Steven Joffe

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Equipoise: asking the right questions for clinical trial design
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Nat Rev Clin Oncol 9:230-5. 2012
  2. doi request reprint Pediatricians' reports of their education in ethics
    Jennifer Cohn Kesselheim
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 162:368-73. 2008
  3. ncbi request reprint Advance care planning in patients undergoing hematopoietic cell transplantation
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biol Blood Marrow Transplant 13:65-73. 2007
  4. ncbi request reprint Views of American oncologists about the purposes of clinical trials
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 94:1847-53. 2002
  5. pmc What do patients value in their hospital care? An empirical perspective on autonomy centred bioethics
    S Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Med Ethics 29:103-8. 2003
  6. ncbi request reprint Public dialogue and the boundaries of moral community
    Steven Joffe
    Dana Farber Cancer Institute and Children s Hospital, USA
    J Clin Ethics 14:101-8. 2003
  7. pmc Satisfaction of the uncertainty principle in cancer clinical trials: retrospective cohort analysis
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    BMJ 328:1463. 2004
  8. ncbi request reprint Involving children with cancer in decision-making about research participation
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Pediatr 149:862-868. 2006
  9. ncbi request reprint Comparison of outcomes in cancer patients treated within and outside clinical trials: conceptual framework and structured review
    Jeffrey M Peppercorn
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Lancet 363:263-70. 2004
  10. doi request reprint Considerations about hastening death among parents of children who die of cancer
    Veronica Dussel
    Center for Outcomes and Policy Research and Department of Psychosocial Oncology and Palliative Care, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 164:231-7. 2010

Detail Information

Publications41

  1. doi request reprint Equipoise: asking the right questions for clinical trial design
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Nat Rev Clin Oncol 9:230-5. 2012
    ..An alternate approach to risk-benefit assessment that is congruent with the scientific purpose of RCTs can better guide ethical evaluation of these trials, as discussed in this Perspective...
  2. doi request reprint Pediatricians' reports of their education in ethics
    Jennifer Cohn Kesselheim
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 162:368-73. 2008
    ..To study pediatricians' assessments of the quality of their ethics education, the impact of various learning methods, and their confidence in confronting ethical dilemmas arising in pediatric practice...
  3. ncbi request reprint Advance care planning in patients undergoing hematopoietic cell transplantation
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biol Blood Marrow Transplant 13:65-73. 2007
    ..Even though ACP was more prevalent among this sample than in the general population, its use still could be enhanced, given the high risks of decisional incapacity and death that HCT patients face...
  4. ncbi request reprint Views of American oncologists about the purposes of clinical trials
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 94:1847-53. 2002
    ..Many research subjects believe incorrectly that the primary purpose of clinical trials is to benefit the participants rather than to improve therapy for future patients. However, few data are available about how physicians view trials...
  5. pmc What do patients value in their hospital care? An empirical perspective on autonomy centred bioethics
    S Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Med Ethics 29:103-8. 2003
    ..We sought to examine the relative influence of involvement in decisions, confidence and trust in providers, and treatment with respect and dignity on patients' evaluations of their hospital care...
  6. ncbi request reprint Public dialogue and the boundaries of moral community
    Steven Joffe
    Dana Farber Cancer Institute and Children s Hospital, USA
    J Clin Ethics 14:101-8. 2003
  7. pmc Satisfaction of the uncertainty principle in cancer clinical trials: retrospective cohort analysis
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    BMJ 328:1463. 2004
    ..This principle is violated if trials systematically favour either the experimental or the standard treatment...
  8. ncbi request reprint Involving children with cancer in decision-making about research participation
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Pediatr 149:862-868. 2006
  9. ncbi request reprint Comparison of outcomes in cancer patients treated within and outside clinical trials: conceptual framework and structured review
    Jeffrey M Peppercorn
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Lancet 363:263-70. 2004
    ..Many oncologists believe that patients with cancer who enroll in clinical trials have better outcomes than those who do not enroll. We aimed to assess the empirical evidence that such a trial effect exists...
  10. doi request reprint Considerations about hastening death among parents of children who die of cancer
    Veronica Dussel
    Center for Outcomes and Policy Research and Department of Psychosocial Oncology and Palliative Care, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 164:231-7. 2010
    ....
  11. pmc A randomized study of how physicians interpret research funding disclosures
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    N Engl J Med 367:1119-27. 2012
    ..The effects of clinical-trial funding on the interpretation of trial results are poorly understood. We examined how such support affects physicians' reactions to trials with a high, medium, or low level of methodologic rigor...
  12. ncbi request reprint Rethinking risk-benefit assessment for phase I cancer trials
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 24:2987-90. 2006
  13. pmc Private cord blood banking: experiences and views of pediatric hematopoietic cell transplantation physicians
    Ian Thornley
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Pediatrics 123:1011-7. 2009
    ..Pediatric hematopoietic cell transplantation physicians are currently best situated to use cord blood therapeutically. We sought to describe the experiences and views of these physicians regarding private cord blood banking...
  14. ncbi request reprint Direct-to-consumer advertising in oncology
    Gregory A Abel
    Department of Medicine, Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114 2617, USA
    Oncologist 11:217-26. 2006
    ..Although sparse, the medical literature on this increasingly prevalent type of medical communication is also reviewed...
  15. pmc Relationships between authorship contributions and authors' industry financial ties among oncology clinical trials
    Susannah L Rose
    Department of Health Care Policy, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 28:1316-21. 2010
    ..CONCLUSION Authors who perform key roles in the conception and design, analysis, and interpretation, or reporting of oncology clinical trials are more likely than authors who do not perform such roles to have financial ties to industry...
  16. ncbi request reprint Physicians' attitudes about quality-of-life issues in hematopoietic stem cell transplantation
    Stephanie J Lee
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 104:2194-200. 2004
    ....
  17. ncbi request reprint Oncology physician and nurse practices and attitudes regarding offering clinical trial results to study participants
    Ann H Partridge
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 96:629-32. 2004
    ..Future studies should consider sharing trial results with patients and evaluating the process and its effect on both patients and clinicians...
  18. doi request reprint Ethics consultation in children's hospitals: results from a survey of pediatric clinical ethicists
    Jennifer C Kesselheim
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Pediatrics 125:742-6. 2010
    ..We conducted a national survey of ethicists at freestanding children's hospitals to explore the structures and processes of their ethics-consultation services and committees and to characterize their training and professional activities...
  19. pmc Clinical trial participation among ethnic/racial minority and majority patients with advanced cancer: what factors most influence enrollment?
    Rachel Jimenez
    Department of Radiation Oncology, Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    J Palliat Med 16:256-62. 2013
    ....
  20. pmc Parents' views of cancer-directed therapy for children with no realistic chance for cure
    Jennifer W Mack
    Center for Outcomes and Policy Research and Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 26:4759-64. 2008
    ..We assessed parents' experiences with treatment for their children with cancer and no realistic chance of cure...
  21. ncbi request reprint Inflammatory bowel disease associated with immune thrombocytopenic purpura in children
    L M Higuchi
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Pediatr Gastroenterol Nutr 33:582-7. 2001
    ..To date, only five children with both diseases have been described. The aim of the study was to describe the characteristics of children with IBD and ITP...
  22. ncbi request reprint Compact versus contract--industry sponsors' obligations to their research subjects
    Michelle M Mello
    Harvard School of Public Health, Boston, USA
    N Engl J Med 356:2737-43. 2007
  23. doi request reprint Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes
    Karen K Ballen
    Division of Hematology Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Biol Blood Marrow Transplant 18:903-12. 2012
    ..These results suggest that blacks have inferior survival to whites after single UCBT, but outcomes are improved when units with a higher cell dose are used...
  24. pmc Discontinuing bevacizumab in patients with glioblastoma: an ethical analysis
    Jennifer C Kesselheim
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Oncologist 16:1435-9. 2011
    ..With the increasing availability of new, modestly toxic, expensive drugs for patients with advanced cancer, questions of when to stop these drugs will become increasingly relevant...
  25. doi request reprint The challenge of research on ethics education
    Jennifer C Kesselheim
    Dana Farber Cancer Institute, Department of Pediatric Oncology, Boston, MA 02115, USA
    Am J Bioeth 8:12-3; author reply W1-2. 2008
  26. ncbi request reprint Informed consent for medical treatment and research: a review
    Marcela G del Carmen
    Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Oncologist 10:636-41. 2005
    ..S., highlight how consent to research differs from consent to treatment, and explore the difficulties that arise in research involving cancer patients and certain vulnerable populations...
  27. ncbi request reprint Ethical issues in cancer genetics: I 1) whose information is it?
    Katherine A Schneider
    Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, SM331, Boston, MA 02115, USA
    J Genet Couns 15:491-503. 2006
    ..e. duty to warn). We also provide a summary of consensus points and additional discussion questions for each case...
  28. ncbi request reprint Rethink "affirmative agreement," but abandon "assent"
    Steven Joffe
    Dana Farber Cancer Institute and Children s Hospital, Boston
    Am J Bioeth 3:9-11. 2003
  29. ncbi request reprint Quality of informed consent in cancer clinical trials: a cross-sectional survey
    S Joffe
    Department of Paediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
    Lancet 358:1772-7. 2001
    ..Efforts to educate providers and participants about the underlying goals of clinical trials are needed...
  30. ncbi request reprint Dana-Farber Cancer Institute ethics rounds: life-threatening illness and the desire to adopt
    Margaret O Little
    Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA
    Kennedy Inst Ethics J 15:385-93. 2005
    ....
  31. ncbi request reprint Children are not small adults: documentation of assent for research involving children
    David Ungar
    Division of Pediatric Hematology Oncology, Penn State Children s Hospital, Hershey, PA 17033, USA
    J Pediatr 149:S31-3. 2006
    ..Current practice for documenting assent is derived largely from documentation of informed consent for adults as there is little guidance in federal regulations. We propose a new approach to documenting assent...
  32. ncbi request reprint Altruistic discourse and therapeutic misconception in research informed consent
    Steven Joffe
    Dana Farber Cancer Institute and Children s Hospital
    Am J Bioeth 6:53-4. 2006
  33. ncbi request reprint Patients' views on financial conflicts of interest in cancer research trials
    Lindsay A Hampson
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 355:2330-7. 2006
    ..Financial ties between researchers or medical centers and companies whose drugs are being tested have come under increasing scrutiny...
  34. pmc Clinical trials and medical care: defining the therapeutic misconception
    Gail E Henderson
    University of North Carolina at ChapelHill, Chapel Hill, North Carolina, United Statesof America
    PLoS Med 4:e324. 2007
  35. ncbi request reprint Bench to bedside: mapping the moral terrain of clinical research
    Steven Joffe
    Hastings Cent Rep 38:30-42. 2008
    ..We need an entirely new conception of clinical research ethics - one that looks to science instead of the doctor-patient relationship...
  36. ncbi request reprint Evaluating the therapeutic misconception
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD, USA
    Kennedy Inst Ethics J 16:353-66. 2006
    ..After clarifying the ethical significance of the therapeutic misconception with respect to the decision making of patients, we offer policy recommendations for obtaining informed consent to participation in clinical trials...
  37. doi request reprint Individual physician practice variation in hematopoietic cell transplantation
    Stephanie J Lee
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D5 290, Seattle, WA 98109, USA
    J Clin Oncol 26:2162-70. 2008
    ..Previous studies have evaluated practice variation in hematopoietic cell transplantation (HCT) among transplant centers and countries. There are no studies investigating individual physician practice variation in HCT...
  38. ncbi request reprint Informed consent from the doctor?
    Steven Joffe
    Harvard Medical School, USA
    Hastings Cent Rep 34:12; discussion 12-3. 2004
  39. ncbi request reprint Frequency, type, and monetary value of financial conflicts of interest in cancer clinical research
    Lindsay A Hampson
    Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Clin Oncol 25:3609-14. 2007
    ..Using data from American Society of Clinical Oncology (ASCO) Annual Meetings, we determined the frequency, type, and monetary value of researchers' financial interests...
  40. ncbi request reprint ASCO core values
    Rebecca D Pentz
    Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    J Clin Oncol 24:5780-2. 2006
  41. pmc Incidental findings in human subjects research: what do investigators owe research participants?
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, USA
    J Law Med Ethics 36:271-9, 211. 2008
    ....

Research Grants6

  1. Returning Individual Genetic Results to Participants in Cohort Studies
    Steven Joffe; Fiscal Year: 2009
    ..These data will help shape practice and policy regarding the return of individual results from genomic research. ..
  2. Ethical Challenges in Cancer Clinical Research
    Steven Joffe; Fiscal Year: 2006
    ..Joffe's development as a local and national resource in research ethics for the oncology community. ..
  3. Compliance with adverse event reporting requirements in cancer clinical trials
    Steven Joffe; Fiscal Year: 2007
    ..Finally, public trust in and support for the research enterprise itself requires rigorous attention to the identification and management of adverse events. ..
  4. Returning Individual Genetic Results to Participants in Cohort Studies
    Steven Joffe; Fiscal Year: 2010
    ..These data will help shape practice and policy regarding the return of individual results from genomic research. ..
  5. Accountability and the Role of the Principal Investigator in Multicenter Trials
    Steven Joffe; Fiscal Year: 2010
    ..The findings of this proposal will either reaffirm trust in these trials, or will stimulate the development of enhanced systems of accountability for clinical research ..