Jonathan C Kagan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Signaling organelles of the innate immune system
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 151:1168-78. 2012
  2. ncbi Defining the subcellular sites of innate immune signal transduction
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Trends Immunol 33:442-8. 2012
  3. ncbi Phagosome as the organelle linking innate and adaptive immunity
    Jonathan C Kagan
    Division of Gastroenterology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Ave, Enders 649, Boston, MA 02115, USA
    Traffic 13:1053-61. 2012
  4. ncbi "Complementing" toll signaling
    Jonathan C Kagan
    Division of Gastroenterology and Harvard Medical School, Department of Pediatrics, Children s Hospital Boston, Boston, MA 02115, USA
    Sci Signal 3:pe15. 2010
  5. ncbi TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    Jonathan C Kagan
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 9:361-8. 2008
  6. ncbi Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
    Jonathan C Kagan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 125:943-55. 2006
  7. ncbi A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, Room 354b, 295 Congress Avenue, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 102:826-31. 2005
  8. ncbi CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
    Ivan Zanoni
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 147:868-80. 2011
  9. ncbi Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA
    J Exp Med 199:1201-11. 2004
  10. ncbi Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    Gregory M Barton
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nat Immunol 7:49-56. 2006

Collaborators

Detail Information

Publications15

  1. ncbi Signaling organelles of the innate immune system
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 151:1168-78. 2012
    ....
  2. ncbi Defining the subcellular sites of innate immune signal transduction
    Jonathan C Kagan
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Trends Immunol 33:442-8. 2012
    ..Rather, a structurally unrelated class of proteins called 'sorting adaptors' functions in this capacity...
  3. ncbi Phagosome as the organelle linking innate and adaptive immunity
    Jonathan C Kagan
    Division of Gastroenterology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Ave, Enders 649, Boston, MA 02115, USA
    Traffic 13:1053-61. 2012
    ..In this regard, we propose that at the subcellular level, phagosomes represent the smallest definable unit that links innate and adaptive immunity...
  4. ncbi "Complementing" toll signaling
    Jonathan C Kagan
    Division of Gastroenterology and Harvard Medical School, Department of Pediatrics, Children s Hospital Boston, Boston, MA 02115, USA
    Sci Signal 3:pe15. 2010
    ..A new study attempts to model such conditions in vitro and reveals that when macrophages encounter bacteria, two signal transduction pathways interact in a way that profoundly alters the cellular response to infection...
  5. ncbi TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    Jonathan C Kagan
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 9:361-8. 2008
    ..Our data emphasize a unifying theme in innate immune recognition whereby all type I interferon-inducing receptors signal from an intracellular location...
  6. ncbi Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
    Jonathan C Kagan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 125:943-55. 2006
    ..TIRAP then functions to facilitate MyD88 delivery to activated TLR4 to initiate signal transduction. These results establish that phosphoinositide-mediated adaptor recruitment initiates a specific signal-transduction pathway...
  7. ncbi A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, Room 354b, 295 Congress Avenue, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 102:826-31. 2005
    ..Thus, Legionella has the ability to engage synthesized substrate proteins and transfer them into host cells on contact, enabling Legionella to rapidly alter transport of the vacuole in which it resides...
  8. ncbi CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
    Ivan Zanoni
    Harvard Medical School and Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 147:868-80. 2011
    ..This innate immune trafficking cascade illustrates how pathogen detection systems operate to induce both membrane transport and signal transduction...
  9. ncbi Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA
    J Exp Med 199:1201-11. 2004
    ....
  10. ncbi Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    Gregory M Barton
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nat Immunol 7:49-56. 2006
    ..These data demonstrated that intracellular localization of TLR9 was not required for ligand recognition. Instead, localization of the nucleic acid-sensing TLRs is critical in discriminating between self and nonself nucleic acid...
  11. ncbi Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila
    Lorri R Marek
    Division of Gasteroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Immunity 36:612-22. 2012
    ..We therefore propose that dMyD88 is the functional homolog of TIRAP and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors...
  12. ncbi Intracellular Pathogen Detection by RIG-I-Like Receptors
    Evelyn Dixit
    Harvard Medical School and Division of Gastroenterology, Boston Children s Hospital, Boston, Massachusetts, USA
    Adv Immunol 117:99-125. 2013
    ..RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction...
  13. ncbi Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
    Jonathan C Kagan
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536-0812, USA
    Nat Cell Biol 4:945-54. 2002
    ..These data indicate that L. pneumophila intercepts vesicular traffic from endoplasmic-reticulum exit sites to create an organelle that permits intracellular replication and prevents destruction by the host cell...
  14. ncbi MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties
    Sen Wang
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 187:141-50. 2011
    ..Thus, MyD88-dependent TLR2 signals are necessary and sufficient to educate DC with gut-specific imprinting properties and contribute in vivo to the generation of gut-tropic T cells...
  15. ncbi Peroxisomes are signaling platforms for antiviral innate immunity
    Evelyn Dixit
    Division of Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cell 141:668-81. 2010
    ..The interferon regulatory factor IRF1 plays a crucial role in regulating MAVS-dependent signaling from peroxisomes. These results establish that peroxisomes are an important site of antiviral signal transduction...