M E Kadin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The t(2;5) in human lymphomas
    M E Kadin
    Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, MA 02115, USA
    Leuk Lymphoma 29:249-56. 1998
  2. ncbi request reprint Pathobiology of CD30+ cutaneous T-cell lymphomas
    Marshall E Kadin
    Laboratory Medicine, Yamins 309, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cutan Pathol 33:10-7. 2006
  3. ncbi request reprint Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses
    W Kempf
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Cutan Pathol 28:29-33. 2001
  4. ncbi request reprint Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligand
    M E Kadin
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 941:59-68. 2001
  5. ncbi request reprint Hodgkin's lymphoma of T-cell type: clonal association with a CD30+ cutaneous lymphoma
    M E Kadin
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Hum Pathol 32:1269-72. 2001
  6. pmc Immunohistochemical distinction of lymphomatoid papulosis and pityriasis lichenoides et varioliformis acuta
    F J Varga
    Department of Pathology, Harvard Medical School, Boston, Massachusetts
    Am J Pathol 136:979-87. 1990
  7. ncbi request reprint Apoptosis in CD30-positive lymphoproliferative disorders of the skin
    Johannes Greisser
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Exp Dermatol 14:380-5. 2005
  8. ncbi request reprint Fascin expression in CD30-positive cutaneous lymphoproliferative disorders
    Werner Kempf
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    J Cutan Pathol 29:295-300. 2002
  9. ncbi request reprint Polymorphism of the CD30 promoter microsatellite repressive element is associated with development of primary cutaneous lymphoproliferative disorders
    Maria Franchina
    The Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Level 6, MRF Building, 50 Rear Murray Street, Perth, Western Australia, Australia
    Cancer Epidemiol Biomarkers Prev 14:1322-5. 2005
  10. ncbi request reprint JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma
    Mariko Watanabe
    Fourth Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
    Cancer Res 65:7628-34. 2005

Collaborators

  • W Kempf
  • R Drews
  • O Kocher
  • G Burg
  • Eric C Vonderheid
  • Ryouichi Horie
  • Daniela Massi
  • L Cerroni
  • C Hallermann
  • Reinhard Dummer
  • M Santucci
  • Anas Younes
  • Olivier Dereure
  • Christine Fuller
  • K Willenbrock
  • Rein Willemze
  • F O Nestle
  • Mariko Watanabe
  • Masaaki Higashihara
  • Toshiki Watanabe
  • Lawrence J Abraham
  • Igor B Rosenwald
  • Valeria R Fantin
  • Claudia Droc
  • Kinji Itoh
  • Yuji Ogawa
  • Johannes Greisser
  • Maria Franchina
  • Amy E Adams
  • Martin Kleinhans
  • Mitchell S Cairo
  • Jörg Willers
  • Ronald C Hendrickson
  • Andrey Loboda
  • Tukasa Koiwa
  • Susan Korenchuk
  • Xiaoli S Hou
  • Frank Gooden
  • Jennifer A Roth
  • Stanley R Frankel
  • Lixia Li
  • Christopher M Ware
  • Bruce A Woda
  • Sophia Randolph
  • Cloud P Paweletz
  • Jacqueline W Pierce
  • Victoria M Richon
  • Larisa Koifman
  • Jane Jane Chen
  • John F Reilly
  • Elizabeth A Harrington
  • Isao Okayasu
  • Lou Savas
  • Hernani D Cualing
  • Masataka Sasaki
  • Beatrix Mueller
  • Malgorzata Roos
  • Udo Doebbeling
  • Mirka Schmid
  • Kazuo Umezawa
  • Kenneth R Falchuk
  • Clara Curiel
  • Jeffrey Zwicker
  • Thomas S Kupper
  • Mark D Krailo
  • Warren Sanger
  • Stuart E Siegel
  • Adrian Tun-Kyi
  • Sherrie L Perkins
  • Richard Sposto
  • Nicole Tedeschi-Blok
  • Anna T Meadows
  • Margo L Hoover-Regan
  • Carl R Kjeldsberg
  • James R Anderson
  • John F Wilson
  • Michel Gilliet
  • Kinji Ito
  • Mark A Lones
  • Erin Morris
  • Thomas Kündig
  • Jonathan L Finlay
  • F J Varga
  • S M Olbricht

Detail Information

Publications30

  1. ncbi request reprint The t(2;5) in human lymphomas
    M E Kadin
    Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, MA 02115, USA
    Leuk Lymphoma 29:249-56. 1998
    ....
  2. ncbi request reprint Pathobiology of CD30+ cutaneous T-cell lymphomas
    Marshall E Kadin
    Laboratory Medicine, Yamins 309, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cutan Pathol 33:10-7. 2006
    ..The possible role of the CD30+ cell as a regulatory T-cell is introduced and a model for progression of LyP to ALCL is illustrated...
  3. ncbi request reprint Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses
    W Kempf
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Cutan Pathol 28:29-33. 2001
    ..Ultrastructural and clinical features of LyP suggest that it has a viral etiology. Human herpesviruses have been proposed as causative cofactors for LyP because of their oncogenic potential and their association with other lymphomas...
  4. ncbi request reprint Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligand
    M E Kadin
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 941:59-68. 2001
    ..The results suggest that progression of LyP to lymphoma is associated with escape of lymphoma cells from growth regulation by TGF-beta and CD30 ligand...
  5. ncbi request reprint Hodgkin's lymphoma of T-cell type: clonal association with a CD30+ cutaneous lymphoma
    M E Kadin
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Hum Pathol 32:1269-72. 2001
    ..This article supports the concept of a T-cell derivation for rare cases of Hodgkin's lymphoma and provides evidence of a novel mechanism of pathogenesis from chronic inflammation in the skin...
  6. pmc Immunohistochemical distinction of lymphomatoid papulosis and pityriasis lichenoides et varioliformis acuta
    F J Varga
    Department of Pathology, Harvard Medical School, Boston, Massachusetts
    Am J Pathol 136:979-87. 1990
    ..We conclude that LyP and PLEVA can be distinguished immunohistochemically in most, if not all, cases. Furthermore these results suggest that LyP and PLEVA are separate disorders, thus accounting for their variable prognoses...
  7. ncbi request reprint Apoptosis in CD30-positive lymphoproliferative disorders of the skin
    Johannes Greisser
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Exp Dermatol 14:380-5. 2005
    ..Pro-apoptotic protein Bax is expressed at high levels in CD30+ CLPD and may play a crucial role in mediating apoptosis of tumour cells...
  8. ncbi request reprint Fascin expression in CD30-positive cutaneous lymphoproliferative disorders
    Werner Kempf
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    J Cutan Pathol 29:295-300. 2002
    ..Currently there is no marker to predict the development of systemic lymphomas in patients with LyP. Fascin, an actin bundling protein, has recently been shown to be a unique marker found in almost 100% of classical HL...
  9. ncbi request reprint Polymorphism of the CD30 promoter microsatellite repressive element is associated with development of primary cutaneous lymphoproliferative disorders
    Maria Franchina
    The Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Level 6, MRF Building, 50 Rear Murray Street, Perth, Western Australia, Australia
    Cancer Epidemiol Biomarkers Prev 14:1322-5. 2005
    ..These findings suggest that allele-specific differences in the control of CD30 transcription may determine the pathogenesis of the spectrum of CD30+ cutaneous lymphoproliferative disorders...
  10. ncbi request reprint JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma
    Mariko Watanabe
    Fourth Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
    Cancer Res 65:7628-34. 2005
    ..These results show a common mechanism of CD30 overexpression in ALCL and HL, although the outcome of CD30 signaling differs between NPM-ALK-positive ALCL and NPM-ALK-negative ALCL, cutaneous ALCL, and HL as we recently reported...
  11. ncbi request reprint Aggressive cutaneous T-cell lymphomas after TNFalpha blockade
    Amy E Adams
    Department of Dermatology at Harvard Medical School, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Am Acad Dermatol 51:660-2. 2004
    ..Both cases were characterized by rapid onset, a fulminant clinical course with extensive cutaneous and systemic involvement, and death within months of diagnosis...
  12. ncbi request reprint Papular mycosis fungoides: a variant of mycosis fungoides or lymphomatoid papulosis?
    Eric C Vonderheid
    J Am Acad Dermatol 55:177-80. 2006
  13. ncbi request reprint Need for an improved molecular/genetic classification for CD30+ lymphomas involving the skin
    Claudia Droc
    Hematopathology and Laboratory Medicine Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Control 14:124-32. 2007
    ..The border between these diseases is sometimes difficult to establish and there are many grey zones in their classification...
  14. ncbi request reprint Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma
    Mariko Watanabe
    Department of Hematology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
    Lab Invest 88:48-57. 2008
    ....
  15. doi request reprint Expression of the translation initiation factors eIF-4E and eIF-2* is frequently increased in neoplastic cells of Hodgkin lymphoma
    Igor B Rosenwald
    Department of Pathology, New England Medical Center, Boston, MA 02111, USA
    Hum Pathol 39:910-6. 2008
    ....
  16. doi request reprint Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma
    Valeria R Fantin
    Merck Research Laboratories, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 68:3785-94. 2008
    ..Furthermore, these findings may be of prognostic value in predicting the response of CTCL patients to vorinostat...
  17. ncbi request reprint The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kappaB activation in anaplastic large cell lymphoma
    Ryouichi Horie
    Fourth Department of Internal Medicine, Faculty of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Cancer Cell 5:353-64. 2004
    ..Thus, NPM-ALK abrogates CD30-driven NF-kappaB activation and can also induce an ALCL phenotype, distinguishing ALCL cells from H-RS cells of T cell origin...
  18. ncbi request reprint Improved sensitivity of T-cell clonality detection in mycosis fungoides by hand microdissection and heteroduplex analysis
    Olivier Dereure
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Arch Dermatol 139:1571-5. 2003
    ..Procedures based on polymerase chain reaction (PCR) are the most sensitive to detect clonality, but heteroduplex analysis is less sensitive than other methods such as denaturing gradient gel electrophoresis...
  19. ncbi request reprint Emerging applications of the tumor necrosis factor family of ligands and receptors in cancer therapy
    Anas Younes
    Department of Lymphoma and Myeloma, Unit 429, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 21:3526-34. 2003
    ....
  20. ncbi request reprint Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells
    Ryouichi Horie
    Division of Pathology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Oncogene 21:2493-503. 2002
    ..Inhibition of NF-kappaB activation by adenovirus vector-mediated gene transfer may provide a novel strategy of cell- and target molecule-specific therapy for patients with HD...
  21. ncbi request reprint Infrequent Fas mutations but no Bax or p53 mutations in early mycosis fungoides: a possible mechanism for the accumulation of malignant T lymphocytes in the skin
    Olivier Dereure
    Department of Pathology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts 02215, USA
    J Invest Dermatol 118:949-56. 2002
    ..These results support the hypothesis that Fas defects may play a role in the pathogenesis of MF...
  22. ncbi request reprint T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction
    Klaus Willenbrock
    Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt am Main, Germany
    Lab Invest 82:1103-9. 2002
    ....
  23. ncbi request reprint Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma
    Martin Kleinhans
    Department of Dermatology, University of Zurich Medical School, Switzerland
    Blood 101:1487-93. 2003
    ..These results suggest that expression of CCR3 and its ligand eotaxin/CCL11 plays a role in the recruitment and retention of CD30(+) malignant T cells to the skin...
  24. ncbi request reprint Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop
    Marco Santucci
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Cancer 97:610-27. 2003
    ....
  25. ncbi request reprint Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin
    Werner Kempf
    Department of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
    Carcinogenesis 24:301-6. 2003
  26. ncbi request reprint Burkitt's and Burkitt-like lymphoma in children and adolescents: a review of the Children's Cancer Group experience
    Mitchell S Cairo
    Department of Pediatrics, Children s Hospital New York, Columbia University, New York, NY, USA
    Br J Haematol 120:660-70. 2003
    ..001). In summary, the outcome for childhood Burkitt's and Burkitt-like lymphoma has recently improved with the use of short and intensive B-cell non-Hodgkin's lymphoma-directed therapy...
  27. ncbi request reprint Genetic and molecular genetic studies in the diagnosis of T-cell malignancies
    Marshall E Kadin
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA
    Hum Pathol 34:322-9. 2003
  28. ncbi request reprint Proliferation of CD30+ T-helper 2 lymphoma cells can be inhibited by CD30 receptor cross-linking with recombinant CD30 ligand
    Jörg Willers
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Clin Cancer Res 9:2744-54. 2003
    ..Proliferation and apoptosis of cultured cells were measured by 5-bromo-2-desoxyuridine and propidium iodine incorporation...
  29. pmc AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells
    Mariko Watanabe
    Fourth Department of Internal Medicine, Kitasato University School of Medicine, Kanagawa, Japan
    Am J Pathol 163:633-41. 2003
    ....
  30. doi request reprint Primary cutaneous ALCL with phosphorylated/activated cytoplasmic ALK and novel phenotype: EMA/MUC1+, cutaneous lymphocyte antigen negative
    Marshall E Kadin
    Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Am J Surg Pathol 32:1421-6. 2008
    ..Primary cutaneous ALCL of this novel subtype should be distinguished from systemic ALCL to ensure proper clinical management...