Ferenc Jolesz

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity
    Byoung Kyong Min
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Neurosci 12:23. 2011
  2. ncbi Compatible instrumentation for intraoperative MRI: expanding resources
    F A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Magn Reson Imaging 8:8-11. 1998
  3. ncbi Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors
    Ferenc A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neuroimaging Clin N Am 12:665-83. 2002
  4. ncbi MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery
    Ferenc A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Magn Reson Imaging Clin N Am 13:545-60. 2005
  5. ncbi Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound
    Ferenc A Jolesz
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 127:S242-7. 2004
  6. ncbi Neuronavigation in interventional MR imaging. Frameless stereotaxy
    F A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neuroimaging Clin N Am 11:685-93, ix. 2001
  7. ncbi Neurosurgical suite of the future. II
    F A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neuroimaging Clin N Am 11:581-92. 2001
  8. ncbi Intraoperative imaging in neurosurgery: where will the future take us?
    Ferenc A Jolesz
    Division of MRI and Image Guided Therapy Program, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Acta Neurochir Suppl 109:21-5. 2011
  9. ncbi Future perspectives for intraoperative MRI
    Ferenc A Jolesz
    Division of MRI and Image Guided Therapy Program, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neurosurg Clin N Am 16:201-13. 2005
  10. ncbi Integration of interventional MRI with computer-assisted surgery
    F A Jolesz
    Department of Radiology MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Magn Reson Imaging 13:69-77. 2001

Research Grants

  1. Multidisciplinary Training in Image Guided Therapy
    Ferenc Jolesz; Fiscal Year: 2005
  2. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2009
  3. IMAGE GUIDED THERAPY CENTER
    Ferenc A Jolesz; Fiscal Year: 2010
  4. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2007
  5. IMAGE GUIDED THERAPY (MR Guided Therapy)
    Ferenc Jolesz; Fiscal Year: 2007
  6. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2006
  7. Intraoperative 3T MRI Scanner for Minimally Invasive Therapy
    Ferenc Jolesz; Fiscal Year: 2007
  8. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2005

Detail Information

Publications92

  1. ncbi Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity
    Byoung Kyong Min
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Neurosci 12:23. 2011
    ....
  2. ncbi Compatible instrumentation for intraoperative MRI: expanding resources
    F A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Magn Reson Imaging 8:8-11. 1998
    ..Suppliers/manufacturers of MR-compatible instrumentation were few in 1994, but now there are more than 50. We present fundamental issues of MR compatibility and a list of known suppliers/manufacturers...
  3. ncbi Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors
    Ferenc A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neuroimaging Clin N Am 12:665-83. 2002
    ....
  4. ncbi MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery
    Ferenc A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Magn Reson Imaging Clin N Am 13:545-60. 2005
    ....
  5. ncbi Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound
    Ferenc A Jolesz
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 127:S242-7. 2004
    ..In this article, we review previous work with focused ultrasound in the liver and recent experimental results with magnetic resonance imaging guidance...
  6. ncbi Neuronavigation in interventional MR imaging. Frameless stereotaxy
    F A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neuroimaging Clin N Am 11:685-93, ix. 2001
    ....
  7. ncbi Neurosurgical suite of the future. II
    F A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neuroimaging Clin N Am 11:581-92. 2001
    ..Obviously, the operating room of the future will accommodate various instruments, tools and devices, which are attached to the imaging systems and controlled by image-based feedback...
  8. ncbi Intraoperative imaging in neurosurgery: where will the future take us?
    Ferenc A Jolesz
    Division of MRI and Image Guided Therapy Program, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Acta Neurochir Suppl 109:21-5. 2011
    ..A call to action is made to have other researchers and clinicians in the field of image guided therapy to work together to integrate imaging with therapy delivery systems (such as laser, MRgFUS, endoscopic, and robotic surgery devices)...
  9. ncbi Future perspectives for intraoperative MRI
    Ferenc A Jolesz
    Division of MRI and Image Guided Therapy Program, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neurosurg Clin N Am 16:201-13. 2005
    ..We can also expect improvements in intraoperative imaging systems as well as increased use of nonimaging sensors and robotics to facilitate more widespread use of intraoperative MRI...
  10. ncbi Integration of interventional MRI with computer-assisted surgery
    F A Jolesz
    Department of Radiology MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Magn Reson Imaging 13:69-77. 2001
    ..The integration of intraoperative MRI guidance and computer-assisted surgery will greatly accelerate the clinical utility of image-guided therapy in general and interventional MRI in particular. J. Magn. Reson. Imaging 2001;13:69-77...
  11. ncbi MRI-guided focused ultrasound surgery
    Ferenc A Jolesz
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Med 60:417-30. 2009
    ..A disruptive technology, MRgFUS provides new therapeutic approaches and may cause major changes in patient management and several medical disciplines...
  12. ncbi Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Magn Reson Imaging 28:1026-32. 2008
    ..To clinically assess a previously described method (Rieke et.al., Magn Reson Med 2004) to produce more motion-robust MRI-based temperature images using data acquired during MRI-guided focused ultrasound surgery (MRgFUS) of uterine fibroids...
  13. ncbi Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 32:1399-409. 2006
    ....
  14. ncbi Survival rates in patients with low-grade glioma after intraoperative magnetic resonance image guidance
    Elizabeth B Claus
    Department of Neurosurgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer 103:1227-33. 2005
    ....
  15. ncbi Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosurgery 66:323-32; discussion 332. 2010
    ..This work evaluated the clinical feasibility of transcranial magnetic resonance imaging-guided focused ultrasound surgery...
  16. ncbi White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study
    Hae-Jeong Park
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
    Neuroimage 23:213-23. 2004
    ..These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neurodevelopmental abnormalities in schizophrenia...
  17. ncbi Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Neurosurg 105:445-54. 2006
    ....
  18. ncbi Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 54:1171-80. 2003
    ..These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities...
  19. ncbi Compensation of geometric distortion effects on intraoperative magnetic resonance imaging for enhanced visualization in image-guided neurosurgery
    Neculai Archip
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosurgery 62:209-15; discussion 215-6. 2008
    ..We propose and evaluate a novel method to compensate for the geometric distortion of intraoperative 0.5-T MRI in image-guided neurosurgery...
  20. ncbi Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
    Kiyoto Kasai
    Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 160:156-64. 2003
    ..CONCLUSIONS: These findings demonstrate a progressive volume reduction of the left posterior superior temporal gyrus gray matter in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis...
  21. ncbi Collateral nerve fibers in human spinal cord: visualization with magnetic resonance diffusion tensor imaging
    Hatsuho Mamata
    Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neuroimage 31:24-30. 2006
    ..Diffusion tensor MRI can reveal non-invasively and in great detail the intricate fiber architecture of the human spinal cord...
  22. ncbi High-resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy
    Hatsuho Mamata
    Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
    AJNR Am J Neuroradiol 23:67-75. 2002
    ..Near large bone structures, line scan produces images with minimal susceptibility artifacts...
  23. ncbi Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosis
    Kiyoto Kasai
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System/Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Arch Gen Psychiatry 60:1069-77. 2003
    ....
  24. ncbi Evaluation of three-dimensional temperature distributions produced by a low-frequency transcranial focused ultrasound system within ex vivo human skulls
    Nathan Mcdannold
    Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 57:1967-76. 2010
    ..The MRTI noise level prevented the identification of possible hotspots with a lower temperature rise. These results suggest that significant secondary heating by this TcMRgFUS system at points distant from the focal point are not common...
  25. ncbi Image-guided thermal therapy of uterine fibroids
    Shu Huei Shen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Semin Ultrasound CT MR 30:91-104. 2009
    ....
  26. ncbi Focused ultrasound effects on nerve action potential in vitro
    Vincent Colucci
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Ultrasound Med Biol 35:1737-47. 2009
    ..These results indicate that a thermal mechanism of focused ultrasound can be used to block nerve conduction, either temporarily or permanently...
  27. ncbi Defining the rectal dose constraint for permanent radioactive seed implantation of the prostate
    Michele Albert
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Urol Oncol 26:147-52. 2008
    ..This study was performed to define the rectal dose constraint that would predict late rectal bleeding requiring argon plasma coagulation (APC) following prostate brachy mono-therapy...
  28. ncbi Late genitourinary and gastrointestinal toxicity after magnetic resonance image-guided prostate brachytherapy with or without neoadjuvant external beam radiation therapy
    Michele Albert
    Department of Radiation Oncology, Brigham and Women s Hospital, 75 Francis Street, L 2 Level, Boston, MA 02115, USA
    Cancer 98:949-54. 2003
    ..This study was designed to estimate the rates of late genitourinary (GU) and rectal toxicity after magnetic resonance image (MRI)-guided prostate brachytherapy exclusively or in conjunction with external beam radiation therapy (EBRT)...
  29. ncbi Volumetric assessment of tumor infiltration of adjacent white matter based on anatomic MRI and diffusion tensor tractography
    Ion Florin Talos
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Acad Radiol 14:431-6. 2007
    ..We hypothesized that white matter infiltration may be common among different types of tumor...
  30. ncbi A global goodness-of-fit test for receiver operating characteristic curve analysis via the bootstrap method
    Kelly H Zou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, MIT, MA, USA
    J Biomed Inform 38:395-403. 2005
    ..The main objective was to develop a global statistical hypothesis test for assessing the goodness-of-fit (GOF) for parametric ROC curves via the bootstrap...
  31. ncbi MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 31:1527-37. 2005
    ..These findings indicate that this method is safe for targeted drug delivery, at least when compared with the currently available invasive methods...
  32. ncbi Connectivity among semantic associates: an fMRI study of semantic priming
    Cynthia G Wible
    Clinical Neuroscience Division, Laboratory of Neuroscience, Harvard Medical School, Boston, MA, USA
    Brain Lang 97:294-305. 2006
    ..fMRI activity located primarily in bilateral posterior superior and middle temporal regions showed modulation by connectivity and relatedness. The results suggest that these regions are involved in semantic processing...
  33. ncbi Application of open source image guided therapy software in MR-guided therapies
    Nobuhiko Hata
    National Center for Image guided Therapy, Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, USA
    Med Image Comput Comput Assist Interv 10:491-8. 2007
    ..Our future studies include use of the software in non-MR-guided therapies...
  34. ncbi Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Radiol 59:149-56. 2006
    ..The acoustic intensity values during the 20 s sonications were adequate for thermal ablation in the human brain provided that surface cooling is used...
  35. ncbi A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia
    James J Levitt
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Brockton, MA 02301 and Harvard Medical School, Boston, MA 02115, United States
    Psychiatry Res 184:143-50. 2010
    ..Despite not demonstrating a group difference in FA, we found that AL-IC FA was a good predictor of spatial and verbal declarative/episodic memory performance in schizophrenia...
  36. ncbi Independent vector analysis (IVA): multivariate approach for fMRI group study
    Jong Hwan Lee
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neuroimage 40:86-109. 2008
    ..IVA can be used as a potential alternative or an adjunct to current ICA-based fMRI group processing methods...
  37. ncbi Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Ave LMRC, 007c, Boston, MA 02115, USA
    Radiology 240:263-72. 2006
    ..To retrospectively evaluate magnetic resonance (MR) imaging-based thermometry and thermal dosimetry during focused ultrasound treatments of uterine leiomyomas (ie, fibroids)...
  38. ncbi Functional magnetic resonance imaging-mediated learning of increased activity in auditory areas
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuroreport 18:1915-20. 2007
    ....
  39. ncbi Renal ultrafiltration changes induced by focused US
    Krisztina Fischer
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Focused Ultrasound Laboratory, 221 Longwood Ave, Room 515, Boston, MA 02215, USA
    Radiology 253:697-705. 2009
    ..To determine if focused ultrasonography (US) combined with a diagnostic microbubble-based US contrast agent can be used to modulate glomerular ultrafiltration and size selectivity...
  40. ncbi Increasing cortical activity in auditory areas through neurofeedback functional magnetic resonance imaging
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuroreport 17:1273-8. 2006
    ..Results showed that the group of individuals who received the feedback were able to increase the activation volume and blood oxygenation level-dependent signal to a greater degree than the control group...
  41. ncbi A validation framework for brain tumor segmentation
    Neculai Archip
    Harvard Medical School, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Acad Radiol 14:1242-51. 2007
    ..We introduce a validation framework for the segmentation of brain tumors from magnetic resonance (MR) images. A novel unsupervised semiautomatic brain tumor segmentation algorithm is also presented...
  42. ncbi Atlas-based multichannel monitoring of functional MRI signals in real-time: automated approach
    Jong Hwan Lee
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, MA 02115, USA
    Hum Brain Mapp 29:157-66. 2008
    ..The proposed method may be applied to various applications such as neurofeedback, brain-computer-interface, and functional mapping for surgical planning where real-time monitoring of region-specific brain activity is needed...
  43. ncbi Image-guided neurosurgery at Brigham and Women's Hospital
    Simon P DiMaio
    Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA
    IEEE Eng Med Biol Mag 25:67-73. 2006
  44. ncbi A deficit in the ability to form new human memories without sleep
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Neurosci 10:385-92. 2007
    ..It therefore appears that sleep before learning is critical in preparing the human brain for next-day memory formation-a worrying finding considering society's increasing erosion of sleep time...
  45. ncbi Reproducibility of trial-based functional MRI on motor imagery
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Neurosci 117:215-27. 2007
    ..The results suggest that a measurement of BOLD signal itself is a more reliable indicator of paradigm-related brain activation during repeated fMRI scans...
  46. ncbi MR imaging--guided breast ablative therapy
    Daniel F Kacher
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA
    Radiol Clin North Am 42:947-62, vii. 2004
    ..Procedures have been validated by histopathology subsequent to resection...
  47. ncbi Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal P300 amplitude in first-episode schizophrenia
    Robert W McCarley
    Deprtment of Psychiatry, Harvard Medical School, Veterans Affairs Boston Healthcare System, 940 Belmont St, Brockton, MA 02301, USA
    Arch Gen Psychiatry 59:321-31. 2002
    ..The present study investigated whether the left temporal P300-left posterior STG volume association is selectively present in first-episode schizophrenia...
  48. ncbi Brain-computer interface using fMRI: spatial navigation by thoughts
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neuroreport 15:1591-5. 2004
    ..The proposed fMRI-BCI method allowed volunteer subjects to navigate through a simple 2D maze solely through their thought processes...
  49. ncbi Modulation of cerebellar activities by acupuncture stimulation: evidence from fMRI study
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 22:932-40. 2004
    ..Our data suggest that cerebellum serves as important activation loci during the acupuncture stimulation of PC6, and clinical efficacy of PC6 may be mediated by the cerebellar vestibular neuromatrix...
  50. ncbi Characterization of central nervous system structures by magnetic resonance diffusion anisotropy
    Hatsuho Mamata
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neurochem Int 45:553-60. 2004
    ..Characterization of various central nervous system structures with diffusion anisotropy is possible and may be useful to monitor degenerative diseases in the central nervous system...
  51. ncbi MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Magn Reson Med 51:913-23. 2004
    ..The temperature information was better than the applied acoustic power or energy for predicting the damage than the ultrasound parameters. MRI was sensitive in detecting threshold-level damage...
  52. ncbi Comparison of single-shot echo-planar and line scan protocols for diffusion tensor imaging
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Acad Radiol 11:224-32. 2004
    ..CONCLUSION: Results indicate that both EPI- and LSDI-derived FA measures are sufficiently robust. However, when higher accuracy is needed, LSDI provides smaller error and smaller inter-subject and inter-session variability than EPI...
  53. ncbi Biexponential diffusion tensor analysis of human brain diffusion data
    Stephan E Maier
    Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Magn Reson Med 51:321-30. 2004
    ..The second and third diffusion eigenvector directions also appeared to be aligned, but they exhibited significant deviations in localized areas...
  54. ncbi The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison)
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Ultrasound Med Biol 29:473-81. 2003
    ..However, one should be aware that brain damage can be induced if the exposure level is increased...
  55. ncbi MRI-guided focused ultrasound surgery in the brain: tests in a primate model
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Magn Reson Med 49:1188-91. 2003
    ..The capabilities demonstrated in this study will be of benefit for clinical ultrasound therapies in the brain...
  56. ncbi 500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Magn Reson Med 52:100-7. 2004
    ..As a conclusion, this study demonstrates that it is possible to create ultrasound-induced lesions in vivo through a human skull under MRI guidance with this large-scale phased array...
  57. ncbi Neural substrates of tactile imagery: a functional MRI study
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroreport 14:581-5. 2003
    ..Our results suggest that the primary and secondary somatosensory areas are recruited during tactile imagery, and have partially overlapping neural substrates for the perception of tactile stimulation...
  58. ncbi MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study
    Clare M C Tempany
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 226:897-905. 2003
    ..MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences...
  59. ncbi The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 29:356-65. 2002
    ..Even with this underestimation of the power, this method will be useful because it will allow an estimate of the proper power to use during FUS surgery without exact knowledge of the tissue parameters...
  60. ncbi Apparent diffusion coefficient and fractional anisotropy in spinal cord: age and cervical spondylosis-related changes
    Hatsuho Mamata
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Magn Reson Imaging 22:38-43. 2005
    ..To present the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) change with age in the normal spinal cord and in cervical spondylosis...
  61. ncbi Capturing intraoperative deformations: research experience at Brigham and Women's Hospital
    Simon K Warfield
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Med Image Anal 9:145-62. 2005
    ..This paper reviews the experience at Brigham and Women's Hospital through the process of developing and applying novel algorithms for capturing intraoperative deformations in support of image guided therapy...
  62. ncbi Prefrontal cortical thickness in first-episode psychosis: a magnetic resonance imaging study
    Laura C Wiegand
    Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 55:131-40. 2004
    ....
  63. ncbi Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 24:12-20. 2005
    ..The electron microscopy findings demonstrated HRP passage through vessel walls via both transendothelial and paraendothelial routes. These results demonstrate that completely noninvasive focal disruption of the BBB is possible...
  64. ncbi High b-value apparent diffusion-weighted images from CURVE-ball DTI
    Sharon Peled
    Radiology Department, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Magn Reson Imaging 30:243-8. 2009
    ..To investigate the utility of a proposed clinical diffusion imaging scheme for rapidly generating multiple b-value diffusion contrast in brain magnetic resonance imaging (MRI) with high signal-to-noise ratio (SNR)...
  65. ncbi Comparing PSA outcome after radical prostatectomy or magnetic resonance imaging-guided partial prostatic irradiation in select patients with clinically localized adenocarcinoma of the prostate
    Clare M Tempany
    Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Urology 62:1063-7. 2003
    ..CONCLUSIONS: Despite only partial prostatic irradiation using intraoperative magnetic resonance imaging-guided brachytherapy, similar 5-year estimates of PSA control were found for both brachytherapy and RP-managed patients...
  66. ncbi Application of independent component analysis for the data mining of simultaneous Eeg-fMRI: preliminary experience on sleep onset
    Jong Hwan Lee
    Department of Radiology Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Int J Neurosci 119:1118-36. 2009
    ..These results suggest that the ICA technique may be useful for the preprocessing of simultaneous EEG-fMRI acquisitions, especially when a reference paradigm is unavailable...
  67. ncbi Automated classification of fMRI data employing trial-based imagery tasks
    Jong Hwan Lee
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Med Image Anal 13:392-404. 2009
    ..Our proposed study for the automated classification of fMRI data may be utilized in further investigations to monitor/identify human thought processes and their potential link to hardware/computer control...
  68. ncbi Brain-machine interface via real-time fMRI: preliminary study on thought-controlled robotic arm
    Jong Hwan Lee
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA
    Neurosci Lett 450:1-6. 2009
    ..The movement was broadcasted visually back to the subject as a feedback. We demonstrated that real-time control of the robotic arm only through the subjects' thought processes was possible using the rtfMRI-based BMI trials...
  69. ncbi Functional MRI for neurofeedback: feasibility study on a hand motor task
    Seung-Schik Yoo
    Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Neuroreport 13:1377-81. 2002
    ..This method may offer a potential utility for fMRI-based neurofeedback...
  70. ncbi MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals
    Francois Cotton
    Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurology 60:640-6. 2003
    ..Early lesion growth parameters may predict final lesion size. Within-patient heterogeneity of lesion evolution suggests that individual lesions develop independently...
  71. ncbi Future potential of MRI-guided focused ultrasound brain surgery
    Rivka R Colen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Neuroimaging Clin N Am 20:355-66. 2010
    ..Although challenges still remain, this integrated noninvasive therapy delivery system is anticipated to change current treatment paradigms in neurosurgery and the clinical neurosciences...
  72. ncbi A review of diffusion tensor imaging studies in schizophrenia
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System Brockton Division, Department of Psychiatry, Harvard Medical School, 940 Belmont Street, Brockton, Boston, MA 02301, United States
    J Psychiatr Res 41:15-30. 2007
    ..Finally, we review MR-DTI findings in schizophrenia...
  73. ncbi Does the phase of menstrual cycle affect MR-guided focused ultrasound surgery of uterine leiomyomas?
    Minna J So
    Department of Radiology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Eur J Radiol 59:203-7. 2006
    ..To determine whether the phase of menstrual cycle at the time of MR-guided focused ultrasound surgery (MRgFUS) treatment for uterine leiomyomas affects treatment outcome...
  74. ncbi Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols
    Fiona M Fennessy
    Department of Radiology, Harvard Medical School Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Radiology 243:885-93. 2007
    ..To prospectively assess patient response (after 12 months) to magnetic resonance (MR) imaging-guided focused ultrasound surgery in treatment of uterine leiomyomas by using two treatment protocols...
  75. ncbi Geometrically constrained two-tensor model for crossing tracts in DWI
    Sharon Peled
    Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA
    Magn Reson Imaging 24:1263-70. 2006
    ..Upon evaluation in simulations and application to in vivo human brain DTI data, the method appears to be robust and practical and, if correctly applied, could elucidate tract directions at critical points of uncertainty...
  76. ncbi An intraoperative brain shift monitor using shear mode transcranial ultrasound: preliminary results
    P Jason White
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Ultrasound Med 28:191-203. 2009
    ....
  77. ncbi Challenges in image-guided therapy system design
    Simon Dimaio
    Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Neuroimage 37:S144-51. 2007
    ..This report elaborates on these key points and proposes research challenges that are to be addressed by a joint effort between academic, industry, and NIH participants...
  78. ncbi Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study
    Toshiaki Onitsuka
    Department of Psychiatry (116A, Boston VA Healthcare System, Brockton Division, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Am J Psychiatry 161:1603-11. 2004
    ....
  79. ncbi Spatial normalization of diffusion tensor MRI using multiple channels
    Hae-Jeong Park
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 20:1995-2009. 2003
    ....
  80. ncbi Radiofrequency ablation of thoracic lesions: part 1, experiments in the normal porcine thorax
    Paul R Morrison
    Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA
    AJR Am J Roentgenol 184:375-80. 2005
    ..Radiofrequency-induced lesions in the normal porcine lung can be visualized with both CT and MRI; image appearance is concordant with histologic tissue changes...
  81. ncbi Neuronavigation in the surgical management of brain tumors: current and future trends
    Daniel A Orringer
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Expert Rev Med Devices 9:491-500. 2012
    ..Finally, emerging concepts and future challenges relating to the development and implementation of experimental imaging technologies in the navigational environment are explored...
  82. ncbi Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 30:979-89. 2004
    ..free passage through the injured endothelium (with the higher power sonications). These findings could be considered in further development of the strategy for drug delivery to brain parenchyma...
  83. ncbi Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery
    Neculai Archip
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Neuroimage 35:609-24. 2007
    ....
  84. ncbi Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study
    Kiyoto Kasai
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, Mass, USA
    Arch Gen Psychiatry 60:766-75. 2003
    ..Schizophrenia but not affective psychosis seems to be characterized by a postonset progression of neocortical gray matter volume loss in the left superior temporal gyrus and thus may not be developmentally fixed...
  85. ncbi Feasibility of internally referenced brain temperature imaging with a metabolite signal
    Kagayaki Kuroda
    Department of Image Based Medicine, Institute of Biomedical Research and Innovation, Kobe, Japan
    Magn Reson Med Sci 2:17-22. 2003
    ..5 cm3 and 4.5 min. A higher signal-to-noise ratio and optimization of the water and outer-volume suppression capabilities will be required to further enhance the temperature-mapping capabilities...
  86. ncbi Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System-Brockton Division, MA 02301, USA
    Am J Psychiatry 159:813-20. 2002
    ....
  87. ncbi Robust nonrigid registration to capture brain shift from intraoperative MRI
    Olivier Clatz
    Epidaure Research Project, INRIA Sophia Antipolis, 06902 Sophia Antipolis Cedex, France
    IEEE Trans Med Imaging 24:1417-27. 2005
    ..The results show a good ability to recover large displacements, and a limited decrease of accuracy near the tumor resection cavity...
  88. ncbi Simultaneous ultrasound and MRI system for breast biopsy: compatibility assessment and demonstration in a dual modality phantom
    Annie M Tang
    Department of Electrical and Electronic Engneering, The University of Hong Kong, Hong Kong
    IEEE Trans Med Imaging 27:247-54. 2008
    ..US can be used for real time display of the needle trajectory, while MRI can be used to confirm needle placement...
  89. ncbi Serial registration of intraoperative MR images of the brain
    Matthieu Ferrant
    Communications and Remote Sensing Laboratory, , B-1348, Louvain-la-Neuve, Belgium
    Med Image Anal 6:337-59. 2002
    ..7+/-0.6 mm (mean+/-S.D.) for boundary surface landmarks, of 0.9+/-0.6 mm for landmarks inside the boundary surfaces, and 1.6+/-0.9 mm for landmarks in the vicinity of the tumor...
  90. ncbi Hybrid formulation of the model-based non-rigid registration problem to improve accuracy and robustness
    Olivier Clatz
    Epidaure Research Project, INRIA Sophia Antipolis, France
    Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8:295-302. 2005
    ..The algorithm has been tested on six cases of brain tumor resection, presenting a brain shift up to 13 mm...
  91. ncbi Shape of caudate nucleus and its cognitive correlates in neuroleptic-naive schizotypal personality disorder
    James J Levitt
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 55:177-84. 2004
    ....
  92. ncbi Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia
    Toshiaki Onitsuka
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton, MA 02301, USA
    Arch Gen Psychiatry 60:349-55. 2003
    ..CONCLUSION: These results suggest that neuroanatomic FG abnormalities underlie at least some of the deficits associated with facial recognition in schizophrenia...

Research Grants14

  1. Multidisciplinary Training in Image Guided Therapy
    Ferenc Jolesz; Fiscal Year: 2005
    ..We plan to develop a specialized curriculum to augment the research and education and to attract highly qualified candidates for this exciting area of translational research. ..
  2. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2009
    ..abstract_text> ..
  3. IMAGE GUIDED THERAPY CENTER
    Ferenc A Jolesz; Fiscal Year: 2010
    ..We are also committed to making our technology broadly available to a large community of clinician. Our mission is to develop and implement novel, innovative technologies to decrease the invasiveness of surgeries and interventions. ..
  4. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2007
    ..abstract_text> ..
  5. IMAGE GUIDED THERAPY (MR Guided Therapy)
    Ferenc Jolesz; Fiscal Year: 2007
    ..These five projects will work synergistically to not only develop better imaging methods for defining the cancers, but will also work to facilitate the improved, targeted treatment of brain tumors and prostate cancer. ..
  6. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2006
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT ..
  7. Intraoperative 3T MRI Scanner for Minimally Invasive Therapy
    Ferenc Jolesz; Fiscal Year: 2007
    ....
  8. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2005
    ....