2005
    ..Furthermore, PTEN may be a promising target for nutritional and/or pharmacological interventions aimed at reversing insulin resistance...
  46. pmc GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization
    Ko Kotani
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 114:1666-75. 2004
    ..Genetic determinants limiting this "metabolic flexibility" may contribute to insulin resistance and type 2 diabetes in humans...
  47. ncbi request reprint Nutrient sensor links obesity with diabetes risk
    Mary Elizabeth Patti
    Nat Med 10:1049-50. 2004
  48. pmc Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice
    Katja A Lamia
    Beth Israel Hospital, Harvard Institutes of Medicine, Division of Signal Transduction, 10th Floor, 330 Brookline, MA 02215, USA
    Mol Cell Biol 24:5080-7. 2004
    ....
  49. pmc Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
    Julie R Jones
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:6207-12. 2005
    ..Our findings further illustrate the essential role for PPARgamma in the development of adipose tissues and suggest that a compensatory induction of hepatic PPARgamma may stimulate an increase in glucose disposal by the liver...
  50. ncbi request reprint Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:31891-901. 2004
    ..These data suggest an intrinsic heterogeneity of adipocytes with differences in gene expression related to adipocyte size and insulin signaling...
  51. ncbi request reprint AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    Yasuhiko Minokoshi
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 428:569-74. 2004
    ..Thus, hypothalamic AMPK plays a critical role in hormonal and nutrient-derived anorexigenic and orexigenic signals and in energy balance...
  52. ncbi request reprint Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice
    Fawaz G Haj
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, 02215, USA
    J Biol Chem 280:15038-46. 2005
    ..Our findings show that the liver is a major site of the peripheral action of PTP1B in regulating glucose homeostasis...
  53. ncbi request reprint Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects
    Young Bum Kim
    Diabetes Unit, Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 51:443-8. 2002
    ..We conclude that the mechanism for the insulin-sensitizing effect of troglitazone, but not metformin, involves enhanced PI 3-kinase pathway activation in skeletal muscle of obese type 2 diabetic subjects...
  54. ncbi request reprint Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3
    Young Bum Kim
    Diabetes Unit, Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:32915-22. 2002
    ....
  55. ncbi request reprint Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression
    Peter Kovacs
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    Diabetes 56:3095-100. 2007
    ..Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes...
  56. ncbi request reprint Peripheral signals set the tone for central regulation of metabolism
    Thierry Alquier
    Endocrinology 145:4022-4. 2004
  57. ncbi request reprint Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
    Nora Kloting
    Department of Internal Medicine III, University of Leipzig, D 04103 Leipzig, Germany
    Cell Metab 6:79-87. 2007
    ..RBP4 mRNA correlated inversely with GLUT4 mRNA in Vis fat and positively with adipocyte size in both depots. RBP4 levels are therefore linked to Vis adiposity, and Vis fat may be a major source of RBP4 in insulin-resistant states...
  58. ncbi request reprint A high-fat, ketogenic diet induces a unique metabolic state in mice
    Adam R Kennedy
    Division of Endocrinology, Departmentof Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 292:E1724-39. 2007
    ..Additionally, AMP kinase activity was increased, with a corresponding decrease in ACC activity. These data indicate that KD induces a unique metabolic state congruous with weight loss...

Research Grants30

  1. Role of PTP1B in Body Mass Regulation
    Barbara B Kahn; Fiscal Year: 2010
    ..These studies will advance our understanding of the mechanisms for resistance to leptin action. The results will have important implications for understanding normal body mass control and its dysregulation in obesity. ..
  2. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2004
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  3. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  4. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 1999
    ....
  5. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2007
    ..These studies will elucidate a novel mechanism underlying the inter-tissue communication that plays an important role in the pathogenesis of type 2 diabetes. ..
  6. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to prevent or ameliorate type 2 diabetes. ..
  7. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2004
    ..Our goal is to find new therapeutic targets to prevent or ameliorate type 2 diabetes. ..
  8. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2003
    ..Our goal is to find new therapeutic targets to prevent or ameliorate type 2 diabetes. ..
  9. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2003
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  10. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2002
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  11. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2002
    ..Our goal is to find new therapeutic targets to prevent or ameliorate type 2 diabetes. ..
  12. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2001
    ..Our goal is to find new therapeutic targets to prevent or ameliorate type 2 diabetes. ..
  13. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2004
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  14. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  15. Role of PTP1B in Body Mass Regulation
    Barbara Kahn; Fiscal Year: 2009
    ..These studies will advance our understanding of the mechanisms for resistance to leptin action. The results will have important implications for understanding normal body mass control and its dysregulation in obesity. ..
  16. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 1992
    ..These studies will increase our understanding of the cellular and molecular mechanisms underlying the insulin resistance of obesity and diabetes and the link between obesity and Type II diabetes...
  17. FASEB Research Conf: Glucose Transporter Biology
    Barbara Kahn; Fiscal Year: 2003
    ..abstract_text> ..
  18. Role of PTP1B in Body Mass Regulation
    Barbara Kahn; Fiscal Year: 2007
    ..These studies will advance our understanding of the mechanisms for resistance to leptin action. The results will have important implications for understanding normal body mass control and its dysregulation in obesity. ..
  19. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 1993
    ..These studies will increase our understanding of the cellular and molecular mechanisms underlying the insulin resistance of obesity and diabetes and the link between obesity and Type II diabetes...
  20. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2000
    ....
  21. INTEGRATED ENDOCRINE AND METABOLIC RESEARCH TRAINING
    Barbara Kahn; Fiscal Year: 2007
    The Endocrine Training Program at Beth Israel Deaconess Medical Center, directed by Dr. Barbara Kahn, trains MD, MD/PhD and PhD postdoctoral candidates in research areas of endocrinology, diabetes, and metabolism...