M M Jonas

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Pegylated interferon for chronic hepatitis C in children affects growth and body composition: results from the pediatric study of hepatitis C (PEDS-C) trial
    Maureen M Jonas
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Hepatology 56:523-31. 2012
  2. doi request reprint Efficacy and safety of long-term adefovir dipivoxil therapy in children with chronic hepatitis B infection
    Maureen M Jonas
    Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Pediatr Infect Dis J 31:578-82. 2012
  3. doi request reprint Treatment of children with chronic hepatitis B virus infection in the United States: patient selection and therapeutic options
    Maureen M Jonas
    Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Hepatology 52:2192-205. 2010
  4. doi request reprint Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B
    Maureen M Jonas
    Children s Hospital Boston, Boston, MA 02115, USA
    Hepatology 47:1863-71. 2008
  5. ncbi request reprint Long-term lamivudine treatment of children with chronic hepatitis B: durability of therapeutic responses and safety
    M M Jonas
    Division of Gastroenterology, Children s Hospital Boston, MA 02115, USA
    J Viral Hepat 15:20-7. 2008
  6. ncbi request reprint Rapid recurrence of nonalcoholic fatty liver disease after transplantation in a child with hypopituitarism and hepatopulmonary syndrome
    Maureen M Jonas
    Division of Gastroenterology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Liver Transpl 11:108-10. 2005
  7. ncbi request reprint Predictors of virologic response to Lamivudine treatment in children with chronic hepatitis B infection
    Xenia Hom
    Division of Gastroenterology, Children s Hospital Boston, Boston, MA, USA
    Pediatr Infect Dis J 23:441-5. 2004
  8. ncbi request reprint Clinical trial of lamivudine in children with chronic hepatitis B
    Maureen M Jonas
    of Gastroenterology, Children s Hospital, Boston, MA 02115, USA
    N Engl J Med 346:1706-13. 2002
  9. pmc Impact of hepatitis C virus infection on children and their caregivers: quality of life, cognitive, and emotional outcomes
    James R Rodrigue
    The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Pediatr Gastroenterol Nutr 48:341-7. 2009
  10. ncbi request reprint Mesogonadal shunts for extrahepatic portal vein thrombosis and variceal hemorrhage
    Heung Bae Kim
    Department of Pediatric Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    Liver Transpl 11:1389-94. 2005

Detail Information

Publications36

  1. pmc Pegylated interferon for chronic hepatitis C in children affects growth and body composition: results from the pediatric study of hepatitis C (PEDS-C) trial
    Maureen M Jonas
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Hepatology 56:523-31. 2012
    ..Percent body fat, fat-free mass z scores, and triceps skinfold z scores decreased with therapy. Dietary energy intake and levels of physical activity did not change during treatment...
  2. doi request reprint Efficacy and safety of long-term adefovir dipivoxil therapy in children with chronic hepatitis B infection
    Maureen M Jonas
    Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Pediatr Infect Dis J 31:578-82. 2012
    ..Those children were followed for 4 more years, and many continued to receive ADV for all or part of this time...
  3. doi request reprint Treatment of children with chronic hepatitis B virus infection in the United States: patient selection and therapeutic options
    Maureen M Jonas
    Division of Gastroenterology, Children s Hospital Boston, Boston, MA 02115, USA
    Hepatology 52:2192-205. 2010
    ..There is still much to be elucidated about the appropriate use of HBV therapy in children. Until more clinical data and therapeutic options are available, a conservative approach is warranted...
  4. doi request reprint Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B
    Maureen M Jonas
    Children s Hospital Boston, Boston, MA 02115, USA
    Hepatology 47:1863-71. 2008
    ..ADV was not different from placebo in subjects aged 2 to 11 years despite adequate plasma ADV exposure in all three age groups...
  5. ncbi request reprint Long-term lamivudine treatment of children with chronic hepatitis B: durability of therapeutic responses and safety
    M M Jonas
    Division of Gastroenterology, Children s Hospital Boston, MA 02115, USA
    J Viral Hepat 15:20-7. 2008
    ..Favourable outcomes from lamivudine treatment of CHB in children are maintained for at least several years after completion of treatment. Up to 3 years of lamivudine treatment is safe in children...
  6. ncbi request reprint Rapid recurrence of nonalcoholic fatty liver disease after transplantation in a child with hypopituitarism and hepatopulmonary syndrome
    Maureen M Jonas
    Division of Gastroenterology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Liver Transpl 11:108-10. 2005
    ..The NAFLD recurred very quickly after a successful liver transplant. Hepatopulmonary syndrome may be more common in cirrhosis associated with pituitary dysfunction than in other types of cirrhosis...
  7. ncbi request reprint Predictors of virologic response to Lamivudine treatment in children with chronic hepatitis B infection
    Xenia Hom
    Division of Gastroenterology, Children s Hospital Boston, Boston, MA, USA
    Pediatr Infect Dis J 23:441-5. 2004
    ..A recent large, multicenter study demonstrated that lamivudine was superior to placebo in eliciting loss of hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA from serum in children (2 to 17 years) treated for 52 weeks...
  8. ncbi request reprint Clinical trial of lamivudine in children with chronic hepatitis B
    Maureen M Jonas
    of Gastroenterology, Children s Hospital, Boston, MA 02115, USA
    N Engl J Med 346:1706-13. 2002
    ..Lamivudine therapy is effective for chronic hepatitis B infection in adults. We evaluated the efficacy and tolerability of lamivudine as a treatment for chronic infection with hepatitis B virus (HBV) in children...
  9. pmc Impact of hepatitis C virus infection on children and their caregivers: quality of life, cognitive, and emotional outcomes
    James R Rodrigue
    The Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Pediatr Gastroenterol Nutr 48:341-7. 2009
    ..Hepatitis C virus (HCV) infection is associated with decreased quality of life (QOL) and neurocognitive dysfunction in adults, but little is known about its impact on children and their caregivers...
  10. ncbi request reprint Mesogonadal shunts for extrahepatic portal vein thrombosis and variceal hemorrhage
    Heung Bae Kim
    Department of Pediatric Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    Liver Transpl 11:1389-94. 2005
    ..In conclusion, the right and left mesogonadal shunts may be useful as salvage operations for patients with EHPVT who have failed standard surgical shunt procedures...
  11. ncbi request reprint Primary sclerosing cholangitis in childhood is associated with abnormalities in cystic fibrosis-mediated chloride channel function
    Harpreet Pall
    Division of Pediatric Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr 151:255-9. 2007
    ..To determine whether primary sclerosing cholangitis (PSC) in childhood is associated with abnormalities in cystic fibrosis transmembrane conductance regulator (CFTR)...
  12. ncbi request reprint Nonalcoholic fatty liver disease
    Maureen M Jonas
    Division of Gastroenterology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Adolesc Med Clin 15:159-73, xi. 2004
    ..Treatment options are currently limited...
  13. ncbi request reprint Children with hepatitis C
    Maureen M Jonas
    Division of Gastroenterology, Children s Hospital Boston, MA 02115, USA
    Hepatology 36:S173-8. 2002
    ..Clearly, there are important needs for future epidemiologic and clinical research on hepatitis C in childhood...
  14. pmc Peginterferon with or without ribavirin has minimal effect on quality of life, behavioral/emotional, and cognitive outcomes in children
    James R Rodrigue
    Beth Israel Deaconess Medical Center, Boston, MA
    Hepatology 53:1468-75. 2011
    ..CONCLUSION: Overall QOL and psychosocial functioning are not deleteriously impacted by PEG 2a + RV or PL treatment of children with HCV...
  15. ncbi request reprint Viral hepatitis. From prevention to antivirals
    M M Jonas
    Department of Pediatrics, Harvard Medical School, and the Division of Gastroenterology, Children s Hospital, Boston, Massachusetts, USA
    Clin Liver Dis 4:849-77. 2000
    ....
  16. ncbi request reprint Pediatric hepatobiliary disease
    Harpreet Pall
    Division of Gastroenterology, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Gastroenterol 21:344-7. 2005
    ..This review summarizes recent advancements occurring over the past year in the field of pediatric hepatology. They have helped in the understanding and treatment of several liver and biliary tract disorders of childhood...
  17. doi request reprint Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B
    Barbara A Haber
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:e1007-13. 2009
    ....
  18. ncbi request reprint Hepatitis B in children
    Annemarie L Broderick
    Gastroenterology and Nutrition, Division of Gastroenterology, Department of Medicine, Children s Hospital, Boston, Massachusetts, USA
    Semin Liver Dis 23:59-68. 2003
    ..Universal infant vaccination has been shown to decrease the frequency of HBV infection and its sequelae. This article addresses aspects of HBV infection that are either unique to or different in children...
  19. pmc Prevalence and predictors of abnormal liver enzymes in young women with anorexia nervosa
    Hiu Fai Fong
    Harvard MIT Division of Health Sciences and Technology, Harvard Medical School, Children s Hospital Boston, Boston, MA 02215, USA
    J Pediatr 153:247-53. 2008
    ..To determine the prevalence and predictors of abnormal liver enzyme levels in ambulatory young women with anorexia nervosa (AN)...
  20. doi request reprint Multivisceral transplantation using a 2.9 kg neonatal donor
    R P Cauley
    Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    Pediatr Transplant 16:E379-82. 2012
    ..We propose a re-examination of the brain death guidelines for premature and young infants to potentially increase the availability of organs for infant recipients...
  21. ncbi request reprint Treatment of chronic hepatitis C in pediatric patients
    M M Jonas
    Division of Gastroenterology, Department of Medicine, Children s Hospital, Boston, Massachusetts, USA
    Clin Liver Dis 3:855-67. 1999
    ....
  22. ncbi request reprint Challenges in the treatment of hepatitis C in children
    M M Jonas
    Department of Pediatrics, Harvard Medical School, and Children s Hospital, Boston, Massachusetts, USA
    Clin Liver Dis 5:1063-71. 2001
    ..Understanding of these differences will allow optimal care for affected children and perhaps better understanding of the pathophysiology and pure natural history of this disease...
  23. ncbi request reprint Treatment of chronic hepatitis B in children
    Maureen M Jonas
    Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Gastroenterol Nutr 43:S56-60. 2006
    ..This article describes rationale for treatment, patient selection and pros and cons of the current and expected therapeutic options...
  24. doi request reprint Safety of minimal immunosuppression in liver transplantation for hepatoblastoma
    Matthew Y Suh
    Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    J Pediatr Surg 43:1148-52. 2008
    ..Unfortunately, little is known about the effects of immunosuppression on recurrence and posttransplant outcomes. We hypothesized that minimal immunosuppression can be safely used in these recipients...
  25. ncbi request reprint Hepatitis B and C in children: current treatment and future strategies
    Scott A Elisofon
    Division of Gastroenterology, Children s Hospital Boston, Hunnewell Ground, 300 Longwood Avenue, Boston, MA 02115, USA
    Clin Liver Dis 10:133-48, vii. 2006
    ..Treatment options are discussed, including patient selection, specific medications, ongoing studies, and future treatment options...
  26. ncbi request reprint Pediatric hepatobiliary disease
    Christine K Lee
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Gastroenterol 23:306-9. 2007
    ..These studies contribute to the understanding of the epidemiology, histopathology, predictors of outcome and treatment of some important pediatric liver and biliary disorders...
  27. doi request reprint Hepatitis B and pregnancy: an underestimated issue
    Maureen M Jonas
    Children s Hospital Boston, Center for Childhood Liver Disease, Division of Gastroenterology, Boston, MA 02115, USA
    Liver Int 29:133-9. 2009
    ..This paper reviews the current experience in each of these areas, and highlights the need for further investigation into this critical but often underestimated topic...
  28. ncbi request reprint Long-term lamivudine therapy for children with HBeAg-positive chronic hepatitis B
    Etienne M Sokal
    Departement de Pediatrie, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Hepatology 43:225-32. 2006
    ..However, the incidence of YMMD mutations increased over time and resulted in lower response rates. VR was maintained in most patients who had initially responded to lamivudine in the first 12 months...
  29. doi request reprint Safety and efficacy of pegylated interferon alpha-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia
    Paul Harmatz
    Children s Hospital and Research Center Oakland, 747 52 Street, Oakland, CA 94609, USA
    Haematologica 93:1247-51. 2008
    ..The molar efficacy of deferoxamine improved with reduction in liver inflammation on biopsy (p=0.001). In conclusion, antiviral treatment is safe if transfusion requirement, iron toxicities and neutropenia are monitored...
  30. ncbi request reprint Management of hepatitis B in children
    Annemarie Broderick
    Department of Paediatrics, University College, Dublin, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Clin Liver Dis 8:387-401. 2004
    ..Prevention of new HBV infections is an important part of management in children, and working with public health campaigns will hopefully reduce both vertical and horizontal transmission...
  31. pmc Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group
    Robert H Squires
    University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    J Pediatr 148:652-658. 2006
    ..To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors...
  32. ncbi request reprint Re: ganciclovir treatment in infants with cytomegalovirus infection and cholestasis
    Maureen M Jonas
    J Pediatr Gastroenterol Nutr 35:399-400; author reply 400. 2002
  33. ncbi request reprint Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokinetics
    Regino P Gonzalez-Peralta
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL 32610, USA
    Hepatology 42:1010-8. 2005
    ..In conclusion, interferon alfa-2b in combination with ribavirin is effective and safe in children with chronic hepatitis C virus...
  34. ncbi request reprint The role of liver transplantation in cystic fibrosis re-examined
    Maureen M Jonas
    Liver Transpl 11:1463-5. 2005
  35. pmc Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial
    Zachary D Goodman
    Armed Forces Institute of Pathology and Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA
    Hepatology 47:836-43. 2008
    ....
  36. ncbi request reprint Finding adolescents and young adults with transfusion-associated hepatitis C: looking forward to looking back
    Maureen M Jonas
    Arch Pediatr Adolesc Med 161:202-3. 2007