M E Kadin
Affiliation: Harvard University
- The t(2;5) in human lymphomasM E Kadin
Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, MA 02115, USA
Leuk Lymphoma 29:249-56. 1998....
- Pathobiology of CD30+ cutaneous T-cell lymphomasMarshall E Kadin
Laboratory Medicine, Yamins 309, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Cutan Pathol 33:10-7. 2006..The possible role of the CD30+ cell as a regulatory T-cell is introduced and a model for progression of LyP to ALCL is illustrated...
- Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesvirusesW Kempf
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
J Cutan Pathol 28:29-33. 2001..Ultrastructural and clinical features of LyP suggest that it has a viral etiology. Human herpesviruses have been proposed as causative cofactors for LyP because of their oncogenic potential and their association with other lymphomas...
- Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligandM E Kadin
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 941:59-68. 2001..The results suggest that progression of LyP to lymphoma is associated with escape of lymphoma cells from growth regulation by TGF-beta and CD30 ligand...
- Hodgkin's lymphoma of T-cell type: clonal association with a CD30+ cutaneous lymphomaM E Kadin
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Hum Pathol 32:1269-72. 2001..This article supports the concept of a T-cell derivation for rare cases of Hodgkin's lymphoma and provides evidence of a novel mechanism of pathogenesis from chronic inflammation in the skin...
- Immunohistochemical distinction of lymphomatoid papulosis and pityriasis lichenoides et varioliformis acutaF J Varga
Department of Pathology, Harvard Medical School, Boston, Massachusetts
Am J Pathol 136:979-87. 1990..We conclude that LyP and PLEVA can be distinguished immunohistochemically in most, if not all, cases. Furthermore these results suggest that LyP and PLEVA are separate disorders, thus accounting for their variable prognoses...
- Apoptosis in CD30-positive lymphoproliferative disorders of the skinJohannes Greisser
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
Exp Dermatol 14:380-5. 2005..Pro-apoptotic protein Bax is expressed at high levels in CD30+ CLPD and may play a crucial role in mediating apoptosis of tumour cells...
- Fascin expression in CD30-positive cutaneous lymphoproliferative disordersWerner Kempf
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
J Cutan Pathol 29:295-300. 2002..Currently there is no marker to predict the development of systemic lymphomas in patients with LyP. Fascin, an actin bundling protein, has recently been shown to be a unique marker found in almost 100% of classical HL...
- Polymorphism of the CD30 promoter microsatellite repressive element is associated with development of primary cutaneous lymphoproliferative disordersMaria Franchina
The Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Level 6, MRF Building, 50 Rear Murray Street, Perth, Western Australia, Australia
Cancer Epidemiol Biomarkers Prev 14:1322-5. 2005..These findings suggest that allele-specific differences in the control of CD30 transcription may determine the pathogenesis of the spectrum of CD30+ cutaneous lymphoproliferative disorders...
- JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphomaMariko Watanabe
Fourth Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
Cancer Res 65:7628-34. 2005..These results show a common mechanism of CD30 overexpression in ALCL and HL, although the outcome of CD30 signaling differs between NPM-ALK-positive ALCL and NPM-ALK-negative ALCL, cutaneous ALCL, and HL as we recently reported...
- Aggressive cutaneous T-cell lymphomas after TNFalpha blockadeAmy E Adams
Department of Dermatology at Harvard Medical School, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA
J Am Acad Dermatol 51:660-2. 2004..Both cases were characterized by rapid onset, a fulminant clinical course with extensive cutaneous and systemic involvement, and death within months of diagnosis...
- Papular mycosis fungoides: a variant of mycosis fungoides or lymphomatoid papulosis?Eric C Vonderheid
J Am Acad Dermatol 55:177-80. 2006
- Need for an improved molecular/genetic classification for CD30+ lymphomas involving the skinClaudia Droc
Hematopathology and Laboratory Medicine Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Control 14:124-32. 2007..The border between these diseases is sometimes difficult to establish and there are many grey zones in their classification...
- Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphomaMariko Watanabe
Department of Hematology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
Lab Invest 88:48-57. 2008....
- Expression of the translation initiation factors eIF-4E and eIF-2* is frequently increased in neoplastic cells of Hodgkin lymphomaIgor B Rosenwald
Department of Pathology, New England Medical Center, Boston, MA 02111, USA
Hum Pathol 39:910-6. 2008....
- Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphomaValeria R Fantin
Merck Research Laboratories, Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 68:3785-94. 2008..Furthermore, these findings may be of prognostic value in predicting the response of CTCL patients to vorinostat...
- The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kappaB activation in anaplastic large cell lymphomaRyouichi Horie
Fourth Department of Internal Medicine, Faculty of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
Cancer Cell 5:353-64. 2004..Thus, NPM-ALK abrogates CD30-driven NF-kappaB activation and can also induce an ALCL phenotype, distinguishing ALCL cells from H-RS cells of T cell origin...
- Improved sensitivity of T-cell clonality detection in mycosis fungoides by hand microdissection and heteroduplex analysisOlivier Dereure
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Arch Dermatol 139:1571-5. 2003..Procedures based on polymerase chain reaction (PCR) are the most sensitive to detect clonality, but heteroduplex analysis is less sensitive than other methods such as denaturing gradient gel electrophoresis...
- Emerging applications of the tumor necrosis factor family of ligands and receptors in cancer therapyAnas Younes
Department of Lymphoma and Myeloma, Unit 429, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 21:3526-34. 2003....
- Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cellsRyouichi Horie
Division of Pathology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Oncogene 21:2493-503. 2002..Inhibition of NF-kappaB activation by adenovirus vector-mediated gene transfer may provide a novel strategy of cell- and target molecule-specific therapy for patients with HD...
- Infrequent Fas mutations but no Bax or p53 mutations in early mycosis fungoides: a possible mechanism for the accumulation of malignant T lymphocytes in the skinOlivier Dereure
Department of Pathology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts 02215, USA
J Invest Dermatol 118:949-56. 2002..These results support the hypothesis that Fas defects may play a role in the pathogenesis of MF...
- T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reactionKlaus Willenbrock
Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt am Main, Germany
Lab Invest 82:1103-9. 2002....
- Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphomaMartin Kleinhans
Department of Dermatology, University of Zurich Medical School, Switzerland
Blood 101:1487-93. 2003..These results suggest that expression of CCR3 and its ligand eotaxin/CCL11 plays a role in the recruitment and retention of CD30(+) malignant T cells to the skin...
- Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force WorkshopMarco Santucci
Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
Cancer 97:610-27. 2003....
- Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skinWerner Kempf
Department of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Carcinogenesis 24:301-6. 2003
- Burkitt's and Burkitt-like lymphoma in children and adolescents: a review of the Children's Cancer Group experienceMitchell S Cairo
Department of Pediatrics, Children s Hospital New York, Columbia University, New York, NY, USA
Br J Haematol 120:660-70. 2003..001). In summary, the outcome for childhood Burkitt's and Burkitt-like lymphoma has recently improved with the use of short and intensive B-cell non-Hodgkin's lymphoma-directed therapy...
- Genetic and molecular genetic studies in the diagnosis of T-cell malignanciesMarshall E Kadin
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA
Hum Pathol 34:322-9. 2003
- Proliferation of CD30+ T-helper 2 lymphoma cells can be inhibited by CD30 receptor cross-linking with recombinant CD30 ligandJörg Willers
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
Clin Cancer Res 9:2744-54. 2003..Proliferation and apoptosis of cultured cells were measured by 5-bromo-2-desoxyuridine and propidium iodine incorporation...
- AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cellsMariko Watanabe
Fourth Department of Internal Medicine, Kitasato University School of Medicine, Kanagawa, Japan
Am J Pathol 163:633-41. 2003....
- Primary cutaneous ALCL with phosphorylated/activated cytoplasmic ALK and novel phenotype: EMA/MUC1+, cutaneous lymphocyte antigen negativeMarshall E Kadin
Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
Am J Surg Pathol 32:1421-6. 2008..Primary cutaneous ALCL of this novel subtype should be distinguished from systemic ALCL to ensure proper clinical management...